mitomycin has been researched along with Leukemia, Myeloid in 17 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 1774 patients with breast cancer given mitoxantrone (MTZ) with methotrexate (n = 492) or with methotrexate and mitomycin C (n = 1282), nine developed MDS/AML after a median of 2." | 3.70 | Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma. ( Ashley, S; Kuan, A; Kulkarni, S; Mehta, J; Mitchell, P; Powles, R; Powles, T; Saso, R; Swansbury, GJ; Treleaven, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Korgaonkar, S | 1 |
| Ghosh, K | 1 |
| Vundinti, BR | 1 |
| HIBINO, S | 1 |
| WAKISAKA, G | 1 |
| UCHINO, H | 1 |
| NAKAMURA, T | 1 |
| SHIRAKAWA, S | 1 |
| ADACHI, A | 1 |
| SAKURAI, M | 1 |
| MIYAMOTO, K | 1 |
| KOISO, K | 1 |
| Amadori, S | 1 |
| Suciu, S | 1 |
| Willemze, R | 1 |
| Mandelli, F | 1 |
| Selleslag, D | 1 |
| Stauder, R | 1 |
| Ho, A | 1 |
| Denzlinger, C | 1 |
| Leone, G | 1 |
| Fabris, P | 1 |
| Muus, P | 1 |
| Vignetti, M | 1 |
| Hagemeijer, A | 1 |
| Beeldens, F | 1 |
| Anak, O | 1 |
| De Witte, T | 1 |
| Chen, F | 2 |
| Medhurst, AL | 2 |
| de Winter, JP | 2 |
| Waisfisz, Q | 2 |
| Rooimans, MA | 1 |
| Oostra, AB | 2 |
| Meyer, S | 2 |
| Zhang, KJ | 1 |
| Xia, B | 1 |
| Pals, G | 1 |
| Arwert, F | 1 |
| Zwaan, CM | 1 |
| Joenje, H | 2 |
| Fergusson, WD | 1 |
| Carr, TF | 1 |
| Clayton-Smith, J | 1 |
| Clancy, T | 1 |
| Green, M | 1 |
| Barber, L | 1 |
| Eden, OB | 1 |
| Will, AM | 1 |
| Taylor, GM | 1 |
| Mitchell, J | 1 |
| Keung, YK | 1 |
| Becher, R | 1 |
| Zimmer, G | 1 |
| Schmidt, CG | 1 |
| Sandberg, AA | 1 |
| Nishiyama, M | 3 |
| Saeki, S | 3 |
| Aogi, K | 3 |
| Hirabayashi, N | 3 |
| Toge, T | 3 |
| Philpott, NJ | 1 |
| Bevan, DH | 1 |
| Gordon-Smith, EC | 1 |
| Emoto, Y | 1 |
| Kisaki, H | 1 |
| Manome, Y | 1 |
| Kharbanda, S | 1 |
| Kufe, D | 1 |
| Saso, R | 1 |
| Kulkarni, S | 1 |
| Mitchell, P | 1 |
| Treleaven, J | 1 |
| Swansbury, GJ | 1 |
| Mehta, J | 1 |
| Powles, R | 1 |
| Ashley, S | 1 |
| Kuan, A | 1 |
| Powles, T | 1 |
| Nagasawa, M | 1 |
| Ishii, S | 1 |
| Kariya, Y | 1 |
| Itoh, O | 1 |
| Yamamoto, H | 1 |
| Kawaharajo, K | 1 |
| Takeuchi, T | 1 |
| Neville, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gemtuzumab Ozogamicin (CMA-676) Followed or Not by Intensive Chemotherapy as Initial Treatment for Elderly Patients With Acute Myeloid Leukemia: An EORTC-LG Pilot Phase II Study[NCT00006122] | Phase 2 | 106 participants (Actual) | Interventional | 2000-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mitomycin and Leukemia, Myeloid
| Article | Year |
|---|---|
Sequential administration of gemtuzumab ozogamicin and conventional chemotherapy as first line therapy in elderly patients with acute myeloid leukemia: a phase II study (AML-15) of the EORTC and GIMEMA leukemia groups.
Topics: Acute Disease; Aged; Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Ant | 2004 |
16 other studies available for mitomycin and Leukemia, Myeloid
| Article | Year |
|---|---|
Clinical, genetic and cytogenetic study of Fanconi anemia in an Indian population.
Topics: Adolescent; Carcinoma, Squamous Cell; Cells, Cultured; Child; Child, Preschool; Chromosome Breakage; | 2010 |
CHEMOTHERAPY OF LEUKEMIA AND ALLIED DISEASES, WITH SPECIAL REFERENCE TO MYTOMYCIN C.
Topics: Blood; Bone Marrow; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Mitomycin; Neoplasms | 1964 |
PRESENT STATUS OF LEUKEMIA IN JAPAN WITH SPECIAL REFERENCE TO EPIDEMIOLOGY AND STUDIES ON THE EFFECT OF CHEMOTHERAPY.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Asian People; Busulfan; DNA; DNA, Neoplasm; Epidemio | 1964 |
[STUDIES ON THE NUCLEIC ACID METABOLISM OF HUMAN LEUKEMIC LEUKOCYTES IN VITRO].
Topics: Adenine Nucleotides; Bone Marrow; Cyclophosphamide; DNA; Formates; Guanine Nucleotides; Humans; In V | 1964 |
Apparent absence of BRCA2 protein in a proportion of acute myeloid leukemia cell lines.
Topics: Acute Disease; Antibiotics, Antineoplastic; BRCA2 Protein; Drug Resistance, Neoplasm; Humans; Leukem | 2004 |
A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations.
Topics: Alleles; Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Child, Prescho | 2005 |
Acute myeloid leukemia following intraperitoneal hyperthermic mitomycin C.
Topics: Acute Disease; Adenocarcinoma; Adult; Chromosome Inversion; Chromosomes, Human, Pair 16; Female; Hum | 2006 |
Sister chromatid exchange in normal and Ph1-positive leukemic cells after mitomycin-C treatment in vitro.
Topics: Adolescent; Adult; Cells, Cultured; Chromosomes, Human, 21-22 and Y; Crossing Over, Genetic; Female; | 1984 |
[Mitomycin C and its bioreduction: relevance of NAD(P)H: quinone oxidoreductase activity to mitomycin C-induced DNA damage and cytotoxicity].
Topics: Carcinoma, Squamous Cell; Cell Division; Dicumarol; DNA Damage; Humans; Leukemia, Myeloid; Mitomycin | 1993 |
Secondary leukaemia after MMM combined modality therapy for breast carcinoma.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; F | 1993 |
Relevance of DT-diaphorase activity to mitomycin C (MMC) efficacy on human cancer cells: differences in in vitro and in vivo systems.
Topics: Animals; Humans; Leukemia, Myeloid; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; NAD(P)H | 1993 |
Activation of protein kinase Cdelta in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine.
Topics: Amino Acid Sequence; Apoptosis; Camptothecin; Cytarabine; DNA Damage; Endopeptidases; Enzyme Activat | 1996 |
Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma.
Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 2000 |
[Combination of a biscoclaurine alkaloid, cepharanthine, and anticancer agents: effects and mechanism in human gastric and pancreatic carcinoma cell lines].
Topics: Alkaloids; Antineoplastic Agents; Benzylisoquinolines; Cell Division; Doxorubicin; Drug Synergism; F | 1991 |
[In vitro combined effects of pirarubicin (THP) and various antitumor drugs on human tumor cell lines].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Doxorubicin; Dr | 1990 |
51Cr-uptake assay. A sensitive and reliable method to quantitate cell viability and cell death.
Topics: Azides; Cell Line; Cell Survival; Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; Dactinomy | 1987 |