mitomycin has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 3 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "FANCD2-Ub was upregulated in CD34+ chronic myeloid leukemia (CML) cells and in BCR-ABL1 kinase-positive cell lines in response to elevated levels of reactive oxygen species (ROS) and DNA cross-linking agent mitomycin C." | 1.37 | Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis. ( Blasiak, J; Glodkowska-Mrowka, E; Hoser, G; Klejman, A; Koptyra, M; Seferynska, I; Skorski, T; Stoklosa, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koptyra, M | 1 |
| Stoklosa, T | 1 |
| Hoser, G | 1 |
| Glodkowska-Mrowka, E | 1 |
| Seferynska, I | 1 |
| Klejman, A | 1 |
| Blasiak, J | 1 |
| Skorski, T | 2 |
| Falinski, R | 1 |
| Nieborowska-Skorska, M | 1 |
| Konstantinov, SM | 1 |
| Topashka-Ancheva, M | 1 |
| Benner, A | 1 |
| Berger, MR | 1 |
3 other studies available for mitomycin and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis.
Topics: Animals; Cell Line; DNA Breaks, Double-Stranded; Fanconi Anemia Complementation Group D2 Protein; Fu | 2011 |
BCR-ABL1 kinase facilitates localization of acetylated histones 3 and 4 on DNA double-strand breaks.
Topics: Acetylation; Animals; Cells, Cultured; Chromatin Assembly and Disassembly; DNA Breaks, Double-Strand | 2012 |
Alkylphosphocholines: Effects on human leukemic cell lines and normal bone marrow cells.
Topics: Alkylation; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Cell Cycle; Cell Division; | 1998 |