Page last updated: 2024-11-06

mitomycin and Infertility

mitomycin has been researched along with Infertility in 5 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Infertility: A reduced or absent capacity to reproduce.

Research Excerpts

ExcerptRelevanceReference
" Compared with Fancc(-)(/)(-) mice lacking FANCC, a component of the FA core complex, Helq(gt/gt) mice exhibited a mild of form of FA-like phenotypes including hypogonadism and cellular sensitivity to the crosslinker mitomycin C."3.79Helq acts in parallel to Fancc to suppress replication-associated genome instability. ( Akre, MK; Johnson, CS; Kawabata, T; Lee, WL; Luebben, SW; O'Sullivan, MG; Shima, N, 2013)
"Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation."3.71Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. ( D'Andrea, AD; Hays, T; Kuang, Y; Lu, N; Montes De Oca, R; Moreau, L; Seed, B; Yang, Y, 2001)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Pan, Y1
Yang, X1
Zhang, F1
Chen, S1
Zhou, Z1
Yin, H1
Ma, H1
Shang, L1
Yang, J1
Li, G1
Wang, Y1
Jin, L1
Shi, Q1
Wu, Y1
Luebben, SW1
Kawabata, T1
Akre, MK1
Lee, WL1
Johnson, CS1
O'Sullivan, MG1
Shima, N1
Bleuyard, JY1
Gallego, ME1
Savigny, F1
White, CI1
Yang, Y1
Kuang, Y1
Montes De Oca, R1
Hays, T1
Moreau, L1
Lu, N1
Seed, B1
D'Andrea, AD1
Koomen, M1
Cheng, NC1
van de Vrugt, HJ1
Godthelp, BC1
van der Valk, MA1
Oostra, AB1
Zdzienicka, MZ1
Joenje, H1
Arwert, F1

Other Studies

5 other studies available for mitomycin and Infertility

ArticleYear
A heterozygous hypomorphic mutation of Fanca causes impaired follicle development and subfertility in female mice.
    Molecular genetics and genomics : MGG, 2021, Volume: 296, Issue:1

    Topics: Alkylating Agents; Animals; Base Sequence; Disease Models, Animal; DNA Repair; Embryo, Mammalian; Fa

2021
Helq acts in parallel to Fancc to suppress replication-associated genome instability.
    Nucleic acids research, 2013, Volume: 41, Issue:22

    Topics: Alleles; Animals; Cells, Cultured; Chromosomal Proteins, Non-Histone; Cross-Linking Reagents; DNA He

2013
Differing requirements for the Arabidopsis Rad51 paralogs in meiosis and DNA repair.
    The Plant journal : for cell and molecular biology, 2005, Volume: 41, Issue:4

    Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Cross-Linking Reagents; DNA Repair; DNA-Bind

2005
Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.
    Blood, 2001, Dec-01, Volume: 98, Issue:12

    Topics: Alleles; Animals; Chromosome Breakage; Disease Models, Animal; DNA-Binding Proteins; Fanconi Anemia;

2001
Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice.
    Human molecular genetics, 2002, Feb-01, Volume: 11, Issue:3

    Topics: Animals; DNA; DNA Damage; DNA-Binding Proteins; Drug Hypersensitivity; Fanconi Anemia; Fanconi Anemi

2002