mitomycin has been researched along with Hypoxia in 31 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We determined the increase in antineoplastic activities of mitomycin C (MMC) and carboquone (CQ) against human tumor cells under conditions of in vitro hypoxia, with the following results." | 7.67 | Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro. ( Kusumoto, T; Maehara, Y; Sakaguchi, Y; Saku, M; Sugimachi, K, 1989) |
| "The response rate and time to disease progression were the primary endpoints, with overall survival as the secondary endpoint." | 6.71 | Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: a pilot study. ( Amicucci, G; Deraco, M; Di Filippo, F; Fiorentini, G; Guadagni, S; Miotto, D; Patuzzo, R; Pilati, PL; Rossi, CR; Santinami, M; Valenti, M, 2003) |
| "In contrast to earlier reports HAP and CAI with MMC and Melphalan did not demonstrate any benefit in terms of tumour response, median survival and pain reduction, compared to less invasive treatment options." | 5.11 | Balloon catheter hypoxic abdominal perfusion with Mitomycin C and Melphalan for locally advanced pancreatic cancer: a phase I-II trial. ( de Bruijn, EA; Eggermont, AM; Guetens, G; Jeekel, J; ten Hagen, TL; van Eijck, CH; van Etten, B; van IJken, MG, 2004) |
| " In contrast, porfiromycin was considerably less cytotoxic to wild-type parental cells than was mitomycin C in air and markedly more cytotoxic under hypoxia." | 3.69 | Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase. ( Belcourt, MF; Hodnick, WF; Rockwell, S; Sartorelli, AC, 1996) |
| " We determined the increase in antineoplastic activities of mitomycin C (MMC) and carboquone (CQ) against human tumor cells under conditions of in vitro hypoxia, with the following results." | 3.67 | Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro. ( Kusumoto, T; Maehara, Y; Sakaguchi, Y; Saku, M; Sugimachi, K, 1989) |
| " A pharmacokinetic study was performed in 18 patients." | 2.84 | Mitomycin C hypoxic pelvic perfusion for unresectable recurrent rectal cancer: pharmacokinetic comparison of surgical and percutaneous techniques. ( Clementi, M; Fiorentini, G; Guadagni, S; Mambrini, A; Masedu, F; Palumbo, P, 2017) |
| "The response rate and time to disease progression were the primary endpoints, with overall survival as the secondary endpoint." | 2.71 | Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: a pilot study. ( Amicucci, G; Deraco, M; Di Filippo, F; Fiorentini, G; Guadagni, S; Miotto, D; Patuzzo, R; Pilati, PL; Rossi, CR; Santinami, M; Valenti, M, 2003) |
| " MMC was assayed by high-pressure liquid chromatography (HPLC), and pharmacokinetic parameters were determined using an open, two-compartment model and linear kinetics." | 1.31 | Pharmacokinetics of intraarterial mitomycin C in hypoxic hepatic infusion with embolization in the treatment of liver metastases. ( Cerretani, D; Civeli, L; Correale, P; De Manzoni, G; Francini, G; Giorgi, G; Marrelli, D; Pieraccini, M; Pinto, E; Roviello, F, 2002) |
| "Hypoxic cells of solid tumors are relatively resistant to therapeutic assault." | 1.27 | Therapeutic attack of hypoxic cells of solid tumors: presidential address. ( Sartorelli, AC, 1988) |
| "Cellular subpopulations of solid tumors can be divided into compartments based upon their degree of oxygenation and their rate of proliferation." | 1.26 | Hypoxic cell specific chemotherapeutic agents. ( Sartorelli, AC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (25.81) | 18.7374 |
| 1990's | 10 (32.26) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, S | 1 |
| Yao, H | 2 |
| Pei, L | 1 |
| Hu, M | 1 |
| Li, D | 1 |
| Qiu, Y | 1 |
| Wang, G | 1 |
| Wu, L | 1 |
| Zhu, Z | 1 |
| Xu, J | 1 |
| Guadagni, S | 3 |
| Fiorentini, G | 2 |
| Clementi, M | 1 |
| Palumbo, P | 1 |
| Mambrini, A | 1 |
| Masedu, F | 1 |
| Cowen, RL | 1 |
| Garside, EJ | 1 |
| Fitzpatrick, B | 1 |
| Papadopoulou, MV | 1 |
| Williams, KJ | 1 |
| Palom, Y | 1 |
| Suresh Kumar, G | 1 |
| Tang, LQ | 1 |
| Paz, MM | 1 |
| Musser, SM | 1 |
| Rockwell, S | 4 |
| Tomasz, M | 1 |
| Santinami, M | 1 |
| Patuzzo, R | 1 |
| Pilati, PL | 1 |
| Miotto, D | 1 |
| Deraco, M | 1 |
| Rossi, CR | 1 |
| Di Filippo, F | 1 |
| Valenti, M | 1 |
| Amicucci, G | 1 |
| Cerretani, D | 1 |
| Roviello, F | 1 |
| Pieraccini, M | 1 |
| Civeli, L | 1 |
| Correale, P | 1 |
| Francini, G | 1 |
| Marrelli, D | 1 |
| De Manzoni, G | 1 |
| Pinto, E | 1 |
| Giorgi, G | 1 |
| Kaluzová, M | 1 |
| Kaluz, S | 1 |
| Lerman, MI | 1 |
| Stanbridge, EJ | 1 |
| van IJken, MG | 2 |
| van Etten, B | 1 |
| Guetens, G | 1 |
| ten Hagen, TL | 2 |
| Jeekel, J | 1 |
| de Bruijn, EA | 2 |
| Eggermont, AM | 2 |
| van Eijck, CH | 2 |
| de Boeck, G | 1 |
| Gadaleta, CD | 1 |
| Catino, A | 1 |
| Ranieri, G | 1 |
| Armenise, F | 1 |
| Console, G | 1 |
| Mattioli, V | 1 |
| Takeda, S | 1 |
| Funakoshi, Y | 1 |
| Kadota, Y | 1 |
| Koma, M | 1 |
| Maeda, H | 1 |
| Kawamura, S | 1 |
| Matsubara, Y | 1 |
| Kennedy, KA | 1 |
| Siegfried, JM | 1 |
| Sartorelli, AC | 6 |
| Tritton, TR | 1 |
| Ludwig, C | 1 |
| Falk, SJ | 1 |
| Ramsay, JR | 1 |
| Ward, R | 1 |
| Miles, K | 1 |
| Dixon, AK | 1 |
| Bleehen, NM | 1 |
| Belcourt, MF | 2 |
| Hodnick, WF | 2 |
| Kang, Y | 1 |
| Greaves, B | 1 |
| Perry, RR | 1 |
| Ben-Ari, GY | 1 |
| Roversi, R | 1 |
| Ricci, S | 1 |
| Rossi, G | 1 |
| Roversi, M | 1 |
| Cavallo, G | 1 |
| Lorenz, M | 1 |
| Petrowsky, H | 1 |
| Heinrich, S | 1 |
| Janshon, G | 1 |
| Staib-Sebler, E | 1 |
| Poloczek, Y | 1 |
| Gog, C | 1 |
| Oremek, G | 1 |
| Encke, A | 1 |
| Jiang, HB | 1 |
| Ichikawa, M | 1 |
| Furukawa, A | 1 |
| Tomita, S | 1 |
| Ohnishi, T | 1 |
| Ichikawa, Y | 1 |
| Peh, HL | 1 |
| Toh, A | 1 |
| Murugasu-Oei, B | 1 |
| Dick, T | 1 |
| Krishna, MC | 1 |
| DeGraff, W | 1 |
| Tamura, S | 1 |
| Gonzalez, FJ | 1 |
| Samuni, A | 1 |
| Russo, A | 2 |
| Mitchell, JB | 2 |
| Hoban, PR | 1 |
| Walton, MI | 1 |
| Robson, CN | 1 |
| Godden, J | 1 |
| Stratford, IJ | 1 |
| Workman, P | 1 |
| Harris, AL | 1 |
| Hickson, ID | 1 |
| Keyes, SR | 1 |
| Kusumoto, T | 1 |
| Maehara, Y | 1 |
| Sakaguchi, Y | 1 |
| Saku, M | 1 |
| Sugimachi, K | 1 |
| Ashwell, JD | 1 |
| Schwartz, RH | 1 |
| Sheldon, R | 1 |
| Slaughter, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Study on Second Line Treatment of Colorectal Liver Metastases (KRas wt) by Hepatic Intra-arterial Chemoembolization With Dc Beads 70-150 μm Microspheres Preloaded With Irinotecan 200 Mgr Plus Systemic Cetuximab[NCT01891552] | 40 participants (Actual) | Observational [Patient Registry] | 2013-05-31 | Completed | |||
| Prospective Observational Study on Isolated Limb Perfusion of Melphalan in Treating Patients With Metastasis or Recidivism of Limb Melanoma or Sarcoma That Are Not Operable[NCT01920516] | 40 participants (Anticipated) | Observational | 2013-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mitomycin and Hypoxia
| Article | Year |
|---|---|
Gene therapy approaches to enhance bioreductive drug treatment.
Topics: Alkylating Agents; Animals; Anthraquinones; Breast Neoplasms; Cytochrome P-450 Enzyme System; Cytoch | 2008 |
7 trials available for mitomycin and Hypoxia
| Article | Year |
|---|---|
Mitomycin C hypoxic pelvic perfusion for unresectable recurrent rectal cancer: pharmacokinetic comparison of surgical and percutaneous techniques.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Carcinoma, Squamous Cel | 2017 |
Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusio | 2003 |
Balloon catheter hypoxic abdominal perfusion with Mitomycin C and Melphalan for locally advanced pancreatic cancer: a phase I-II trial.
Topics: Aged; Antineoplastic Agents; Balloon Occlusion; Chemotherapy, Cancer, Regional Perfusion; Female; Hu | 2004 |
Hypoxic stop-flow perfusion with mitomycin-C in the treatment of multifocal liver metastases. Usefulness of a vascular arterial stent to prevent iatrogenic lesions of the hepatic arterial wall.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Balloon Occlusion; Chemotherapy, Cancer, Regional Perfusio | 2003 |
BW12C perturbs normal and tumour tissue oxygenation and blood flow in man.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzaldehydes; Cohort Studies; Erythrocytes; Gastroi | 1994 |
Isolated hypoxic perfusion with mitomycin C in patients with advanced pancreatic cancer.
Topics: Aged; Antibiotics, Antineoplastic; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Hypoxia | 1998 |
Isolated hypoxic perfusion with mitomycin C in patients with advanced pancreatic cancer.
Topics: Antibiotics, Antineoplastic; Chemotherapy, Cancer, Regional Perfusion; Humans; Hypoxia; Mitomycin; N | 1999 |
23 other studies available for mitomycin and Hypoxia
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Diterpenes, Kaurane; Drug | 2017 |
Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Breast Neoplasm | 2002 |
Pharmacokinetics of intraarterial mitomycin C in hypoxic hepatic infusion with embolization in the treatment of liver metastases.
Topics: Adult; Aged; Area Under Curve; Colorectal Neoplasms; Embolization, Therapeutic; Female; Humans; Hypo | 2002 |
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.
Topics: Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Line, Tumor; Cysteine Endopepti | 2004 |
Balloon catheter hypoxic abdominal and pelvic perfusion with tumour necrosis factor-alpha, Melphalan and Mitomycin C: a pharmacokinetic study in pigs.
Topics: Abdominal Neoplasms; Animals; Antineoplastic Agents; Balloon Occlusion; Chemotherapy, Cancer, Region | 2004 |
Fall in diffusing capacity associated with induction therapy for lung cancer: a predictor of postoperative complication?
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbon Monoxide; Carcinoma, La | 2006 |
Effects of anthracyclines on oxygenated and hypoxic tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Carmustine; Cell Survival; Chromatography, High Pressure Liqui | 1983 |
Drug resistance of hypoxic tumour cells in vitro.
Topics: Animals; Anthracenes; Cell Line; DNA, Single-Stranded; Drug Evaluation, Preclinical; Drug Resistance | 1984 |
Hypoxic cell specific chemotherapeutic agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry, P | 1982 |
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
Topics: Aerobiosis; Animals; Biotransformation; CHO Cells; Cricetinae; Glutathione Transferase; Humans; Hypo | 1996 |
Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase.
Topics: Animals; Cell Survival; CHO Cells; Cricetinae; Dihydrolipoamide Dehydrogenase; Dose-Response Relatio | 1996 |
Effect of acute and chronic intermittent hypoxia on DNA topoisomerase II alpha expression and mitomycin C-induced DNA damage and cytotoxicity in human colon cancer cells.
Topics: Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; Humans; Hypoxia; Isomerases; M | 1996 |
Treatment of abdominal malignancies using total abdominal stop-flow infusion and hypoxic perfusion.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, | 1997 |
[Locoregional therapy with hypoxic liver perfusion in malignant neoplasms of the gallbladder. Preliminary experience].
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Carcinoid Tumor; Chemotherapy, Cancer, Regional P | 1997 |
Metabolic activation of mitomycin C by NADPH-ferredoxin reductase in vitro.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Biotransformation; Cattle; DNA Damage; Escherichia | 2001 |
In vitro activities of mitomycin C against growing and hypoxic dormant tubercle bacilli.
Topics: Antibiotics, Antineoplastic; Cell Survival; Colony Count, Microbial; Humans; Hypoxia; In Vitro Techn | 2001 |
Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.
Topics: Aerobiosis; Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Cyclic N-Oxides; Elect | 1991 |
Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.
Topics: Aerobiosis; Alkylating Agents; Anaerobiosis; Animals; Biotransformation; Cell Line; Cell Survival; C | 1990 |
Modulation of the cytotoxicity of mitomycin C to EMT6 mouse mammary tumor cells by dicoumarol in vitro.
Topics: Animals; Cell Line; Cell Survival; Dicumarol; Drug Synergism; Hypoxia; Mammary Neoplasms, Experiment | 1988 |
Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro.
Topics: Azirines; Carbazilquinone; Carcinoma; Cells, Cultured; Colorectal Neoplasms; HeLa Cells; Humans; Hyp | 1989 |
Effect of gamma radiation on resting B lymphocytes. I. Oxygen-dependent damage to the plasma membrane results in increased permeability and cell enlargement.
Topics: Animals; B-Lymphocytes; Cell Line; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Cispl | 1986 |
A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Female; Hemolytic-Uremic Syndrome; Humans; Hypoxia; | 1986 |
Therapeutic attack of hypoxic cells of solid tumors: presidential address.
Topics: Animals; Humans; Hypoxia; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental | 1988 |