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mitomycin and Hyperplasia

mitomycin has been researched along with Hyperplasia in 11 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
"MRI showed that the scar adhesion and scar area of the MMC-PLA group were significantly reduced compared with those of the PLA, MMC, and saline groups."5.46Controlled-release mitomycin C-polylactic acid film prevents epidural scar hyperplasia after laminectomy by inducing fibroblast autophagy and regulating the expression of miRNAs. ( Gu, Y; Liu, J; Tang, F; Wang, BB; Wu, J; Wu, T; Xie, H; Xie, N, 2017)
"Local delivery of mitomycin C had no favorable effect on the inhibition of intimal hyperplasia compared with control saline-treated arteries."3.69Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine. ( Escaned, J; Murphy, ES; Serruys, PW; Strauss, BH; van der Giessen, WJ; van Houten, R; van Suylen, RJ; Verdouw, PD; Wilson, RA, 1994)
"The authors studied the effect of bladder instillation of mitomycin C (MMC), a potential carcinogen, on the duration and severity of the hyperplasia induced by transurethral fulguration."3.67Mutual neoplastic promotion by instillation of mitomycin C and cauterization on rat bladder urothelium. ( Akaza, H; Koseki, K; Niijima, T, 1986)
"MRI showed that the scar adhesion and scar area of the MMC-PLA group were significantly reduced compared with those of the PLA, MMC, and saline groups."1.46Controlled-release mitomycin C-polylactic acid film prevents epidural scar hyperplasia after laminectomy by inducing fibroblast autophagy and regulating the expression of miRNAs. ( Gu, Y; Liu, J; Tang, F; Wang, BB; Wu, J; Wu, T; Xie, H; Xie, N, 2017)
"Although experimental induction of bladder cancer with powerful carcinogens may completely overwhelm host defenses and result in more and higher grade neoplasms, similar tumors may occur after exposure to substances not generally considered to be carcinogenic."1.27Bladder cancer induced by noncarcinogenic substances. ( Akaza, H; Murphy, WM; Soloway, MS, 1984)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19906 (54.55)18.7374
1990's2 (18.18)18.2507
2000's0 (0.00)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, BB1
Xie, H1
Wu, T1
Xie, N1
Wu, J1
Gu, Y1
Tang, F1
Liu, J1
Ma, IH1
Hu, FR1
Wang, IJ1
Chen, WL1
Hsu, YJ1
Chu, HS1
Yuan, CT1
Hou, YC1
Kim, BH1
Kim, MK1
Wee, WR1
Oh, JY1
Ohtani, M2
Fukushima, S3
Ito, N2
Koiso, K2
Niijima, T3
Akaza, H2
Murphy, WM1
Soloway, MS1
Okamura, T2
Sakata, T1
Strauss, BH1
Wilson, RA1
van Houten, R1
van Suylen, RJ1
Murphy, ES1
Escaned, J1
Verdouw, PD1
Serruys, PW1
van der Giessen, WJ1
Shibata, MA1
Hasegawa, R1
Kurata, Y1
Yamada, M1
Tamano, S1
Koseki, K1
Maier, U1
Holzner, JH1

Trials

1 trial available for mitomycin and Hyperplasia

ArticleYear
[Significance of urothelial dysplasia in macroscopically normal mucosa in patients with bladder tumors. Results of a randomized study with and without intravesical mitomycin C in the prevention of recurrence].
    Onkologie, 1985, Volume: 8, Issue:4

    Topics: Aged; Biopsy; Clinical Trials as Topic; Female; Humans; Hyperplasia; Male; Middle Aged; Mitomycin; M

1985

Other Studies

10 other studies available for mitomycin and Hyperplasia

ArticleYear
Controlled-release mitomycin C-polylactic acid film prevents epidural scar hyperplasia after laminectomy by inducing fibroblast autophagy and regulating the expression of miRNAs.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:10

    Topics: Animals; Autophagy; Cicatrix; Collagen; Delayed-Action Preparations; Drug Delivery Systems; Dura Mat

2017
Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019, Volume: 118, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Conjunctival Neopla

2019
Clinical and pathological characteristics of ocular surface squamous neoplasia in an Asian population.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013, Volume: 251, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Asian People; Carcinoma in Situ; Carcinoma, S

2013
Effects of intravesical instillation of antitumor drugs on the induction of preneoplastic bladder lesions in rats.
    Cancer chemotherapy and pharmacology, 1983, Volume: 11 Suppl

    Topics: Animals; Butylhydroxybutylnitrosamine; Doxorubicin; Female; Hyperplasia; Mitomycin; Mitomycins; Prec

1983
Bladder cancer induced by noncarcinogenic substances.
    The Journal of urology, 1984, Volume: 131, Issue:1

    Topics: Administration, Topical; Animals; Carcinoma, Papillary; Cisplatin; Female; Hyperplasia; Mitomycin; M

1984
Effects of intravesical instillation of antitumor chemotherapeutic agents on bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
    Cancer, 1984, Oct-15, Volume: 54, Issue:8

    Topics: Animals; Antineoplastic Agents; Butylhydroxybutylnitrosamine; Doxorubicin; Drug Synergism; Female; H

1984
Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine.
    Coronary artery disease, 1994, Volume: 5, Issue:7

    Topics: Acetylcholine; Angioplasty, Balloon; Animals; Endothelium, Vascular; Hemodynamics; Hyperplasia; Ilia

1994
Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C.
    Cancer letters, 1990, Volume: 49, Issue:1

    Topics: Administration, Intravesical; Animals; DNA; Doxorubicin; Epithelium; Female; Hyperplasia; Microscopy

1990
Mutual neoplastic promotion by instillation of mitomycin C and cauterization on rat bladder urothelium.
    Cancer, 1986, Feb-15, Volume: 57, Issue:4

    Topics: Animals; Cautery; Cocarcinogenesis; Female; Hyperplasia; Microscopy, Electron, Scanning; Mitomycin;

1986
[Effect of intrabladder instillation of various anticancer agents on carcinogenesis in rat bladder].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:11

    Topics: Administration, Intravesical; Animals; Antineoplastic Agents; Butylhydroxybutylnitrosamine; Doxorubi

1988