mitomycin has been researched along with Huntington Disease in 2 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The expanded CAG repeat in the Huntington's disease (HD) gene may display tissue-specific variability (e." | 1.35 | DNA instability in replicating Huntington's disease lymphoblasts. ( Cannella, M; Frati, L; Li, GM; Maglione, V; Martino, T; Ragona, G; Squitieri, F, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cannella, M | 1 |
| Maglione, V | 1 |
| Martino, T | 1 |
| Ragona, G | 1 |
| Frati, L | 1 |
| Li, GM | 1 |
| Squitieri, F | 1 |
| Evans, HJ | 1 |
| Newton, MS | 1 |
2 other studies available for mitomycin and Huntington Disease
| Article | Year |
|---|---|
DNA instability in replicating Huntington's disease lymphoblasts.
Topics: Cell Division; Cell Line; Cross-Linking Reagents; Ethidium; Ethyl Methanesulfonate; Female; Humans; | 2009 |
The response of cells from patients with Huntington's chorea to mutagen-induced chromosome damage.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Crossing Over, Genetic; DNA; Ethyl Meth | 1982 |