Page last updated: 2024-11-06

mitomycin and Hemolysis

mitomycin has been researched along with Hemolysis in 8 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

Research Excerpts

ExcerptRelevanceReference
"Patients with refractory solid tumors (n = 51) were treated with a 48-h continuous intravenous infusion of menadione followed by a bolus intravenous dose of mitomycin C at the completion of the menadione infusion."2.68Phase I study of mitomycin C and menadione in advanced solid tumors. ( Ahn, C; Akman, SA; Doroshow, JH; Leong, LA; Margolin, KA; Morgan, RJ; Raschko, JW; Somlo, G, 1995)
"Mitomycin C (MMC) is a water-soluble anticancer drug extensively used in first-line chemotherapy but is limited by its poor aqueous stability in vitro, rapid elimination from the body, and lack of target specificity."1.40Mitomycin C-soybean phosphatidylcholine complex-loaded self-assembled PEG-lipid-PLA hybrid nanoparticles for targeted drug delivery and dual-controlled drug release. ( Hou, Z; Huang, Y; Jia, M; Li, Y; Lin, J; Wu, H; Wu, S; Yang, X, 2014)
"Mitomycin C (MMC) has been known to be nephrotoxic since 1971."1.27Mitomycin C-induced renal toxicity, a dose-dependent side effect? ( de Vries, J; Pinedo, HM; Verwey, J, 1987)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, Y2
Wu, H1
Yang, X1
Jia, M1
Huang, Y1
Lin, J1
Wu, S1
Hou, Z1
Papo, N1
Shai, Y1
SOKAWA, Y1
EGAMI, F1
Shen, AY1
Tsai, JH1
Teng, HC1
Huang, MH1
Wu, SN1
Margolin, KA1
Akman, SA1
Leong, LA1
Morgan, RJ1
Somlo, G1
Raschko, JW1
Ahn, C1
Doroshow, JH1
Sugiyama, K1
Inoue, K1
Sakazaki, R1
Oscarsson, J1
Westermark, M1
Beutin, L1
Uhlin, BE1
Verwey, J1
de Vries, J1
Pinedo, HM1

Trials

1 trial available for mitomycin and Hemolysis

ArticleYear
Phase I study of mitomycin C and menadione in advanced solid tumors.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Erythrocytes; Female; Glucosephosphate

1995

Other Studies

7 other studies available for mitomycin and Hemolysis

ArticleYear
Mitomycin C-soybean phosphatidylcholine complex-loaded self-assembled PEG-lipid-PLA hybrid nanoparticles for targeted drug delivery and dual-controlled drug release.
    Molecular pharmaceutics, 2014, Aug-04, Volume: 11, Issue:8

    Topics: Animals; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Glycine max; HeLa Cells; Hemolysis;

2014
New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells.
    Biochemistry, 2003, Aug-12, Volume: 42, Issue:31

    Topics: Anti-Infective Agents; Antimicrobial Cationic Peptides; Cell Death; Cell Membrane; Fluoresceins; Hem

2003
RELEASE OF THE HEMOLYTIC COMPONENT OF STREPTOLYSIN S BY ATP AND MAGNESIUM ION FROM A PROTOPLAST MEMBRANE FRACTION OF STREPTOCOCCI.
    Journal of biochemistry, 1965, Volume: 57

    Topics: Adenosine Triphosphate; Bacterial Proteins; Biochemical Phenomena; Biochemistry; Chloramphenicol; Ch

1965
Inhibition of intermediate-conductance Ca2+-activated K+ channel and cytoprotective properties of 4-piperidinomethyl-2-isopropyl-5-methylphenol.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:5

    Topics: Antioxidants; Cells, Cultured; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysi

2007
Mitomycin-supplemented washed blood agar for the isolation of Shiga toxin-producing Escherichia coli other than O157:H7.
    Letters in applied microbiology, 2001, Volume: 33, Issue:3

    Topics: Blood; Culture Media; Escherichia coli; Escherichia coli Proteins; Feces; Hemolysin Proteins; Hemoly

2001
The bacteriophage-associated ehly1 and ehly2 determinants from Escherichia coli O26:H- strains do not encode enterohemolysins per se but cause release of the ClyA cytolysin.
    International journal of medical microbiology : IJMM, 2002, Volume: 291, Issue:8

    Topics: Bacterial Toxins; Bacteriophage P1; Blotting, Western; Erythrocytes; Escherichia coli; Escherichia c

2002
Mitomycin C-induced renal toxicity, a dose-dependent side effect?
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:2

    Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Hemolysis; Hemolytic-Uremic Syndrome; Humans;

1987