mitomycin has been researched along with Genome Instability in 29 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Compared with Fancc(-)(/)(-) mice lacking FANCC, a component of the FA core complex, Helq(gt/gt) mice exhibited a mild of form of FA-like phenotypes including hypogonadism and cellular sensitivity to the crosslinker mitomycin C." | 3.79 | Helq acts in parallel to Fancc to suppress replication-associated genome instability. ( Akre, MK; Johnson, CS; Kawabata, T; Lee, WL; Luebben, SW; O'Sullivan, MG; Shima, N, 2013) |
| "BCR/ABL-positive leukemia cells accumulated more replication-dependent DNA double-strand breaks (DSBs) than normal counterparts after treatment with cisplatin and mitomycin C (MMC, as assessed by pulse field gel electrophoresis (PFGE) and neutral comet assay." | 3.73 | ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks. ( Blasiak, J; Czechowska, A; Datta, M; Koptyra, M; Krszyna, K; Nieborowska-Skorska, M; Rink, L; Seferynska, I; Skorski, T; Slupianek, A; Stoklosa, T, 2006) |
| " In chromosomal breakage assays, all control cells were mitomycin C (MMC) resistant, but eight samples (five of the six high-risk and three of the eight ovarian cancer) were hypersensitive." | 3.73 | Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer. ( Akkari, Y; Ameziane, N; Bagby, GC; Bale, AE; Cain, JM; Cappuccini, F; Errami, A; Hays, LE; Keeble, W; Liu, HY; Olson, SB; Pejovic, T; Rathbun, RK; Rodgers, WH; Thuillier, P; Torimaru, Y; Yates, JE; Zwaan, CM, 2006) |
| "Homologous recombination (HR) prevents genomic instability by repair and protection of replication." | 1.56 | Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer. ( Becker, S; Borgmann, K; Classen, S; Jasin, M; Mansour, WY; Meyer, F; Parplys, AC; Petersen, C; Riepen, B; Rothkamm, K; Ruebe, C; Timm, S; Wikman, H, 2020) |
| "Furthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extent of genomic instability in primary VX2 tumor tissue." | 1.42 | Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells. ( Bei, J; Feng, F; Feng, Q; Hong, J; Hu, W; Kang, T; Liang, Y; Peng, R; Sang, Y; Xu, M; Zeng, Y, 2015) |
| "To gain direct evidence that genomic instability is involved in the induction of SLCCs, we utilized multiple approaches to enhance genomic instability and monitored the percentage of SLCC in cultured cancer cells." | 1.36 | Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. ( Cao, J; Deng, W; Huang, Y; Kang, T; Liang, Y; Liu, Q; Pei, D; Tsao, G; Zeng, YX; Zhong, Z, 2010) |
| "The disease Fanconi anemia is a genome instability syndrome characterized by cellular sensitivity to DNA interstrand cross-linking agents, manifest by decreased cellular survival and chromosomal aberrations after such treatment." | 1.35 | Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway. ( Al-Dhalimy, M; Hejna, J; Hemphill, A; Hines, J; Holtorf, M; Mathewson, L; Moses, RE; Olson, SB, 2008) |
| "Therefore, genomic instability generated NCCAs are a key driving force in cancer progression." | 1.33 | Stochastic cancer progression driven by non-clonal chromosome aberrations. ( Bremer, SW; Heng, HH; Liu, G; Reddy, PV; Stevens, JB; Tainsky, MA; Wang, YA; Wu, GS; Ye, CJ; Ye, KJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 15 (51.72) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, F | 1 |
| Becker, S | 1 |
| Classen, S | 1 |
| Parplys, AC | 2 |
| Mansour, WY | 1 |
| Riepen, B | 1 |
| Timm, S | 1 |
| Ruebe, C | 1 |
| Jasin, M | 2 |
| Wikman, H | 1 |
| Petersen, C | 1 |
| Rothkamm, K | 1 |
| Borgmann, K | 1 |
| Wei, B | 1 |
| Peng, Z | 1 |
| Huang, T | 1 |
| Guan, Q | 1 |
| Xie, M | 1 |
| Xiong, T | 1 |
| Shi, R | 1 |
| Wang, Y | 1 |
| Gao, Y | 1 |
| Xu, X | 1 |
| Mao, S | 1 |
| Xiao, Y | 1 |
| Song, S | 1 |
| Wang, L | 1 |
| Tian, B | 1 |
| Zhao, Y | 1 |
| Hua, Y | 1 |
| Xu, H | 1 |
| Awate, S | 1 |
| Sommers, JA | 2 |
| Datta, A | 1 |
| Nayak, S | 1 |
| Bellani, MA | 1 |
| Yang, O | 1 |
| Dunn, CA | 1 |
| Nicolae, CM | 1 |
| Moldovan, GL | 1 |
| Seidman, MM | 1 |
| Cantor, SB | 2 |
| Brosh, RM | 2 |
| Nolan, M | 1 |
| Knudson, K | 1 |
| Holz, MK | 1 |
| Chaudhury, I | 1 |
| Frye, SA | 1 |
| Beyene, GT | 1 |
| Namouchi, A | 1 |
| Gómez-Muñoz, M | 1 |
| Homberset, H | 1 |
| Kalayou, S | 1 |
| Riaz, T | 1 |
| Tønjum, T | 1 |
| Balasingham, SV | 1 |
| Francies, FZ | 1 |
| Wainwright, R | 1 |
| Poole, J | 1 |
| De Leeneer, K | 1 |
| Coene, I | 1 |
| Wieme, G | 1 |
| Poirel, HA | 1 |
| Brichard, B | 1 |
| Vermeulen, S | 1 |
| Vral, A | 1 |
| Slabbert, J | 1 |
| Claes, K | 1 |
| Baeyens, A | 1 |
| Erikel, E | 1 |
| Yuzbasioglu, D | 1 |
| Unal, F | 1 |
| Luebben, SW | 1 |
| Kawabata, T | 1 |
| Akre, MK | 1 |
| Lee, WL | 1 |
| Johnson, CS | 1 |
| O'Sullivan, MG | 1 |
| Shima, N | 1 |
| Bharti, SK | 1 |
| Khan, I | 1 |
| Banerjee, T | 1 |
| Wu, Y | 1 |
| Moreno-Palomo, J | 1 |
| Creus, A | 1 |
| Marcos, R | 1 |
| Hernández, A | 1 |
| Zhou, D | 1 |
| Lin, G | 1 |
| Zeng, SC | 1 |
| Xiong, B | 1 |
| Xie, PY | 1 |
| Cheng, DH | 1 |
| Zheng, Q | 1 |
| Ouyang, Q | 1 |
| Zhou, XY | 1 |
| Tang, WL | 1 |
| Sun, Y | 1 |
| Lu, GY | 1 |
| Lu, GX | 1 |
| Liang, Y | 2 |
| Feng, Q | 1 |
| Hong, J | 1 |
| Feng, F | 1 |
| Sang, Y | 1 |
| Hu, W | 1 |
| Xu, M | 1 |
| Peng, R | 1 |
| Kang, T | 2 |
| Bei, J | 1 |
| Zeng, Y | 1 |
| Zhao, W | 1 |
| Sharma, N | 1 |
| Groesser, T | 1 |
| Liang, F | 1 |
| Maranon, DG | 1 |
| Leung, SG | 1 |
| Grundt, K | 1 |
| Dray, E | 1 |
| Idate, R | 1 |
| Østvold, AC | 1 |
| Schild, D | 1 |
| Sung, P | 1 |
| Wiese, C | 1 |
| Ogrunc, M | 1 |
| Martinez-Zamudio, RI | 1 |
| Sadoun, PB | 1 |
| Dore, G | 1 |
| Schwerer, H | 1 |
| Pasero, P | 1 |
| Lemaitre, JM | 1 |
| Dejean, A | 1 |
| Bischof, O | 1 |
| Marsden, CG | 1 |
| Jensen, RB | 1 |
| Zagelbaum, J | 1 |
| Rothenberg, E | 1 |
| Morrical, SW | 1 |
| Wallace, SS | 1 |
| Sweasy, JB | 1 |
| Xiao, H | 1 |
| Zhang, K | 1 |
| Xia, B | 1 |
| Hemphill, AW | 1 |
| Akkari, Y | 2 |
| Newell, AH | 1 |
| Schultz, RA | 1 |
| Grompe, M | 1 |
| North, PS | 1 |
| Hickson, ID | 1 |
| Jakobs, PM | 1 |
| Rennie, S | 1 |
| Pauw, D | 1 |
| Hejna, J | 2 |
| Olson, SB | 3 |
| Moses, RE | 2 |
| Zhong, Z | 1 |
| Huang, Y | 1 |
| Deng, W | 1 |
| Cao, J | 1 |
| Tsao, G | 1 |
| Liu, Q | 1 |
| Pei, D | 1 |
| Zeng, YX | 1 |
| Xie, J | 1 |
| Litman, R | 1 |
| Wang, S | 1 |
| Peng, M | 1 |
| Guillemette, S | 1 |
| Rooney, T | 1 |
| Orsburn, B | 1 |
| Escudero, B | 1 |
| Prakash, M | 1 |
| Gesheva, S | 1 |
| Liu, G | 2 |
| Huso, DL | 1 |
| Franco, S | 1 |
| Smeenk, G | 1 |
| de Groot, AJ | 1 |
| Romeijn, RJ | 1 |
| van Buul, PP | 1 |
| Zdzienicka, MZ | 1 |
| Mullenders, LH | 1 |
| Pastink, A | 1 |
| Godthelp, BC | 1 |
| McPherson, JP | 1 |
| Lemmers, B | 1 |
| Chahwan, R | 1 |
| Pamidi, A | 2 |
| Migon, E | 1 |
| Matysiak-Zablocki, E | 2 |
| Moynahan, ME | 1 |
| Essers, J | 1 |
| Hanada, K | 1 |
| Poonepalli, A | 2 |
| Sanchez-Sweatman, O | 1 |
| Khokha, R | 1 |
| Kanaar, R | 1 |
| Hande, MP | 2 |
| Hakem, R | 2 |
| Raouf, A | 1 |
| Brown, L | 1 |
| Vrcelj, N | 1 |
| To, K | 1 |
| Kwok, W | 1 |
| Huntsman, D | 1 |
| Eaves, CJ | 1 |
| Nieborowska-Skorska, M | 1 |
| Stoklosa, T | 1 |
| Datta, M | 1 |
| Czechowska, A | 1 |
| Rink, L | 1 |
| Slupianek, A | 1 |
| Koptyra, M | 1 |
| Seferynska, I | 1 |
| Krszyna, K | 1 |
| Blasiak, J | 1 |
| Skorski, T | 1 |
| Heng, HH | 1 |
| Stevens, JB | 1 |
| Bremer, SW | 1 |
| Ye, KJ | 1 |
| Reddy, PV | 1 |
| Wu, GS | 1 |
| Wang, YA | 1 |
| Tainsky, MA | 1 |
| Ye, CJ | 1 |
| Pejovic, T | 1 |
| Yates, JE | 1 |
| Liu, HY | 1 |
| Hays, LE | 1 |
| Torimaru, Y | 1 |
| Keeble, W | 1 |
| Rathbun, RK | 1 |
| Rodgers, WH | 1 |
| Bale, AE | 1 |
| Ameziane, N | 1 |
| Zwaan, CM | 1 |
| Errami, A | 1 |
| Thuillier, P | 1 |
| Cappuccini, F | 1 |
| Cain, JM | 1 |
| Bagby, GC | 1 |
| Cardoso, R | 1 |
| Hakem, A | 1 |
| Tamblyn, L | 1 |
| Perez-Ordonez, B | 1 |
| Sanchez, O | 1 |
| Holtorf, M | 1 |
| Hines, J | 1 |
| Mathewson, L | 1 |
| Hemphill, A | 1 |
| Al-Dhalimy, M | 1 |
1 review available for mitomycin and Genome Instability
| Article | Year |
|---|---|
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome.
Topics: Abnormalities, Multiple; DEAD-box RNA Helicases; DNA Breaks; DNA Helicases; G-Quadruplexes; Genomic | 2014 |
28 other studies available for mitomycin and Genome Instability
| Article | Year |
|---|---|
Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Cell Line, T | 2020 |
Stability of potential prophages in commercial strain Lactobacillus plantarum NCU116 under various stressors.
Topics: Antibiotics, Antineoplastic; Genome, Bacterial; Genomic Instability; Lactobacillus plantarum; Mitomy | 2020 |
Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability.
Topics: Camptothecin; Cell Cycle Proteins; DNA Damage; DNA Repair; DNA Replication; Exonucleases; Flap Endon | 2020 |
FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.
Topics: BRCA1 Protein; Chromosomal Instability; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA-Bin | 2020 |
Fanconi anemia and mTOR pathways functionally interact during stalled replication fork recovery.
Topics: Aphidicolin; Cell Survival; DNA; DNA Repair; DNA Replication; Fanconi Anemia; Fanconi Anemia Complem | 2021 |
The helicase DinG responds to stress due to DNA double strand breaks.
Topics: Bacterial Proteins; DNA Breaks, Double-Stranded; DNA Helicases; DNA, Bacterial; Gene Expression Regu | 2017 |
Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei.
Topics: Adolescent; Adult; Case-Control Studies; Cell Cycle; Child; DNA Damage; DNA Mutational Analysis; DNA | 2018 |
In vitro genotoxic and antigenotoxic effects of cynarin.
Topics: Adult; Anticarcinogenic Agents; Cells, Cultured; Chromosome Aberrations; Cinnamates; Comet Assay; DN | 2019 |
Helq acts in parallel to Fancc to suppress replication-associated genome instability.
Topics: Alleles; Animals; Cells, Cultured; Chromosomal Proteins, Non-Histone; Cross-Linking Reagents; DNA He | 2013 |
Genomic instability in newborn with short telomeres.
Topics: Fetal Blood; Genomic Instability; Humans; Infant, Newborn; Micronucleus Tests; Mitomycin; Mutagens; | 2014 |
Trace levels of mitomycin C disrupt genomic integrity and lead to DNA damage response defect in long-term-cultured human embryonic stem cells.
Topics: Apoptosis; Cell Culture Techniques; Cell Cycle; Cells, Cultured; Chromatography, High Pressure Liqui | 2015 |
Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Genomic Instability; Humans; Mice; Mitom | 2015 |
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Topics: Cell Line; Chromatin; Chromosome Aberrations; DNA; DNA Damage; DNA Replication; DNA-Binding Proteins | 2015 |
RETRACTED: USP1 Regulates Cellular Senescence by Controlling Genomic Integrity.
Topics: Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Nucleus; Cellular Senescence; Chromatin; Cyclin-De | 2016 |
The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.
Topics: BRCA2 Protein; Breast Neoplasms; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Damage; DN | 2016 |
[Search for Fanconi anemia/BRCA pathway defects in lymphoma cell lines].
Topics: Animals; Antibiotics, Antineoplastic; Base Sequence; BRCA2 Protein; Cell Cycle; Cell Line, Tumor; Ce | 2008 |
Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents.
Topics: Animals; Cell Line; Cross-Linking Reagents; DNA; DNA Topoisomerases, Type I; Fanconi Anemia; Genomic | 2009 |
Stem-like cancer cells are inducible by increasing genomic instability in cancer cells.
Topics: AC133 Antigen; Antigens, CD; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Ca | 2010 |
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Topics: Adaptor Proteins, Signal Transducing; Basic-Leucine Zipper Transcription Factors; BRCA1 Protein; Cel | 2010 |
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Topics: Aging; Animals; B-Lymphocytes; Chromosomal Proteins, Non-Histone; DNA; DNA Breaks, Double-Stranded; | 2010 |
Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.
Topics: Animals; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Damage; DNA-Binding Proteins; Embryonic | 2010 |
Involvement of mammalian Mus81 in genome integrity and tumor suppression.
Topics: Alleles; Animals; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Embryo, Mammalian; Embry | 2004 |
Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY.
Topics: Aneuploidy; Antibiotics, Antineoplastic; BRCA2 Protein; Breast; Breast Neoplasms; Cross-Linking Reag | 2005 |
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Checkpoint Kinas | 2006 |
Stochastic cancer progression driven by non-clonal chromosome aberrations.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cul | 2006 |
Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer.
Topics: Adult; Aged; Chromosome Breakage; DNA Methylation; DNA, Complementary; Epithelial Cells; Fanconi Ane | 2006 |
Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Cell Growth Processes; DNA; DNA Damage; DNA-Binding Pr | 2007 |
Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway.
Topics: Active Transport, Cell Nucleus; Cell Line; Cell Nucleus; Cell Survival; Chromatin Assembly and Disas | 2008 |