mitomycin has been researched along with Genetic Predisposition in 27 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with superficial bladder cancer, the occurrence of primary carcinoma in situ was significantly greater in patients with the AA genotype compared with those with the GA or GG genotypes (P = 0." | 5.32 | Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer. ( Habuchi, T; Higashi, S; Ito, M; Kamoto, T; Nishiyama, H; Ogawa, O; Tsuchiya, N; Wang, L; Watanabe, J, 2004) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " A total of 21 genetic variants were studied in 35 breast cancer patients treated with 5-FluoroUracil, mitomycin (FUMI) and in a similar cohort of 90 doxorubicin treated breast cancer patients." | 3.74 | Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival. ( Alnaes, GI; Børresen-Dale, AL; Hihn, B; Kristensen, VN; Liestøl, K; Lingjaerde, OC; Lønning, PE; Nordgard, SH; Sørlie, T; Tsalenko, A, 2008) |
| " In chromosomal breakage assays, all control cells were mitomycin C (MMC) resistant, but eight samples (five of the six high-risk and three of the eight ovarian cancer) were hypersensitive." | 3.73 | Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer. ( Akkari, Y; Ameziane, N; Bagby, GC; Bale, AE; Cain, JM; Cappuccini, F; Errami, A; Hays, LE; Keeble, W; Liu, HY; Olson, SB; Pejovic, T; Rathbun, RK; Rodgers, WH; Thuillier, P; Torimaru, Y; Yates, JE; Zwaan, CM, 2006) |
| " To assess DNA repair for breast cancer susceptibility, we developed a modified HCR assay using a plasmid containing a firefly luciferase gene damaged by mitomycin C (MMC), which forms interstrand cross-link (ICL) adducts." | 3.72 | Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay. ( Ahn, B; Kang, D; Kim, H; Wei, Q, 2004) |
| "Of 1774 patients with breast cancer given mitoxantrone (MTZ) with methotrexate (n = 492) or with methotrexate and mitomycin C (n = 1282), nine developed MDS/AML after a median of 2." | 3.70 | Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma. ( Ashley, S; Kuan, A; Kulkarni, S; Mehta, J; Mitchell, P; Powles, R; Powles, T; Saso, R; Swansbury, GJ; Treleaven, J, 2000) |
| "Oral squamous cell carcinoma (OSCC) may develop in young adults." | 1.43 | Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma. ( Braakhuis, BJ; Brakenhoff, RH; Flach, GB; Graveland, AP; Joenje, H; Leemans, CR; Nieuwint, AW; Oostra, AB, 2016) |
| "Leukemias and squamous cell carcinomas (SCCs) are the most predominant FA-associated cancers, with the latter exhibiting markedly early disease onset and aggressiveness." | 1.35 | Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. ( Cha, E; Duensing, S; Higginbotham, JM; Hoskins, EE; Kelly, P; Morris, TA; Spardy, N; Wells, SI; Wikenheiser-Brokamp, KA; Williams, DA, 2009) |
| "There is evidence to suggest that the breast cancer predisposing gene, BRCA1, is involved in cell cycle control and the response to damage but mouse brca1+/- heterozygotes have no distinctive phenotype." | 1.32 | Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment. ( Eccles, D; Eeles, R; Latham, H; McMillan, TJ; Peacock, JH; Shorrocks, J; Tobi, SE, 2004) |
| "In patients with superficial bladder cancer, the occurrence of primary carcinoma in situ was significantly greater in patients with the AA genotype compared with those with the GA or GG genotypes (P = 0." | 1.32 | Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer. ( Habuchi, T; Higashi, S; Ito, M; Kamoto, T; Nishiyama, H; Ogawa, O; Tsuchiya, N; Wang, L; Watanabe, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 14 (51.85) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Frost, MG | 1 |
| Mazloumi Aboukheili, AM | 1 |
| Toth, R | 1 |
| Walden, H | 1 |
| Gayarre, J | 1 |
| Martín-Gimeno, P | 1 |
| Osorio, A | 1 |
| Paumard, B | 1 |
| Barroso, A | 1 |
| Fernández, V | 1 |
| de la Hoya, M | 1 |
| Rojo, A | 1 |
| Caldés, T | 1 |
| Palacios, J | 1 |
| Urioste, M | 1 |
| Benítez, J | 2 |
| García, MJ | 1 |
| Colombo, M | 1 |
| Lòpez-Perolio, I | 1 |
| Meeks, HD | 1 |
| Caleca, L | 1 |
| Parsons, MT | 1 |
| Li, H | 1 |
| De Vecchi, G | 1 |
| Tudini, E | 1 |
| Foglia, C | 1 |
| Mondini, P | 1 |
| Manoukian, S | 1 |
| Behar, R | 1 |
| Garcia, EBG | 1 |
| Meindl, A | 1 |
| Montagna, M | 1 |
| Niederacher, D | 1 |
| Schmidt, AY | 1 |
| Varesco, L | 1 |
| Wappenschmidt, B | 1 |
| Bolla, MK | 1 |
| Dennis, J | 1 |
| Michailidou, K | 1 |
| Wang, Q | 1 |
| Aittomäki, K | 1 |
| Andrulis, IL | 1 |
| Anton-Culver, H | 1 |
| Arndt, V | 1 |
| Beckmann, MW | 1 |
| Beeghly-Fadel, A | 1 |
| Boeckx, B | 1 |
| Bogdanova, NV | 1 |
| Bojesen, SE | 1 |
| Bonanni, B | 1 |
| Brauch, H | 1 |
| Brenner, H | 1 |
| Burwinkel, B | 1 |
| Chang-Claude, J | 1 |
| Conroy, DM | 1 |
| Couch, FJ | 2 |
| Cox, A | 2 |
| Cross, SS | 1 |
| Czene, K | 1 |
| Devilee, P | 1 |
| Dörk, T | 1 |
| Eriksson, M | 1 |
| Fasching, PA | 1 |
| Figueroa, J | 1 |
| Fletcher, O | 1 |
| Flyger, H | 1 |
| Gabrielson, M | 1 |
| García-Closas, M | 1 |
| Giles, GG | 1 |
| González-Neira, A | 1 |
| Guénel, P | 1 |
| Haiman, CA | 1 |
| Hall, P | 1 |
| Hamann, U | 1 |
| Hartman, M | 1 |
| Hauke, J | 1 |
| Hollestelle, A | 1 |
| Hopper, JL | 1 |
| Jakubowska, A | 1 |
| Jung, A | 1 |
| Kosma, VM | 1 |
| Lambrechts, D | 1 |
| Le Marchand, L | 1 |
| Lindblom, A | 1 |
| Lubinski, J | 1 |
| Mannermaa, A | 1 |
| Margolin, S | 1 |
| Miao, H | 1 |
| Milne, RL | 1 |
| Neuhausen, SL | 1 |
| Nevanlinna, H | 1 |
| Olson, JE | 1 |
| Peterlongo, P | 1 |
| Peto, J | 1 |
| Pylkäs, K | 1 |
| Sawyer, EJ | 1 |
| Schmidt, MK | 1 |
| Schmutzler, RK | 1 |
| Schneeweiss, A | 1 |
| Schoemaker, MJ | 1 |
| See, MH | 1 |
| Southey, MC | 1 |
| Swerdlow, A | 1 |
| Teo, SH | 1 |
| Toland, AE | 1 |
| Tomlinson, I | 1 |
| Truong, T | 1 |
| van Asperen, CJ | 1 |
| van den Ouweland, AMW | 1 |
| van der Kolk, LE | 1 |
| Winqvist, R | 1 |
| Yannoukakos, D | 1 |
| Zheng, W | 1 |
| Dunning, AM | 1 |
| Easton, DF | 1 |
| Henderson, A | 1 |
| Hogervorst, FBL | 1 |
| Izatt, L | 1 |
| Offitt, K | 1 |
| Side, LE | 1 |
| van Rensburg, EJ | 1 |
| Embrace, S | 1 |
| Hebon, S | 1 |
| McGuffog, L | 1 |
| Antoniou, AC | 1 |
| Chenevix-Trench, G | 1 |
| Spurdle, AB | 1 |
| Goldgar, DE | 1 |
| Hoya, M | 1 |
| Radice, P | 1 |
| Xu, X | 1 |
| Zhang, Y | 1 |
| Zhao, S | 1 |
| Bian, Y | 1 |
| Ning, Y | 1 |
| Qin, Y | 1 |
| Moiseyenko, VM | 1 |
| Chubenko, VA | 1 |
| Moiseyenko, FV | 1 |
| Zhabina, AS | 1 |
| Gorodnova, TV | 1 |
| Komarov, YI | 1 |
| Bogdanov, AA | 1 |
| Sokolenko, AP | 1 |
| Imyanitov, EN | 1 |
| Deng, X | 1 |
| Zhang, X | 1 |
| Cheng, Y | 1 |
| Yang, X | 1 |
| Zhao, R | 1 |
| Liu, X | 1 |
| Li, X | 1 |
| Qin, C | 1 |
| Lu, Q | 1 |
| Yin, C | 1 |
| El Hamichi, S | 1 |
| Messaoudi, R | 1 |
| Belmalih, M | 1 |
| Iferkhass, S | 1 |
| Zerrouk, R | 1 |
| Reda, K | 1 |
| Oubaaz, A | 1 |
| Braakhuis, BJ | 1 |
| Nieuwint, AW | 1 |
| Oostra, AB | 1 |
| Joenje, H | 1 |
| Flach, GB | 1 |
| Graveland, AP | 1 |
| Brakenhoff, RH | 1 |
| Leemans, CR | 1 |
| Matsuzaki, K | 1 |
| Borel, V | 1 |
| Adelman, CA | 1 |
| Schindler, D | 1 |
| Boulton, SJ | 1 |
| Hoskins, EE | 1 |
| Morris, TA | 1 |
| Higginbotham, JM | 1 |
| Spardy, N | 1 |
| Cha, E | 1 |
| Kelly, P | 1 |
| Williams, DA | 1 |
| Wikenheiser-Brokamp, KA | 1 |
| Duensing, S | 1 |
| Wells, SI | 1 |
| Auerbach, AD | 1 |
| Hayakawa, T | 1 |
| Zhang, F | 1 |
| Hayakawa, N | 1 |
| Ohtani, Y | 1 |
| Shinmyozu, K | 1 |
| Nakayama, J | 1 |
| Andreassen, PR | 1 |
| Wark, L | 1 |
| Novak, D | 1 |
| Sabbaghian, N | 1 |
| Amrein, L | 1 |
| Jangamreddy, JR | 1 |
| Cheang, M | 1 |
| Pouchet, C | 1 |
| Aloyz, R | 1 |
| Foulkes, WD | 1 |
| Mai, S | 1 |
| Tischkowitz, M | 1 |
| Stewart, G | 1 |
| Elledge, SJ | 1 |
| Shorrocks, J | 1 |
| Tobi, SE | 1 |
| Latham, H | 1 |
| Peacock, JH | 1 |
| Eeles, R | 1 |
| Eccles, D | 1 |
| McMillan, TJ | 1 |
| Han, J | 1 |
| Colditz, GA | 1 |
| Samson, LD | 1 |
| Hunter, DJ | 1 |
| McPherson, JP | 1 |
| Lemmers, B | 1 |
| Chahwan, R | 1 |
| Pamidi, A | 1 |
| Migon, E | 1 |
| Matysiak-Zablocki, E | 1 |
| Moynahan, ME | 1 |
| Essers, J | 1 |
| Hanada, K | 1 |
| Poonepalli, A | 1 |
| Sanchez-Sweatman, O | 1 |
| Khokha, R | 1 |
| Kanaar, R | 1 |
| Jasin, M | 1 |
| Hande, MP | 1 |
| Hakem, R | 1 |
| Ito, M | 1 |
| Habuchi, T | 1 |
| Watanabe, J | 1 |
| Higashi, S | 1 |
| Nishiyama, H | 1 |
| Wang, L | 1 |
| Tsuchiya, N | 1 |
| Kamoto, T | 1 |
| Ogawa, O | 1 |
| Ahn, B | 1 |
| Kang, D | 1 |
| Kim, H | 1 |
| Wei, Q | 1 |
| Wu, K | 1 |
| Hinson, SR | 1 |
| Ohashi, A | 1 |
| Farrugia, D | 1 |
| Wendt, P | 1 |
| Tavtigian, SV | 1 |
| Deffenbaugh, A | 1 |
| Goldgar, D | 1 |
| Pejovic, T | 1 |
| Yates, JE | 1 |
| Liu, HY | 1 |
| Hays, LE | 1 |
| Akkari, Y | 1 |
| Torimaru, Y | 1 |
| Keeble, W | 1 |
| Rathbun, RK | 1 |
| Rodgers, WH | 1 |
| Bale, AE | 1 |
| Ameziane, N | 1 |
| Zwaan, CM | 1 |
| Errami, A | 1 |
| Thuillier, P | 1 |
| Cappuccini, F | 1 |
| Olson, SB | 1 |
| Cain, JM | 1 |
| Bagby, GC | 1 |
| Nordgard, SH | 1 |
| Alnaes, GI | 1 |
| Hihn, B | 1 |
| Lingjaerde, OC | 1 |
| Liestøl, K | 1 |
| Tsalenko, A | 1 |
| Sørlie, T | 1 |
| Lønning, PE | 1 |
| Børresen-Dale, AL | 1 |
| Kristensen, VN | 1 |
| Liou, SH | 1 |
| Gu, TL | 1 |
| Chen, CJ | 1 |
| Yu, VP | 1 |
| Koehler, M | 1 |
| Steinlein, C | 1 |
| Schmid, M | 1 |
| Hanakahi, LA | 1 |
| van Gool, AJ | 1 |
| West, SC | 1 |
| Venkitaraman, AR | 1 |
| Saso, R | 1 |
| Kulkarni, S | 1 |
| Mitchell, P | 1 |
| Treleaven, J | 1 |
| Swansbury, GJ | 1 |
| Mehta, J | 1 |
| Powles, R | 1 |
| Ashley, S | 1 |
| Kuan, A | 1 |
| Powles, T | 1 |
| Rafii, S | 1 |
| O'Regan, P | 1 |
| Xinarianos, G | 1 |
| Azmy, I | 1 |
| Stephenson, T | 1 |
| Reed, M | 1 |
| Meuth, M | 1 |
| Thacker, J | 1 |
2 reviews available for mitomycin and Genetic Predisposition
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Fanconi anemia and its diagnosis.
Topics: Congenital Abnormalities; DNA Damage; Endocrine System Diseases; Epoxy Compounds; Fanconi Anemia; Ge | 2009 |
1 trial available for mitomycin and Genetic Predisposition
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
25 other studies available for mitomycin and Genetic Predisposition
| Article | Year |
|---|---|
Characterization of FANCL variants observed in patient cancer cells.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Bone Neoplasms; Cell Line, Tumor; Cell Surviva | 2020 |
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Breast Neoplasms; Carcinoma; Case-Control Studies; Cell | 2017 |
The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity.
Topics: Base Sequence; BRCA2 Protein; Calibration; Cell Line; Exons; Female; Genetic Predisposition to Disea | 2018 |
Mutational analysis of theFAM175A gene in patients with premature ovarian insufficiency.
Topics: Adult; BRCA1 Protein; Carrier Proteins; DNA Damage; DNA Mutational Analysis; DNA Repair; Female; Gen | 2019 |
Evidence for clinical efficacy of mitomycin C in heavily pretreated ovarian cancer patients carrying germ-line BRCA1 mutation.
Topics: Adult; Aged; Alkylating Agents; BRCA1 Protein; Female; Genetic Predisposition to Disease; Germ-Line | 2014 |
XRCC1 polymorphisms associated with survival among Chinese bladder cancer patients receiving epirubicin and mitomycin C.
Topics: Aged; Alleles; Biomarkers, Pharmacological; China; Disease-Free Survival; DNA-Binding Proteins; Epir | 2015 |
Bilateral enucleation avoided by excision with mitomycin C for bilateral infiltrating conjunctival squamous cell carcinoma in a girl with xeroderma pigmentosum.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Child; Combined Modality Therapy; Conjunctival Neop | 2015 |
Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.
Topics: Adult; Carcinoma, Squamous Cell; Chromosome Breakage; DNA Damage; Fanconi Anemia; Female; Genetic Pr | 2016 |
FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Topics: Animals; Antineoplastic Agents; Basic-Leucine Zipper Transcription Factors; Camptothecin; Cell Line; | 2015 |
Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.
Topics: Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Proliferation; C | 2009 |
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Topics: Breast Neoplasms; Chromatin; Chromosome Breakage; Comet Assay; Cross-Linking Reagents; DNA; DNA Repa | 2010 |
Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.
Topics: Adolescent; Adult; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, In | 2013 |
The two faces of BRCA2, a FANCtastic discovery.
Topics: Animals; BRCA2 Protein; DNA Damage; DNA Repair; Fanconi Anemia; Fanconi Anemia Complementation Group | 2002 |
Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment.
Topics: Alkylating Agents; Breast Neoplasms; Cell Cycle; DNA Damage; Fibroblasts; G1 Phase; Genes, BRCA1; Ge | 2004 |
Polymorphisms in DNA double-strand break repair genes and skin cancer risk.
Topics: Adult; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Case-Control Studies; Cell Survival; DNA Dam | 2004 |
Involvement of mammalian Mus81 in genome integrity and tumor suppression.
Topics: Alleles; Animals; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Embryo, Mammalian; Embry | 2004 |
Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer.
Topics: Aged; Alternative Splicing; Antineoplastic Agents, Alkylating; BCG Vaccine; Carcinoma in Situ; Carci | 2004 |
Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay.
Topics: Animals; Breast Neoplasms; Cell Line; Cross-Linking Reagents; DNA Damage; DNA Repair; Fireflies; Gen | 2004 |
Functional evaluation and cancer risk assessment of BRCA2 unclassified variants.
Topics: Animals; BRCA2 Protein; Centrosome; Chromosome Segregation; Cross-Linking Reagents; DNA, Complementa | 2005 |
Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer.
Topics: Adult; Aged; Chromosome Breakage; DNA Methylation; DNA, Complementary; Epithelial Cells; Fanconi Ane | 2006 |
Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antibiotics, Antineoplastic; Antimetabolites, | 2008 |
Hypersensitivity to mitomycin C-induced sister chromatid exchange as a biomarker of past exposure to arsenic.
Topics: Aged; Arsenic; Biomarkers; Carcinogens; Environmental Exposure; Feasibility Studies; Female; Fresh W | 1996 |
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.
Topics: Animals; Annexin A5; BRCA2 Protein; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cross-Link | 2000 |
Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma.
Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 2000 |
A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.
Topics: Aged; Amino Acid Substitution; Breast Neoplasms; Cell Survival; DNA Repair; DNA-Binding Proteins; Fe | 2002 |