mitomycin has been researched along with Gallbladder Neoplasms in 30 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Gallbladder Neoplasms: Tumors or cancer of the gallbladder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based on a recent pharmacokinetic study suggesting that high biliary levels of mitomycin C (MMC) may be achieved as a result of an entero-hepatic recycling mechanism, we conducted a Phase II EORTC trial which involved MMC administration to patients with non-resectable biliary tract carcinoma." | 9.07 | Phase II trial of mitomycin C (MMC) in advanced gallbladder and biliary tree carcinoma. An EORTC Gastrointestinal Tract Cancer Cooperative Group Study. ( Audisio, RA; Bleiberg, H; Blijham, GH; Duez, N; Neijt, JP; Sahmoud, T; Taal, BG; Veenhof, CH, 1993) |
| "A case of carcinoid tumor of the gallbladder, which was sensitive to mitomycin-C is reported." | 7.68 | [Mitomycin-C-sensitive carcinoid tumor of the gallbladder: report of a case]. ( Morisaki, Y; Shima, S; Sugiura, Y; Tanaka, S; Yoshizumi, Y, 1992) |
| "Based on a recent pharmacokinetic study suggesting that high biliary levels of mitomycin C (MMC) may be achieved as a result of an entero-hepatic recycling mechanism, we conducted a Phase II EORTC trial which involved MMC administration to patients with non-resectable biliary tract carcinoma." | 5.07 | Phase II trial of mitomycin C (MMC) in advanced gallbladder and biliary tree carcinoma. An EORTC Gastrointestinal Tract Cancer Cooperative Group Study. ( Audisio, RA; Bleiberg, H; Blijham, GH; Duez, N; Neijt, JP; Sahmoud, T; Taal, BG; Veenhof, CH, 1993) |
| "A case of carcinoid tumor of the gallbladder, which was sensitive to mitomycin-C is reported." | 3.68 | [Mitomycin-C-sensitive carcinoid tumor of the gallbladder: report of a case]. ( Morisaki, Y; Shima, S; Sugiura, Y; Tanaka, S; Yoshizumi, Y, 1992) |
| "Four patients with gallbladder cancer and two with bile duct cancer were treated with mitomycin C, carboquone, 5-fluorouracil and OK-432 (MQF-OK therapy) plus tegafur (FT) or UFT." | 3.67 | [MQF-FT and MQF-UFT in gallbladder and bile duct cancer]. ( Fukushi, G; Itoh, T; Kimura, M; Kimura, T; Kishibe, T; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y; Tsushima, K, 1988) |
| " Main adverse events grades 2/3/4 were (n): leukocytopenia 3/2/2, anemia 13/4/0, thrombocytopenia 3/1/0, nausea/vomiting 2/1/0, diarrhea 5/1/0, hand-foot-skin reaction 7/0/0." | 2.75 | Efficacy and safety of capecitabine in combination with docetaxel and mitomycin C in patients with pre-treated pancreatic, gallbladder, and bile duct carcinoma. ( Ernst, T; Hochhaus, A; Hofheinz, RD; Hofmann, WK; Kripp, M; Kruth, J; Lukan, N; Merx, K; Nissen, J, 2010) |
| "Seven patients with advanced gallbladder cancer were treated by arterial infusion chemotherapy." | 2.67 | [Evaluation of arterial infusion chemotherapy for advanced gallbladder cancer using implantable port]. ( Fujiwara, Y; Hata, Y; Higaki, T; Hisa, N; Kamiike, O; Morita, S; Yoshida, D; Yoshida, S, 1994) |
| "They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas." | 2.58 | Gemcitabine-based chemotherapy for advanced biliary tract carcinomas. ( Abdel-Rahman, O; Elhalawani, H; Elsayed, Z, 2018) |
| "Gallbladder cancer is an aggressive tumor." | 2.46 | [Chemotherapy in gallbladder carcinoma]. ( Abahssain, H; Afchain, P; Errihani, H; Ismaili, N; Melas, N; Rabti, HM; Rahali, R, 2010) |
| "Mitomycin C (88." | 1.40 | Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: outcomes from a single tertiary institution. ( Hiotis, S; Jibara, G; Labow, DM; Romanoff, A; Sarpel, U; Shrager, B; Tabrizian, P; Yang, MJ, 2014) |
| " Since a curative operation is impossible in this case, we started systemic chemotherapy employing S-1 combined with hepatic arterial infusion using epirubicin hydrochloride and mitomycin C." | 1.34 | [A case of unresectable advanced gallbladder cancer treated by systemic chemotherapy combined with hepatic arterial infusion]. ( Ishiguro, A; Itoh, J; Munakata, A; Munakata, M; Sakata, Y; Shitara, K; Suzuki, K; Takahata, T, 2007) |
| "Thirty-five patients with gallbladder cancer were treated with superselective intra-arterial chemotherapy (SIAC) with mitomycin C during 1981-1996." | 1.33 | Intra-arterial chemotherapy with mitomycin C in gallbladder cancer: a follow-up study. ( Bode, MK; Leinonen, S; Mäkelä, JT; Perälä, J, 2005) |
| "Although gallbladder cancer (GBC) is believed to be chemoresistant, the effectiveness of chemotherapy against lymph node metastasis has been reported." | 1.30 | Lymph node recurrence of gallbladder carcinoma successfully managed by systemic chemotherapy with 5-fluorouracil and mitomycin C: report of a 5-year survivor. ( Hatakeyama, K; Ohtani, T; Shirai, Y; Tsukada, K, 1997) |
| " Furthermore, the effectiveness of this therapy is greatly anticipated for the unresectable abdominal cancer, evaluating the selection of anti-cancer drugs and their administration dosage etc." | 1.30 | [Aortic stop flow and hypoxic perfusion chemotherapy for unresectable gallbladder cancer]. ( Aoki, T; Asami, K; Inoue, K; Kasuya, K; Koyanagi, Y; Masuhara, S; Ozawa, T; Tsuchida, A; Uda, O, 1998) |
| "In the case of gall bladder cancer cell line (NOZ), combination of adriamycin and hyperthermia showed more effective inhibition for cell proliferation than MMC + hyperthermia and 5-FU + hyperthermia." | 1.28 | [Combination therapy of hyperthermia and other methods in liver and bile tract cancers--evaluation of these methods using cancer cell lines in vitro]. ( Fujise, K; Hasumura, S; Homma, S; Kameda, H; Matsuura, T; Nagamori, S; Niiya, M; Shimizu, K; Sujino, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 11 (36.67) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Rahman, O | 1 |
| Elsayed, Z | 1 |
| Elhalawani, H | 1 |
| Tabrizian, P | 1 |
| Shrager, B | 1 |
| Jibara, G | 1 |
| Yang, MJ | 1 |
| Romanoff, A | 1 |
| Hiotis, S | 1 |
| Sarpel, U | 1 |
| Labow, DM | 1 |
| Randle, RW | 1 |
| Levine, EA | 1 |
| Clark, CJ | 1 |
| Stewart, JH | 1 |
| Shen, P | 1 |
| Votanopoulos, KI | 1 |
| Kruth, J | 1 |
| Nissen, J | 1 |
| Ernst, T | 1 |
| Kripp, M | 1 |
| Lukan, N | 1 |
| Merx, K | 1 |
| Hofmann, WK | 1 |
| Hochhaus, A | 1 |
| Hofheinz, RD | 1 |
| Abahssain, H | 1 |
| Afchain, P | 1 |
| Melas, N | 1 |
| Ismaili, N | 1 |
| Rahali, R | 1 |
| Rabti, HM | 1 |
| Errihani, H | 1 |
| Ishii, H | 1 |
| Furuse, J | 1 |
| Yonemoto, N | 1 |
| Nagase, M | 1 |
| Yoshino, M | 1 |
| Sato, T | 1 |
| Soma, I | 1 |
| Hasuike, Y | 1 |
| Hayashi, N | 1 |
| Fukuchi, N | 1 |
| Izawa, H | 1 |
| Yoshida, T | 1 |
| Ebisui, C | 1 |
| Sakita, I | 1 |
| Fujimoto, T | 1 |
| Koshino, T | 1 |
| Izumiyama, K | 1 |
| Bode, MK | 1 |
| Perälä, J | 1 |
| Mäkelä, JT | 2 |
| Leinonen, S | 1 |
| Ishiguro, A | 1 |
| Munakata, M | 1 |
| Shitara, K | 1 |
| Suzuki, K | 1 |
| Takahata, T | 1 |
| Itoh, J | 1 |
| Sakata, Y | 2 |
| Munakata, A | 1 |
| Smith, GW | 1 |
| Bukowski, RM | 1 |
| Hewlett, JS | 1 |
| Groppe, CW | 1 |
| Hata, Y | 1 |
| Morita, S | 1 |
| Hisa, N | 1 |
| Fujiwara, Y | 1 |
| Higaki, T | 1 |
| Kamiike, O | 1 |
| Yoshida, D | 1 |
| Yoshida, S | 1 |
| Kato, K | 1 |
| Koike, A | 1 |
| Koide, T | 1 |
| Kojima, T | 1 |
| Kawai, Y | 1 |
| Kuroda, H | 1 |
| Tanaka, K | 1 |
| Takeshige, K | 1 |
| Taal, BG | 1 |
| Audisio, RA | 1 |
| Bleiberg, H | 1 |
| Blijham, GH | 1 |
| Neijt, JP | 1 |
| Veenhof, CH | 1 |
| Duez, N | 1 |
| Sahmoud, T | 1 |
| Kairaluoma, MI | 3 |
| Mäkelä, J | 1 |
| Tikkakoski, T | 1 |
| Leinonen, A | 2 |
| Siniluoto, T | 2 |
| Karttunen, A | 1 |
| Shirai, Y | 1 |
| Ohtani, T | 1 |
| Tsukada, K | 1 |
| Hatakeyama, K | 1 |
| Roversi, R | 1 |
| Ricci, S | 1 |
| Rossi, G | 1 |
| Roversi, M | 1 |
| Cavallo, G | 1 |
| Aoki, T | 2 |
| Tsuchida, A | 1 |
| Asami, K | 1 |
| Uda, O | 1 |
| Inoue, K | 1 |
| Masuhara, S | 1 |
| Kasuya, K | 1 |
| Ozawa, T | 1 |
| Koyanagi, Y | 1 |
| Hara, Y | 1 |
| Kawasaki, T | 1 |
| Yabata, E | 1 |
| Gen, T | 1 |
| Jibiki, M | 1 |
| Kudoh, A | 1 |
| Noguchi, N | 1 |
| Kataoka, T | 1 |
| Teramoto, K | 1 |
| Iwai, T | 1 |
| Ishizaki, M | 1 |
| Akiyama, N | 1 |
| Tanaka, S | 2 |
| Motegi, M | 1 |
| Sasamoto, H | 1 |
| Osawa, H | 1 |
| Wada, W | 1 |
| Nakajima, M | 1 |
| Puhalla, H | 1 |
| Bareck, E | 1 |
| Scheithauer, W | 1 |
| Ploner, M | 1 |
| Stiglbauer, W | 1 |
| Depisch, D | 1 |
| Takada, T | 1 |
| Kato, H | 1 |
| Sasaki, M | 1 |
| Matsushiro, T | 1 |
| Yamauchi, H | 1 |
| Kajihara, T | 1 |
| Watanabe, G | 1 |
| Hanaue, H | 1 |
| Yoshida, K | 1 |
| Shimizu, T | 1 |
| Yoshizumi, Y | 1 |
| Sugiura, Y | 1 |
| Morisaki, Y | 1 |
| Shima, S | 1 |
| Okada, S | 1 |
| Okazaki, N | 1 |
| Yasutake, K | 1 |
| Imamura, Y | 1 |
| Yoshimura, Y | 1 |
| Oya, M | 1 |
| Matsusita, K | 1 |
| Tokisue, M | 1 |
| Okutani, T | 1 |
| Ono, S | 1 |
| Hasumura, S | 1 |
| Nagamori, S | 1 |
| Fujise, K | 1 |
| Homma, S | 1 |
| Sujino, H | 1 |
| Matsuura, T | 1 |
| Shimizu, K | 1 |
| Niiya, M | 1 |
| Kameda, H | 1 |
| Kurokawa, H | 1 |
| Kamita, N | 1 |
| Sasaki, K | 1 |
| Nagahori, J | 1 |
| Okazaki, M | 1 |
| Kijima, Y | 1 |
| Saito, H | 1 |
| Ritsuno, H | 1 |
| Yamaguchi, Y | 1 |
| Inaniwa, K | 1 |
| Niemelä, R | 1 |
| Kiviniemi, H | 1 |
| Ståhlberg, M | 1 |
| Fukushi, G | 1 |
| Tsushima, K | 1 |
| Suzuki, H | 1 |
| Kimura, T | 1 |
| Kimura, M | 1 |
| Tamura, Y | 1 |
| Kishibe, T | 1 |
| Saitoh, S | 1 |
| Itoh, T | 1 |
| Hirabayashi, N | 1 |
| Nosoh, Y | 1 |
| Nishiyama, M | 1 |
| Yamaguchi, M | 1 |
| Yoshinaka, K | 1 |
| Niimoto, M | 1 |
| Hattori, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PD-1 Antibody Plus Gemcitabine and Oxaliplatin (GEMOX) as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma Patients With Positively Metastatic Lymph Nodes : a Single Arm, Phase II Trial[NCT05430698] | Phase 2 | 62 participants (Anticipated) | Interventional | 2023-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mitomycin and Gallbladder Neoplasms
| Article | Year |
|---|---|
Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.
Topics: Ampulla of Vater; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; B | 2018 |
[Chemotherapy in gallbladder carcinoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Capecitabine; Cisplatin; Deoxyc | 2010 |
5 trials available for mitomycin and Gallbladder Neoplasms
| Article | Year |
|---|---|
Efficacy and safety of capecitabine in combination with docetaxel and mitomycin C in patients with pre-treated pancreatic, gallbladder, and bile duct carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Ne | 2010 |
[Evaluation of arterial infusion chemotherapy for advanced gallbladder cancer using implantable port].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Epirubicin; Fema | 1994 |
Phase II trial of mitomycin C (MMC) in advanced gallbladder and biliary tree carcinoma. An EORTC Gastrointestinal Tract Cancer Cooperative Group Study.
Topics: Biliary Tract Neoplasms; Carcinoma; Female; Gallbladder Neoplasms; Humans; Male; Middle Aged; Mitomy | 1993 |
[Prospective randomized trial comparing modified FAM (5-fluorouracil (5-FU) + adriamycin + mitomycin C) versus 5-FU alone for the treatment of non-resectable pancreatic and biliary tract carcinomas (the 1st trial in non-resectable patients). Study Group o
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Chemotherapy, | 1992 |
Superselective intra-arterial chemotherapy with mitomycin C in liver and gallbladder cancer.
Topics: Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Gallbladder Neoplasms; Humans; I | 1988 |
23 other studies available for mitomycin and Gallbladder Neoplasms
| Article | Year |
|---|---|
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: outcomes from a single tertiary institution.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Blood Transfusio | 2014 |
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for gallbladder cancer: a retrospective review.
Topics: Abdominal Cavity; Abdominal Neoplasms; Adenocarcinoma; Adult; Antineoplastic Agents; Chemotherapy, C | 2014 |
Chemotherapy in the treatment of advanced gallbladder cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Do | 2004 |
[A case report--Efficacy of combination therapy to unresectable advanced gall bladder carcinoma--palliative operation, hepatic arterial infusion therapy, and radiation therapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Combined | 2004 |
Intra-arterial chemotherapy with mitomycin C in gallbladder cancer: a follow-up study.
Topics: Adenocarcinoma; Adult; Antibiotics, Antineoplastic; Combined Modality Therapy; Drug Administration S | 2005 |
[A case of unresectable advanced gallbladder cancer treated by systemic chemotherapy combined with hepatic arterial infusion].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Epi | 2007 |
Hepatic artery infusion of 5-fluorouracil and mitomycin C in cholangiocarcinoma and gallbladder carcinoma.
Topics: Adenoma, Bile Duct; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms | 1984 |
[Efficacy of 48-hour infusion of 5-fluorouracil for gall bladder cancer].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chem | 1993 |
Superselective intra-arterial chemotherapy with mitomycin for gallbladder cancer.
Topics: Aged; Aged, 80 and over; Female; Gallbladder Neoplasms; Humans; Infusions, Intra-Arterial; Male; Mid | 1993 |
Superselective intra-arterial chemotherapy with mitomycin C in hepatic neoplasms.
Topics: Aged; Carcinoma, Hepatocellular; Colorectal Neoplasms; Female; Gallbladder Neoplasms; Hepatic Artery | 1993 |
Lymph node recurrence of gallbladder carcinoma successfully managed by systemic chemotherapy with 5-fluorouracil and mitomycin C: report of a 5-year survivor.
Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemothe | 1997 |
[Locoregional therapy with hypoxic liver perfusion in malignant neoplasms of the gallbladder. Preliminary experience].
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Carcinoid Tumor; Chemotherapy, Cancer, Regional P | 1997 |
[Aortic stop flow and hypoxic perfusion chemotherapy for unresectable gallbladder cancer].
Topics: Anesthesia, General; Antineoplastic Combined Chemotherapy Protocols; Aorta, Abdominal; Chemotherapy, | 1998 |
[A case of unresectable gallbladder cancer responding to combination therapy with hyperthermia and local chemotherapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Femal | 2000 |
[Long-term survival of a patient with postoperative liver metastasis of stage IVa gallbladder cancer responding to hepatic arterial infusion chemotherapy].
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; C | 2001 |
[Therapy of gallbladder carcinoma. Experience of a central hospital].
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antine | 2002 |
[Mitomycin-C-sensitive carcinoid tumor of the gallbladder: report of a case].
Topics: Animals; Carcinoid Tumor; Chemotherapy, Adjuvant; Drug Screening Assays, Antitumor; Gallbladder Neop | 1992 |
[Chemotherapy in cancers of the gallbladder and bile ducts].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Cytarabine; | 1991 |
[A study of combined chemotherapy with MMC, ADM, CDDP, VP-16 and 5'DFUR (MAC-VD) in advanced cancers of digestive organs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Coloni | 1989 |
[Combination therapy of hyperthermia and other methods in liver and bile tract cancers--evaluation of these methods using cancer cell lines in vitro].
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Combined Modality Therapy; Doxorubicin; | 1989 |
[Intra-arterial embolization of microcapsulated mitomycin C in the treatment of advanced carcinoma].
Topics: Adult; Aged; Capsules; Embolization, Therapeutic; Female; Gallbladder Neoplasms; Humans; Injections, | 1986 |
[MQF-FT and MQF-UFT in gallbladder and bile duct cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Car | 1988 |
[Comparison of human tumor clonogenic and nude mouse-isotope assays in anticancer-agent sensitivity tests].
Topics: Animals; Breast Neoplasms; Colony-Forming Units Assay; Cyclophosphamide; Doxorubicin; Drug Evaluatio | 1985 |