mitomycin has been researched along with Experimental Leukemia in 38 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration." | 7.66 | Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system. ( Ashizawa, T; Imai, R; Morimoto, M; Nakamura, N; Urakawa, C, 1980) |
| "The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration." | 3.66 | Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system. ( Ashizawa, T; Imai, R; Morimoto, M; Nakamura, N; Urakawa, C, 1980) |
| "A new dosage form of mitomycin C (MMC-CH) was tested for toxicity and therapeutic efficacy against intraperitoneally inoculated cancer cells in mice." | 1.27 | Enhanced anticancer efficacy by use of mitomycin C adsorbed on small activated carbon particles in mice. ( Hagiwara, A; Nakagawa, Y; Takahashi, T; Ueda, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (86.84) | 18.7374 |
| 1990's | 5 (13.16) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mott, J | 1 |
| Remers, WA | 6 |
| Cheng, L | 2 |
| Iyengar, BS | 3 |
| Bradner, WT | 7 |
| Casner, ML | 1 |
| Sami, SM | 1 |
| Tarnow, SE | 1 |
| Schurig, JE | 3 |
| Selassie, CD | 1 |
| Hansch, C | 1 |
| Khwaja, TA | 1 |
| Dias, CB | 1 |
| Pentecost, S | 1 |
| Lin, HJ | 1 |
| SAKAI, S | 1 |
| SAITO, G | 1 |
| SUGAYAMA, J | 1 |
| KAMASUKA, T | 1 |
| TAKANO, T | 1 |
| TAKADA, S | 1 |
| EVANS, JS | 1 |
| BOSTWICK, L | 1 |
| MENGEL, GD | 1 |
| BACHMAN, S | 1 |
| PINDELL, MH | 1 |
| KOSHIURA, R | 1 |
| KOSHIMURA, S | 1 |
| BANDO, Y | 1 |
| DAWSON, PJ | 1 |
| FIELDSTEEL, AH | 1 |
| BOSTICK, WL | 1 |
| Majone, F | 1 |
| Montaldi, A | 1 |
| Ronchese, F | 1 |
| Bianchi, V | 1 |
| Levis, AG | 1 |
| Imamishi, J | 1 |
| Tanaka, A | 1 |
| Kurashige, S | 2 |
| Kodama, K | 1 |
| Yoshida, T | 1 |
| Tsukagoshi, S | 2 |
| Oishi, M | 1 |
| Rose, WC | 2 |
| Schlein, A | 1 |
| Huftalen, JB | 2 |
| Imai, R | 1 |
| Ashizawa, T | 1 |
| Urakawa, C | 1 |
| Morimoto, M | 1 |
| Nakamura, N | 1 |
| Ueda, H | 1 |
| Manda, T | 1 |
| Matsumoto, S | 1 |
| Mukumoto, S | 1 |
| Nishigaki, F | 1 |
| Kawamura, I | 1 |
| Shimomura, K | 1 |
| Nakajima, T | 1 |
| Masuda, H | 1 |
| Okamoto, T | 1 |
| Watanabe, M | 1 |
| Yokoyama, K | 1 |
| Yamada, N | 1 |
| Fujimoto, S | 1 |
| Taguchi, T | 1 |
| Shibata, R | 1 |
| Noguchi, T | 1 |
| Sato, T | 1 |
| Akiyoshi, K | 1 |
| Sunamoto, J | 1 |
| Shiku, H | 1 |
| Nakayama, E | 1 |
| Steven, FS | 1 |
| Griffin, MM | 1 |
| Barnett, FB | 1 |
| Epenetos, AA | 1 |
| Uchida, T | 1 |
| Nagahata, T | 1 |
| Arakawa, M | 1 |
| Ekimoto, H | 1 |
| Takahashi, K | 1 |
| Wehrmaker, A | 2 |
| Lehmann, V | 1 |
| Dröge, W | 2 |
| Neville, ME | 1 |
| Begleiter, A | 1 |
| Robotham, E | 1 |
| Lacey, G | 1 |
| Leith, MK | 1 |
| Hagiwara, A | 1 |
| Takahashi, T | 1 |
| Ueda, T | 1 |
| Nakagawa, Y | 1 |
| Ward, PE | 1 |
| McKenna, PG | 3 |
| Shiomi, T | 1 |
| Hieda-Shiomi, N | 1 |
| Sato, K | 1 |
| Yoshizumi, T | 1 |
| Nakazawa, T | 1 |
| Eck, HP | 1 |
| McKelvey, VJ | 1 |
| Omote, Y | 1 |
| Akuzawa, Y | 1 |
| Mitsuhashi, S | 1 |
| Wang, DR | 1 |
| Slomski, R | 1 |
| Cohen, EP | 1 |
| Machida, S | 1 |
| Ito, Y | 1 |
| Hoshino, A | 1 |
| Yasseen, AA | 1 |
| Florczyk, AP | 1 |
| Catino, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of Romidepsin Given on Days One, Three, and Five in Patients With Thyroid and Other Advanced Cancers[NCT00048334] | Phase 1 | 28 participants (Actual) | Interventional | 2002-10-26 | Completed | ||
| Phase I Study of Topical Romidepsin (Depsipeptide) in Early Stage Cutaneous T-Cell Lymphoma[NCT01445340] | Phase 1 | 6 participants (Actual) | Interventional | 2007-04-21 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
38 other studies available for mitomycin and Experimental Leukemia
| Article | Year |
|---|---|
Mitomycin antibiotics. Synthesis of 7-methoxy-1-(N-pyrrolidino)mitosene and its methiodide.
Topics: Animals; Bacillus subtilis; Coliphages; Leukemia, Experimental; Mice; Mitomycins | 1978 |
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Coliphages; Hydrolysis; Leukemia, Expe | 1977 |
Preparation and antitumor activity of 7-substituted 1,2-aziridinomitosenes.
Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Leukemia, Experimental; Mice; Mitomycins; Stru | 1986 |
Synthesis and biological activity of 6-substituted mitosene analogues of the mitomycins.
Topics: Animals; Bacteriophages; Chemical Phenomena; Chemistry; Escherichia coli; Female; Leukemia P388; Leu | 1985 |
Mitomycin C analogues with secondary amines at position 7.
Topics: Animals; Antibiotics, Antineoplastic; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemi | 1983 |
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; | 1984 |
Development of new mitomycin C and porfiromycin analogues.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Leukemia, Experimental; Melanoma; | 1981 |
ANTICANCER EFFECT OF POLYSACCHARIDE FRACTION PREPARED FROM BAMBOO GRASS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Japan; Leukemia; Leukemia Virus, Murine; L | 1964 |
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; | 1964 |
STUDIES OF LEUKEMIA L1210 HOMOGRAFT IN SWISS HA-ICR MICE.
Topics: Allografts; Animals; Antineoplastic Agents; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbr | 1964 |
[EXPERIMENTAL ANTICANCER STUDIES. 23. FURTHER EXPERIMENTS ON THE ANTITUMOR ACTIVITY OF 4-AMINO-6-OCTYLRESORCINOL HYDROCHLORIDE].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Leukemia; Leuke | 1964 |
EFFECT OF DRUGS ON CELL AND VIRUS GROWTH IN FRIEND LEUKEMIA AND A TUMOR VARIANT.
Topics: Animals; Estradiol; Friends; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Lymphoma, Lar | 1965 |
Sister chromatid exchanges and chromosomal aberrations induced by mitomycin C in mouse lymphocytes carrying a leukemogenic virus.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Crossing Over, Genetic; Leukemia, Experimental; Mice; | 1983 |
[Experimental research to clinical application of interferons].
Topics: Animals; Bleomycin; Cytarabine; Drug Therapy, Combination; Humans; Interferon Inducers; Interferon T | 1984 |
Synergistic anti-tumor effect of mini-cells prepared from Salmonella typhimurium with mitomycin C in EL4-bearing mice.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Immunotherapy; Leukemia, Experimental; Lymphocytes; | 1983 |
[Studies and progress on the enhancement of therapeutic effects of antitumor drugs].
Topics: Amphotericin B; Angiotensin II; Animals; Antineoplastic Agents; Doxorubicin; Drug Resistance; Drug T | 1983 |
[Molecular mechanism of erythroid differentiation in mouse Friend cells].
Topics: Animals; Cell Differentiation; Cell Fusion; Cells, Cultured; Dimethyl Sulfoxide; DNA Repair; Erythro | 1984 |
Antitumor activity and toxicity in animals of RR-150 (7-cysteaminomitosane), a new mitomycin derivative.
Topics: Animals; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistan | 1984 |
Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system.
Topics: Animals; Leukemia P388; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Structure-Activity Rela | 1980 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
[Cross-resistance of HO-221 and various antitumor agents in sublines of mouse leukemia].
Topics: Animals; Antineoplastic Agents; Benzamides; Cisplatin; Doxorubicin; Drug Resistance; Leukemia L1210; | 1991 |
Induction of in vitro and in vivo anti-tumor responses by sensitization of mice with liposomes containing a crude butanol extract of leukemia cells and transferred inter-membranously with cell-surface proteins.
Topics: 1-Butanol; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Butanols; Crosses, Genetic; Cytot | 1991 |
Competitive inhibition of a tumour cell surface protease. A rapid technique for in vitro testing of selective targeting systems.
Topics: Agmatine; Aminacrine; Animals; Binding Sites; Binding, Competitive; Biomarkers, Tumor; Carboxylic Es | 1990 |
[Experimental combination chemotherapy of YNK01, a novel analog of cytarabine, with other antitumor agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleotides; | 1990 |
Analysis of protective and cytotoxic immune responses in vivo against metabolically inactivated and untreated cells of a mutagenized tumor line (requirements for tumor immunogenicity).
Topics: Animals; Antigens, Neoplasm; Cell Line; Epitopes; Histocompatibility Antigens Class II; Immunity, Ce | 1986 |
51Cr-uptake assay. A sensitive and reliable method to quantitate cell viability and cell death.
Topics: Azides; Cell Line; Cell Survival; Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; Dactinomy | 1987 |
Increased sensitivity of quinone resistant cells to mitomycin C.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Survival; Dicumarol; DNA Damage; Drug | 1989 |
Enhanced anticancer efficacy by use of mitomycin C adsorbed on small activated carbon particles in mice.
Topics: Adsorption; Animals; Carbon; Leukemia P388; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Sol | 1987 |
Mutation at the APRT locus in Friend erythroleukaemia cells. 2. Sensitivity to mitomycin C induced cytogenetic damage.
Topics: Adenine Phosphoribosyltransferase; Animals; Cell Line; Chromosome Aberrations; Clone Cells; DNA Dama | 1987 |
Cell fusion-mediated improvement in transfection competence for repair-deficient mutant of mouse T cell line.
Topics: Animals; Cell Fusion; Cell Survival; DNA; DNA Repair; Leukemia L5178; Leukemia, Experimental; Mice; | 1988 |
Alanine inhibits cytotoxic responses: its production by different tumor cell lines explains differences in their immunogenicity.
Topics: Alanine; Animals; Cell Line; Cytotoxicity, Immunologic; Female; Immunosuppression Therapy; Lactates; | 1988 |
Enhanced synergism between caffeine and mitomycin C in the induction of cytogenetic aberrations in thymidine kinase-deficient Friend murine erythroleukaemia cells.
Topics: Animals; Caffeine; Cell Line; Chromosome Aberrations; Dose-Response Relationship, Drug; Drug Synergi | 1986 |
[An experimental attempt to potentiate therapeutic effects of combined use of pulsing magnetic fields and antitumor agents].
Topics: Adenocarcinoma; Animals; Cell Division; Combined Modality Therapy; Cricetinae; DNA, Neoplasm; Electr | 1988 |
Synergistic anti-suppressor effect of mini cells prepared from Salmonella typhimurium and mitomycin C in EL 4-bearing mice.
Topics: Animals; Combined Modality Therapy; Female; Leukemia, Experimental; Lymphocyte Activation; Male; Mic | 1985 |
Leukemia X fibroblast hybrid cells prolong the lives of leukemic mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fibroblasts; Hyb | 1985 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubi | 1985 |
Hypersensitivity of thymidine kinase-deficient Friend leukaemia cells to the induction of cytogenetic aberrations by mitomycin C.
Topics: Animals; Chromosome Aberrations; Clone Cells; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; N | 1985 |
Antitumor activity and toxicity in animals of BMY-25282, a new mitomycin derivative.
Topics: Animals; Blood Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Female; Ferrets; Leuke | 1985 |