mitomycin has been researched along with Experimental Hepatoma in 81 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antitumor effects of adoptive immunotherapy using LAK cells treated with sizofiran (SPG) following in vivo antigen sensitization with EL-4 lymphoma (EsLAK), comparing nonsensitized LAK cells (sLAK), were studied in mice with intraperitoneal implantation of EL-4 lymphoma." | 7.70 | Augmentation of the antitumor effect of adoptive immunotherapy by in vivo sensitization of EL-4 lymphoma and pre-treatment with sizofiran. ( Hashimoto, J; Kakuta, H; Kano, Y, 1998) |
| "The amounts of mitomycin C (MMC) taken up into rat ascites hepatoma cells were determined by measuring the decrease in the absorbance of the incubation medium at 363 nm." | 7.67 | Enhancement of mitomycin C uptake by isoproterenol in rat ascites hepatoma. ( Koshiura, R; Matsunaga, T; Miyamoto, K; Waki, Y, 1986) |
| "In an attempt to improve tumor response and survival among patients with colorectal cancer metastases confined to the liver, we developed an experimental (rats and pigs) and clinical isolated hepatic perfusion (IHP) technique to exploit maximally the steep dose-response relation of may anticancer drugs." | 6.40 | Phase I/II studies of isolated hepatic perfusion with mitomycin C or melphalan in patients with colorectal cancer hepatic metastases. ( Marinelli, A; Vahrmeijer, AL; van de Velde, CJ, 1998) |
| "The antitumor effects of adoptive immunotherapy using LAK cells treated with sizofiran (SPG) following in vivo antigen sensitization with EL-4 lymphoma (EsLAK), comparing nonsensitized LAK cells (sLAK), were studied in mice with intraperitoneal implantation of EL-4 lymphoma." | 3.70 | Augmentation of the antitumor effect of adoptive immunotherapy by in vivo sensitization of EL-4 lymphoma and pre-treatment with sizofiran. ( Hashimoto, J; Kakuta, H; Kano, Y, 1998) |
| "Chuling (Polyporus umbellatus), one of the commonly used Chinese medical herbs, was combined with mitomycin C and then studied against intrahepatic implantation of sarcoma 180 tumor cells in mice." | 3.69 | Combined effects of chuling (Polyporus umbellatus) extract and mitomycin C on experimental liver cancer. ( Chen, KT; Hau, DM; Huang, HF; You, JS, 1994) |
| "The amounts of mitomycin C (MMC) taken up into rat ascites hepatoma cells were determined by measuring the decrease in the absorbance of the incubation medium at 363 nm." | 3.67 | Enhancement of mitomycin C uptake by isoproterenol in rat ascites hepatoma. ( Koshiura, R; Matsunaga, T; Miyamoto, K; Waki, Y, 1986) |
| "In an attempt to improve tumor response and survival among patients with colorectal cancer metastases confined to the liver, we developed an experimental (rats and pigs) and clinical isolated hepatic perfusion (IHP) technique to exploit maximally the steep dose-response relation of may anticancer drugs." | 2.40 | Phase I/II studies of isolated hepatic perfusion with mitomycin C or melphalan in patients with colorectal cancer hepatic metastases. ( Marinelli, A; Vahrmeijer, AL; van de Velde, CJ, 1998) |
| "To evaluate the anti-tumor effect of intra-arterial IL-12 gene delivery alone and in combination with transcatheter arterial chemoembolization (TACE) in rabbit VX2 liver cancer model." | 1.39 | Intra-arterial interleukin-12 gene delivery combined with chemoembolization: anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model. ( Feng, G; Li, X; Liang, H; Xia, X; Zheng, C; Zhou, G, 2013) |
| "To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide (Plcg) -microspheres in the transarterial chemoembolization (TACE) in this model, as well the value of this model in the experiments of interventional therapy." | 1.32 | Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma. ( Claussen, C; Eul, T; Graepler, F; Huppert, P; Pereira, P; Qian, J; Truebenbach, J; Wiemann, G, 2003) |
| "Transplantable murine hepatoma 22 model was used to evaluate the antitumor activity of drugs in vivo." | 1.31 | Synergistic effects of geldanamycin and antitumor drugs. ( Liao, ZY; Zhang, SH; Zhen, YS, 2001) |
| "12 days after inoculation of the Morris hepatoma 3924 A in 15 male ACI rats, TACE with Mitomycin C (0." | 1.31 | [Animal experiment studies on the effectiveness of permanent occlusion of the hepatic artery in transarterial chemoembolization]. ( Claussen, CD; Duda, SH; Eul, T; Graepler, F; Huppert, PE; König, CW; Pereira, PL; Trübenbach, J, 2000) |
| " These results provide a rationale for using short duration of FUdR in combination with other drugs." | 1.29 | Short-term intrahepatic FUdR infusion combined with bolus mitomycin C: reduced risk for developing drug resistance. ( Arisawa, Y; Dalton, RR; Sigurdson, ER; Sutanto-Ward, E, 1994) |
| "AH109A rat ascites hepatoma cells (2 x 10(6)) were subcutaneously implanted in the back of male Donryu rats (n = 32, body weight 150-200 g) on Day 0." | 1.29 | Effect of glutamine and chemotherapy on protein metabolism in tumor-bearing rats. ( Ishibashi, N; Kaibara, A; Kakegawa, T; Yamasaki, K; Yoshida, S, 1994) |
| "Pancreatic cancer is a disease with essentially no effective treatment." | 1.29 | A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice. ( Furukawa, T; Hoffman, RM; Kitajima, M; Kubota, T; Watanabe, M, 1993) |
| "2 mg/kg) given intra-arterially in combination with a temporary embolizing material, degradable starch microspheres (DSM, 5 mg/kg), to rabbits in which VX2 tumors had been implanted into the liver." | 1.29 | [Effect of intra-arterial chemotherapy combined with degradable starch microspheres against liver cancer--a study by experimental VX2 liver tumor model]. ( Itani, K; Kokura, S; Kondo, M; Oyamada, H; Yoshikawa, T, 1993) |
| "This metastatic model of human stomach cancer shows that locally growing and metastatic tumors may have different chemosensitivities, and provides the opportunity to test both with various treatment regimens." | 1.29 | Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice. ( Furukawa, T; Hoffman, RM; Kitajima, M; Kubota, T; Kuo, TH; Watanabe, M, 1993) |
| "Three cases of ruptured hepatocellular carcinomas were treated: one case by emergency hepatectomy, and two cases by hepatectomy following TAE." | 1.28 | [Influence of hepatic ischemia on liver regeneration following hepatectomy, with special reference to the therapeutic choice for ruptured hepatoma]. ( Itoh, H; Kaiho, T; Kanno, Y; Kimura, F; Koshikawa, H; Matsumoto, J; Miyazaki, M; Nakajima, T; Teramoto, O; Udagawa, I, 1989) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| "Nucleotide biosynthesis in Novikoff hepatoma cells is markedly altered by a variety of chemical mutagens, whether the mechanism of mutagenesis is by base substitution, covalent binding (adduct formation), intercalation, or cross-linking of DNA." | 1.27 | The effect of chemical mutagens on purine and pyrimidine nucleotide biosynthesis. ( Boling, ME; Jones, MH; Lee, WH; Volkin, E, 1983) |
| "The MMC MS treatment for metastatic hepatic cancer had superiority to the conventional infusion treatment at p = 0." | 1.27 | [Intra-arterial chemoembolization with albumin microspheres including mitomycin C in inoperable hepatic cancer]. ( Endoh, F, 1987) |
| "(3) Mitomycin C treated group (MMC: active control) and (4) plasma exchange + MMC treated group (combination therapy)." | 1.27 | [A basic study on plasma exchange therapy of malignant tumor in tumor bearing rats]. ( Suzuki, M, 1986) |
| "5 mg/kg) reduced the semiconservative DNA synthesis of the hepatocytes, but simultaneous dosing of fumaric acid (40 mg/kg) enhanced the recovery of the DNA synthesis." | 1.27 | Fumaric acid enhances DNA synthesis of rat hepatocytes by counteracting the toxicities of mitomycin C and aflatoxin B1. ( Akao, M; Kuroda, K; Terao, K, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (43.21) | 18.7374 |
| 1990's | 27 (33.33) | 18.2507 |
| 2000's | 17 (20.99) | 29.6817 |
| 2010's | 2 (2.47) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, X | 1 |
| Li, X | 1 |
| Feng, G | 2 |
| Zheng, C | 1 |
| Liang, H | 1 |
| Zhou, G | 1 |
| Hou, Z | 1 |
| Li, Y | 2 |
| Huang, Y | 1 |
| Zhou, C | 1 |
| Lin, J | 1 |
| Wang, Y | 1 |
| Cui, F | 1 |
| Zhou, S | 1 |
| Jia, M | 1 |
| Ye, S | 1 |
| Zhang, Q | 2 |
| Huang, T | 1 |
| Wu, W | 1 |
| Zhang, J | 1 |
| Huang, L | 1 |
| Qian, J | 5 |
| Truebenbach, J | 1 |
| Graepler, F | 2 |
| Pereira, P | 1 |
| Huppert, P | 1 |
| Eul, T | 2 |
| Wiemann, G | 1 |
| Claussen, C | 1 |
| Liao, ZY | 1 |
| Zhang, SH | 1 |
| Zhen, YS | 1 |
| You, JS | 3 |
| Huang, HF | 2 |
| Hau, DM | 3 |
| Zheng, ZS | 1 |
| Wu, HP | 1 |
| Li, WY | 1 |
| Vossoughi, D | 2 |
| Elsie, O | 1 |
| Thomas, V | 1 |
| Feng, GS | 1 |
| Ni, L | 2 |
| Oppermann, E | 2 |
| Maataoui, A | 2 |
| Vogl, TJ | 1 |
| Vogt, TJ | 1 |
| Yamaura, G | 1 |
| Yoshioka, T | 1 |
| Fukuda, H | 1 |
| Yamaguchi, K | 1 |
| Suzuki, M | 6 |
| Furumoto, S | 1 |
| Iwata, R | 1 |
| Ishioka, C | 1 |
| Chen, YB | 1 |
| Yan, ML | 1 |
| Gong, JP | 1 |
| Xia, RP | 1 |
| Liu, LX | 1 |
| Li, N | 1 |
| Lu, SC | 1 |
| Zhang, JG | 1 |
| Zeng, DB | 1 |
| Xie, JG | 1 |
| Yang, JY | 1 |
| Yan, LN | 1 |
| Hiroshi, K | 1 |
| Masanori, O | 1 |
| Kaoru, A | 1 |
| Gompachi, Y | 1 |
| Hiroshi, S | 1 |
| Matsuzaki, T | 1 |
| Kato, I | 1 |
| Yokokura, T | 1 |
| Mutai, M | 1 |
| Horie, K | 2 |
| Yamasaki, T | 2 |
| Nishimura, K | 1 |
| Tsuchiya, S | 1 |
| Yoshizawa, A | 1 |
| Akimoto, R | 3 |
| Watanabe, H | 2 |
| Shirasawa, K | 2 |
| Tsujimoto, Y | 2 |
| Matsunaga, T | 8 |
| Iwasaki, M | 1 |
| Miyamoto, K | 9 |
| Koshiura, R | 8 |
| Volkin, E | 1 |
| Boling, ME | 1 |
| Lee, WH | 1 |
| Jones, MH | 1 |
| Kidokoro, T | 1 |
| Kaminagayoshi, S | 1 |
| Miyauchi, Y | 3 |
| Bazarnova, TM | 1 |
| Bul'diaeva, TV | 1 |
| Kuz'mina, SN | 1 |
| Zbarskiĭ, IB | 1 |
| Hamazoe, R | 1 |
| Murasawa, K | 1 |
| Ichihashi, H | 1 |
| Mabuchi, H | 1 |
| Suenaga, M | 1 |
| Kondo, T | 1 |
| Sato, H | 2 |
| Taguchi, H | 1 |
| Kobayashi, Y | 1 |
| Moriyama, M | 1 |
| Miwa, H | 1 |
| Moriya, N | 1 |
| Orita, K | 2 |
| Tafazoli, M | 1 |
| Van Hummelen, P | 1 |
| Kiefer, F | 1 |
| Kirsch-Volders, M | 1 |
| Arisawa, Y | 1 |
| Sutanto-Ward, E | 1 |
| Dalton, RR | 1 |
| Sigurdson, ER | 1 |
| Chen, KT | 1 |
| Kaibara, A | 1 |
| Yoshida, S | 1 |
| Yamasaki, K | 1 |
| Ishibashi, N | 1 |
| Kakegawa, T | 1 |
| Kohda, H | 1 |
| Sekiya, C | 1 |
| Torimoto, Y | 1 |
| Mizuno, M | 1 |
| Fujimoto, Y | 1 |
| Tanaka, T | 3 |
| Matsumoto, A | 1 |
| Murazumi, Y | 1 |
| Ohhira, M | 1 |
| Hasebe, C | 1 |
| Furukawa, T | 2 |
| Kubota, T | 2 |
| Watanabe, M | 2 |
| Kitajima, M | 2 |
| Hoffman, RM | 2 |
| Chen, TH | 1 |
| Cheng, JF | 1 |
| Naomoto, Y | 1 |
| Gochi, A | 1 |
| Hizuta, A | 1 |
| Iwagaki, H | 1 |
| Matsuno, T | 1 |
| Hamazaki, K | 1 |
| Tanaka, N | 1 |
| Yoshikawa, T | 1 |
| Itani, K | 1 |
| Kokura, S | 1 |
| Oyamada, H | 1 |
| Kondo, M | 1 |
| Wang, LQ | 1 |
| Persson, BG | 1 |
| Bengmark, S | 1 |
| Kuo, TH | 1 |
| Kurth, S | 1 |
| Bulian, D | 1 |
| Kreft, B | 1 |
| Riemenschneider, T | 1 |
| Feng, H | 1 |
| Yamazaki, M | 2 |
| Matsuki, N | 1 |
| Saito, H | 1 |
| Wakusawa, S | 2 |
| Nakamura, S | 2 |
| Kuramitsu, Y | 1 |
| Ohiro, Y | 1 |
| Matsushita, K | 1 |
| Obara, M | 1 |
| Kobayashi, M | 1 |
| Hosokawa, M | 1 |
| Kano, Y | 1 |
| Kakuta, H | 1 |
| Hashimoto, J | 1 |
| Marinelli, A | 2 |
| Vahrmeijer, AL | 1 |
| van de Velde, CJ | 2 |
| Kamphorst, EJ | 1 |
| Bödeker, H | 1 |
| Koroma, S | 1 |
| Linnemann, U | 1 |
| Berger, MR | 2 |
| Trübenbach, J | 1 |
| Pereira, PL | 2 |
| Huppert, PE | 2 |
| König, CW | 1 |
| Duda, SH | 1 |
| Claussen, CD | 2 |
| Sano, M | 1 |
| Kojima, T | 2 |
| Naruse, T | 2 |
| Tokunaga, Y | 1 |
| Matsumoto, K | 1 |
| Konno, H | 1 |
| Baba, M | 1 |
| Kanai, T | 1 |
| Kamiya, K | 1 |
| Ohba, K | 1 |
| Li, H | 1 |
| Sasano, Y | 1 |
| Hori, K | 1 |
| Manabu, K | 1 |
| Saito, S | 1 |
| Fujishima, Y | 1 |
| Kaneo, Y | 1 |
| Kawamura, I | 1 |
| Morishita, R | 1 |
| Tsujimoto, S | 1 |
| Manda, T | 1 |
| Tomoi, M | 1 |
| Tomita, N | 1 |
| Goto, T | 1 |
| Ogihara, T | 1 |
| Kaneda, Y | 1 |
| Trübenbach, L | 1 |
| Kato, Y | 2 |
| Onishi, H | 2 |
| Machida, Y | 2 |
| Adachi, Y | 1 |
| Arii, S | 1 |
| Funaki, N | 1 |
| Higashitsuji, H | 1 |
| Fujita, S | 1 |
| Furutani, M | 1 |
| Mise, M | 1 |
| Zhang, W | 1 |
| Tobe, T | 1 |
| Matsuda, H | 2 |
| Tong, CN | 2 |
| Kubo, M | 2 |
| Mizutani, J | 1 |
| Hiraoka, T | 1 |
| Yamashita, R | 1 |
| Pons, DH | 1 |
| Vreeken, JA | 1 |
| Nagesser, SK | 1 |
| Kuppen, PJ | 1 |
| Tjaden, UR | 1 |
| Clement, O | 1 |
| Schouman-Claeys, E | 1 |
| Frija, G | 1 |
| Konno, T | 1 |
| Rozycki-Gerlach, W | 1 |
| Friedl, P | 1 |
| Yi, J | 1 |
| Schmähl, D | 1 |
| Schlag, P | 1 |
| Aizawa, K | 1 |
| Matsumoto, T | 1 |
| Tsukada, K | 1 |
| Ito, A | 1 |
| Suzuki, S | 1 |
| Miyazaki, M | 2 |
| Udagawa, I | 1 |
| Koshikawa, H | 1 |
| Itoh, H | 1 |
| Kanno, Y | 1 |
| Teramoto, O | 1 |
| Nakajima, T | 1 |
| Kaiho, T | 1 |
| Kimura, F | 1 |
| Matsumoto, J | 1 |
| Tsukada, Y | 1 |
| Takagi, K | 2 |
| Satake, T | 2 |
| Hasegawa, T | 2 |
| Shimizu, T | 1 |
| Sako, M | 1 |
| Hirota, S | 1 |
| Waki, Y | 3 |
| Endoh, F | 3 |
| Izumi, B | 1 |
| Tashiro, S | 1 |
| Kuroda, K | 1 |
| Akao, M | 1 |
| Terao, K | 1 |
| Sanae, F | 1 |
| Itoh, J | 2 |
| Nakagawa, H | 2 |
| Sasaki, H | 2 |
| Takahashi, T | 2 |
| Kobayashi, H | 1 |
| Ojima, M | 1 |
| Satoh, H | 1 |
| Gatanaga, T | 1 |
| Takahashi, K | 1 |
| Mizuno, D | 1 |
| Abe, S | 1 |
| Fujimoto, S | 1 |
| Takahashi, O | 1 |
| Okui, K | 1 |
| Sugibayashi, K | 1 |
| Morimoto, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy, Safety, and Patient Reported Outcomes of Different Regimens of Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma[NCT00493402] | Phase 3 | 365 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mitomycin and Experimental Hepatoma
| Article | Year |
|---|---|
Phase I/II studies of isolated hepatic perfusion with mitomycin C or melphalan in patients with colorectal cancer hepatic metastases.
Topics: Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topi | 1998 |
80 other studies available for mitomycin and Experimental Hepatoma
| Article | Year |
|---|---|
Intra-arterial interleukin-12 gene delivery combined with chemoembolization: anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model.
Topics: Analysis of Variance; Animals; Apoptosis; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; | 2013 |
Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Delivery Systems; | 2013 |
[Interventional therapy combining Seed of Job's-stears with lipiodol for hepatoma-bearing rats].
Topics: Animals; Cell Division; Coix; Drug Therapy, Combination; Iodized Oil; Liver Neoplasms, Experimental; | 2002 |
Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Arteries; Carcinoma, Hepatocellular; Chemoembolization, Therap | 2003 |
Synergistic effects of geldanamycin and antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzoquinones; | 2001 |
Effects of Xuefu Zhuyu Tang and mitomycin C on liver tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Drug Therapy, Combination; Drugs, Chinese Herbal; Liver Neoplasms, E | 2003 |
[The application of Bletilla striata in the interventional therapy of hepatocellular carcinoma: a comparative study using ACI rats].
Topics: Animals; Chemoembolization, Therapeutic; Drugs, Chinese Herbal; Iodized Oil; Liver Neoplasms, Experi | 2005 |
[Experimental study in the effects of transarterial immuno-chemoembolization in hepatocellular carcinoma].
Topics: Animals; Antibiotics, Antineoplastic; Chemoembolization, Therapeutic; Combined Modality Therapy; Imm | 2005 |
[Experimental study in the effects of combined transarterial chemoembolization and laser thermotherapy in hepatocellular carcinoma].
Topics: Animals; Antibiotics, Antineoplastic; Chemoembolization, Therapeutic; Combined Modality Therapy; Hyp | 2005 |
O-[18F]fluoromethyl-L-tyrosine is a potential tracer for monitoring tumour response to chemotherapy using PET: an initial comparative in vivo study with deoxyglucose and thymidine.
Topics: Animals; Antibiotics, Antineoplastic; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line, Tu | 2006 |
Establishment of hepatocellular carcinoma multidrug resistant monoclone cell line HepG2/mdr1.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Li | 2007 |
[Effect of 6-keto prostaglandin E1 on the ascitic hepatoma-130 in vivo. Comparison with chemotherapeutic agent].
Topics: Alprostadil; Animals; Cell Survival; Drug Therapy, Combination; Female; Inclusion Bodies; Liver Neop | 1984 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
[Anti-tumor activity of peripheral lymphocytes of tumor-bearing rats by in vitro culture].
Topics: Animals; Cells, Cultured; Female; Interleukin-2; Liver Neoplasms, Experimental; Lymphocyte Culture T | 1984 |
Relationship between enhancement of cytotoxic effect of mitomycin C and increase of intracellular cyclic adenosine 3':5'-monophosphate by isoproterenol in rat ascites hepatoma cells.
Topics: Animals; Bucladesine; Cell Survival; Cells, Cultured; Cyclic AMP; Female; Isoproterenol; Liver Neopl | 1983 |
The effect of chemical mutagens on purine and pyrimidine nucleotide biosynthesis.
Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphate; Aminacrine; Animals; Cytidine Triphosphate; Cytosi | 1983 |
[Experimental studies of plasma exchange therapy for malignant tumor].
Topics: Animals; Female; Liver Neoplasms, Experimental; Mitomycin; Mitomycins; Plasma Exchange; Rats; Rats, | 1984 |
[Inhibition by antibiotics of the incorporation of labelled amino acids into the nuclear matrix proteins of the Zajdela hepatoma].
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Cell Nucleus; Chlorampheni | 1984 |
[Experimental studies on continuous hyperthermic peritoneal perfusion in the treatment for peritoneal metastases of cancer].
Topics: Animals; Antibiotics, Antineoplastic; Cell Survival; Cells, Cultured; Combined Modality Therapy; Hyp | 1983 |
[Enhancing effect of mitomycin C on hematogenous metastases of ascites hepatoma in rat].
Topics: Animals; Antibiotics, Antineoplastic; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1983 |
Liver regeneration and tumor growth in the rat after partial hepatectomy.
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Hepatectomy; Liver; Liver Neoplasms, Experiment | 1984 |
[Antitumor spectrum of 7-N-(p-hydroxyphenyl) mitomycin C (KW 2083) in rat ascites hepatoma].
Topics: Animals; Drug Evaluation, Preclinical; Female; Liver Neoplasms, Experimental; Mitomycin; Mitomycins; | 1982 |
[Antitumor effect of polysaccharide lentinan on C3H/He mice bearing MH134 ascites hepatoma].
Topics: Animals; Cell Migration Inhibition; Cytarabine; Drug Therapy, Combination; Fluorouracil; Lentinan; L | 1982 |
Induction of micronuclei in metabolically competent rat hepatoma cell lines by the promutagens 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene and cyclophosphamide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cyclophosphamide; Live | 1995 |
Short-term intrahepatic FUdR infusion combined with bolus mitomycin C: reduced risk for developing drug resistance.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration S | 1994 |
Combined effects of chuling (Polyporus umbellatus) extract and mitomycin C on experimental liver cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Body Wei | 1994 |
Effect of glutamine and chemotherapy on protein metabolism in tumor-bearing rats.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Glutamine; Intestinal Mucosa; Leucine; Li | 1994 |
Importance of cytotoxic T lymphocytes in the rejection of transplanted hepatocellular carcinoma.
Topics: Animals; CD8 Antigens; Flow Cytometry; Graft Rejection; Immunotherapy, Adoptive; Liver Neoplasms, Ex | 1994 |
A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice.
Topics: Animals; Disease Models, Animal; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neopl | 1993 |
Combined therapy of mitomycin C and Chinese medical herbs on experimental liver cancer.
Topics: Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combinatio | 1993 |
[In vivo comparative study of the pharmacokinetics of chemotherapeutic agents infused via hepatic artery or portal vein against hepatic metastases. DRC Group].
Topics: Animals; Cisplatin; Fluorouracil; Hepatic Artery; Infusion Pumps; Infusions, Intra-Arterial; Infusio | 1993 |
[Effect of intra-arterial chemotherapy combined with degradable starch microspheres against liver cancer--a study by experimental VX2 liver tumor model].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemoembolization, Therapeutic; Doxorubicin | 1993 |
Bioreduction of RSU 1069 and mitomycin C after dearterialization.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Chemotherapy, Adjuvant; Hepatic Artery; Humans; Ligati | 1993 |
Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Combined Modali | 1993 |
Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.
Topics: Angiography; Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Floxuridin | 1996 |
Anti-tumor effects of orally administered soft-shelled turtle powder in mice.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Ascites; Liver Ne | 1996 |
Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin | 1997 |
The mechanism of locally enhanced production of tumor necrosis factor-alpha in tumor tissues by the administration of a new synthetic lipid A analog, ONO-4007, in hepatoma-bearing rats.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Coculture Techniques; Extrac | 1997 |
Augmentation of the antitumor effect of adoptive immunotherapy by in vivo sensitization of EL-4 lymphoma and pre-treatment with sizofiran.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Antigens, Neoplasm; Antineoplastic Age | 1998 |
New technique for superselective arterial (chemo-) embolization of the rat liver.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capillaries; C | 1999 |
[Animal experiment studies on the effectiveness of permanent occlusion of the hepatic artery in transarterial chemoembolization].
Topics: Animals; Antibiotics, Antineoplastic; Chemoembolization, Therapeutic; Contrast Media; Data Interpret | 2000 |
Effect of red blood cells on the antitumor activity of oxycellulose.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blood Proteins; Cisplatin; Cocultur | 2000 |
Antitumor effect of oxycellulose as a hemostatic during operation.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; DNA, Neoplasm; Erythrocytes; Etopo | 1998 |
Combination therapy with vascular endothelial growth factor neutralizing antibody and mitomycin C on human gastric cancer xenograft.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Body Weight; Cell Divi | 2000 |
Hypercoagulable state and disseminated intravascular coagulation following an effective chemotherapy in tumor-bearing rats.
Topics: Angiotensins; Animals; Antibiotics, Antineoplastic; Disseminated Intravascular Coagulation; Liver Ne | 1998 |
Receptor mediated endocytosis and cytotoxicity of transferrin-mitomycin C conjugate in the HepG2 cell and primary cultured rat hepatocyte.
Topics: Algorithms; Animals; Antibiotics, Antineoplastic; Cell Death; Endocytosis; Hepatocytes; Humans; Live | 2001 |
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Binding Sites; Combined Modality Therapy; Female; Gene Express | 2001 |
[Experimental research about effectiveness of transarterial chemoembolization (TACE) in an animal model of hepatocellular carcinoma].
Topics: Animals; Antibiotics, Antineoplastic; Chemoembolization, Therapeutic; Injections, Intra-Arterial; Io | 2001 |
Lactosaminated and intact N-succinyl-chitosans as drug carriers in liver metastasis.
Topics: Animals; Area Under Curve; Chitin; Chitosan; Drug Carriers; Injections, Intravenous; Lactose; Liver | 2001 |
Efficacy of lactosaminated and intact N-succinylchitosan-mitomycin C conjugates against M5076 liver metastatic cancer.
Topics: Amino Sugars; Animals; Area Under Curve; Chitin; Chitosan; Drug Administration Schedule; Fluorescein | 2002 |
Tumoricidal activity of Kupffer cells augmented by anticancer drugs.
Topics: Animals; Antigens, Surface; Doxorubicin; Fluorescent Antibody Technique; Kupffer Cells; Liver Neopla | 1992 |
[Pharmacological study on Panax ginseng C. A. Meyer. XIV. Effect of 70% methanolic extract from red ginseng on the cytocidal effect of mitomycin c against rat ascites hepatoma AH 130].
Topics: Animals; Drug Screening Assays, Antitumor; Drug Synergism; Drugs, Chinese Herbal; Female; Liver Neop | 1992 |
[Pharmacological study on Panax ginseng C. A. Meyer. XV. Effects of 70% methanolic extract from red and white ginseng on the antitumor activity of mitomycin C].
Topics: Animals; Carcinoma, Ehrlich Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Drugs, Chinese | 1992 |
Promotion of hepatic metastases by liver resection in the rat.
Topics: Animals; Fluorouracil; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Regeneration; Mi | 1992 |
High mitomycin C concentration in tumour tissue can be achieved by isolated liver perfusion in rats.
Topics: Animals; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Chromatography, High Press | 1991 |
Ferrite particles (AMI25). Influence of cirrhosis and chemotherapy on magnetic resonance imaging of metastasis.
Topics: Animals; Contrast Media; Dextrans; Ferrosoferric Oxide; Iron; Liver Cirrhosis, Experimental; Liver N | 1990 |
Targeting cancer chemotherapeutic agents by use of lipiodol contrast medium.
Topics: Aclarubicin; Animals; Antineoplastic Agents; Carbon Radioisotopes; Doxorubicin; Female; Injections, | 1990 |
First experiments with locoregional chemotherapy in the treatment of autochthonous rat hepatoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Diethylnitrosamine; Femal | 1988 |
Antitumor effect of a baker's yeast mannan-mitomycin C conjugate against mouse hepatoma, MH134, in vivo and in vitro.
Topics: Animals; Dextrans; Liver Neoplasms, Experimental; Male; Mannans; Mice; Mice, Inbred C3H; Mitomycin; | 1989 |
[Influence of hepatic ischemia on liver regeneration following hepatectomy, with special reference to the therapeutic choice for ruptured hepatoma].
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Embolization, Therapeutic; Hepatectomy; Humans; Isc | 1989 |
[Chemical modification of anti-cancer drugs to increase their affinity to tumor antigens].
Topics: alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Agents; Da | 1985 |
Multiform combination effects of smooth muscle relaxants with antitumor agents in rat ascites hepatoma AH66 cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cyclic AMP; Liver Neoplasms, Experim | 1987 |
Comparative studies on the combined cytotoxic effect of forskolin with mitomycin C and responsiveness to forskolin in rat ascites hepatoma AH66 cells and AH66F cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bucladesine; Cell Line; Cell Survival; Colf | 1987 |
[Intra-arterial infusion therapy with polysaccharide solution as a carrier of anticancer agents--a new method of intra-arterial infusion therapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Delayed-Action P | 1988 |
Enhancement of the cytotoxic effect of mitomycin C by beta-adrenergic stimulants in rat ascites hepatoma AH130 cells.
Topics: Adrenergic beta-Agonists; Animals; Cell Line; Cell Survival; Cyclic AMP; Drug Synergism; Female; Liv | 1986 |
Enhancement of mitomycin C uptake by isoproterenol in rat ascites hepatoma.
Topics: Animals; Ascites; Bucladesine; Cell Line; Cell Survival; Cells, Cultured; Cyclic AMP; Dose-Response | 1986 |
The action of mitomycin C on the induction of cyclic AMP phosphodiesterase and the development of desensitization of adenylate cyclase by isoproterenol in rat ascites hepatoma AH130 cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Drug Interactions; Enzyme Induction | 1986 |
[Intra-arterial chemoembolization with albumin microspheres including mitomycin C in inoperable hepatic cancer].
Topics: Adult; Aged; Albumins; Animals; Carcinoma, Hepatocellular; Female; Hepatic Artery; Humans; Infusions | 1987 |
[A basic study on plasma exchange therapy of malignant tumor in tumor bearing rats].
Topics: Animals; Body Weight; Liver Neoplasms, Experimental; Mitomycin; Mitomycins; Orosomucoid; Plasmaphere | 1986 |
Anticancer effects of local administration of mitomycin C via the hepatic artery or portal vein on implantation and growth of VX2 cancer injected into rabbit liver.
Topics: Animals; Hepatic Artery; Injections; Liver Neoplasms, Experimental; Mitomycin; Mitomycins; Neoplasm | 1986 |
Fumaric acid enhances DNA synthesis of rat hepatocytes by counteracting the toxicities of mitomycin C and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Line; Cell Nucleus; DNA; Fumarates; Liver; Liver Neoplasms, | 1986 |
[The mode of mitomycin C uptake in rat ascites hepatoma AH130 cells].
Topics: Animals; Cells, Cultured; Female; Liver Neoplasms, Experimental; Mitomycin; Mitomycins; Rats | 1986 |
Effect of mitomycin C on the activation of adenylate cyclase in rat ascites hepatoma AH130 cells.
Topics: Adenylyl Cyclases; Aerobiosis; Anaerobiosis; Animals; Drug Interactions; Enzyme Activation; Female; | 1986 |
[A fibrin clot containing of anticancer drug for intra-arterial chemo-embolization therapy. (1) Experimental study on basic characteristics in dogs].
Topics: Animals; Calcium Chloride; Delayed-Action Preparations; Dogs; Embolization, Therapeutic; Fibrinogen; | 1985 |
[A fibrin clot containing of anticancer drug for intra-arterial chemo-embolization therapy. (2) Chemotherapeutic effects on a model hepatoma using VX-2 carcinoma in rabbits].
Topics: Animals; Calcium Chloride; Embolization, Therapeutic; Fibrinogen; Hepatic Artery; Infusions, Intra-A | 1985 |
Effects of 6-keto-prostaglandin E1 on ascitic hepatoma-130 in vivo comparison with chemotherapeutic agents.
Topics: Alprostadil; Animals; Antineoplastic Agents; Female; Liver Neoplasms, Experimental; Microscopy, Elec | 1985 |
Combination antitumor therapy with rabbit tumor necrosis factor and chemo- and immuno-therapeutic agents against murine tumors.
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Dactinomycin; Doxorubicin; Glycoproteins; | 1985 |
[Intra-arterial infusion chemotherapy with mitomycin C containing albumin microspheres].
Topics: Albumins; Animals; Embolization, Therapeutic; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Li | 1985 |
Mitomycin C carrying microspheres as a novel method of drug delivery.
Topics: Albumins; Animals; Delayed-Action Preparations; Kinetics; Liver; Liver Neoplasms, Experimental; Male | 1985 |
[An experimental study on enhancement of the effect of an anti-cancer drug by ultrasound].
Topics: Animals; Antibiotics, Antineoplastic; Drug Synergism; Liver Neoplasms, Experimental; Mitomycin; Mito | 1985 |