mitomycin and Endophthalmitis studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Endophthalmitis: Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.

Research Excerpts

Excerpt	Relevance	Reference
"The purpose of the study was to investigate the incidence for endophthalmitis and blebitis after deep sclerectomy (DS) and trabeculectomy with routine use of Mitomycin C (MMC) 0."	8.31	Endophthalmitis and blebitis following deep sclerectomy and trabeculectomy with routine use of mitomycin C. ( Harju, M; Kankainen, T, 2023)
"Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C."	7.75	Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C. ( Katada, T; Kawakami, H; Mikamo, H; Mochizuki, K; Sawada, A; Watanabe, K; Yamamoto, T, 2009)
"To evaluate the safety and effectiveness of trabeculectomy with mitomycin C in the management of childhood glaucoma."	7.74	Efficacy and safety of trabeculectomy with mitomycin C for childhood glaucoma: a study of results with long-term follow-up. ( Borges-Giampani, AS; Carani, JC; Giampani, J; Oltrogge, EW; Susanna, R, 2008)
"To assess the outcomes of patients who had late infections after undergoing filtering surgery with mitomycin C with respect to treatment, resultant vision, and maintenance of intraocular pressure."	7.72	Late-onset blebitis/endophthalmitis: incidence and outcomes with mitomycin C. ( Lehrer, RA; Muckley, ED, 2004)
"To present two cases of delayed-onset postoperative endophthalmitis following trabeculectomy combined with mitomycin C for secondary glaucoma after penetrating keratoplasty."	7.70	Late bleb-related endophthalmitis after trabeculectomy with mitomycin C. ( Akova, YA; Bulut, S; Dabil, H; Duman, S, 1999)
"To determine whether filtering blebs resulting from adjunctive use of mitomycin C (MMC) leads to an increased risk of endophthalmitis."	7.69	Bleb-related endophthalmitis after trabeculectomy with mitomycin C. ( Bergstrom, TJ; Higginbotham, EJ; Karp, KO; Lichter, PR; Musch, DC; Skuta, GL; Stevens, RK, 1996)
"To identify the incidence, causative organisms, and clinical outcomes of eyes with bleb-associated endophthalmitis after glaucoma filtering procedures with adjunctive mitomycin."	7.69	Endophthalmitis after filtering surgery with mitomycin. ( Flynn, HW; Greenfield, DS; Kangas, TA; Miller, MP; Palmberg, PF; Suñer, IJ, 1996)
"With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections."	4.82	Glaucoma-filtering bleb infections. ( Mac, I; Soltau, JB, 2003)
"The purpose of the study was to investigate the incidence for endophthalmitis and blebitis after deep sclerectomy (DS) and trabeculectomy with routine use of Mitomycin C (MMC) 0."	4.31	Endophthalmitis and blebitis following deep sclerectomy and trabeculectomy with routine use of mitomycin C. ( Harju, M; Kankainen, T, 2023)
"Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)."	3.91	Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019)
"Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C."	3.75	Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C. ( Katada, T; Kawakami, H; Mikamo, H; Mochizuki, K; Sawada, A; Watanabe, K; Yamamoto, T, 2009)
"To evaluate the safety and effectiveness of trabeculectomy with mitomycin C in the management of childhood glaucoma."	3.74	Efficacy and safety of trabeculectomy with mitomycin C for childhood glaucoma: a study of results with long-term follow-up. ( Borges-Giampani, AS; Carani, JC; Giampani, J; Oltrogge, EW; Susanna, R, 2008)
"To assess the outcomes of patients who had late infections after undergoing filtering surgery with mitomycin C with respect to treatment, resultant vision, and maintenance of intraocular pressure."	3.72	Late-onset blebitis/endophthalmitis: incidence and outcomes with mitomycin C. ( Lehrer, RA; Muckley, ED, 2004)
"To present two cases of delayed-onset postoperative endophthalmitis following trabeculectomy combined with mitomycin C for secondary glaucoma after penetrating keratoplasty."	3.70	Late bleb-related endophthalmitis after trabeculectomy with mitomycin C. ( Akova, YA; Bulut, S; Dabil, H; Duman, S, 1999)
"The use of adjunctive antimetabolites such as 5-fluorouracil (5-FU) and mitomycin C (MMC) in trabeculectomy has caused an increased concern as to the risk of bleb-associated endophthalmitis."	3.70	Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents. ( Frucht-Pery, J; Solomon, A; Ticho, U, 1999)
"To determine whether filtering blebs resulting from adjunctive use of mitomycin C (MMC) leads to an increased risk of endophthalmitis."	3.69	Bleb-related endophthalmitis after trabeculectomy with mitomycin C. ( Bergstrom, TJ; Higginbotham, EJ; Karp, KO; Lichter, PR; Musch, DC; Skuta, GL; Stevens, RK, 1996)
"To identify the incidence, causative organisms, and clinical outcomes of eyes with bleb-associated endophthalmitis after glaucoma filtering procedures with adjunctive mitomycin."	3.69	Endophthalmitis after filtering surgery with mitomycin. ( Flynn, HW; Greenfield, DS; Kangas, TA; Miller, MP; Palmberg, PF; Suñer, IJ, 1996)
"The mean follow-up time after treatment for endophthalmitis was 6."	2.41	Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes. ( Budenz, DL; Flynn, HW; Scott, IU; Song, A, 2002)
"Postoperative endophthalmitis is a devastating complication after trabeculectomy."	1.40	Endophthalmitis and severe blebitis following trabeculectomy. Epidemiology and risk factors; a single-centre retrospective study. ( Al-ahramy, AM; Lundström, M; Montan, P; Wallin, Ö, 2014)
"Postoperative complications were: ocular hypotony (1 case), bleb fibrosis (2 cases), bleb-related endophthalmitis (1 case)."	1.36	[Non-pentrating deep sclerectomy--between safety and efficacy]. ( Cantemir, A; Chiseliţă, D; Ilieş, I, 2010)
"To report delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis."	1.32	Delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis. ( Cruz-Villegas, V; Flynn, HW; Miller, D; Scott, IU, 2004)
"In the study 6 patients with cystic blebs after trabeculectomy with mitomycin C was presented."	1.32	[Surgical management of pathologic filtering blebs in pediatric glaucoma]. ( Chipczyńska, B; Grałek, M; Kanigowska, K; Klimczak-Slaczka, D, 2004)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (22.58)	18.2507
2000's	12 (38.71)	29.6817
2010's	10 (32.26)	24.3611
2020's	2 (6.45)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Chinese Primary Angle Closure Glaucoma[NCT02964676]	246 participants (Anticipated)	Interventional	2017-01-31	Not yet recruiting
[NCT02665884]	40 participants (Anticipated)	Observational	2016-02-29	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Glaucoma-filtering bleb infections. Current opinion in ophthalmology, 2003, Volume: 14, Issue:2 Topics: Anti-Bacterial Agents; Drug Administration Schedule; Endophthalmitis; Fibrosis; Filtering Surgery; F	2003
Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes. Ophthalmology, 2002, Volume: 109, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Bacteria; Endophthalmitis; Eye Infections, Bacteri	2002

Article	Year
Endophthalmitis and blebitis following deep sclerectomy and trabeculectomy with routine use of mitomycin C. Acta ophthalmologica, 2023, Volume: 101, Issue:3 Topics: Cohort Studies; Endophthalmitis; Glaucoma; Humans; Mitomycin; Retrospective Studies; Trabeculectomy	2023
Leftover mitomycin-c sponge causing blebitis. Indian journal of ophthalmology, 2019, Volume: 67, Issue:10 Topics: Endophthalmitis; Humans; Male; Mitomycin; Nucleic Acid Synthesis Inhibitors; Postoperative Complicat	2019
Bleb-related tuberculous endophthalmitis following combined phacoemulsification and trabeculectomy with mitomycin C. BMJ case reports, 2020, Mar-24, Volume: 13, Issue:3 Topics: Aged; Antitubercular Agents; Endophthalmitis; Glaucoma; Humans; Male; Mitomycin; Mycobacterium tuber	2020
Ab Interno Gel Implant-associated Bleb-related Infection. American journal of ophthalmology, 2018, Volume: 189 Topics: Aged; Alkylating Agents; Anti-Bacterial Agents; Endophthalmitis; Female; Follow-Up Studies; Gelatin;	2018
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. Journal of glaucoma, 2019, Volume: 28, Issue:6 Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis	2019
Endophthalmitis and severe blebitis following trabeculectomy. Epidemiology and risk factors; a single-centre retrospective study. Acta ophthalmologica, 2014, Volume: 92, Issue:5 Topics: Aged; Aged, 80 and over; Alkylating Agents; Case-Control Studies; Cataract Extraction; Conjunctiva;	2014
Blebitis with scleral abscess in a case of operated trabeculectomy with mitomycin C and a subcunjunctival ologen implant. Eye (London, England), 2014, Volume: 28, Issue:3 Topics: Abscess; Alkylating Agents; Anti-Bacterial Agents; Ceftriaxone; Collagen; Drug Therapy, Combination;	2014
Endophthalmitis With Corneal Infiltrate After EX-PRESS Glaucoma Drainage Device Implantation. Journal of glaucoma, 2016, Volume: 25, Issue:3 Topics: Alkylating Agents; Anti-Bacterial Agents; Corneal Diseases; Device Removal; Drug Combinations; Endop	2016
Efficacy and safety of trabeculectomy with mitomycin C for childhood glaucoma: a study of results with long-term follow-up. Clinics (Sao Paulo, Brazil), 2008, Volume: 63, Issue:4 Topics: Adolescent; Age Distribution; Antibiotics, Antineoplastic; Child; Child, Preschool; Combined Modalit	2008
Streptococcus intermedius-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C. Journal of glaucoma, 2009, Volume: 18, Issue:1 Topics: Adult; Alkylating Agents; Anti-Bacterial Agents; Combined Modality Therapy; DNA, Bacterial; Drug The	2009
Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C. Journal of glaucoma, 2009, Volume: 18, Issue:6 Topics: Adult; Anti-Bacterial Agents; Blister; Conjunctiva; Drug Therapy, Combination; Endophthalmitis; Eye	2009
Conjunctival and corneal findings in bleb-associated endophthalmitis: an in vivo confocal microscopy study. Acta ophthalmologica, 2011, Volume: 89, Issue:4 Topics: Aged; Aged, 80 and over; Blister; Case-Control Studies; Conjunctivitis; Endophthalmitis; Female; Gla	2011
[Non-pentrating deep sclerectomy--between safety and efficacy]. Oftalmologia (Bucharest, Romania : 1990), 2010, Volume: 54, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antihypertensive Agents; Blister; Drug Therapy, Comb	2010
Changing trends in the incidence of bleb-related infection in trabeculectomy. The British journal of ophthalmology, 2012, Volume: 96, Issue:7 Topics: Adult; Aged; Alkylating Agents; Combined Modality Therapy; Conjunctiva; Endophthalmitis; Eye Infecti	2012
Delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis. American journal of ophthalmology, 2004, Volume: 137, Issue:3 Topics: Antifungal Agents; Blister; Combined Modality Therapy; Cryotherapy; Endophthalmitis; Eye Infections,	2004
Late-onset blebitis/endophthalmitis: incidence and outcomes with mitomycin C. Optometry and vision science : official publication of the American Academy of Optometry, 2004, Volume: 81, Issue:7 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Cataract Extraction	2004
[Surgical management of pathologic filtering blebs in pediatric glaucoma]. Klinika oczna, 2004, Volume: 106, Issue:1-2 Suppl Topics: Adolescent; Anti-Bacterial Agents; Blister; Child; Endophthalmitis; Female; Glaucoma; Humans; Male;	2004
Bleb-related endophthalmitis after trabeculectomy with mitomycin C. Ophthalmology, 1996, Volume: 103, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Aqueous Humor; Bacteria	1996
Endophthalmitis after filtering surgery with mitomycin. Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Bact	1996
Filtering bleb infection as a complication of orthokeratology. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:8 Topics: Adult; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Contact Lenses; Drug Therapy, Combination	1997
Bleb-related ocular infection in children after trabeculectomy with mitomycin C. Ophthalmology, 1997, Volume: 104, Issue:12 Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chemotherapy, Adjuvant; Child; Child, Preschool;	1997
Bleb-related ocular infection. Journal of glaucoma, 1998, Volume: 7, Issue:2 Topics: Aged; Anti-Bacterial Agents; Aqueous Humor; Drug Therapy, Combination; Endophthalmitis; Exfoliation	1998
Late bleb-related endophthalmitis after trabeculectomy with mitomycin C. Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:2 Topics: Adult; Anti-Bacterial Agents; Drug Therapy, Combination; Endophthalmitis; Eye Infections, Bacterial;	1999
Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1999, Volume: 15, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Endophthalmitis; Female; Filtration; Fluoro	1999
Risk factors for development of post-trabeculectomy endophthalmitis. The British journal of ophthalmology, 2000, Volume: 84, Issue:12 Topics: Aged; Antimetabolites; Case-Control Studies; Diabetes Complications; Endophthalmitis; Female; Fluoro	2000
Trabeculectomy with mitomycin-C in pediatric glaucomas. Ophthalmology, 2001, Volume: 108, Issue:5 Topics: Child; Endophthalmitis; Glaucoma; Humans; Male; Mitomycin; Patient Education as Topic; Surgical Woun	2001
Trabeculectomy with mitomycin-C in pediatric glaucomas. Ophthalmology, 2001, Volume: 108, Issue:5 Topics: Endophthalmitis; Glaucoma; Humans; Incidence; Infant; Mitomycin; Risk Factors; Surgical Wound Infect	2001
Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin. Archives of ophthalmology (Chicago, Ill. : 1960), 2002, Volume: 120, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Conjunctival Diseases; Cross-Linking Reagents; En	2002
Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin. Archives of ophthalmology (Chicago, Ill. : 1960), 2002, Volume: 120, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Conjunctival Diseases; Cross-Linking Reagents; En	2002
Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin. Archives of ophthalmology (Chicago, Ill. : 1960), 2002, Volume: 120, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Conjunctival Diseases; Cross-Linking Reagents; En	2002
Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin. Archives of ophthalmology (Chicago, Ill. : 1960), 2002, Volume: 120, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Conjunctival Diseases; Cross-Linking Reagents; En	2002

mitomycin and Endophthalmitis

Research Excerpts

Research

Studies (31)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Kankainen, T	1
Harju, M	1
Khamar, M	1
Bhojwani, D	1
Patel, P	1
Vasavada, A	1
Seth, PK	1
Sharma, S	2
Senthil, S	1
Kerr, NM	1
Wang, J	1
Sandhu, A	1
Harasymowycz, PJ	1
Barton, K	3
Swann, FB	1
Singh, S	1
Blake, D	1
John, V	1
Le, C	1
Fullerton, M	1
Margo, C	1
Zhang, Z	1
Muddasani, N	1
Wall, J	1
Satija, C	1
Greenberg, E	1
Mancera, N	1
Zurakowski, D	1
Ayyala, RS	1
Wallin, Ö	1
Al-ahramy, AM	1
Lundström, M	1
Montan, P	1
Gupta, S	1
Wadhwani, M	1
Sehgal, V	1
Dada, T	1
Cherof, AM	1
SooHoo, JR	1
Kahook, MY	1
Seibold, LK	1
Giampani, J	1
Borges-Giampani, AS	1
Carani, JC	1
Oltrogge, EW	1
Susanna, R	1
Mochizuki, K	2
Kumada, M	1
Suemori, S	1
Kawakami, H	2
Sawada, A	2
Yamamoto, T	2
Mikamo, H	2
Katada, T	1
Watanabe, K	1
Carpineto, P	1
Agnifili, L	1
Nubile, M	1
Fasanella, V	1
Doronzo, E	1
Mastropasqua, A	1
Ciancaglini, M	1
Chiseliţă, D	1
Cantemir, A	1
Ilieş, I	1
Rai, P	1
Kotecha, A	1
Kaltsos, K	1
Ruddle, JB	1
Murdoch, IE	1
Bunce, C	2
Zahid, S	1
Musch, DC	2
Niziol, LM	1
Lichter, PR	2
Mac, I	1
Soltau, JB	1
Scott, IU	2
Cruz-Villegas, V	1
Flynn, HW	3
Miller, D	1
Muckley, ED	1
Lehrer, RA	1
Klimczak-Slaczka, D	1
Grałek, M	1
Chipczyńska, B	1
Kanigowska, K	1
Higginbotham, EJ	1
Stevens, RK	1
Karp, KO	1
Bergstrom, TJ	1
Skuta, GL	1
Greenfield, DS	3
Suñer, IJ	1
Miller, MP	1
Kangas, TA	1
Palmberg, PF	1
Gupta, N	1
Weinreb, RN	1
Waheed, S	1
Ritterband, DC	1
Liebmann, JM	1
Sidoti, PA	1
Ritch, R	1
Akova, YA	1
Bulut, S	1
Dabil, H	1
Duman, S	1
Solomon, A	1
Ticho, U	1
Frucht-Pery, J	1
Lehmann, OJ	1
Matheson, MM	1
Maurino, V	1
Khaw, PT	1
Wormald, R	1
Paciuc, M	1
Velasco, CF	1
Beck, AD	1
Freedman, SF	1
DeBry, PW	1
Perkins, TW	1
Heatley, G	1
Kaufman, P	1
Brumback, LC	1
Song, A	1
Budenz, DL	1