mitomycin has been researched along with EHS Tumor in 44 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Concanavalin A (ConA)-bound-tumor cell vaccine of methylchoranthrene-induced fibrosarcoma (Meth 1) induced tumor-specific immunoprophylactic and immunotherapeutic response against an inoculum of live Meth 1 cells in histocompatible animals." | 7.66 | Chemo-immunotherapy of methylchoranthrene-induced fibrosarcoma by concanavalin A-bound tumor vaccine, levamisole and mitomycin C. ( Marumo, H; Morimoto, M; Okabe, M, 1982) |
| "We investigated the effects of a combination treatment involving a pulsing magnetic field (PMF) and an antitumor drug, mitomycin C (MMC), on two experimental tumors (fibrosarcoma KMT-17 and hepatocellular carcinoma KDH-8) in WKA rats, paying attention to possible potentiation of the therapeutic effect of the antitumor drug." | 3.68 | Treatment of experimental tumors with a combination of a pulsing magnetic field and an antitumor drug. ( Hosokawa, M; Kobayashi, H; Komatsumoto, M; Kubo, Y; Nakajima, S; Namieno, T; Omote, Y, 1990) |
| "Concanavalin A (ConA)-bound-tumor cell vaccine of methylchoranthrene-induced fibrosarcoma (Meth 1) induced tumor-specific immunoprophylactic and immunotherapeutic response against an inoculum of live Meth 1 cells in histocompatible animals." | 3.66 | Chemo-immunotherapy of methylchoranthrene-induced fibrosarcoma by concanavalin A-bound tumor vaccine, levamisole and mitomycin C. ( Marumo, H; Morimoto, M; Okabe, M, 1982) |
| "Virogenic cell cultures of a hamster ependymoma originally produced by Simian Virus 40 were treated with proflavine, hydrogen peroxide, or mitomycin C." | 3.64 | VIROGENIC HAMSTER TUMOR CELLS: INDUCTION OF VIRUS SYNTHESIS. ( GERBER, P, 1964) |
| " Chitosan is used as an excipient in oral dosage form." | 2.42 | Application of chitin and chitosan derivatives in the pharmaceutical field. ( Kato, Y; Machida, Y; Onishi, H, 2003) |
| " MMC microspheres, alone or combined with Dox microspheres, were injected i." | 1.33 | In vivo efficacy and toxicity of intratumorally delivered mitomycin C and its combination with doxorubicin using microsphere formulations. ( Cheung, RY; Rauth, AM; Yu Wu, X, 2005) |
| "Treatment with mitomycin C and hyperthermia resulted in additive tumor-cell killing, and minocycline administration further increased that effect." | 1.29 | Minocycline as a modulator of chemotherapy and hyperthermia in vitro and in vivo. ( Ara, G; Herman, TS; Holden, SA; Liu, CJ; Teicher, BA, 1994) |
| " The seven agents combined with CI-973 were mitomycin C, cyclophosphamide, doxorubicin, vinblastine, etoposide, ifosfamide, and methotrexate." | 1.29 | Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo. ( Elliott, WL; Howard, CT; Leopold, WR; Roberts, BJ, 1994) |
| "To compare the effect on the RIF-1 murine sarcoma of nine bioreductive agents from five different classes when used in combination with either photodynamic therapy or clamping." | 1.29 | Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT). ( Adams, GE; Bradley, JK; Bremner, JC; Naylor, MA; Sansom, JM; Stratford, IJ, 1994) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| "Solid tumors are known to contain hypoxic cells and are relatively resistant to ionizing radiation and some chemotherapeutic agents." | 1.27 | Cytotoxicity of mitomycin C on clonogenic human carcinoma cells is not enhanced by hypoxia. ( Beaudry, JN; Ludwig, CU; Peng, YM; Salmon, SE, 1984) |
| " By considering these pharmacokinetic behaviors, a suitable method of administration should be established." | 1.27 | [Chemical modification of anticancer agents from viewpoints of their pharmacokinetics]. ( Fujita, H, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (61.36) | 18.7374 |
| 1990's | 13 (29.55) | 18.2507 |
| 2000's | 4 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arai, H | 2 |
| Kanda, Y | 2 |
| Ashizawa, T | 2 |
| Morimoto, M | 3 |
| Gomi, K | 2 |
| Kono, M | 2 |
| Kasai, M | 2 |
| YAMAMOTO, T | 2 |
| YAMAOKA, S | 1 |
| UMEZAWA, H | 1 |
| TAKEUCHI, T | 1 |
| NITTA, K | 1 |
| MERKER, PC | 2 |
| REYES, C | 1 |
| ANIDO, P | 1 |
| HATA, T | 2 |
| HOSSENLOPP, C | 1 |
| TAKITA, H | 1 |
| SUGIURA, K | 1 |
| HANDLER, AH | 1 |
| SARRIS, TG | 1 |
| WILLS, C | 1 |
| USUBUCHI, I | 1 |
| GERBER, P | 1 |
| HAGIHARA, K | 1 |
| SAKURAI, Y | 1 |
| MATSUYAMA, M | 1 |
| Kato, Y | 1 |
| Onishi, H | 1 |
| Machida, Y | 1 |
| Cheung, RY | 1 |
| Rauth, AM | 1 |
| Yu Wu, X | 1 |
| Pamidi, A | 1 |
| Cardoso, R | 1 |
| Hakem, A | 1 |
| Matysiak-Zablocki, E | 1 |
| Poonepalli, A | 1 |
| Tamblyn, L | 1 |
| Perez-Ordonez, B | 1 |
| Hande, MP | 1 |
| Sanchez, O | 1 |
| Hakem, R | 1 |
| Matsuzaki, T | 1 |
| Kato, I | 1 |
| Yokokura, T | 1 |
| Mutai, M | 1 |
| Minami, A | 1 |
| Ishii, S | 1 |
| Ogino, T | 1 |
| Oikawa, T | 1 |
| Kobayashi, H | 2 |
| Ichihashi, H | 1 |
| Kuzuya, H | 1 |
| Kondo, T | 1 |
| Schlager, SI | 1 |
| Ohanian, SH | 1 |
| Ludwig, CU | 1 |
| Peng, YM | 1 |
| Beaudry, JN | 1 |
| Salmon, SE | 1 |
| Fujita, H | 1 |
| Yasunaga, T | 1 |
| Ohgaki, K | 1 |
| Inamoto, T | 1 |
| Kan, N | 1 |
| Hikasa, Y | 1 |
| Ogura, T | 4 |
| Shindo, H | 3 |
| Namba, M | 3 |
| Yamamura, Y | 3 |
| Okabe, M | 1 |
| Marumo, H | 1 |
| Kawalec, M | 1 |
| Jakóbisiak, M | 1 |
| Skórski, T | 1 |
| Kawiak, J | 1 |
| Shinzato, O | 2 |
| Masuno, T | 1 |
| Inoue, T | 1 |
| Kishimoto, S | 2 |
| Sakatani, M | 1 |
| Yano, K | 2 |
| Matsuoka, H | 2 |
| Baba, H | 1 |
| Konoe, S | 1 |
| Seo, Y | 2 |
| Saito, T | 2 |
| Tomoda, H | 2 |
| Kitamura, M | 1 |
| Arai, K | 1 |
| Iwasaki, Y | 1 |
| Teicher, BA | 1 |
| Holden, SA | 1 |
| Liu, CJ | 1 |
| Ara, G | 1 |
| Herman, TS | 1 |
| Elliott, WL | 1 |
| Roberts, BJ | 1 |
| Howard, CT | 1 |
| Leopold, WR | 1 |
| Ueda, H | 1 |
| Manda, T | 1 |
| Matsumoto, S | 1 |
| Mukumoto, S | 1 |
| Nishigaki, F | 1 |
| Kawamura, I | 1 |
| Shimomura, K | 1 |
| Bremner, JC | 2 |
| Bradley, JK | 1 |
| Adams, GE | 2 |
| Naylor, MA | 1 |
| Sansom, JM | 1 |
| Stratford, IJ | 2 |
| Ohasi, K | 1 |
| Satonaka, K | 1 |
| Yamazaki, M | 1 |
| Kimura, S | 1 |
| Abe, S | 1 |
| Yamaguchi, H | 1 |
| Katsuta, Y | 1 |
| Morita, M | 1 |
| Kounoe, S | 1 |
| Hosokawa, M | 2 |
| Otaki, S | 1 |
| Kaneko, H | 1 |
| Fukuma, E | 1 |
| Yamakawa, T | 1 |
| Bowler, J | 1 |
| Omote, Y | 1 |
| Komatsumoto, M | 1 |
| Namieno, T | 1 |
| Nakajima, S | 1 |
| Kubo, Y | 1 |
| Sartorelli, AC | 1 |
| Hagiwara, A | 1 |
| Takahashi, T | 1 |
| Kondoh, S | 1 |
| Iwamoto, A | 1 |
| Sawai, K | 1 |
| Wing, MG | 1 |
| Rogers, K | 1 |
| Jacob, G | 1 |
| Rees, RC | 1 |
| Komiyama, K | 1 |
| Hirokawa, Y | 1 |
| Zhibo, Y | 1 |
| Umezawa, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of Romidepsin Given on Days One, Three, and Five in Patients With Thyroid and Other Advanced Cancers[NCT00048334] | Phase 1 | 28 participants (Actual) | Interventional | 2002-10-26 | Completed | ||
| Phase I Study of Topical Romidepsin (Depsipeptide) in Early Stage Cutaneous T-Cell Lymphoma[NCT01445340] | Phase 1 | 6 participants (Actual) | Interventional | 2007-04-21 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for mitomycin and EHS Tumor
| Article | Year |
|---|---|
Application of chitin and chitosan derivatives in the pharmaceutical field.
Topics: Adjuvants, Pharmaceutic; Animals; Cell Survival; Chitin; Chitosan; Delayed-Action Preparations; Drug | 2003 |
[Possible clinical application of immunochemotherapy experimented in animals].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bleo | 2000 |
[Targeting chemotherapy with activated carbon particles adsorbing anti-cancer drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Carbon; Drug Carriers; Humans; Lymphatic Metastasis; Mito | 1988 |
1 trial available for mitomycin and EHS Tumor
| Article | Year |
|---|---|
[Evaluation of intraperitoneal chemotherapy using CDDP combined with MMC in gastric carcinomatous peritonitis].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fe | 1994 |
40 other studies available for mitomycin and EHS Tumor
| Article | Year |
|---|---|
Synthesis and antitumor activity of novel mitomycin derivatives containing functional groups at the C-6-methyl position.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia P388; | 1994 |
Synthesis and antitumor activity of novel 6-alkyl-6-demethylmitomycins.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice; Mitomyci | 1994 |
[Effects of mitomycin and some other substances produced by streptomyces upon Yoshida sarcoma].
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Humans; Mitomycin; | 1953 |
A mitomycin C-resistant Jensen rat sarcoma: isolation and transplantation studies.
Topics: Animals; Mitomycin; Mitomycins; Neoplasms; Rats; Sarcoma; Sarcoma, Experimental | 1962 |
Comparative studies of antitumor activities of mitomycin C and 6-mercaptopurine.
Topics: Animals; Antineoplastic Agents; Carcinoma; Mercaptopurine; Mitomycin; Sarcoma, Experimental | 1961 |
A MITOMYCIN C-RESISTANT JENSEN RAT SARCOMA: CHEMOTHERAPY STUDIES.
Topics: Animals; Antineoplastic Agents; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Pharmacol | 1963 |
CHEMOTHERAPY STUDIES ON PRIMARY TUMOR GRAFTS AND METASTASES IN HAMSTERS AND MICE.
Topics: Antineoplastic Agents; Cricetinae; Cyclophosphamide; Dactinomycin; Melphalan; Mice; Mitomycin; Mitom | 1964 |
ADMINISTRATION METHOD OF MITOMYCIN C.
Topics: Carcinoma, Hepatocellular; Liver Neoplasms; Methylcholanthrene; Mitomycin; Mitomycins; Neoplasms; Ne | 1964 |
VIROGENIC HAMSTER TUMOR CELLS: INDUCTION OF VIRUS SYNTHESIS.
Topics: Acridines; Adenoviridae; Adenoviridae Infections; Complement Fixation Tests; Cricetinae; Ependymoma; | 1964 |
THE USE OF RAT ASCITES TUMORS HETEROGRAFTED IN MICE FOR SCREENING OF ANTICANCEROUS AGENTS.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Ascites; Carcinoma, Ehrlich Tumor; Carcinoma, | 1963 |
IN VITRO CULTURE OF YOSHIDA SARCOMA CELLS: METHODS FOR DETERMINING ACQUIRED RESISTANCE TO DRUGS.
Topics: Animals; Antineoplastic Agents; Azaguanine; Culture Media; Cyclophosphamide; Dactinomycin; Drug Tole | 1964 |
The influences of mitomycin C and carzinophilin upon methylcholanthrene sarcoma in rats. (A preliminary report).
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Antineoplastic Agents; Methylcholan | 1961 |
In vivo efficacy and toxicity of intratumorally delivered mitomycin C and its combination with doxorubicin using microsphere formulations.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Delayed-Action Preparations; D | 2005 |
Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Cell Growth Processes; DNA; DNA Damage; DNA-Binding Pr | 2007 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
Effect of the immunological antigenicity of the allogeneic tendons on tendon grafting.
Topics: Achilles Tendon; Animals; Complement Fixation Tests; Cytotoxicity Tests, Immunologic; Formaldehyde; | 1982 |
Enhancement of the cytocidal effect of mitomycin C by means of simultaneous administration of prostaglandin E1.
Topics: Alprostadil; Animals; Colonic Neoplasms; Drug Synergism; Humans; Injections, Intra-Arterial; Injecti | 1983 |
Role of membrane lipids in the immunological killing of tumor cells: I. Target cell lipids.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Membrane; Cytotoxicity, Immunologic; Doxorubic | 1983 |
Cytotoxicity of mitomycin C on clonogenic human carcinoma cells is not enhanced by hypoxia.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Colonic Neoplasms; Humans; Mice; Mitomycin; Mitomyc | 1984 |
[Chemical modification of anticancer agents from viewpoints of their pharmacokinetics].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Doxorubicin; Fibrosarcoma; | 1984 |
Protective effect of vitamin E against immunosuppression induced by adriamycin, mitomycin C and 5-fluorouracil in mice.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Fibrosarcoma; Fluorouracil; Immunity, Cellular; I | 1983 |
Tumoricidal activity of peritoneal exudate cells from rats treated with mitomycin C.
Topics: Animals; Ascitic Fluid; Cells, Cultured; Fibrosarcoma; Macrophages; Male; Mitomycin; Mitomycins; Rat | 1980 |
Chemo-immunotherapy of methylchoranthrene-induced fibrosarcoma by concanavalin A-bound tumor vaccine, levamisole and mitomycin C.
Topics: Animals; Concanavalin A; Drug Therapy, Combination; Fibrosarcoma; Immunotherapy; Levamisole; Male; M | 1982 |
Immunogenicity of cyclophosphamide-treated leukaemia cells.
Topics: Animals; Antibiotics, Antineoplastic; Cyclophosphamide; Immune Tolerance; Leukemia L1210; Mice; Mice | 1982 |
In vitro tumor cell killing by peritoneal macrophages from mitomycin C-treated rats.
Topics: Animals; Antibiotics, Antineoplastic; Cell Adhesion; Cytotoxicity, Immunologic; Deoxyglucose; Fibros | 1982 |
Analysis of therapeutic effect in experimental chemoimmunotherapy for rat ascites tumor.
Topics: Adjuvants, Immunologic; Animals; Ascites; Cell Line; Fibrosarcoma; Male; Mitomycin; Mitomycins; Noca | 1982 |
[Antitumor effect of MMC mixed in Beriplast P].
Topics: Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Drug Combinations; Fibrin Tissue | 1995 |
Minocycline as a modulator of chemotherapy and hyperthermia in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Hyperthermia, Induce | 1994 |
Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Neoplasms; Cyclophosph | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT).
Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Nitroimidazoles; Ph | 1994 |
[Antitumor activity of Enterococcus faecalis FK-23 preparation against murine syngeneic tumors].
Topics: Animals; Biological Products; Combined Modality Therapy; Cyclophosphamide; Enterococcus faecalis; Ma | 1993 |
Advantages and safety of local treatment with MMC/Beriplast P for cancer tumors.
Topics: Animals; Antibiotics, Antineoplastic; Aorta; Carcinoma, Squamous Cell; Delayed-Action Preparations; | 1996 |
[Experimental study on the effect of injection with anticancer agent-oil suspension].
Topics: Animals; Doxorubicin; Injections, Intralesional; Iodized Oil; Lung Neoplasms; Lymph Nodes; Lymphatic | 1992 |
Bioreductive drugs and the selective induction of tumour hypoxia.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Constriction; Hydralazine; Mice; Mice, Inbred C3H; Mis | 1990 |
Treatment of experimental tumors with a combination of a pulsing magnetic field and an antitumor drug.
Topics: Animals; Antineoplastic Agents; Cell Division; Combined Modality Therapy; Fibrosarcoma; Hot Temperat | 1990 |
The role of mitomycin antibiotics in the chemotherapy of solid tumors.
Topics: Anaerobiosis; Animals; Biotransformation; Cytochromes; Dicumarol; Drug Synergism; Female; Mammary Ne | 1986 |
Characterisation of suppressor cells generated following cryosurgery of an HSV-2-induced fibrosarcoma.
Topics: Animals; Antigen-Presenting Cells; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Cycle; Cell T | 1988 |
[Induction of activated macrophages by intraperitoneal injection of mitomycin C in mice and rats].
Topics: Animals; Concanavalin A; Dose-Response Relationship, Drug; Fibrosarcoma; Injections; Lymphokines; Ma | 1986 |
[Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh].
Topics: Animals; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Synergism; Drugs, Chinese Herbal; Female; Fi | 1988 |