Page last updated: 2024-11-06

mitomycin and Dysphagia

mitomycin has been researched along with Dysphagia in 17 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Research Excerpts

ExcerptRelevanceReference
"This prospective study aimed to evaluate the feasibility and safety of locoregional mitomycin C (MMC) injection to treat refractory esophageal strictures after endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma."9.16Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection. ( Arakawa, T; Fujiwara, Y; Machida, H; Minamino, H; Okazaki, H; Sugimori, S; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T; Yamagami, H, 2012)
"To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures."8.93Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review. ( Bartel, MJ; Clayton, D; Jeffers, K; Raimondo, M; Seeger, K; Wallace, MB; Woodward, TA, 2016)
"There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group (p=0."7.81A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children. ( Ezzat, WF; Fawaz, SA; Sabri, SM; Sweed, AS, 2015)
"Intramuscular injection of mitomycin C or dexamethasone may prolong the dysphagia-free period and decrease the frequency of repeat dilations compared with conventional endoscopic dilations in patients with benign esophageal strictures."7.81Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures. ( Chen, JP; Fan, ZN; Liu, L; Wang, X; Zhang, Y, 2015)
" In 12 patients of caustic induced esophageal stricture, who failed to respond despite rigorous dilatation regimen for more than one year, a trial of topical mitomycin-C application to improve dilatation results was undertaken, considering the recently reported efficacy and safety of this agent."7.80Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures. ( Katiyar, P; Nagaich, N; Nijhawan, S; Rathore, M; Sharma, R, 2014)
" We report the successful use of mitomycin C in a young boy in whom we could achieve ongoing relief of dysphagia after the unsuccessful long-term use of frequent endoscopic dilatations."7.74[Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy]. ( Fröhlich, T; Greess, H; Köhler, H, 2007)
"We describe a novel technique of endoluminal delivery and focused application of mitomycin-C to an esophageal stricture that avoids inadvertent topical application to adjacent mucosa."7.74Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. ( Baird, R; Blair, GK; Heran, MK; Skarsgard, ED, 2008)
"To assess the role of mitomycin C (MMC) in the management of pharyngoesophageal stricture after total laryngopharyngectomy and free flap reconstruction."7.72Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction. ( Annino, DJ; Goguen, LA, 2003)
"The median dysphagia score decreased from 2 (1 to 3) to 0 (0 to 2) after application (P<0."5.46Topical Mitomycin C Application Is Effective Even in Esophageal Strictures Resistant to Dilatation Therapy in Children. ( Divarci, E; Dokumcu, Z; Erdener, A; Kilic, O; Ozcan, C, 2017)
"This prospective study aimed to evaluate the feasibility and safety of locoregional mitomycin C (MMC) injection to treat refractory esophageal strictures after endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma."5.16Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection. ( Arakawa, T; Fujiwara, Y; Machida, H; Minamino, H; Okazaki, H; Sugimori, S; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T; Yamagami, H, 2012)
"To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures."4.93Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review. ( Bartel, MJ; Clayton, D; Jeffers, K; Raimondo, M; Seeger, K; Wallace, MB; Woodward, TA, 2016)
"There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group (p=0."3.81A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children. ( Ezzat, WF; Fawaz, SA; Sabri, SM; Sweed, AS, 2015)
"Intramuscular injection of mitomycin C or dexamethasone may prolong the dysphagia-free period and decrease the frequency of repeat dilations compared with conventional endoscopic dilations in patients with benign esophageal strictures."3.81Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures. ( Chen, JP; Fan, ZN; Liu, L; Wang, X; Zhang, Y, 2015)
" In 12 patients of caustic induced esophageal stricture, who failed to respond despite rigorous dilatation regimen for more than one year, a trial of topical mitomycin-C application to improve dilatation results was undertaken, considering the recently reported efficacy and safety of this agent."3.80Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures. ( Katiyar, P; Nagaich, N; Nijhawan, S; Rathore, M; Sharma, R, 2014)
"Twelve patients with progressive dysphagia and video-fluoroscopic evidence of upper digestive tract stricture after head and neck cancer treatment were dilated by Maloney or Savory dilators followed by the application of mitomycin C (0."3.74Role of mitomycin in upper digestive tract stricture. ( Brodsky, MB; Day, TA; Gillespie, MB; Martin-Harris, B; Sharma, AK, 2007)
" We report the successful use of mitomycin C in a young boy in whom we could achieve ongoing relief of dysphagia after the unsuccessful long-term use of frequent endoscopic dilatations."3.74[Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy]. ( Fröhlich, T; Greess, H; Köhler, H, 2007)
"We describe a novel technique of endoluminal delivery and focused application of mitomycin-C to an esophageal stricture that avoids inadvertent topical application to adjacent mucosa."3.74Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. ( Baird, R; Blair, GK; Heran, MK; Skarsgard, ED, 2008)
"To assess the role of mitomycin C (MMC) in the management of pharyngoesophageal stricture after total laryngopharyngectomy and free flap reconstruction."3.72Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction. ( Annino, DJ; Goguen, LA, 2003)
"Between 1994 and 1997, 22 patients with dysphagia from advanced incurable esophageal cancer were enrolled in a phase I/II prospective study to assess the palliative benefit and toxicity of a short course of radiotherapy with chemotherapy."2.69A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer. ( Hayter, CR; Huff-Winters, C; Paszat, L; Schulze, K; Shelley, WE; Youssef, YM, 2000)
"The median dysphagia score decreased from 2 (1 to 3) to 0 (0 to 2) after application (P<0."1.46Topical Mitomycin C Application Is Effective Even in Esophageal Strictures Resistant to Dilatation Therapy in Children. ( Divarci, E; Dokumcu, Z; Erdener, A; Kilic, O; Ozcan, C, 2017)
"Acute toxicity was well tolerated and dysphagia was improved in 35 patients (65%), with 28 (52%) eating a normal diet by week 12."1.30Continuous hyperfractionated accelerated radiotherapy (CHART) in localized cancer of the esophagus. ( Dische, S; Foy, CJ; Hoskin, PJ; Powell, ME; Saunders, MI, 1997)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's6 (35.29)29.6817
2010's9 (52.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Divarci, E1
Kilic, O1
Dokumcu, Z1
Ozcan, C1
Erdener, A1
Patterson, JM1
McColl, E1
Carding, PN1
Hildreth, AJ1
Kelly, C1
Wilson, JA1
Nagaich, N1
Nijhawan, S1
Katiyar, P1
Sharma, R1
Rathore, M1
El-Asmar, KM1
Hassan, MA1
Abdelkader, HM1
Hamza, AF1
Sweed, AS1
Fawaz, SA1
Ezzat, WF1
Sabri, SM1
Zhang, Y1
Wang, X1
Liu, L1
Chen, JP1
Fan, ZN1
Manfredi, MA1
Bartel, MJ1
Seeger, K1
Jeffers, K1
Clayton, D1
Wallace, MB1
Raimondo, M1
Woodward, TA1
Machida, H1
Tominaga, K1
Minamino, H1
Sugimori, S1
Okazaki, H1
Yamagami, H1
Tanigawa, T1
Watanabe, K1
Watanabe, T1
Fujiwara, Y1
Arakawa, T1
Annino, DJ1
Goguen, LA1
Gillespie, MB1
Day, TA1
Sharma, AK1
Brodsky, MB1
Martin-Harris, B1
Fröhlich, T1
Greess, H1
Köhler, H1
Heran, MK1
Baird, R1
Blair, GK1
Skarsgard, ED1
Powell, ME1
Hoskin, PJ1
Saunders, MI1
Foy, CJ1
Dische, S1
Hayter, CR1
Huff-Winters, C1
Paszat, L1
Youssef, YM1
Shelley, WE1
Schulze, K1
Seitz, JF1
Duffaud, F1
Dahan, L1
Ries, P1
Ville, E1
Laugier, R1
Schifter, M1
Barrett, AP1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Use of Triamcinolone Injection in Treatment of Refractory Benign Esophageal Stricture in Children[NCT04524897]Phase 420 participants (Anticipated)Interventional2020-12-01Not yet recruiting
Effectiveness Evaluation of Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Early Esophageal Cancer Invading More Than 2/3 Esophageal Perimeter[NCT03165344]66 participants (Actual)Interventional2017-02-10Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for mitomycin and Dysphagia

ArticleYear
Endoscopic Management of Anastomotic Esophageal Strictures Secondary to Esophageal Atresia.
    Gastrointestinal endoscopy clinics of North America, 2016, Volume: 26, Issue:1

    Topics: Alkylating Agents; Deglutition Disorders; Dilatation; Esophageal Atresia; Esophageal Stenosis; Esoph

2016
Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2016, Volume: 48, Issue:9

    Topics: Aged; Alkylating Agents; Anastomosis, Surgical; Balloon Occlusion; Caustics; Constriction, Pathologi

2016

Trials

3 trials available for mitomycin and Dysphagia

ArticleYear
Topical mitomycin C can effectively alleviate dysphagia in children with long-segment caustic esophageal strictures.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2015, Volume: 28, Issue:5

    Topics: Administration, Topical; Alkylating Agents; Burns, Chemical; Caustics; Child, Preschool; Deglutition

2015
Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection.
    Endoscopy, 2012, Volume: 44, Issue:6

    Topics: Aged; Carcinoma; Catheterization; Deglutition Disorders; Dissection; Esophageal Neoplasms; Esophagea

2012
A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2000, Volume: 56, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Th

2000

Other Studies

12 other studies available for mitomycin and Dysphagia

ArticleYear
Topical Mitomycin C Application Is Effective Even in Esophageal Strictures Resistant to Dilatation Therapy in Children.
    Surgical laparoscopy, endoscopy & percutaneous techniques, 2017, Volume: 27, Issue:5

    Topics: Administration, Topical; Adolescent; Alkylating Agents; Chemotherapy, Adjuvant; Child; Child, Presch

2017
Swallowing in the first year after chemoradiotherapy for head and neck cancer: clinician- and patient-reported outcomes.
    Head & neck, 2014, Volume: 36, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Deglutition; Deglutition Disorders

2014
Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2014, Volume: 27, Issue:3

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Burns, Chemical; Deglutition Disorders; Dilata

2014
A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children.
    International journal of pediatric otorhinolaryngology, 2015, Volume: 79, Issue:1

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Burns, Chemical; Caustics; Child; Child, Presc

2015
Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures.
    Journal of digestive diseases, 2015, Volume: 16, Issue:7

    Topics: Aged; Alkylating Agents; Anti-Inflammatory Agents; Combined Modality Therapy; Deglutition Disorders;

2015
Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction.
    The Laryngoscope, 2003, Volume: 113, Issue:9

    Topics: Adenocarcinoma; Administration, Topical; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy;

2003
Role of mitomycin in upper digestive tract stricture.
    Head & neck, 2007, Volume: 29, Issue:1

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Degl

2007
[Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy].
    Zeitschrift fur Gastroenterologie, 2007, Volume: 45, Issue:3

    Topics: Administration, Topical; Burns, Chemical; Caustics; Child, Preschool; Deglutition Disorders; Esophag

2007
Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery.
    Journal of pediatric surgery, 2008, Volume: 43, Issue:5

    Topics: Administration, Topical; Adult; Burns, Chemical; Catheterization; Child, Preschool; Deglutition Diso

2008
Continuous hyperfractionated accelerated radiotherapy (CHART) in localized cancer of the esophagus.
    International journal of radiation oncology, biology, physics, 1997, Apr-01, Volume: 38, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cisp

1997
[Adenocarcinomas of the distal esophagus and gastric cardia: what chemotherapy or chemoradiotherapy for recurrent or metastatic disease?].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2001, Volume: 5 Suppl 1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cardia; Cisplatin; Combined Modality

2001
Multiple cranial nerve involvement leading to diagnosis of nasopharyngeal carcinoma: case report.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1992, Volume: 50, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cranial Nerves; Deglutition Disorders; Fl

1992