mitomycin has been researched along with Dysphagia in 17 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective study aimed to evaluate the feasibility and safety of locoregional mitomycin C (MMC) injection to treat refractory esophageal strictures after endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma." | 9.16 | Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection. ( Arakawa, T; Fujiwara, Y; Machida, H; Minamino, H; Okazaki, H; Sugimori, S; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T; Yamagami, H, 2012) |
| "To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures." | 8.93 | Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review. ( Bartel, MJ; Clayton, D; Jeffers, K; Raimondo, M; Seeger, K; Wallace, MB; Woodward, TA, 2016) |
| "There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group (p=0." | 7.81 | A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children. ( Ezzat, WF; Fawaz, SA; Sabri, SM; Sweed, AS, 2015) |
| "Intramuscular injection of mitomycin C or dexamethasone may prolong the dysphagia-free period and decrease the frequency of repeat dilations compared with conventional endoscopic dilations in patients with benign esophageal strictures." | 7.81 | Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures. ( Chen, JP; Fan, ZN; Liu, L; Wang, X; Zhang, Y, 2015) |
| " In 12 patients of caustic induced esophageal stricture, who failed to respond despite rigorous dilatation regimen for more than one year, a trial of topical mitomycin-C application to improve dilatation results was undertaken, considering the recently reported efficacy and safety of this agent." | 7.80 | Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures. ( Katiyar, P; Nagaich, N; Nijhawan, S; Rathore, M; Sharma, R, 2014) |
| " We report the successful use of mitomycin C in a young boy in whom we could achieve ongoing relief of dysphagia after the unsuccessful long-term use of frequent endoscopic dilatations." | 7.74 | [Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy]. ( Fröhlich, T; Greess, H; Köhler, H, 2007) |
| "We describe a novel technique of endoluminal delivery and focused application of mitomycin-C to an esophageal stricture that avoids inadvertent topical application to adjacent mucosa." | 7.74 | Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. ( Baird, R; Blair, GK; Heran, MK; Skarsgard, ED, 2008) |
| "To assess the role of mitomycin C (MMC) in the management of pharyngoesophageal stricture after total laryngopharyngectomy and free flap reconstruction." | 7.72 | Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction. ( Annino, DJ; Goguen, LA, 2003) |
| "The median dysphagia score decreased from 2 (1 to 3) to 0 (0 to 2) after application (P<0." | 5.46 | Topical Mitomycin C Application Is Effective Even in Esophageal Strictures Resistant to Dilatation Therapy in Children. ( Divarci, E; Dokumcu, Z; Erdener, A; Kilic, O; Ozcan, C, 2017) |
| "This prospective study aimed to evaluate the feasibility and safety of locoregional mitomycin C (MMC) injection to treat refractory esophageal strictures after endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma." | 5.16 | Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection. ( Arakawa, T; Fujiwara, Y; Machida, H; Minamino, H; Okazaki, H; Sugimori, S; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T; Yamagami, H, 2012) |
| "To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures." | 4.93 | Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review. ( Bartel, MJ; Clayton, D; Jeffers, K; Raimondo, M; Seeger, K; Wallace, MB; Woodward, TA, 2016) |
| "There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group (p=0." | 3.81 | A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children. ( Ezzat, WF; Fawaz, SA; Sabri, SM; Sweed, AS, 2015) |
| "Intramuscular injection of mitomycin C or dexamethasone may prolong the dysphagia-free period and decrease the frequency of repeat dilations compared with conventional endoscopic dilations in patients with benign esophageal strictures." | 3.81 | Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures. ( Chen, JP; Fan, ZN; Liu, L; Wang, X; Zhang, Y, 2015) |
| " In 12 patients of caustic induced esophageal stricture, who failed to respond despite rigorous dilatation regimen for more than one year, a trial of topical mitomycin-C application to improve dilatation results was undertaken, considering the recently reported efficacy and safety of this agent." | 3.80 | Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures. ( Katiyar, P; Nagaich, N; Nijhawan, S; Rathore, M; Sharma, R, 2014) |
| "Twelve patients with progressive dysphagia and video-fluoroscopic evidence of upper digestive tract stricture after head and neck cancer treatment were dilated by Maloney or Savory dilators followed by the application of mitomycin C (0." | 3.74 | Role of mitomycin in upper digestive tract stricture. ( Brodsky, MB; Day, TA; Gillespie, MB; Martin-Harris, B; Sharma, AK, 2007) |
| " We report the successful use of mitomycin C in a young boy in whom we could achieve ongoing relief of dysphagia after the unsuccessful long-term use of frequent endoscopic dilatations." | 3.74 | [Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy]. ( Fröhlich, T; Greess, H; Köhler, H, 2007) |
| "We describe a novel technique of endoluminal delivery and focused application of mitomycin-C to an esophageal stricture that avoids inadvertent topical application to adjacent mucosa." | 3.74 | Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. ( Baird, R; Blair, GK; Heran, MK; Skarsgard, ED, 2008) |
| "To assess the role of mitomycin C (MMC) in the management of pharyngoesophageal stricture after total laryngopharyngectomy and free flap reconstruction." | 3.72 | Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction. ( Annino, DJ; Goguen, LA, 2003) |
| "Between 1994 and 1997, 22 patients with dysphagia from advanced incurable esophageal cancer were enrolled in a phase I/II prospective study to assess the palliative benefit and toxicity of a short course of radiotherapy with chemotherapy." | 2.69 | A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer. ( Hayter, CR; Huff-Winters, C; Paszat, L; Schulze, K; Shelley, WE; Youssef, YM, 2000) |
| "The median dysphagia score decreased from 2 (1 to 3) to 0 (0 to 2) after application (P<0." | 1.46 | Topical Mitomycin C Application Is Effective Even in Esophageal Strictures Resistant to Dilatation Therapy in Children. ( Divarci, E; Dokumcu, Z; Erdener, A; Kilic, O; Ozcan, C, 2017) |
| "Acute toxicity was well tolerated and dysphagia was improved in 35 patients (65%), with 28 (52%) eating a normal diet by week 12." | 1.30 | Continuous hyperfractionated accelerated radiotherapy (CHART) in localized cancer of the esophagus. ( Dische, S; Foy, CJ; Hoskin, PJ; Powell, ME; Saunders, MI, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Divarci, E | 1 |
| Kilic, O | 1 |
| Dokumcu, Z | 1 |
| Ozcan, C | 1 |
| Erdener, A | 1 |
| Patterson, JM | 1 |
| McColl, E | 1 |
| Carding, PN | 1 |
| Hildreth, AJ | 1 |
| Kelly, C | 1 |
| Wilson, JA | 1 |
| Nagaich, N | 1 |
| Nijhawan, S | 1 |
| Katiyar, P | 1 |
| Sharma, R | 1 |
| Rathore, M | 1 |
| El-Asmar, KM | 1 |
| Hassan, MA | 1 |
| Abdelkader, HM | 1 |
| Hamza, AF | 1 |
| Sweed, AS | 1 |
| Fawaz, SA | 1 |
| Ezzat, WF | 1 |
| Sabri, SM | 1 |
| Zhang, Y | 1 |
| Wang, X | 1 |
| Liu, L | 1 |
| Chen, JP | 1 |
| Fan, ZN | 1 |
| Manfredi, MA | 1 |
| Bartel, MJ | 1 |
| Seeger, K | 1 |
| Jeffers, K | 1 |
| Clayton, D | 1 |
| Wallace, MB | 1 |
| Raimondo, M | 1 |
| Woodward, TA | 1 |
| Machida, H | 1 |
| Tominaga, K | 1 |
| Minamino, H | 1 |
| Sugimori, S | 1 |
| Okazaki, H | 1 |
| Yamagami, H | 1 |
| Tanigawa, T | 1 |
| Watanabe, K | 1 |
| Watanabe, T | 1 |
| Fujiwara, Y | 1 |
| Arakawa, T | 1 |
| Annino, DJ | 1 |
| Goguen, LA | 1 |
| Gillespie, MB | 1 |
| Day, TA | 1 |
| Sharma, AK | 1 |
| Brodsky, MB | 1 |
| Martin-Harris, B | 1 |
| Fröhlich, T | 1 |
| Greess, H | 1 |
| Köhler, H | 1 |
| Heran, MK | 1 |
| Baird, R | 1 |
| Blair, GK | 1 |
| Skarsgard, ED | 1 |
| Powell, ME | 1 |
| Hoskin, PJ | 1 |
| Saunders, MI | 1 |
| Foy, CJ | 1 |
| Dische, S | 1 |
| Hayter, CR | 1 |
| Huff-Winters, C | 1 |
| Paszat, L | 1 |
| Youssef, YM | 1 |
| Shelley, WE | 1 |
| Schulze, K | 1 |
| Seitz, JF | 1 |
| Duffaud, F | 1 |
| Dahan, L | 1 |
| Ries, P | 1 |
| Ville, E | 1 |
| Laugier, R | 1 |
| Schifter, M | 1 |
| Barrett, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Triamcinolone Injection in Treatment of Refractory Benign Esophageal Stricture in Children[NCT04524897] | Phase 4 | 20 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | ||
| Effectiveness Evaluation of Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Early Esophageal Cancer Invading More Than 2/3 Esophageal Perimeter[NCT03165344] | 66 participants (Actual) | Interventional | 2017-02-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mitomycin and Dysphagia
| Article | Year |
|---|---|
Endoscopic Management of Anastomotic Esophageal Strictures Secondary to Esophageal Atresia.
Topics: Alkylating Agents; Deglutition Disorders; Dilatation; Esophageal Atresia; Esophageal Stenosis; Esoph | 2016 |
Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review.
Topics: Aged; Alkylating Agents; Anastomosis, Surgical; Balloon Occlusion; Caustics; Constriction, Pathologi | 2016 |
3 trials available for mitomycin and Dysphagia
| Article | Year |
|---|---|
Topical mitomycin C can effectively alleviate dysphagia in children with long-segment caustic esophageal strictures.
Topics: Administration, Topical; Alkylating Agents; Burns, Chemical; Caustics; Child, Preschool; Deglutition | 2015 |
Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection.
Topics: Aged; Carcinoma; Catheterization; Deglutition Disorders; Dissection; Esophageal Neoplasms; Esophagea | 2012 |
A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Th | 2000 |
12 other studies available for mitomycin and Dysphagia
| Article | Year |
|---|---|
Topical Mitomycin C Application Is Effective Even in Esophageal Strictures Resistant to Dilatation Therapy in Children.
Topics: Administration, Topical; Adolescent; Alkylating Agents; Chemotherapy, Adjuvant; Child; Child, Presch | 2017 |
Swallowing in the first year after chemoradiotherapy for head and neck cancer: clinician- and patient-reported outcomes.
Topics: Adult; Aged; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Deglutition; Deglutition Disorders | 2014 |
Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures.
Topics: Administration, Topical; Antibiotics, Antineoplastic; Burns, Chemical; Deglutition Disorders; Dilata | 2014 |
A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children.
Topics: Administration, Topical; Antibiotics, Antineoplastic; Burns, Chemical; Caustics; Child; Child, Presc | 2015 |
Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures.
Topics: Aged; Alkylating Agents; Anti-Inflammatory Agents; Combined Modality Therapy; Deglutition Disorders; | 2015 |
Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction.
Topics: Adenocarcinoma; Administration, Topical; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; | 2003 |
Role of mitomycin in upper digestive tract stricture.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Degl | 2007 |
[Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy].
Topics: Administration, Topical; Burns, Chemical; Caustics; Child, Preschool; Deglutition Disorders; Esophag | 2007 |
Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery.
Topics: Administration, Topical; Adult; Burns, Chemical; Catheterization; Child, Preschool; Deglutition Diso | 2008 |
Continuous hyperfractionated accelerated radiotherapy (CHART) in localized cancer of the esophagus.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cisp | 1997 |
[Adenocarcinomas of the distal esophagus and gastric cardia: what chemotherapy or chemoradiotherapy for recurrent or metastatic disease?].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cardia; Cisplatin; Combined Modality | 2001 |
Multiple cranial nerve involvement leading to diagnosis of nasopharyngeal carcinoma: case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cranial Nerves; Deglutition Disorders; Fl | 1992 |