Page last updated: 2024-11-06

mitomycin and Down Syndrome

mitomycin has been researched along with Down Syndrome in 5 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
"A possible predisposition to aneuploidy in trisomic 21 individuals, their parents, and a control group was evaluated."1.31Aneuploidy induced in lymphocytes of parents of trisomic 21 children. ( Caria, H; Chaveca, T; Rueff, J, 2001)
"Treatment with mitomycin C (0."1.28Sister-chromatid exchanges in lymphocytes from infants with Down's syndrome. ( Allak, BM; Hamami, HA; Khaleel, AH; Shubber, EK, 1991)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, X1
Zhao, Y1
Zhang, X1
Badie, H1
Zhou, Y1
Mu, Y1
Loo, LS1
Cai, L1
Thompson, RC1
Yang, B1
Chen, Y1
Johnson, PF1
Wu, C1
Bu, G1
Mobley, WC1
Zhang, D1
Gage, FH1
Ranscht, B1
Zhang, YW1
Lipton, SA1
Hong, W1
Xu, H1
Caria, H2
Quintas, A1
Chaveca, T2
Rueff, J2
Bal, F1
Sahin, FI1
Yirmibes, M1
Balci, A1
Menevşe, S1
Shubber, EK1
Hamami, HA1
Allak, BM1
Khaleel, AH1

Other Studies

5 other studies available for mitomycin and Down Syndrome

ArticleYear
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
    Nature medicine, 2013, Volume: 19, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; C-Reactive Protein; CCAAT-Enhancer-Binding

2013
The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells.
    Mutation research, 1997, Jul-03, Volume: 377, Issue:2

    Topics: Benzamides; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Down Syndrome; Enzyme Inh

1997
The in vitro effect of beta-carotene and mitomycin C on SCE frequency in Down's syndrome lymphocyte cultures.
    The Tohoku journal of experimental medicine, 1998, Volume: 184, Issue:4

    Topics: Adolescent; Antioxidants; beta Carotene; Cells, Cultured; Child; Child, Preschool; Down Syndrome; Fe

1998
Aneuploidy induced in lymphocytes of parents of trisomic 21 children.
    Teratogenesis, carcinogenesis, and mutagenesis, 2001, Volume: 21, Issue:5

    Topics: Adult; Aneuploidy; Cyclophosphamide; Down Syndrome; Humans; Lymphocytes; Micronuclei, Chromosome-Def

2001
Sister-chromatid exchanges in lymphocytes from infants with Down's syndrome.
    Mutation research, 1991, Volume: 248, Issue:1

    Topics: Adult; Age Factors; Alkylating Agents; Analysis of Variance; Cell Cycle; DNA Repair; Down Syndrome;

1991