mitomycin has been researched along with Down Syndrome in 5 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Excerpt | Relevance | Reference |
---|---|---|
"A possible predisposition to aneuploidy in trisomic 21 individuals, their parents, and a control group was evaluated." | 1.31 | Aneuploidy induced in lymphocytes of parents of trisomic 21 children. ( Caria, H; Chaveca, T; Rueff, J, 2001) |
"Treatment with mitomycin C (0." | 1.28 | Sister-chromatid exchanges in lymphocytes from infants with Down's syndrome. ( Allak, BM; Hamami, HA; Khaleel, AH; Shubber, EK, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (60.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Wang, X | 1 |
Zhao, Y | 1 |
Zhang, X | 1 |
Badie, H | 1 |
Zhou, Y | 1 |
Mu, Y | 1 |
Loo, LS | 1 |
Cai, L | 1 |
Thompson, RC | 1 |
Yang, B | 1 |
Chen, Y | 1 |
Johnson, PF | 1 |
Wu, C | 1 |
Bu, G | 1 |
Mobley, WC | 1 |
Zhang, D | 1 |
Gage, FH | 1 |
Ranscht, B | 1 |
Zhang, YW | 1 |
Lipton, SA | 1 |
Hong, W | 1 |
Xu, H | 1 |
Caria, H | 2 |
Quintas, A | 1 |
Chaveca, T | 2 |
Rueff, J | 2 |
Bal, F | 1 |
Sahin, FI | 1 |
Yirmibes, M | 1 |
Balci, A | 1 |
Menevşe, S | 1 |
Shubber, EK | 1 |
Hamami, HA | 1 |
Allak, BM | 1 |
Khaleel, AH | 1 |
5 other studies available for mitomycin and Down Syndrome
Article | Year |
---|---|
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; C-Reactive Protein; CCAAT-Enhancer-Binding | 2013 |
The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells.
Topics: Benzamides; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Down Syndrome; Enzyme Inh | 1997 |
The in vitro effect of beta-carotene and mitomycin C on SCE frequency in Down's syndrome lymphocyte cultures.
Topics: Adolescent; Antioxidants; beta Carotene; Cells, Cultured; Child; Child, Preschool; Down Syndrome; Fe | 1998 |
Aneuploidy induced in lymphocytes of parents of trisomic 21 children.
Topics: Adult; Aneuploidy; Cyclophosphamide; Down Syndrome; Humans; Lymphocytes; Micronuclei, Chromosome-Def | 2001 |
Sister-chromatid exchanges in lymphocytes from infants with Down's syndrome.
Topics: Adult; Age Factors; Alkylating Agents; Analysis of Variance; Cell Cycle; DNA Repair; Down Syndrome; | 1991 |