Page last updated: 2024-11-06

mitomycin and Corneal Endothelial Cell Damage

mitomycin has been researched along with Corneal Endothelial Cell Damage in 10 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Research Excerpts

ExcerptRelevanceReference
"To evaluate changes in corneal endothelial cell counts after pterygium surgery with application of mitomycin C (MMC) either on the perilimbal sclera or in the subconjunctival space."9.15Effects of mitomycin C on corneal endothelial cell counts in pterygium surgery: role of application location. ( Behrouz, MJ; Hashemian, H; Izadi, A; Kheirkhah, A; Kiarudi, MY; Nazari, R, 2011)
"The aim of this study was to evaluate the anterior corneal surface regularity and light scattering before and after Descemet membrane endothelial keratoplasty (DMEK) with epithelial debridement and application of mitomycin C in Fuchs dystrophy-affected eyes with preoperative subepithelial fibrosis or anterior basement membrane dystrophy."7.80Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. ( Chaurasia, S; McKee, Y; Price, FW; Price, MO, 2014)
"To evaluate changes in corneal endothelial cell counts after pterygium surgery with application of mitomycin C (MMC) either on the perilimbal sclera or in the subconjunctival space."5.15Effects of mitomycin C on corneal endothelial cell counts in pterygium surgery: role of application location. ( Behrouz, MJ; Hashemian, H; Izadi, A; Kheirkhah, A; Kiarudi, MY; Nazari, R, 2011)
"8% of eyes (n=10) required at least 1 mitomycin C (MMC)-enhanced needling revision to maintain their target intraocular pressure."3.96Impact of Phacoemulsification Combined with XEN Gel Stent Implantation on Corneal Endothelial Cell Density: 2-Year Results. ( Bravetti, GE; Gillmann, K; Mansouri, K; Mermoud, A; Rao, HL, 2020)
"The aim of this study was to evaluate the anterior corneal surface regularity and light scattering before and after Descemet membrane endothelial keratoplasty (DMEK) with epithelial debridement and application of mitomycin C in Fuchs dystrophy-affected eyes with preoperative subepithelial fibrosis or anterior basement membrane dystrophy."3.80Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. ( Chaurasia, S; McKee, Y; Price, FW; Price, MO, 2014)
"Patients with primary open angle glaucoma, not controlled with medication, were selected from the outpatient department."2.87Comparison of Mean Corneal Endothelial Cell Loss after Trabeculectomy with and without Mitomycin C. ( Ahmed, N; Amjad, A; Shaheer, M, 2018)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (90.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Gillmann, K1
Bravetti, GE1
Rao, HL1
Mermoud, A1
Mansouri, K1
Shaheer, M1
Amjad, A1
Ahmed, N1
Higashide, T1
Nishino, T1
Sakaguchi, K1
Yamada, Y1
Sugiyama, K1
Hofmeister, EM1
Bishop, FM1
Kaupp, SE1
Schallhorn, SC1
Ryoo, NK1
Kim, MK1
Wee, WR1
Chaurasia, S1
Price, MO1
McKee, Y1
Price, FW1
Santhiago, MR1
Kheirkhah, A1
Izadi, A1
Kiarudi, MY1
Nazari, R1
Hashemian, H1
Behrouz, MJ1
Gambato, C1
Miotto, S1
Cortese, M1
Ghirlando, A1
Lazzarini, D1
Midena, E1
Zarnowski, T1
Kosior-Jarecka, E1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open-enrollment, Prospective Study of Endothelial Keratoplasty Outcomes[NCT00800111]2,593 participants (Actual)Interventional2008-02-29Completed
The Comparison of Endothelial Cell Count in Pterygium Surgery Relating to the Timing of MMC Application.[NCT02641132]Phase 462 participants (Anticipated)Interventional2015-09-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for mitomycin and Corneal Endothelial Cell Damage

ArticleYear
Comparison of Mean Corneal Endothelial Cell Loss after Trabeculectomy with and without Mitomycin C.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:4

    Topics: Aged; Antimetabolites; Corneal Endothelial Cell Loss; Endothelium, Corneal; Female; Glaucoma, Open-A

2018
Randomized dose-response analysis of mitomycin-C to prevent haze after photorefractive keratectomy for high myopia.
    Journal of cataract and refractive surgery, 2013, Volume: 39, Issue:9

    Topics: Adult; Alkylating Agents; Cell Count; Corneal Endothelial Cell Loss; Corneal Opacity; Dose-Response

2013
Effects of mitomycin C on corneal endothelial cell counts in pterygium surgery: role of application location.
    American journal of ophthalmology, 2011, Volume: 151, Issue:3

    Topics: Adolescent; Adult; Alkylating Agents; Amnion; Cell Count; Combined Modality Therapy; Conjunctiva; Co

2011
Mitomycin C-assisted photorefractive keratectomy in high myopia: a long-term safety study.
    Cornea, 2011, Volume: 30, Issue:6

    Topics: Administration, Topical; Adult; Alkylating Agents; Combined Modality Therapy; Cornea; Corneal Endoth

2011

Other Studies

6 other studies available for mitomycin and Corneal Endothelial Cell Damage

ArticleYear
Impact of Phacoemulsification Combined with XEN Gel Stent Implantation on Corneal Endothelial Cell Density: 2-Year Results.
    Journal of glaucoma, 2020, Volume: 29, Issue:3

    Topics: Aged; Aged, 80 and over; Alkylating Agents; Cell Count; Corneal Endothelial Cell Loss; Endothelium,

2020
Determinants of Corneal Endothelial Cell Loss After Trabeculectomy With Mitomycin C.
    Journal of glaucoma, 2019, Volume: 28, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Cell Count; Combined Modality Therapy; Corneal En

2019
Consequences of accidental mitomycin C intraocular injection.
    JAMA ophthalmology, 2013, Volume: 131, Issue:9

    Topics: Alkylating Agents; Atrophy; Corneal Edema; Corneal Endothelial Cell Loss; Humans; Injections, Intrao

2013
Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy.
    Cornea, 2014, Volume: 33, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Basement Membrane; Corneal Endothelial Cell Loss;

2014
Refractive surgical problem: December consultation #1.
    Journal of cataract and refractive surgery, 2014, Volume: 40, Issue:12

    Topics: Adult; Alkylating Agents; Corneal Endothelial Cell Loss; Endothelium, Corneal; Epikeratophakia; Fema

2014
Progression of normal tension glaucoma in Kearns-Sayre syndrome over 10 years.
    Clinical & experimental ophthalmology, 2012, Volume: 40, Issue:2

    Topics: Adult; Alkylating Agents; Corneal Endothelial Cell Loss; Disease Progression; Female; Follow-Up Stud

2012