mitomycin has been researched along with Chromosome-Defective Micronuclei in 84 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| " CHB were induced by the clastogen mitomycin C (MMC) as well as by the aneuploidogen colcemid, with frequencies similar to MN in both cases, and to multinucleated cells in the case of colcemid." | 3.71 | Micronuclei and chromatid buds are the result of related genotoxic events. ( Montero-Montoya, R; Serrano-García, L, 2001) |
| "Pre-treatment with quercetin significantly reduced the frequency of mitomycin C (MMC) induced MN as well as CA, but no clear correlation between the dose and effect could be observed." | 1.37 | Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo. ( Giri, A; Giri, S; Mazumdar, M, 2011) |
| " After stimulation with phytohemagglutinin for 24 h, the cells were exposed to an adaptive dose of 900 MHz RF radiation used for mobile communications (at a peak specific absorption rate of 10 W/kg) for 20 h and then challenged with a single genotoxic dose of mitomycin C (100 ng/ml) at 48 h." | 1.35 | Induction of adaptive response in human blood lymphocytes exposed to radiofrequency radiation. ( Prihoda, TJ; Reddy, SB; Sannino, A; Sarti, M; Scarfì, MR, 2009) |
| "Mitomycin C (MMC) is a highly active anticancer drug commonly used alone and in combination with other chemotherapeutic agents for the treatment of different cancers." | 1.34 | Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice. ( Jena, G; Pawar, AA; Ramarao, P; Tripathi, DN, 2007) |
| " Maximum Tolerated Dose (MTD) was determined by a dose-response test." | 1.34 | The genotoxicity study of garlic and pasipy herbal drops by peripheral blood micronucleus test. ( Kalantari, H; Larki, A; Latifi, SM, 2007) |
| "Apigenin was found to induce micronuclei in a dose dependent manner indicating potential genotoxic hazard in humans." | 1.33 | Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay. ( Kasinathan, M; Noel, S; Rath, SK, 2006) |
| "Mitomycin C (MMC) was used as a positive control (2 mg/kg BW)." | 1.32 | Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow. ( Aşkin, A; Camlica, Y; Celik, A; Cömelekoglu, U; Mazmanci, B, 2003) |
| "There is evidence to suggest that the breast cancer predisposing gene, BRCA1, is involved in cell cycle control and the response to damage but mouse brca1+/- heterozygotes have no distinctive phenotype." | 1.32 | Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment. ( Eccles, D; Eeles, R; Latham, H; McMillan, TJ; Peacock, JH; Shorrocks, J; Tobi, SE, 2004) |
| "Werner's syndrome (WS) and Bloom's syndrome (BS) are rare autosomal genetic diseases that predispose to cancer and are associated with genomic instability." | 1.31 | Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients. ( Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H, 2002) |
| "Single strand DNA breaks and chromosomal aberrations were measured by comet assay and cytokinesis-blocked micronucleus(CBMN) test in vitro when human lymphocytes were exposed to 2,450-MHz microwave (5." | 1.31 | [Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro]. ( He, J; Jin, L; Lu, D; Zhang, M, 2002) |
| "Mitomycin C, which was used as a positive control, also caused the expected large rises in micronuclei in both bone marrow and peripheral blood cells at 24, 48 and 72 h after its administration." | 1.31 | Genotoxicity of paraquat: micronuclei induced in bone marrow and peripheral blood are inhibited by melatonin. ( Bitzer-Quintero, OK; García, JJ; Melchiorri, D; Oh, CS; Ortiz, GG; Pablos, MI; Reiter, RJ; Sewerynek, E; Zúñiga, G, 2000) |
| " A dose-response relationship was observed after exposing RTG-2 cells to vincristine sulfate and benzo(a)pyrene." | 1.31 | Flow cytometric detection of micronuclei and cell cycle alterations in fish-derived cells after exposure to three model genotoxic agents: mitomycin C, vincristine sulfate and benzo(a)pyrene. ( Castaño, A; Llorente, MT; Sánchez, P, 2000) |
| "A possible predisposition to aneuploidy in trisomic 21 individuals, their parents, and a control group was evaluated." | 1.31 | Aneuploidy induced in lymphocytes of parents of trisomic 21 children. ( Caria, H; Chaveca, T; Rueff, J, 2001) |
| "Pretreatment with tirapazamine, a bioreductive agent, could enhance the sensitivity of tumor cells, including Q cells, to radiation more markedly than mitomycin C pretreatment as judged from an in vivo assay immediately after irradiation." | 1.30 | Effects of bioreductive agents, tirapazamine and mitomycin C, on quiescent cell populations in solid tumors, evaluated by micronucleus assay. ( Akaboshi, M; Hori, H; Kinashi, Y; Masunaga, S; Ono, K; Shibata, T; Suzuki, M; Takagaki, M, 1997) |
| "To determine the fate of chromosome aberrations induced primarily by clastogenic chemicals, aberrations of chromosome 9 in cultured human peripheral blood lymphocytes were analyzed after exposure to mitomycin C (MMC) at G(0) phase." | 1.30 | Chromosome-type aberrations induced in chromosome 9 after treatment of human peripheral blood lymphocytes with mitomycin C at the G(0) phase. ( Kusakabe, H; Takahashi, T; Tanaka, N, 1999) |
| "Moreover, chromosomal aberrations were not detected in bone marrow cells of CD-1 male mice, even at high rhEPO concentrations (100,000 IU/kg) in vivo." | 1.29 | Induction of micronucleated erythrocytes by recombinant human erythropoietin. ( Kurata, Y; Sawai, T; Takeshita, Y; Yajima, N, 1993) |
| "When galangin was given to mice 24 h before the intraperitoneal injection of MMC (1 mg/kg), a more marked decrease in the frequency of MNRETs was observed than in mice with simultaneous and post-treatment of galangin." | 1.29 | Anticlastogenic effects of galangin against mitomycin C-induced micronuclei in reticulocytes of mice. ( Au, WW; Heo, MY; Jae, LH; Jung, SS, 1996) |
| " The toxic activity of MMC in mouse bone marrow was significantly reduced or completely abolished after its inclusion in PBCN." | 1.28 | Diminished genotoxicity of mitomycin C and farmorubicin included in polybutylcyanoacrylate nanoparticles. ( Balansky, RM; Blagoeva, PM; Mircheva, TJ; Simeonova, MI, 1992) |
| "Mitomycin-C-treated cultures were used as control for the micronucleus method, because it is known that mitomycin-C is a potent genotoxic agent, capable of inducing micronuclei." | 1.28 | Spontaneous and mitomycin-C-induced micronuclei in human lymphocytes exposed to extremely low frequency pulsed magnetic fields. ( Bersani, F; Cadossi, R; Castellani, G; Cossarizza, A; Franceschetti, G; Franceschi, C; Monti, D; Scarfi, MR, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (34.52) | 18.2507 |
| 2000's | 36 (42.86) | 29.6817 |
| 2010's | 18 (21.43) | 24.3611 |
| 2020's | 1 (1.19) | 2.80 |
| Authors | Studies |
|---|---|
| Smart, DJ | 1 |
| Helbling, FR | 1 |
| Verardo, M | 1 |
| Huber, A | 1 |
| McHugh, D | 1 |
| Vanscheeuwijck, P | 1 |
| Francies, FZ | 1 |
| Wainwright, R | 1 |
| Poole, J | 1 |
| De Leeneer, K | 1 |
| Coene, I | 1 |
| Wieme, G | 1 |
| Poirel, HA | 1 |
| Brichard, B | 1 |
| Vermeulen, S | 1 |
| Vral, A | 1 |
| Slabbert, J | 1 |
| Claes, K | 1 |
| Baeyens, A | 1 |
| Sannino, A | 3 |
| Zeni, O | 2 |
| Romeo, S | 2 |
| Lioi, MB | 1 |
| Scarfì, MR | 4 |
| Cheong, HS | 1 |
| Seth, I | 1 |
| Joiner, MC | 1 |
| Tucker, JD | 1 |
| Takeiri, A | 1 |
| Motoyama, S | 1 |
| Matsuzaki, K | 1 |
| Harada, A | 1 |
| Taketo, J | 1 |
| Katoh, C | 1 |
| Tanaka, K | 1 |
| Mishima, M | 1 |
| Carneiro, CC | 1 |
| Silva, CR | 1 |
| Menezes, AC | 1 |
| Pérez, CN | 1 |
| Chen-Chen, L | 1 |
| Brüsehafer, K | 1 |
| Rees, BJ | 1 |
| Manshian, BB | 1 |
| Doherty, AT | 1 |
| O'Donovan, MR | 1 |
| Doak, SH | 1 |
| Jenkins, GJ | 1 |
| Simic, MR | 1 |
| Stankovic, M | 1 |
| Mandic, BM | 1 |
| Tesevic, VV | 1 |
| Savic, VM | 1 |
| Testi, S | 1 |
| Azzarà, A | 1 |
| Giovannini, C | 1 |
| Lombardi, S | 1 |
| Piaggi, S | 1 |
| Facioni, MS | 1 |
| Scarpato, R | 3 |
| Mokdad Bzeouich, I | 1 |
| Mustapha, N | 1 |
| Maatouk, M | 1 |
| Ghedira, K | 1 |
| Ghoul, M | 1 |
| Chekir-Ghedira, L | 1 |
| Camelo, RM | 1 |
| Kehdy, FS | 1 |
| Salas, CE | 1 |
| Lopes, MT | 1 |
| Paganucci, L | 1 |
| Bertoli, A | 1 |
| Fiore, L | 1 |
| Pistelli, L | 1 |
| Federico, G | 1 |
| Attia, SM | 1 |
| Sarti, M | 2 |
| Reddy, SB | 1 |
| Prihoda, TJ | 2 |
| Gutiérrez-Enríquez, S | 1 |
| Ramón Y Cajal, T | 1 |
| Alonso, C | 1 |
| Corral, A | 1 |
| Carrasco, P | 1 |
| Cornet, M | 1 |
| Sanz, J | 1 |
| Ribas, M | 1 |
| Baiget, M | 1 |
| Diez, O | 1 |
| Mazumdar, M | 1 |
| Giri, S | 1 |
| Giri, A | 1 |
| Liao, PH | 1 |
| Lin, RH | 1 |
| Yang, ML | 1 |
| Li, YC | 1 |
| Kuan, YH | 1 |
| Kocaman, AY | 1 |
| Istifli, ES | 1 |
| Büyükleyla, M | 1 |
| Rencüzogullari, E | 1 |
| Topaktaş, M | 1 |
| Sulaiman, GM | 1 |
| Massa, R | 1 |
| Reddy, AB | 1 |
| Promkum, C | 1 |
| Butryee, C | 1 |
| Tuntipopipat, S | 1 |
| Kupradinun, P | 1 |
| Hintzsche, H | 1 |
| Jastrow, C | 1 |
| Kleine-Ostmann, T | 1 |
| Kärst, U | 1 |
| Schrader, T | 1 |
| Stopper, H | 1 |
| Rjiba-Touati, K | 1 |
| Ayed-Boussema, I | 1 |
| Guedri, Y | 1 |
| Achour, A | 1 |
| Bacha, H | 1 |
| Abid, S | 1 |
| Honma, M | 1 |
| Tadokoro, S | 1 |
| Sakamoto, H | 1 |
| Tanabe, H | 1 |
| Sugimoto, M | 1 |
| Furuichi, Y | 1 |
| Satoh, T | 1 |
| Sofuni, T | 2 |
| Goto, M | 1 |
| Hayashi, M | 2 |
| Monteiro Gil, O | 2 |
| Oliveira, NG | 2 |
| Rodrigues, AS | 2 |
| Laires, A | 1 |
| Ferreira, TC | 1 |
| Limbert, E | 1 |
| Rueff, J | 3 |
| Sacharczuk, M | 1 |
| Jaszczak, K | 1 |
| Sadowski, B | 1 |
| Krishnaja, AP | 1 |
| Sharma, NK | 1 |
| Celik, A | 2 |
| Mazmanci, B | 1 |
| Camlica, Y | 1 |
| Aşkin, A | 1 |
| Cömelekoglu, U | 2 |
| Suggitt, M | 1 |
| Fearnley, J | 1 |
| Swaine, DJ | 1 |
| Volpato, M | 1 |
| Phillips, RM | 1 |
| Bibby, MC | 1 |
| Loadman, PM | 1 |
| Anderson, D | 1 |
| Zhang, M | 1 |
| Lu, D | 1 |
| He, J | 1 |
| Jin, L | 1 |
| Fimognari, C | 2 |
| Berti, F | 2 |
| Cantelli-Forti, G | 2 |
| Hrelia, P | 2 |
| Shorrocks, J | 1 |
| Tobi, SE | 1 |
| Latham, H | 1 |
| Peacock, JH | 1 |
| Eeles, R | 1 |
| Eccles, D | 1 |
| McMillan, TJ | 1 |
| Ortiz, R | 1 |
| Medina, H | 1 |
| Rodríguez, L | 1 |
| González-Márquez, H | 1 |
| Cortés, E | 1 |
| Rosefort, C | 1 |
| Fauth, E | 2 |
| Zankl, H | 2 |
| Ogenler, O | 1 |
| Gómez-Meda, BC | 1 |
| Zamora-Perez, AL | 1 |
| Luna-Aguirre, J | 1 |
| González-Rodríguez, A | 1 |
| Ramos-Ibarra, ML | 1 |
| Torres-Bugarín, O | 1 |
| Batista-González, CM | 1 |
| Zúñiga-González, GM | 1 |
| Noel, S | 1 |
| Kasinathan, M | 1 |
| Rath, SK | 1 |
| Proudlock, RJ | 1 |
| Pawar, AA | 1 |
| Tripathi, DN | 1 |
| Ramarao, P | 1 |
| Jena, G | 1 |
| Kalantari, H | 1 |
| Larki, A | 1 |
| Latifi, SM | 1 |
| Salvadori, DM | 1 |
| Ribeiro, LR | 1 |
| Natarajan, AT | 1 |
| Schneider, BM | 1 |
| Würgler, FE | 1 |
| Romagna, F | 1 |
| Högstedt, B | 1 |
| Karlsson, A | 1 |
| Bratt, I | 1 |
| Holmén, A | 1 |
| Saggioro, D | 1 |
| Majone, F | 4 |
| Forino, M | 1 |
| Turchetto, L | 1 |
| Leszl, A | 1 |
| Chieco-Bianchi, L | 1 |
| Yajima, N | 1 |
| Kurata, Y | 1 |
| Sawai, T | 1 |
| Takeshita, Y | 1 |
| Heo, MY | 1 |
| Jae, LH | 1 |
| Jung, SS | 1 |
| Au, WW | 1 |
| Sehlmeyer, U | 1 |
| Meister, A | 1 |
| Beisker, W | 1 |
| Wobus, AM | 1 |
| Urlando, C | 1 |
| Krasnoshtein, F | 1 |
| Heddle, JA | 1 |
| Buchwald, M | 1 |
| Verhagen, H | 1 |
| Rauma, AL | 1 |
| Törrönen, R | 1 |
| de Vogel, N | 1 |
| Bruijntjes-Rozier, GC | 1 |
| Drevo, MA | 1 |
| Bogaards, JJ | 1 |
| Mykkänen, H | 1 |
| Veltel, D | 1 |
| Hoheneder, A | 1 |
| Komae, N | 1 |
| Narita, H | 1 |
| Hibino, Y | 1 |
| Sugano, N | 1 |
| Morales-Ramírez, P | 1 |
| Vallarino-Kelly, T | 1 |
| Anguiano-Orozco, G | 1 |
| Rodríguez-Reyes, R | 1 |
| Montero-Montoya, R | 2 |
| Serrano, L | 1 |
| Ostrosky-Wegman, P | 1 |
| Masunaga, S | 1 |
| Ono, K | 1 |
| Hori, H | 1 |
| Shibata, T | 1 |
| Suzuki, M | 1 |
| Kinashi, Y | 1 |
| Takagaki, M | 1 |
| Akaboshi, M | 1 |
| Dass, SB | 1 |
| Ali, SF | 1 |
| Heflich, RH | 1 |
| Casciano, DA | 1 |
| Elhajouji, A | 1 |
| Cunha, M | 1 |
| Kirsch-Volders, M | 1 |
| Vijayalaxmi, KK | 1 |
| Venu, R | 1 |
| Kusakabe, H | 1 |
| Takahashi, T | 1 |
| Tanaka, N | 1 |
| Neves, M | 1 |
| Chaveca, T | 2 |
| Speit, G | 1 |
| Schütz, P | 1 |
| Merk, O | 1 |
| Ortiz, GG | 1 |
| Reiter, RJ | 1 |
| Zúñiga, G | 1 |
| Melchiorri, D | 1 |
| Sewerynek, E | 1 |
| Pablos, MI | 1 |
| Oh, CS | 1 |
| García, JJ | 1 |
| Bitzer-Quintero, OK | 1 |
| Sánchez, P | 1 |
| Llorente, MT | 1 |
| Castaño, A | 1 |
| Nesti, C | 1 |
| Trippi, F | 1 |
| Migliore, L | 1 |
| Turchi, G | 1 |
| Ayllon, F | 2 |
| Garcia-Vazquez, E | 2 |
| Scherthan, H | 1 |
| Jie, YM | 1 |
| Jia, C | 1 |
| Serrano-García, L | 1 |
| Smolewski, P | 1 |
| Ruan, Q | 1 |
| Vellon, L | 1 |
| Darzynkiewicz, Z | 1 |
| Yamagishi, M | 1 |
| Osakabe, N | 1 |
| Natsume, M | 1 |
| Adachi, T | 1 |
| Takizawa, T | 1 |
| Kumon, H | 1 |
| Osawa, T | 1 |
| Caria, H | 1 |
| Meng, Z | 1 |
| Sang, N | 1 |
| Zhang, B | 1 |
| Tonetto, S | 1 |
| Soligo, C | 1 |
| Panozzo, M | 1 |
| Blagoeva, PM | 2 |
| Balansky, RM | 2 |
| Mircheva, TJ | 2 |
| Simeonova, MI | 1 |
| Russo, A | 2 |
| Stocco, A | 2 |
| Renzi, L | 1 |
| Bianco, N | 1 |
| Morita, T | 1 |
| Kodama, Y | 1 |
| Ishidate, M | 1 |
| Bersani, F | 1 |
| Cossarizza, A | 1 |
| Monti, D | 1 |
| Castellani, G | 1 |
| Cadossi, R | 1 |
| Franceschetti, G | 1 |
| Franceschi, C | 1 |
| Rita, P | 1 |
| Geetanjali, D | 1 |
| Reddy, PP | 1 |
| Rudd, NL | 1 |
| Williams, SE | 1 |
| Evans, M | 1 |
| Hennig, UG | 1 |
| Hoar, DI | 1 |
| Miller, BM | 1 |
| Adler, ID | 1 |
| Surrallés, J | 1 |
| Carbonell, E | 1 |
| Puig, M | 1 |
| Xamena, N | 1 |
| Creus, A | 1 |
| Marcos, R | 1 |
84 other studies available for mitomycin and Chromosome-Defective Micronuclei
| Article | Year |
|---|---|
Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.
Topics: 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Cell Line, Tumor; Cyclophosphamide; Diclofenac; DNA; DNA D | 2020 |
Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei.
Topics: Adolescent; Adult; Case-Control Studies; Cell Cycle; Child; DNA Damage; DNA Mutational Analysis; DNA | 2018 |
Treatment with 3-Aminobenzamide Negates the Radiofrequency-Induced Adaptive Response in Two Cell Models.
Topics: Adaptation, Physiological; Animals; Benzamides; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; | 2019 |
Relationships among micronuclei, nucleoplasmic bridges and nuclear buds within individual cells in the cytokinesis-block micronucleus assay.
Topics: Cell Line; Cell Nucleus; DNA Damage; Gamma Rays; Humans; Micronuclei, Chromosome-Defective; Micronuc | 2013 |
New DNA probes to detect aneugenicity in rat bone marrow micronucleated cells by a pan-centromeric FISH analysis.
Topics: Aneugens; Animals; Antibiotics, Antineoplastic; Base Sequence; Bone Marrow; Centromere; Chromosomes; | 2013 |
Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice.
Topics: Animals; Antibiotics, Antineoplastic; Bone Marrow Cells; Chemical Fractionation; Cytotoxins; DNA Dam | 2013 |
Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent.
Topics: Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Survival; Cytarabine; Dose-Response Rela | 2014 |
Synthesis of novel tetrahydrobenzazepine derivatives and their cytoprotective effect on human lymphocytes.
Topics: Alkylating Agents; Amifostine; Antioxidants; Benzazepines; Cells, Cultured; Cytochalasin B; Cytoprot | 2015 |
Vincristine-induced bystander effect in human lymphocytes.
Topics: Adult; Bystander Effect; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Dose-Res | 2016 |
Genotoxic and anti-genotoxic effects of esculin and its oligomer fractions against mitomycin C-induced DNA damages in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antimutagenic Agents; DNA Damage; Dose-Response Relationship, | 2016 |
Amifostine protection against mitomycin-induced chromosomal breakage in fanconi anaemia lymphocytes.
Topics: Adolescent; Adult; Amifostine; Blood Cells; Case-Control Studies; Child; Chromosome Breakage; Fancon | 2008 |
Licoflavone C attenuates the genotoxicity of cancer drugs in human peripheral lymphocytes.
Topics: Antimutagenic Agents; Cytoprotection; Daunorubicin; Flavones; Genista; Humans; Lymphocytes; Male; Mi | 2008 |
Use of centromeric and telomeric DNA probes in in situ hybridization for differentiation of micronuclei induced by lomefloxacin.
Topics: Animals; Anti-Infective Agents; Centromere; Colchicine; DNA Probes; Fluoroquinolones; In Situ Hybrid | 2009 |
Induction of adaptive response in human blood lymphocytes exposed to radiofrequency radiation.
Topics: Adult; Humans; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Mitomycin; Nucleic Acid Synthes | 2009 |
Ionizing radiation or mitomycin-induced micronuclei in lymphocytes of BRCA1 or BRCA2 mutation carriers.
Topics: Adult; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle; Female; Genes, BRCA1; Genes, BRCA2; Humans; | 2011 |
Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo.
Topics: Administration, Oral; Antioxidants; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, | 2011 |
Evaluation of differential representative values between Chinese hamster cells and human lymphocytes in mitomycin C-induced cytogenetic assays and caspase-3 activity.
Topics: Analysis of Variance; Animals; Caspase 3; Caspase Inhibitors; Cell Line; CHO Cells; Chromosome Aberr | 2012 |
In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes.
Topics: Antimutagenic Agents; Bicyclic Monoterpenes; Cell Proliferation; Cell Survival; Cells, Cultured; Chr | 2013 |
Role of caffeic acid phenethyl ester on mitomycin C induced clastogenesis: analysis of chromosome aberrations, micronucleus, mitotic index and adenosine deaminase activity in vivo.
Topics: Adenosine Deaminase; Administration, Oral; Animals; Bone Marrow Cells; Caffeic Acids; Injections, In | 2012 |
Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate.
Topics: Adaptation, Physiological; Cells, Cultured; Dose-Response Relationship, Radiation; Humans; Lymphocyt | 2012 |
Anticlastogenic effect of Eryngium foetidum L. assessed by erythrocyte micronucleus assay.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Body Weight; Dose-Response Relation | 2012 |
Terahertz electromagnetic fields (0.106 THz) do not induce manifest genomic damage in vitro.
Topics: Cell Line; Comet Assay; DNA Breaks; Electromagnetic Fields; Fibroblasts; Humans; Keratinocytes; Micr | 2012 |
Role of recombinant human erythropoietin in mitomycin C-induced genotoxicity: analysis of DNA fragmentation, chromosome aberrations and micronuclei in rat bone-marrow cells.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; DNA Fra | 2013 |
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Stu | 2002 |
Possible transient adaptive response to mitomycin C in peripheral lymphocytes from thyroid cancer patients after iodine-131 therapy.
Topics: Adaptation, Physiological; Adult; Aged; Antibiotics, Antineoplastic; Female; Humans; Iodine Radioiso | 2002 |
Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia.
Topics: Analgesia; Animals; Bone Marrow Cells; Chromosome Aberrations; Cytogenetics; DNA Repair; Gamma Rays; | 2003 |
Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro.
Topics: Adult; Antibiotics, Antineoplastic; Ascorbic Acid; Cells, Cultured; Chromosome Aberrations; Dose-Res | 2003 |
Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow.
Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Erythrocytes; Female; Insecticides; Micronuclei, | 2003 |
Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.
Topics: Cell Cycle; Cells, Cultured; Comet Assay; Cross-Linking Reagents; DNA; DNA Damage; DNA Repair; DNA, | 2003 |
[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro].
Topics: Chromosome Aberrations; Comet Assay; DNA Breaks, Single-Stranded; Female; Humans; Lymphocytes; Male; | 2002 |
Effect of cyanidin 3-O-beta-glucopyranoside on micronucleus induction in cultured human lymphocytes by four different mutagens.
Topics: Adult; Anthocyanins; Antioxidants; Apoptosis; Cells, Cultured; Colchicine; Dose-Response Relationshi | 2004 |
Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment.
Topics: Alkylating Agents; Breast Neoplasms; Cell Cycle; DNA Damage; Fibroblasts; G1 Phase; Genes, BRCA1; Ge | 2004 |
Spontaneous and mitomycin C-induced micronuclei in peripheral blood reticulocytes from severely malnourished rats.
Topics: Alkylating Agents; Animals; Animals, Newborn; Cholesterol; Female; Flow Cytometry; Lactation; Micron | 2004 |
Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay.
Topics: Adult; Aneugens; Aneuploidy; Chromosomes, Human, X; Cytokinesis; Diminazene; Female; Humans; In Vitr | 2004 |
Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Division; Cells, Cultured; Ethyl Methanesulfonate; Humans; | 2005 |
The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate.
Topics: Acridine Orange; Animals; Blood Cells; Erythrocytes; Female; Micronuclei, Chromosome-Defective; Mito | 2005 |
Nuclear abnormalities in erythrocytes of parrots (Aratinga canicularis) related to genotoxic damage.
Topics: Animals; Cell Nucleus; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Female; Male; Mic | 2006 |
Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay.
Topics: Apigenin; Cytochalasin B; Cytokinesis; Dose-Response Relationship, Drug; Humans; Lymphocytes; Micron | 2006 |
Re: The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate. (Mutagenesis, 20, 411-415, 2005).
Topics: Acridine Orange; Animals; Blood Cells; Erythrocytes; Micronuclei, Chromosome-Defective; Mitomycin; O | 2006 |
Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice.
Topics: Animals; Antibiotics, Antineoplastic; Cytoprotection; Male; Mice; Micronuclei, Chromosome-Defective; | 2007 |
The genotoxicity study of garlic and pasipy herbal drops by peripheral blood micronucleus test.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Garlic; Male; Maximum Tolerated Dos | 2007 |
Effect of beta-carotene on clastogenic effects of mitomycin C, methyl methanesulphonate and bleomycin in Chinese hamster ovary cells.
Topics: Animals; Antimutagenic Agents; beta Carotene; Bleomycin; Carotenoids; CHO Cells; Cricetinae; Methyl | 1994 |
Distinct area distribution differences of micronuclei induced by clastogenic and aneuploidogenic chemicals in the bone marrow of the CD-1 mouse.
Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Male; Mice; Micronuclei, Chro | 1995 |
Micronucleus induction in human B and T lymphocytes separated by an immunomagnetic technique.
Topics: B-Lymphocytes; Humans; Immunomagnetic Separation; Micronuclei, Chromosome-Defective; Mitomycin; Mito | 1993 |
Tax protein of human T-lymphotropic virus type I triggers DNA damage.
Topics: Antibodies; Cell Line; Chloramphenicol O-Acetyltransferase; DNA Damage; Fluorescent Antibody Techniq | 1994 |
Induction of micronucleated erythrocytes by recombinant human erythropoietin.
Topics: Animals; Biotransformation; Bone Marrow; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricet | 1993 |
Anticlastogenic effects of galangin against mitomycin C-induced micronuclei in reticulocytes of mice.
Topics: Animals; Antibiotics, Antineoplastic; Antimutagenic Agents; Dose-Response Relationship, Drug; Flavon | 1996 |
Low mutagenic effects of mitomycin C in undifferentiated embryonic P19 cells are correlated with efficient cell cycle control.
Topics: Animals; Antibiotics, Antineoplastic; Cell Cycle; Cell Differentiation; Mice; Micronuclei, Chromosom | 1996 |
Assessment of the flexed-tail mouse as a possible model for Fanconi anemia: analysis of mitomycin C-induced micronuclei.
Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Fanc | 1996 |
Effect of a vegan diet on biomarkers of chemoprevention in females.
Topics: Adult; Aged; Aging; Antibiotics, Antineoplastic; Cells, Cultured; Chemoprevention; Cross-Sectional S | 1996 |
Characterization of cigarette smoke-induced micronuclei in vitro.
Topics: Animals; Cells, Cultured; Colchicine; Cricetinae; Dose-Response Relationship, Drug; Fluorescent Anti | 1996 |
[Morphology and origin of micronuclei induced by mitotic inhibitors].
Topics: Animals; Centromere; Colchicine; Cyclophosphamide; Depression, Chemical; DNA; Male; Micronuclei, Chr | 1997 |
Pharmacokinetic parameters of genotoxic activity inferred from the comparison of the kinetics of MN-PCE induced by chemical agents and ionizing radiation.
Topics: Animals; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Radiation; Erythrocytes; Male; Me | 1997 |
In vitro induction of micronuclei in lymphocytes: the use of bromodeoxyuridine as a proliferation marker.
Topics: Bromodeoxyuridine; Cell Division; Demecolcine; Dose-Response Relationship, Drug; Female; Humans; Lym | 1997 |
Effects of bioreductive agents, tirapazamine and mitomycin C, on quiescent cell populations in solid tumors, evaluated by micronucleus assay.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Division; Cisplati | 1997 |
Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Micronuclei, Chrom | 1997 |
Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay.
Topics: Benzimidazoles; Carbamates; Colchicine; Female; Humans; Leukocyte Count; Leukocytes, Mononuclear; Ma | 1998 |
In vivo anticlastogenic effects of L-ascorbic acid in mice.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Bleomycin; Bone Marrow; Cyclophosphamide; Female; Male | 1999 |
Chromosome-type aberrations induced in chromosome 9 after treatment of human peripheral blood lymphocytes with mitomycin C at the G(0) phase.
Topics: Adult; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, | 1999 |
Assessment of the adaptive response induced by quercetin using the MNCB peripheral blood human lymphocytes assay.
Topics: Adult; Alkylating Agents; Animals; Bleomycin; Cell Division; Cricetinae; Cytochalasin B; Female; Hum | 2000 |
Induction and repair of formaldehyde-induced DNA-protein crosslinks in repair-deficient human cell lines.
Topics: Cell Line; Cross-Linking Reagents; DNA; DNA Repair; Fanconi Anemia; Formaldehyde; Humans; Micronucle | 2000 |
Genotoxicity of paraquat: micronuclei induced in bone marrow and peripheral blood are inhibited by melatonin.
Topics: Animals; Bone Marrow; Chromosome Breakage; DNA; Erythroblasts; Herbicides; Injections, Intraperitone | 2000 |
Flow cytometric detection of micronuclei and cell cycle alterations in fish-derived cells after exposure to three model genotoxic agents: mitomycin C, vincristine sulfate and benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Cell Cycle; Cell Line; Flow Cytometry; Micronuclei, Chromosome-Defective; M | 2000 |
Cytokinesis-block micronucleus assay in primary human liver fibroblasts exposed to griseofulvin and mitomycin C.
Topics: Antifungal Agents; Cells, Cultured; Chromosomes; Dicumarol; DNA Damage; Enzyme Inhibitors; Fibroblas | 2000 |
Induction of micronuclei and other nuclear abnormalities in European minnow Phoxinus phoxinus and mollie Poecilia latipinna: an assessment of the fish micronucleus test.
Topics: Animals; Cadmium; Cell Nucleus; Colchicine; Cyclophosphamide; Cyprinidae; Dose-Response Relationship | 2000 |
Chromosome painting reveals specific patterns of chromosome occurrence in mitomycin C- and diethylstilboestrol-induced micronuclei.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Hormonal; Carcinogens; Cells, Cultured; C | 2000 |
Chromosomal composition of micronuclei in mouse NIH 3T3 cells treated with acrylamide, extract of Tripterygium hypoglaucum (level) hutch, mitomycin C and colchicine, detected by multicolor FISH with centromeric and telomeric DNA probes.
Topics: 3T3 Cells; Acrylamide; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Centromere; Ch | 2001 |
Micronuclei and other nuclear lesions as genotoxicity indicators in rainbow trout Oncorhynchus mykiss.
Topics: Acrylamide; Animals; Cell Nucleus; Colchicine; Cyclophosphamide; Erythrocytes; Injections, Intraperi | 2001 |
Micronuclei and chromatid buds are the result of related genotoxic events.
Topics: Aneuploidy; Animals; Chromatids; Demecolcine; Humans; Micronuclei, Chromosome-Defective; Mitomycin; | 2001 |
Micronuclei assay by laser scanning cytometry.
Topics: Cell Count; DNA, Neoplasm; Dose-Response Relationship, Drug; Double-Blind Method; HL-60 Cells; Human | 2001 |
Anticlastogenic activity of cacao: inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage.
Topics: Animals; Antimutagenic Agents; Bone Marrow; Cacao; DNA Damage; Flavonoids; Mice; Micronuclei, Chromo | 2001 |
Aneuploidy induced in lymphocytes of parents of trisomic 21 children.
Topics: Adult; Aneuploidy; Cyclophosphamide; Down Syndrome; Humans; Lymphocytes; Micronuclei, Chromosome-Def | 2001 |
Effects of derivatives of sulfur dioxide on micronuclei formation in mouse bone marrow cells in vivo.
Topics: Air Pollutants; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Bone Marrow | 2002 |
Identification of kinetochores and DNA synthesis in micronuclei induced by mitomycin C and colchicine in Chinese hamster ovary cells.
Topics: Animals; Cell Cycle; Centromere; CHO Cells; Chromosomes; Colchicine; Cricetinae; DNA Replication; In | 1992 |
Diminished genotoxicity of mitomycin C and farmorubicin included in polybutylcyanoacrylate nanoparticles.
Topics: Animals; Bone Marrow; Drug Carriers; Enbucrilate; Epirubicin; Female; Liver; Maternal-Fetal Exchange | 1992 |
Persistence of chromosomal lesions induced in actively proliferating bone marrow cells of the mouse.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromoso | 1992 |
Identification of kinetochore-containing (CREST+) micronuclei in mouse bone marrow erythrocytes.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Centromere; Chloral Hydrate; Cytoskeletal Proteins; Erythro | 1992 |
The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides.
Topics: Acridine Orange; Alkylating Agents; Animals; Bone Marrow Cells; Male; Mice; Micronuclei, Chromosome- | 1990 |
Potentiation by caffeine of the frequencies of micronuclei induced by mitomycin C and cyclophosphamide in young mice.
Topics: Alkylating Agents; Animals; Caffeine; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Syner | 1991 |
Spontaneous and mitomycin-C-induced micronuclei in human lymphocytes exposed to extremely low frequency pulsed magnetic fields.
Topics: Alkylating Agents; Cells, Cultured; Humans; Lymphocytes; Magnetics; Micronuclei, Chromosome-Defectiv | 1991 |
Effect of glutathione on mitomycin C-induced micronuclei in bone marrow erythrocytes of Swiss albino mice.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactio | 1991 |
Kinetochore analysis of micronuclei allows insights into the actions of colcemid and mitomycin C.
Topics: Aneuploidy; Chromosome Aberrations; Demecolcine; Evaluation Studies as Topic; Fibroblasts; Fluoresce | 1991 |
Application of antikinetochore antibody staining (CREST staining) to micronuclei in erythrocytes induced in vivo.
Topics: Alkylating Agents; Animals; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Colchicine; Eryt | 1990 |
Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes.
Topics: Alkylating Agents; Cells, Cultured; Humans; Insecticides; Lymphocytes; Micronuclei, Chromosome-Defec | 1990 |