mitomycin has been researched along with Chromosomal Translocation in 10 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 1774 patients with breast cancer given mitoxantrone (MTZ) with methotrexate (n = 492) or with methotrexate and mitomycin C (n = 1282), nine developed MDS/AML after a median of 2." | 3.70 | Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma. ( Ashley, S; Kuan, A; Kulkarni, S; Mehta, J; Mitchell, P; Powles, R; Powles, T; Saso, R; Swansbury, GJ; Treleaven, J, 2000) |
| " The dose-response curve for the induction of Robertsonian translocations both in G1 and S peaked at 2 Gy and slightly declined at higher doses." | 1.29 | The induction of Robertsonian translocations by X-rays and mitomycin C in mouse cells. ( Durante, M; Gialanella, G; Grossi, GF; Nappo, M; Pugliese, M, 1994) |
| " Up to now, most of the chemicals tested have shown additive effects when combined with doses of the ascending part of the dose-response curve and potentiating effects when combined with doses of its descending part." | 1.28 | The induction of reciprocal translocations in mouse germ cells by chemicals and ionizing radiations. II. Combined effects of mitomycin C or thio-tepa with two doses of gamma-rays. ( Andrieu, JM; De Luca, JC; Dulout, FN; Furnus, CC; Ulrich, MA, 1990) |
| "Mitomycin C (MMC) treatment of lymphocyte cultures from 6 patients having a Robertsonian translocation showed that in cases 1 and 2, who were already mosaics, MMC induced a statistically significant increase of the number of cells with the dissociated translocation." | 1.27 | Mitomycin C effect on Robertsonian translocations. ( Carnevale, A; Frias, S; Molina, B; Zavaleta, MJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MJ | 1 |
| Dumitrache, LC | 1 |
| Wangsa, D | 1 |
| Ma, SM | 1 |
| Padilla-Nash, H | 1 |
| Ried, T | 1 |
| Hasty, P | 1 |
| Jacquet, P | 1 |
| Pire, P | 1 |
| Durante, M | 1 |
| Gialanella, G | 1 |
| Grossi, GF | 1 |
| Nappo, M | 1 |
| Pugliese, M | 1 |
| Yu, VP | 1 |
| Koehler, M | 1 |
| Steinlein, C | 1 |
| Schmid, M | 1 |
| Hanakahi, LA | 1 |
| van Gool, AJ | 1 |
| West, SC | 1 |
| Venkitaraman, AR | 1 |
| Saso, R | 1 |
| Kulkarni, S | 1 |
| Mitchell, P | 1 |
| Treleaven, J | 1 |
| Swansbury, GJ | 1 |
| Mehta, J | 1 |
| Powles, R | 1 |
| Ashley, S | 1 |
| Kuan, A | 1 |
| Powles, T | 1 |
| Nakagawa, H | 1 |
| Tanaka, S | 1 |
| Takashima, T | 1 |
| Shizumi, Y | 1 |
| Nishigaki, H | 1 |
| Horiike, S | 1 |
| Taniwaki, M | 1 |
| Misawa, S | 1 |
| Kashima, K | 1 |
| Hironaka, T | 1 |
| De Luca, JC | 1 |
| Dulout, FN | 1 |
| Ulrich, MA | 1 |
| Furnus, CC | 1 |
| Andrieu, JM | 1 |
| Uehara, M | 1 |
| Kida, M | 1 |
| Frias, S | 1 |
| Carnevale, A | 1 |
| Zavaleta, MJ | 1 |
| Molina, B | 1 |
| Sonta, S | 1 |
| Kong, Z | 1 |
1 review available for mitomycin and Chromosomal Translocation
| Article | Year |
|---|---|
Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
Topics: Aclarubicin; Adolescent; Adult; Aged; Anemia, Refractory, with Excess of Blasts; Carcinoma, Hepatoce | 1991 |
9 other studies available for mitomycin and Chromosomal Translocation
| Article | Year |
|---|---|
Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells.
Topics: Antineoplastic Agents; Cell Growth Processes; Cell Nucleus; Cisplatin; DNA Damage; Dose-Response Rel | 2007 |
Morphological and cytogenetic studies of dominant lethality induced by mitomycin C and cyclophosphamide in female germ cells. The use of Robertsonian translocations as a 'marker system' to identify the zygote pronuclei.
Topics: Animals; Antibiotics, Antineoplastic; Blastocyst; Chromosome Aberrations; Cyclophosphamide; Female; | 1984 |
The induction of Robertsonian translocations by X-rays and mitomycin C in mouse cells.
Topics: Animals; Cell Line; Chromosomes; Mice; Mice, Inbred C3H; Mitomycin; Mitosis; Translocation, Genetic | 1994 |
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.
Topics: Animals; Annexin A5; BRCA2 Protein; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cross-Link | 2000 |
Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma.
Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 2000 |
The induction of reciprocal translocations in mouse germ cells by chemicals and ionizing radiations. II. Combined effects of mitomycin C or thio-tepa with two doses of gamma-rays.
Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Male; | 1990 |
A complex mosaic with tdic(13;18) (p11;p11), +13p-, +18p-, r(13) etc. in a male infant. II. Increased dissociation of dicentric chromosome by mitomycin C.
Topics: Abnormalities, Multiple; Bromodeoxyuridine; Cells, Cultured; Centromere; Chromosome Aberrations; Chr | 1986 |
Mitomycin C effect on Robertsonian translocations.
Topics: Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 13; | 1988 |
Mitomycin C-induced meiotic crossing-over on the interstitial segments in the Chinese hamster heterozygous for a reciprocal translocation.
Topics: Animals; Cricetinae; Cricetulus; Crossing Over, Genetic; Dose-Response Relationship, Drug; Genetic M | 1988 |