mitomycin has been researched along with Chromosomal Instability in 19 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Chromosomal Instability: An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chromosomal breakage was induced by MMC 0 ng/ml, 40 ng/ml, and 80 ng/ml." | 5.39 | [Correlation of single-cell gel electrophoresis and mitomycin C-induced chromosomal breakage for chromosomal instabiligy in children with Fanconi anemia]. ( Cai, XJ; Chen, XJ; Chen, YM; Guo, Y; Liu, F; Liu, Q; Liu, TF; Liu, XM; Ruan, M; Wang, SC; Yang, WY; Zhang, JY; Zhang, L; Zhu, XF; Zou, Y, 2013) |
| " Chromosomal breakage was induced by (i) Diepoxybutane 0." | 5.13 | Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients. ( Al-Haggar, M; Al-Morsy, Z; Chalaby, N; Mesbah, A; Ragab, A; Yahia, S, 2008) |
| " Using a newly identified small-molecule inhibitor of WRN helicase (NSC 617145), we investigated the role of WRN in the interstrand cross-link (ICL) response in cells derived from patients with Fanconi anemia, a hereditary disorder characterized by bone marrow failure and cancer." | 3.79 | Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. ( Aggarwal, M; Banerjee, T; Brosh, RM; Iannascoli, C; Pichierri, P; Shoemaker, RH; Sommers, JA, 2013) |
| "Investigation of mitomycin C-induced chromosomal breakage was carried out in 163 pediatric patients with AA and siblings of the cases where diagnosis of FA was confirmed." | 3.79 | Cytogenetic assessment of Fanconi anemia in children with aplastic anemia in Tunisia. ( Abdelhak, S; Aissaoui, L; Amouri, A; Bejaoui, M; Benhalim, N; Dellagi, K; Hdiji, S; Kammoun, L; Lakhal, A; Meddeb, M; Mellouli, F; Othmen, TB; Ouederni, M; Talmoudi, F; Torjemane, L, 2013) |
| "Chromosomal breakage was induced by MMC 0 ng/ml, 40 ng/ml, and 80 ng/ml." | 1.39 | [Correlation of single-cell gel electrophoresis and mitomycin C-induced chromosomal breakage for chromosomal instabiligy in children with Fanconi anemia]. ( Cai, XJ; Chen, XJ; Chen, YM; Guo, Y; Liu, F; Liu, Q; Liu, TF; Liu, XM; Ruan, M; Wang, SC; Yang, WY; Zhang, JY; Zhang, L; Zhu, XF; Zou, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Awate, S | 1 |
| Sommers, JA | 2 |
| Datta, A | 1 |
| Nayak, S | 1 |
| Bellani, MA | 1 |
| Yang, O | 1 |
| Dunn, CA | 1 |
| Nicolae, CM | 1 |
| Moldovan, GL | 1 |
| Seidman, MM | 1 |
| Cantor, SB | 1 |
| Brosh, RM | 2 |
| Gayarre, J | 1 |
| Martín-Gimeno, P | 1 |
| Osorio, A | 1 |
| Paumard, B | 1 |
| Barroso, A | 1 |
| Fernández, V | 1 |
| de la Hoya, M | 1 |
| Rojo, A | 1 |
| Caldés, T | 1 |
| Palacios, J | 1 |
| Urioste, M | 1 |
| Benítez, J | 1 |
| García, MJ | 1 |
| Zhang, L | 1 |
| Liu, Q | 1 |
| Zou, Y | 1 |
| Liu, XM | 1 |
| Zhang, JY | 1 |
| Wang, SC | 1 |
| Chen, XJ | 1 |
| Guo, Y | 1 |
| Yang, WY | 1 |
| Ruan, M | 1 |
| Liu, TF | 1 |
| Liu, F | 1 |
| Cai, XJ | 1 |
| Chen, YM | 1 |
| Zhu, XF | 1 |
| Aggarwal, M | 1 |
| Banerjee, T | 1 |
| Iannascoli, C | 1 |
| Pichierri, P | 1 |
| Shoemaker, RH | 1 |
| Liu, G | 1 |
| Stevens, JB | 1 |
| Horne, SD | 1 |
| Abdallah, BY | 1 |
| Ye, KJ | 1 |
| Bremer, SW | 1 |
| Ye, CJ | 1 |
| Chen, DJ | 1 |
| Heng, HH | 1 |
| Wang, F | 1 |
| Gao, C | 1 |
| Lu, J | 1 |
| Tatetsu, H | 1 |
| Williams, DA | 1 |
| Müller, LU | 1 |
| Cui, W | 1 |
| Chai, L | 1 |
| Vuono, EA | 1 |
| Mukherjee, A | 1 |
| Vierra, DA | 1 |
| Adroved, MM | 1 |
| Hodson, C | 1 |
| Deans, AJ | 1 |
| Howlett, NG | 2 |
| Hucl, T | 1 |
| Rago, C | 1 |
| Gallmeier, E | 1 |
| Brody, JR | 1 |
| Gorospe, M | 1 |
| Kern, SE | 1 |
| Al-Haggar, M | 1 |
| Al-Morsy, Z | 1 |
| Yahia, S | 1 |
| Chalaby, N | 1 |
| Ragab, A | 1 |
| Mesbah, A | 1 |
| Lialiaris, T | 2 |
| Polyzou, A | 1 |
| Mpountoukas, P | 1 |
| Tsiggene, A | 1 |
| Kouskoukis, A | 1 |
| Pouliliou, S | 1 |
| Paraskakis, E | 1 |
| Tentes, I | 1 |
| Trypsianis, G | 1 |
| Chatzimichail, A | 1 |
| Rajesh, C | 1 |
| Baker, DK | 1 |
| Pierce, AJ | 1 |
| Pittman, DL | 2 |
| Mason, JM | 1 |
| Sekiguchi, JM | 1 |
| Mauro, M | 1 |
| Rego, MA | 1 |
| Boisvert, RA | 1 |
| Esashi, F | 1 |
| Cavallo, F | 1 |
| Jasin, M | 1 |
| Talmoudi, F | 1 |
| Kammoun, L | 1 |
| Benhalim, N | 1 |
| Torjemane, L | 1 |
| Ouederni, M | 1 |
| Aissaoui, L | 1 |
| Lakhal, A | 1 |
| Mellouli, F | 1 |
| Othmen, TB | 1 |
| Bejaoui, M | 1 |
| Abdelhak, S | 1 |
| Meddeb, M | 1 |
| Dellagi, K | 1 |
| Hdiji, S | 1 |
| Amouri, A | 1 |
| Bobabilla-Morales, L | 1 |
| Corona-Rivera, A | 1 |
| Corona-Rivera, JR | 1 |
| Buenrostro, C | 1 |
| García-Cobián, TA | 1 |
| Corona-Rivera, E | 1 |
| Cantú-Garza, JM | 1 |
| García-Cruz, D | 1 |
| Demuth, I | 1 |
| Digweed, M | 1 |
| Concannon, P | 1 |
| Smiraldo, PG | 1 |
| Gruver, AM | 1 |
| Osborn, JC | 1 |
| Bogliolo, M | 1 |
| Lyakhovich, A | 1 |
| Callén, E | 1 |
| Castellà, M | 1 |
| Cappelli, E | 1 |
| Ramírez, MJ | 1 |
| Creus, A | 1 |
| Marcos, R | 1 |
| Kalb, R | 1 |
| Neveling, K | 1 |
| Schindler, D | 1 |
| Surrallés, J | 1 |
| Papachristou, F | 1 |
| Simopoulou, M | 1 |
| Touloupidis, S | 1 |
| Tsalikidis, C | 1 |
| Sofikitis, N | 1 |
1 trial available for mitomycin and Chromosomal Instability
| Article | Year |
|---|---|
Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients.
Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosomal Instability; Chromosome Breakage; | 2008 |
18 other studies available for mitomycin and Chromosomal Instability
| Article | Year |
|---|---|
FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.
Topics: BRCA1 Protein; Chromosomal Instability; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA-Bin | 2020 |
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Breast Neoplasms; Carcinoma; Case-Control Studies; Cell | 2017 |
[Correlation of single-cell gel electrophoresis and mitomycin C-induced chromosomal breakage for chromosomal instabiligy in children with Fanconi anemia].
Topics: Adolescent; Anemia, Aplastic; Case-Control Studies; Child; Child, Preschool; Chromosomal Instability | 2013 |
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Topics: Alkylating Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Prolif | 2013 |
Genome chaos: survival strategy during crisis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chromosomal Instability; Chromosome | 2014 |
Leukemic survival factor SALL4 contributes to defective DNA damage repair.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chromosomal Instability; Cluster Analysis; | 2016 |
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.
Topics: Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Chromosomal Instability; DNA Helicases; DNA Repair | 2016 |
A syngeneic variance library for functional annotation of human variation: application to BRCA2.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Chromosomal Instability; | 2008 |
Chromosome instability on children with asthma.
Topics: Asthma; Cell Proliferation; Child; Chromosomal Instability; Cross-Linking Reagents; DNA; Humans; Mit | 2009 |
The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion.
Topics: Alkylating Agents; Animals; Cell Cycle; Cell Line; Cell Survival; Chromatids; Chromosomal Instabilit | 2011 |
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.
Topics: Alkylating Agents; Chromosomal Instability; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA | 2011 |
p21 promotes error-free replication-coupled DNA double-strand break repair.
Topics: Animals; BRCA2 Protein; Camptothecin; Chromosomal Instability; Cross-Linking Reagents; Cyclin-Depend | 2012 |
Cytogenetic assessment of Fanconi anemia in children with aplastic anemia in Tunisia.
Topics: Adolescent; Anemia, Aplastic; Child; Child, Preschool; Chromosomal Instability; Chromosome Breakage; | 2013 |
Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients.
Topics: Abnormalities, Multiple; Adolescent; Adult; Child, Preschool; Chromosomal Instability; Cytogenetic A | 2003 |
Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.
Topics: Cell Line, Transformed; Chromosomal Instability; Cisplatin; Cross-Linking Reagents; DNA; DNA Damage; | 2004 |
Extensive chromosomal instability in Rad51d-deficient mouse cells.
Topics: Animals; Cell Culture Techniques; Centrosome; Chromosomal Instability; Cisplatin; DNA Damage; DNA-Bi | 2005 |
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Topics: Animals; BRCA1 Protein; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Survival; Chromosomal Instabil | 2007 |
DNA damage and chromosomal aberrations in various types of male factor infertility.
Topics: Adult; Caffeine; Cell Shape; Cell Survival; Cells, Cultured; Chromosomal Instability; DNA Damage; Hu | 2008 |