mitomycin has been researched along with Chromosomal Breakage in 36 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial." | 7.75 | DNA damage in leukocytes from Fanconi anemia (FA) patients and heterozygotes induced by mitomycin C and ionizing radiation as assessed by the comet and comet-FISH assay. ( Mohseni Meybodi, A; Mozdarani, H, 2009) |
| "This study was conducted to differentiate between Fanconi anemia (FA) and "idiopathic" aplastic anemia on the basis of induced chromosomal breakage study with mitomycin C (MMC)." | 7.72 | Differentiation of Fanconi anemia from idiopathic aplastic anemia by induced chromosomal breakage study using mitomycin-C (MMC). ( Choudhry, VP; Kucheria, K; Talwar, R, 2004) |
| "Chromosomal breakage was induced by MMC 0 ng/ml, 40 ng/ml, and 80 ng/ml." | 5.39 | [Correlation of single-cell gel electrophoresis and mitomycin C-induced chromosomal breakage for chromosomal instabiligy in children with Fanconi anemia]. ( Cai, XJ; Chen, XJ; Chen, YM; Guo, Y; Liu, F; Liu, Q; Liu, TF; Liu, XM; Ruan, M; Wang, SC; Yang, WY; Zhang, JY; Zhang, L; Zhu, XF; Zou, Y, 2013) |
| "Induced chromosomal breakage study was successful in 171 out of 205 aplastic anemia (AA) patients." | 5.39 | Differentiation of Fanconi anemia and aplastic anemia using mitomycin C test in Tunisia. ( Abdelhak, S; Abidli, N; Aissaoui, L; Amouri, A; Ayed, W; Bejaoui, M; Ben Halim, N; Ben Othmane, T; Ben Romdhane, N; Ben Youssef, Y; Chemkhi, I; Elloumi, M; Guermani, H; Hadiji, S; Hentati, S; Kammoun, L; Kilani, O; Mellouli, F; Talmoudi, F; Torjmane, L, 2013) |
| "However, spontaneous chromosomal breakage was not affected." | 5.30 | Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane. ( Hirsch-Kauffmann, M; Meisslitzer, C; Ruppitsch, W; Schweiger, M, 1998) |
| " Chromosomal breakage was induced by (i) Diepoxybutane 0." | 5.13 | Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients. ( Al-Haggar, M; Al-Morsy, Z; Chalaby, N; Mesbah, A; Ragab, A; Yahia, S, 2008) |
| " The diagnostic feature of FA is increased chromosomal breakage in blood lymphocytes cultured with diepoxybutane or mitomycin C." | 3.80 | Comparison of chromosome breakage in non-mosaic and mosaic patients with Fanconi anemia, relatives, and patients with other inherited bone marrow failure syndromes. ( Alter, BP; Fargo, JH; Giri, N; Olson, SB; Rochowski, A; Savage, SA, 2014) |
| "Investigation of mitomycin C-induced chromosomal breakage was carried out in 163 pediatric patients with AA and siblings of the cases where diagnosis of FA was confirmed." | 3.79 | Cytogenetic assessment of Fanconi anemia in children with aplastic anemia in Tunisia. ( Abdelhak, S; Aissaoui, L; Amouri, A; Bejaoui, M; Benhalim, N; Dellagi, K; Hdiji, S; Kammoun, L; Lakhal, A; Meddeb, M; Mellouli, F; Othmen, TB; Ouederni, M; Talmoudi, F; Torjemane, L, 2013) |
| "Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial." | 3.75 | DNA damage in leukocytes from Fanconi anemia (FA) patients and heterozygotes induced by mitomycin C and ionizing radiation as assessed by the comet and comet-FISH assay. ( Mohseni Meybodi, A; Mozdarani, H, 2009) |
| " In chromosomal breakage assays, all control cells were mitomycin C (MMC) resistant, but eight samples (five of the six high-risk and three of the eight ovarian cancer) were hypersensitive." | 3.73 | Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer. ( Akkari, Y; Ameziane, N; Bagby, GC; Bale, AE; Cain, JM; Cappuccini, F; Errami, A; Hays, LE; Keeble, W; Liu, HY; Olson, SB; Pejovic, T; Rathbun, RK; Rodgers, WH; Thuillier, P; Torimaru, Y; Yates, JE; Zwaan, CM, 2006) |
| " Mitomycin C (MMC) was used as a DNA cross-linker to study chromosomal breakage." | 3.73 | Cytogenetic investigation in Iranian patients suspected with Fanconi anemia. ( Hormozian, F; Mahjoubi, F; Manoochehri, F; Mortezapour, F; Nasiri, F; Rahnama, M; Razazian, F; Seyedmortaz, L; Soleymani, S; Tootian, S; Zamanian, M, 2006) |
| "This study was conducted to differentiate between Fanconi anemia (FA) and "idiopathic" aplastic anemia on the basis of induced chromosomal breakage study with mitomycin C (MMC)." | 3.72 | Differentiation of Fanconi anemia from idiopathic aplastic anemia by induced chromosomal breakage study using mitomycin-C (MMC). ( Choudhry, VP; Kucheria, K; Talwar, R, 2004) |
| " The current diagnostic test for FA consists of cytogenetic quantitation of chromosomal breakage in response to diepoxybutane (DEB) or mitomycin C (MMC)." | 3.71 | A novel diagnostic screen for defects in the Fanconi anemia pathway. ( D'Andrea, AD; Haining, N; Montes de Oca, R; Moreau, LA; Nathan, DG; Shimamura, A; Svenson, JL, 2002) |
| "Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation." | 3.71 | Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. ( D'Andrea, AD; Hays, T; Kuang, Y; Lu, N; Montes De Oca, R; Moreau, L; Seed, B; Yang, Y, 2001) |
| "The formaldehyde treatment resulted in the accumulation of chromosomal breakages that were more prominent in tdp1-deficient cells than in wild type cells." | 1.56 | Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells. ( Bessho, T; Hirota, K; Ide, H; Masunaga, SI; Nakano, T; Sasanuma, H; Shoulkamy, MI; Takata, M; Takeda, S; Tano, K; Tsuda, M, 2020) |
| "The sisters also had microcephaly, and one sister was in long-term remission from leukemia, which had been diagnosed when she was 5 years old." | 1.48 | Essential Role of BRCA2 in Ovarian Development and Function. ( Ben-Moshe, A; Dreifuss, A; Gerlitz, O; Goldberg, M; Gulsuner, S; Kalifa, R; King, MC; Levy-Lahad, E; Lobel, O; Rachmiel, M; Renbaum, P; Segel, R; Shore, T; Walsh, T; Weinberg-Shukron, A; Zangen, D; Zeligson, S, 2018) |
| "Oral squamous cell carcinoma (OSCC) may develop in young adults." | 1.43 | Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma. ( Braakhuis, BJ; Brakenhoff, RH; Flach, GB; Graveland, AP; Joenje, H; Leemans, CR; Nieuwint, AW; Oostra, AB, 2016) |
| "Chromosomal breakage was induced by MMC 0 ng/ml, 40 ng/ml, and 80 ng/ml." | 1.39 | [Correlation of single-cell gel electrophoresis and mitomycin C-induced chromosomal breakage for chromosomal instabiligy in children with Fanconi anemia]. ( Cai, XJ; Chen, XJ; Chen, YM; Guo, Y; Liu, F; Liu, Q; Liu, TF; Liu, XM; Ruan, M; Wang, SC; Yang, WY; Zhang, JY; Zhang, L; Zhu, XF; Zou, Y, 2013) |
| "Induced chromosomal breakage study was successful in 171 out of 205 aplastic anemia (AA) patients." | 1.39 | Differentiation of Fanconi anemia and aplastic anemia using mitomycin C test in Tunisia. ( Abdelhak, S; Abidli, N; Aissaoui, L; Amouri, A; Ayed, W; Bejaoui, M; Ben Halim, N; Ben Othmane, T; Ben Romdhane, N; Ben Youssef, Y; Chemkhi, I; Elloumi, M; Guermani, H; Hadiji, S; Hentati, S; Kammoun, L; Kilani, O; Mellouli, F; Talmoudi, F; Torjmane, L, 2013) |
| "Mitomycin C, which was used as a positive control, also caused the expected large rises in micronuclei in both bone marrow and peripheral blood cells at 24, 48 and 72 h after its administration." | 1.31 | Genotoxicity of paraquat: micronuclei induced in bone marrow and peripheral blood are inhibited by melatonin. ( Bitzer-Quintero, OK; García, JJ; Melchiorri, D; Oh, CS; Ortiz, GG; Pablos, MI; Reiter, RJ; Sewerynek, E; Zúñiga, G, 2000) |
| "However, spontaneous chromosomal breakage was not affected." | 1.30 | Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane. ( Hirsch-Kauffmann, M; Meisslitzer, C; Ruppitsch, W; Schweiger, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (19.44) | 18.2507 |
| 2000's | 18 (50.00) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Farkas, G | 1 |
| Székely, G | 1 |
| Goda, V | 1 |
| Kállay, KM | 1 |
| Kocsis, ZS | 1 |
| Szakszon, K | 1 |
| Benyó, G | 1 |
| Erdélyi, D | 1 |
| Liptai, Z | 1 |
| Csordás, K | 1 |
| Kertész, G | 1 |
| Szegedi, I | 1 |
| Kriván, G | 1 |
| Takácsi-Nagy, Z | 1 |
| Polgár, C | 1 |
| Jurányi, Z | 1 |
| Nakano, T | 1 |
| Shoulkamy, MI | 1 |
| Tsuda, M | 1 |
| Sasanuma, H | 1 |
| Hirota, K | 1 |
| Takata, M | 1 |
| Masunaga, SI | 1 |
| Takeda, S | 1 |
| Ide, H | 1 |
| Bessho, T | 1 |
| Tano, K | 1 |
| Weinberg-Shukron, A | 1 |
| Rachmiel, M | 1 |
| Renbaum, P | 1 |
| Gulsuner, S | 1 |
| Walsh, T | 1 |
| Lobel, O | 1 |
| Dreifuss, A | 1 |
| Ben-Moshe, A | 1 |
| Zeligson, S | 1 |
| Segel, R | 1 |
| Shore, T | 1 |
| Kalifa, R | 1 |
| Goldberg, M | 1 |
| King, MC | 1 |
| Gerlitz, O | 1 |
| Levy-Lahad, E | 1 |
| Zangen, D | 1 |
| Zhang, L | 1 |
| Liu, Q | 1 |
| Zou, Y | 1 |
| Liu, XM | 1 |
| Zhang, JY | 1 |
| Wang, SC | 1 |
| Chen, XJ | 1 |
| Guo, Y | 1 |
| Yang, WY | 1 |
| Ruan, M | 1 |
| Liu, TF | 1 |
| Liu, F | 1 |
| Cai, XJ | 1 |
| Chen, YM | 1 |
| Zhu, XF | 1 |
| Talmoudi, F | 2 |
| Kilani, O | 1 |
| Ayed, W | 1 |
| Ben Halim, N | 1 |
| Mellouli, F | 2 |
| Torjmane, L | 1 |
| Aissaoui, L | 2 |
| Ben Youssef, Y | 1 |
| Kammoun, L | 2 |
| Ben Othmane, T | 1 |
| Bejaoui, M | 2 |
| Ben Romdhane, N | 1 |
| Elloumi, M | 1 |
| Hadiji, S | 1 |
| Hentati, S | 1 |
| Chemkhi, I | 1 |
| Abidli, N | 1 |
| Guermani, H | 1 |
| Abdelhak, S | 2 |
| Amouri, A | 2 |
| Fargo, JH | 1 |
| Rochowski, A | 1 |
| Giri, N | 1 |
| Savage, SA | 1 |
| Olson, SB | 2 |
| Alter, BP | 1 |
| Braakhuis, BJ | 1 |
| Nieuwint, AW | 1 |
| Oostra, AB | 1 |
| Joenje, H | 1 |
| Flach, GB | 1 |
| Graveland, AP | 1 |
| Brakenhoff, RH | 1 |
| Leemans, CR | 1 |
| Al-Haggar, M | 1 |
| Al-Morsy, Z | 1 |
| Yahia, S | 1 |
| Chalaby, N | 1 |
| Ragab, A | 1 |
| Mesbah, A | 1 |
| Camelo, RM | 1 |
| Kehdy, FS | 1 |
| Salas, CE | 1 |
| Lopes, MT | 1 |
| Xiao, H | 1 |
| Zhang, K | 1 |
| Xia, B | 1 |
| Mohseni Meybodi, A | 1 |
| Mozdarani, H | 1 |
| Korgaonkar, S | 1 |
| Ghosh, K | 1 |
| Vundinti, BR | 1 |
| Hayakawa, T | 1 |
| Zhang, F | 1 |
| Hayakawa, N | 1 |
| Ohtani, Y | 1 |
| Shinmyozu, K | 1 |
| Nakayama, J | 1 |
| Andreassen, PR | 1 |
| Abo-Elwafa, HA | 1 |
| Attia, FM | 1 |
| Sharaf, AE | 1 |
| Benhalim, N | 1 |
| Torjemane, L | 1 |
| Ouederni, M | 1 |
| Lakhal, A | 1 |
| Othmen, TB | 1 |
| Meddeb, M | 1 |
| Dellagi, K | 1 |
| Hdiji, S | 1 |
| Shimamura, A | 1 |
| Montes de Oca, R | 2 |
| Svenson, JL | 1 |
| Haining, N | 1 |
| Moreau, LA | 2 |
| Nathan, DG | 1 |
| D'Andrea, AD | 4 |
| Nakanishi, K | 1 |
| Taniguchi, T | 2 |
| Ranganathan, V | 1 |
| New, HV | 1 |
| Stotsky, M | 1 |
| Mathew, CG | 1 |
| Kastan, MB | 1 |
| Weaver, DT | 1 |
| Satoh, T | 1 |
| Yamamoto, K | 1 |
| Miura, KF | 1 |
| Sofuni, T | 2 |
| Talwar, R | 1 |
| Choudhry, VP | 1 |
| Kucheria, K | 1 |
| Roncada, T | 1 |
| Vicentini, VE | 1 |
| Mantovani, MS | 1 |
| Henson, SE | 1 |
| Tsai, SC | 1 |
| Malone, CS | 1 |
| Soghomonian, SV | 1 |
| Ouyang, Y | 1 |
| Wall, R | 1 |
| Marahrens, Y | 1 |
| Teitell, MA | 1 |
| Pejovic, T | 1 |
| Yates, JE | 1 |
| Liu, HY | 1 |
| Hays, LE | 1 |
| Akkari, Y | 1 |
| Torimaru, Y | 1 |
| Keeble, W | 1 |
| Rathbun, RK | 1 |
| Rodgers, WH | 1 |
| Bale, AE | 1 |
| Ameziane, N | 1 |
| Zwaan, CM | 1 |
| Errami, A | 1 |
| Thuillier, P | 1 |
| Cappuccini, F | 1 |
| Cain, JM | 1 |
| Bagby, GC | 1 |
| Tootian, S | 1 |
| Mahjoubi, F | 1 |
| Rahnama, M | 1 |
| Hormozian, F | 1 |
| Mortezapour, F | 1 |
| Razazian, F | 1 |
| Manoochehri, F | 1 |
| Zamanian, M | 1 |
| Nasiri, F | 1 |
| Soleymani, S | 1 |
| Seyedmortaz, L | 1 |
| Vinoth, KJ | 1 |
| Heng, BC | 1 |
| Poonepalli, A | 1 |
| Banerjee, B | 1 |
| Balakrishnan, L | 1 |
| Lu, K | 1 |
| Hande, MP | 1 |
| Cao, T | 1 |
| Latour, DR | 1 |
| Vig, BK | 1 |
| Finze, EM | 1 |
| Paweletz, N | 1 |
| Honma, M | 1 |
| Hayashi, M | 1 |
| Kuffel, DG | 1 |
| Lindor, NM | 1 |
| Litzow, MR | 1 |
| Zinsmeister, AR | 1 |
| Dewald, GW | 1 |
| Ruppitsch, W | 1 |
| Meisslitzer, C | 1 |
| Hirsch-Kauffmann, M | 1 |
| Schweiger, M | 1 |
| Johnstone, P | 1 |
| Reifsteck, C | 2 |
| Kohler, S | 1 |
| Worland, P | 1 |
| Olson, S | 2 |
| Moses, RE | 1 |
| Sun, JT | 1 |
| Armstrong, MJ | 1 |
| Galloway, SM | 1 |
| Kraakman-van der Zwet, M | 1 |
| Overkamp, WJ | 1 |
| Friedl, AA | 1 |
| Klein, B | 1 |
| Verhaegh, GW | 1 |
| Jaspers, NG | 1 |
| Midro, AT | 1 |
| Eckardt-Schupp, F | 1 |
| Lohman, PH | 1 |
| Zdzienicka, MZ | 1 |
| Ortiz, GG | 1 |
| Reiter, RJ | 1 |
| Zúñiga, G | 1 |
| Melchiorri, D | 1 |
| Sewerynek, E | 1 |
| Pablos, MI | 1 |
| Oh, CS | 1 |
| García, JJ | 1 |
| Bitzer-Quintero, OK | 1 |
| Dokal, I | 1 |
| Timmers, C | 1 |
| Hejna, J | 1 |
| Lucas, L | 1 |
| Bruun, D | 1 |
| Thayer, M | 1 |
| Cox, B | 1 |
| Moses, R | 1 |
| Grompe, M | 1 |
| Moynahan, ME | 1 |
| Cui, TY | 1 |
| Jasin, M | 1 |
| Yang, Y | 1 |
| Kuang, Y | 1 |
| Hays, T | 1 |
| Moreau, L | 1 |
| Lu, N | 1 |
| Seed, B | 1 |
1 review available for mitomycin and Chromosomal Breakage
| Article | Year |
|---|---|
The genetics of Fanconi's anaemia.
Topics: Cells, Cultured; Chromosome Breakage; DNA Damage; Epoxy Compounds; Fanconi Anemia; Genetic Testing; | 2000 |
1 trial available for mitomycin and Chromosomal Breakage
| Article | Year |
|---|---|
Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients.
Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosomal Instability; Chromosome Breakage; | 2008 |
34 other studies available for mitomycin and Chromosomal Breakage
| Article | Year |
|---|---|
Chromosomal breakage tests in the differential diagnosis of Fanconi anemia and aplastic anemia.
Topics: Anemia, Aplastic; Bleomycin; Chromosome Breakage; Diagnosis, Differential; Fanconi Anemia; Humans; M | 2023 |
Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells.
Topics: Animals; Cell Line; Chickens; Chromosome Breakage; Decitabine; DNA; DNA Breaks; DNA Breaks, Double-S | 2020 |
Essential Role of BRCA2 in Ovarian Development and Function.
Topics: Adolescent; Animals; BRCA2 Protein; Chromosome Breakage; DNA Mutational Analysis; DNA Repair; Drosop | 2018 |
[Correlation of single-cell gel electrophoresis and mitomycin C-induced chromosomal breakage for chromosomal instabiligy in children with Fanconi anemia].
Topics: Adolescent; Anemia, Aplastic; Case-Control Studies; Child; Child, Preschool; Chromosomal Instability | 2013 |
Differentiation of Fanconi anemia and aplastic anemia using mitomycin C test in Tunisia.
Topics: Adolescent; Adult; Anemia, Aplastic; Antibiotics, Antineoplastic; Child; Child, Preschool; Chromosom | 2013 |
Comparison of chromosome breakage in non-mosaic and mosaic patients with Fanconi anemia, relatives, and patients with other inherited bone marrow failure syndromes.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Bone Marrow Diseases; Bone Marrow Failure Disorders; Chil | 2014 |
Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.
Topics: Adult; Carcinoma, Squamous Cell; Chromosome Breakage; DNA Damage; Fanconi Anemia; Female; Genetic Pr | 2016 |
Amifostine protection against mitomycin-induced chromosomal breakage in fanconi anaemia lymphocytes.
Topics: Adolescent; Adult; Amifostine; Blood Cells; Case-Control Studies; Child; Chromosome Breakage; Fancon | 2008 |
[Search for Fanconi anemia/BRCA pathway defects in lymphoma cell lines].
Topics: Animals; Antibiotics, Antineoplastic; Base Sequence; BRCA2 Protein; Cell Cycle; Cell Line, Tumor; Ce | 2008 |
DNA damage in leukocytes from Fanconi anemia (FA) patients and heterozygotes induced by mitomycin C and ionizing radiation as assessed by the comet and comet-FISH assay.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Chromosome Breakage; Chromosomes, | 2009 |
Clinical, genetic and cytogenetic study of Fanconi anemia in an Indian population.
Topics: Adolescent; Carcinoma, Squamous Cell; Cells, Cultured; Child; Child, Preschool; Chromosome Breakage; | 2010 |
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Topics: Breast Neoplasms; Chromatin; Chromosome Breakage; Comet Assay; Cross-Linking Reagents; DNA; DNA Repa | 2010 |
The prognostic value of p53 mutation in pediatric marrow hypoplasia.
Topics: Adolescent; Anemia, Aplastic; Autoimmune Diseases; Bone Marrow Cells; Child; Child, Preschool; Chrom | 2011 |
Cytogenetic assessment of Fanconi anemia in children with aplastic anemia in Tunisia.
Topics: Adolescent; Anemia, Aplastic; Child; Child, Preschool; Chromosomal Instability; Chromosome Breakage; | 2013 |
A novel diagnostic screen for defects in the Fanconi anemia pathway.
Topics: Blotting, Western; Bone Marrow Diseases; Cell Line, Transformed; Chromosome Breakage; Chromosomes, H | 2002 |
Interaction of FANCD2 and NBS1 in the DNA damage response.
Topics: Antibiotics, Antineoplastic; Cell Cycle Proteins; Cell Line, Transformed; Chromosome Breakage; Cross | 2002 |
Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells.
Topics: Azacitidine; Cells, Cultured; Chromatin; Chromosome Breakage; Chromosomes, Human, Pair 15; Cross-Lin | 2004 |
Differentiation of Fanconi anemia from idiopathic aplastic anemia by induced chromosomal breakage study using mitomycin-C (MMC).
Topics: Adolescent; Adult; Anemia, Aplastic; Child; Child, Preschool; Chromosome Breakage; Diagnosis, Differ | 2004 |
Possible modulating actions of plant extracts on the chromosome breaking activity of MMC and Ara-C in human lymphocytes in vitro.
Topics: Achillea; Adolescent; Adult; Antimutagenic Agents; Cells, Cultured; Chromosome Breakage; Cytarabine; | 2004 |
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Topics: Blotting, Northern; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromosome Break | 2006 |
Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer.
Topics: Adult; Aged; Chromosome Breakage; DNA Methylation; DNA, Complementary; Epithelial Cells; Fanconi Ane | 2006 |
Cytogenetic investigation in Iranian patients suspected with Fanconi anemia.
Topics: Chromosome Breakage; Cytogenetics; Fanconi Anemia; Female; Humans; Iran; Male; Mitomycin; Nucleic Ac | 2006 |
Human embryonic stem cells may display higher resistance to genotoxic stress as compared to primary explanted somatic cells.
Topics: Animals; Cells, Cultured; Chromosome Breakage; DNA Damage; Drug Resistance; Embryonic Stem Cells; Fi | 2008 |
The centromeres of the Indian muntjac: evidence for the existence of multiple centromeres?
Topics: Animals; Antibodies; Cells, Cultured; Centromere; Chromosome Breakage; Kinetochores; Methylnitronitr | 1996 |
Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells.
Topics: Cell Line; Chromosome Breakage; Chromosome Deletion; DNA Fingerprinting; Ethyl Methanesulfonate; Gen | 1997 |
Mitomycin C chromosome stress test to identify hypersensitivity to bifunctional alkylating agents in patients with Fanconi anemia or aplastic anemia.
Topics: Alkylating Agents; Chromosome Breakage; Chromosomes, Human; Cross-Linking Reagents; Cytogenetics; Di | 1997 |
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
Topics: Antioxidants; Cell Line; Cell Survival; Chromosome Breakage; Cytokines; DNA Damage; Epoxy Compounds; | 1998 |
Fanconi anemia group A and D cell lines respond normally to inhibitors of cell cycle regulation.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Caffeine; Cell Cycle; Cells, Culture | 1997 |
Rapid method for improving slide quality in the bone marrow micronucleus assay; an adapted cellulose column procedure.
Topics: Animals; Bone Marrow Cells; Cellulose; Chromatography; Chromosome Breakage; Colchicine; Cyclophospha | 1999 |
Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts.
Topics: Abnormalities, Multiple; Antineoplastic Agents; Bleomycin; Camptothecin; Cell Line; Cell Line, Trans | 1999 |
Genotoxicity of paraquat: micronuclei induced in bone marrow and peripheral blood are inhibited by melatonin.
Topics: Animals; Bone Marrow; Chromosome Breakage; DNA; Erythroblasts; Herbicides; Injections, Intraperitone | 2000 |
Positional cloning of a novel Fanconi anemia gene, FANCD2.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line; Chromosome Breakage; Clon | 2001 |
Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.
Topics: Animals; Cell Line; Chromosome Breakage; Cross-Linking Reagents; DNA Damage; DNA Repair; Drug Resist | 2001 |
Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.
Topics: Alleles; Animals; Chromosome Breakage; Disease Models, Animal; DNA-Binding Proteins; Fanconi Anemia; | 2001 |