Page last updated: 2024-11-06

mitomycin and Chloasma

mitomycin has been researched along with Chloasma in 35 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Research Excerpts

ExcerptRelevanceReference
"Local chemotherapy with mitomycin C is a useful option in the treatment of malignant melanomas of the conjunctiva associated with PAM if the tumor stage is pT3 or less."9.10[Management of conjunctival malignant melanoma associated with primary acquired melanosis (PAM) using 0.02% mitomycin C eyedrops]. ( Conway, RM; Groh, MJ; Holbach, LM; Kühnel, B; Naumann, GO, 2003)
"To clinically evaluate topical mitomycin chemotherapy in patients with diffuse, multifocal, or recurrent primary acquired melanosis with atypia and/or conjunctival malignant melanoma and to histopathologically study ocular tissue samples obtained before and after treatment."9.09Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: clinical experience with histopathologic observations. ( Demirci, H; Finger, PT; McCormick, SA, 2000)
"To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia."9.08Topical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia. ( Czechonska, G; Finger, PT; Liarikos, S, 1998)
"To report a case of a large conjunctival melanoma (CM) successfully treated with surgical resection and pre- and postoperative topical mitomycin C (MMC)."8.02Extensive conjunctival melanoma successfully treated with surgical resection and pre- and postoperative topical mitomycin C. ( Giansanti, F; Mazzini, C; Nicolosi, C; Pieretti, G; Vicini, G; Virgili, G, 2021)
"To describe the incidence, characteristics, risk factors, and clinical outcome of limbal stem cell deficiency (LSCD) resulting from topical treatment with mitomycin C (MMC) for primary acquired melanosis (PAM) with atypia."7.76Limbal stem cell deficiency after topical mitomycin C therapy for primary acquired melanosis with atypia. ( Frucht-Pery, J; Lichtinger, A; Pe'er, J; Solomon, A, 2010)
"The most effective dose of mitomycin C (MMC) in the treatment of primary acquired melanosis (PAM) with atypia of the conjunctiva and cornea has yet to be established."7.74Resolution of primary acquired melanosis with atypia after minimal mitomycin C treatment. ( Chappell, AJ; Chen, JY; Klebe, S; Mills, RA, 2007)
"To report our results of 12 consecutive patients with conjunctival primary acquired melanosis (PAM) with atypia who were treated by topical Mitomycin C (MMC)."7.73The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C. ( Frucht-Pery, J; Pe'er, J, 2005)
" Mitomycin was a primary treatment for residual epithelial disease in ten patients (eight with PAM with atypia and two with conjunctival melanoma) and as an adjuvant to excision and cryotherapy in six with conjunctival malignant melanoma."7.73Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience. ( Finger, PT; Kurli, M, 2005)
"A case of primary acquired melanosis of the conjunctiva primarily treated with topical mitomycin chemotherapy is presented."7.72Topical mitomycin treatment for primary acquired melanosis of the conjunctiva. ( Brownstein, S; Dorey, MW; Jordan, DR; Yuen, VH, 2003)
"To present the clinical and histologic findings of a patient in whom intumescent cataract developed after successful topical mitomycin-C (MMC) chemotherapy for conjunctival melanoma originating from primary acquired conjunctival melanosis (PAM) with atypia."7.72Intumescent cataract after topical mitomycin-C for conjunctival malignant melanoma. ( Horvat, R; Lukas, JR; Sacu, S; Ségur-Eltz, N; Zehetmayer, M, 2003)
"Since 1995 we have used Mitomycin C additionally in the treatment of conjunctival melanoma and primary acquired melanosis."7.70[Mitomycin C in treatment of conjunctival melanoma and primary acquired melanosis]. ( Lommatzsch, PK; Werschnik, C, 1998)
" If Mitomycin is used in that low dosage and in that special application as shown, it could be a very efficient therapy with less complications."5.31[The treatment of a primary acquired melanosis of the conjunctiva with atypia by low dose of Mitomycin C 0.02 % - case report with follow up of 2 years]. ( Klaehsen, D; Maier, M; Merté, RL; Schmidt, M; Schmidt, T, 2001)
"Local chemotherapy with mitomycin C is a useful option in the treatment of malignant melanomas of the conjunctiva associated with PAM if the tumor stage is pT3 or less."5.10[Management of conjunctival malignant melanoma associated with primary acquired melanosis (PAM) using 0.02% mitomycin C eyedrops]. ( Conway, RM; Groh, MJ; Holbach, LM; Kühnel, B; Naumann, GO, 2003)
"To clinically evaluate topical mitomycin chemotherapy in patients with diffuse, multifocal, or recurrent primary acquired melanosis with atypia and/or conjunctival malignant melanoma and to histopathologically study ocular tissue samples obtained before and after treatment."5.09Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: clinical experience with histopathologic observations. ( Demirci, H; Finger, PT; McCormick, SA, 2000)
"To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia."5.08Topical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia. ( Czechonska, G; Finger, PT; Liarikos, S, 1998)
"We herein compare topical interferon alpha 2b (IFN-α2b) to topical mitomycin C (MMC) in the adjuvant management after excision of primary acquired melanosis with atypia (PAM) and melanoma of the conjunctiva/cornea (CM)."4.31Real-life data of adjuvant IFN-α2b and MMC in conjunctival melanocytic lesions. ( Auw-Haedrich, C; Boehringer, D; Jiang, J; Nuessle, S; Reinhard, T, 2023)
"To report a case of a large conjunctival melanoma (CM) successfully treated with surgical resection and pre- and postoperative topical mitomycin C (MMC)."4.02Extensive conjunctival melanoma successfully treated with surgical resection and pre- and postoperative topical mitomycin C. ( Giansanti, F; Mazzini, C; Nicolosi, C; Pieretti, G; Vicini, G; Virgili, G, 2021)
"To describe the incidence, characteristics, risk factors, and clinical outcome of limbal stem cell deficiency (LSCD) resulting from topical treatment with mitomycin C (MMC) for primary acquired melanosis (PAM) with atypia."3.76Limbal stem cell deficiency after topical mitomycin C therapy for primary acquired melanosis with atypia. ( Frucht-Pery, J; Lichtinger, A; Pe'er, J; Solomon, A, 2010)
"The most effective dose of mitomycin C (MMC) in the treatment of primary acquired melanosis (PAM) with atypia of the conjunctiva and cornea has yet to be established."3.74Resolution of primary acquired melanosis with atypia after minimal mitomycin C treatment. ( Chappell, AJ; Chen, JY; Klebe, S; Mills, RA, 2007)
"To report our results of 12 consecutive patients with conjunctival primary acquired melanosis (PAM) with atypia who were treated by topical Mitomycin C (MMC)."3.73The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C. ( Frucht-Pery, J; Pe'er, J, 2005)
" Mitomycin was a primary treatment for residual epithelial disease in ten patients (eight with PAM with atypia and two with conjunctival melanoma) and as an adjuvant to excision and cryotherapy in six with conjunctival malignant melanoma."3.73Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience. ( Finger, PT; Kurli, M, 2005)
"A case of primary acquired melanosis of the conjunctiva primarily treated with topical mitomycin chemotherapy is presented."3.72Topical mitomycin treatment for primary acquired melanosis of the conjunctiva. ( Brownstein, S; Dorey, MW; Jordan, DR; Yuen, VH, 2003)
"To present the clinical and histologic findings of a patient in whom intumescent cataract developed after successful topical mitomycin-C (MMC) chemotherapy for conjunctival melanoma originating from primary acquired conjunctival melanosis (PAM) with atypia."3.72Intumescent cataract after topical mitomycin-C for conjunctival malignant melanoma. ( Horvat, R; Lukas, JR; Sacu, S; Ségur-Eltz, N; Zehetmayer, M, 2003)
"Since 1995 we have used Mitomycin C additionally in the treatment of conjunctival melanoma and primary acquired melanosis."3.70[Mitomycin C in treatment of conjunctival melanoma and primary acquired melanosis]. ( Lommatzsch, PK; Werschnik, C, 1998)
"To describe the epithelial changes observed in the conjunctiva secondary to the use of topical mitomycin C (MMC) for treatment of primary acquired melanosis with atypia."3.70Cytologic changes in the conjunctiva mimicking malignancy after topical mitomycin C chemotherapy. ( Cuevas, K; Folberg, R; Mathers, WD; Salomão, DR; Sutphin, JE, 1999)
"We successfully treated nodular melanoma and diffuse PAM in a young black woman using a combination of excision with cryotherapy and topical mitomycin C, suggesting that these lesions are amenable to the same types of therapy previously described for white patients."2.43Conjunctival melanoma arising from diffuse primary acquired melanosis in a young black woman. ( Colby, KA; Nagel, DS, 2005)
" If Mitomycin is used in that low dosage and in that special application as shown, it could be a very efficient therapy with less complications."1.31[The treatment of a primary acquired melanosis of the conjunctiva with atypia by low dose of Mitomycin C 0.02 % - case report with follow up of 2 years]. ( Klaehsen, D; Maier, M; Merté, RL; Schmidt, M; Schmidt, T, 2001)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (14.29)18.2507
2000's23 (65.71)29.6817
2010's4 (11.43)24.3611
2020's3 (8.57)2.80

Authors

AuthorsStudies
Nuessle, S1
Auw-Haedrich, C1
Jiang, J1
Boehringer, D1
Reinhard, T1
Mazzini, C1
Pieretti, G1
Vicini, G1
Nicolosi, C1
Virgili, G1
Giansanti, F1
Soto, H1
Bowen, RC1
Raval, V1
Yeaney, G1
Singh, A1
Schallenberg, M1
Niederdräing, N1
Steuhl, KP1
Meller, D1
Boto-de-Los-Bueis, A1
Díaz-Valle, D1
Llorente-González, S1
Pastora-Salvador, N1
Patrón-Romero, M1
Hernández-González, C1
Rudkin, AK1
Muecke, JS1
Lichtinger, A1
Pe'er, J3
Frucht-Pery, J3
Solomon, A1
Colby, K1
Bhat, P1
Novais, G1
Jakobiec, FA1
Nishikawa, N1
Hanada, K1
Miyokawa, N1
Tokusashi, Y1
Yoshida, A1
Irvine, F1
Kumarasamy, M1
Kemp, E1
Roberts, F1
Rodríguez-Ares, T1
Touriño, R1
De Rojas, V1
Becerra, E1
Capeans, C1
Yuen, VH1
Jordan, DR1
Brownstein, S1
Dorey, MW1
Sacu, S1
Ségur-Eltz, N1
Horvat, R1
Lukas, JR1
Zehetmayer, M1
Groh, MJ1
Holbach, LM1
Kühnel, B1
Conway, RM1
Naumann, GO1
Char, DH2
Colby, KA2
Nagel, DS1
Kurli, M1
Finger, PT3
Krohn, J1
Monge, OR1
Khong, JJ1
Muecke, J1
Sugiura, M1
Mihm, MC1
Zembowicz, A1
Chen, JY1
Chappell, AJ1
Klebe, S1
Mills, RA1
Anandajeya, WV1
Corrêa, ZM1
Augsburger, JJ1
Löffler, KU1
Czechonska, G1
Liarikos, S1
Werschnik, C1
Lommatzsch, PK1
Salomão, DR1
Mathers, WD1
Sutphin, JE1
Cuevas, K1
Folberg, R1
Demirci, H2
McCormick, SA1
Paridaens, D1
Beekhuis, H1
van Den Bosch, W1
Remeyer, L1
Melles, G1
Shields, CL2
Shields, JA2
Armstrong, T1
Tsai, JC1
Sivak-Callcott, JA1
Haik, BG1
Zhang, J1
McLean, IW1
Schmidt, M1
Maier, M1
Schmidt, T1
Klaehsen, D1
Merté, RL1
Spanich, C1

Reviews

2 reviews available for mitomycin and Chloasma

ArticleYear
[Topical Mitomycin C as a therapy of conjunctival tumours].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2008, Volume: 105, Issue:8

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Carcinoma in Situ; Carcinoma, Squamous Cell; C

2008
Conjunctival melanoma arising from diffuse primary acquired melanosis in a young black woman.
    Cornea, 2005, Volume: 24, Issue:3

    Topics: Administration, Topical; Adult; Antibiotics, Antineoplastic; Black People; Combined Modality Therapy

2005

Trials

3 trials available for mitomycin and Chloasma

ArticleYear
[Management of conjunctival malignant melanoma associated with primary acquired melanosis (PAM) using 0.02% mitomycin C eyedrops].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2003, Volume: 100, Issue:9

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Conjunctival Neoplasms; Female; Humans; Male;

2003
Topical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia.
    The British journal of ophthalmology, 1998, Volume: 82, Issue:5

    Topics: Administration, Topical; Adult; Aged; Antibiotics, Antineoplastic; Chemotherapy, Adjuvant; Conjuncti

1998
Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: clinical experience with histopathologic observations.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2000, Volume: 118, Issue:7

    Topics: Administration, Topical; Adult; Aged; Antibiotics, Antineoplastic; Atrophy; Chemotherapy, Adjuvant;

2000

Other Studies

30 other studies available for mitomycin and Chloasma

ArticleYear
Real-life data of adjuvant IFN-α2b and MMC in conjunctival melanocytic lesions.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023, Volume: 261, Issue:4

    Topics: Adjuvants, Immunologic; Conjunctival Neoplasms; Humans; Interferon-alpha; Melanosis; Mitomycin; Neop

2023
Extensive conjunctival melanoma successfully treated with surgical resection and pre- and postoperative topical mitomycin C.
    European journal of ophthalmology, 2021, Volume: 31, Issue:6

    Topics: Antibiotics, Antineoplastic; Conjunctival Neoplasms; Humans; Male; Melanoma; Melanosis; Middle Aged;

2021
Primary acquired melanosis/melanoma: utility of conjunctival map biopsy.
    The British journal of ophthalmology, 2022, Volume: 106, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Biopsy; Conjunctival Neoplasms; Female; Humans; Melanoma; Melanoma,

2022
[Post-traumatic striate melanokeratosis in a Caucasian woman].
    Archivos de la Sociedad Espanola de Oftalmologia, 2009, Volume: 84, Issue:4

    Topics: Conjunctival Diseases; Corneal Diseases; Corneal Ulcer; Eye Color; Female; Fluorometholone; Humans;

2009
Topical mitomycin following cryotherapy for treatment of recurrent ocular surface melanoma.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2009, Volume: 44, Issue:5

    Topics: Administration, Topical; Aged, 80 and over; Antibiotics, Antineoplastic; Combined Modality Therapy;

2009
Limbal stem cell deficiency after topical mitomycin C therapy for primary acquired melanosis with atypia.
    Ophthalmology, 2010, Volume: 117, Issue:3

    Topics: Administration, Topical; Adult; Aged; Antibiotics, Antineoplastic; Cell Count; Conjunctival Diseases

2010
Recurrent primary acquired melanosis with atypia involving a clear corneal phacoemulsification wound.
    Cornea, 2011, Volume: 30, Issue:1

    Topics: Aged, 80 and over; Alkylating Agents; Combined Modality Therapy; Cornea; Corneal Diseases; Cryothera

2011
Pigmented squamous cell carcinoma in situ of the conjunctiva.
    Japanese journal of ophthalmology, 2011, Volume: 55, Issue:5

    Topics: Amnion; Carcinoma in Situ; Carcinoma, Squamous Cell; Combined Modality Therapy; Conjunctival Neoplas

2011
Progression of primary acquired melanosis with atypia during pregnancy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:8

    Topics: Administration, Topical; Adult; Antibiotics, Antineoplastic; Conjunctival Diseases; Disease Progress

2012
Topical mitomycin C in the treatment of pigmented conjunctival lesions.
    Cornea, 2003, Volume: 22, Issue:2

    Topics: Administration, Topical; Aged; Antibiotics, Antineoplastic; Conjunctival Diseases; Female; Humans; M

2003
Topical mitomycin treatment for primary acquired melanosis of the conjunctiva.
    Ophthalmic plastic and reconstructive surgery, 2003, Volume: 19, Issue:2

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Conjunctival Diseases; Female; Humans; Melanos

2003
Intumescent cataract after topical mitomycin-C for conjunctival malignant melanoma.
    American journal of ophthalmology, 2003, Volume: 136, Issue:2

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Cataract; Cataract Extraction; Conjunctival Ne

2003
The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C.
    American journal of ophthalmology, 2005, Volume: 139, Issue:2

    Topics: Administration, Topical; Adult; Aged; Antibiotics, Antineoplastic; Conjunctival Diseases; Female; Fo

2005
Mitomycin for pigmented conjunctival lesions.
    American journal of ophthalmology, 2005, Volume: 139, Issue:2

    Topics: Antibiotics, Antineoplastic; Conjunctival Diseases; Humans; Melanosis; Mitomycin

2005
Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005, Volume: 243, Issue:11

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Conjunctival N

2005
[Conjunctival primary acquired melanosis].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2005, Sep-22, Volume: 125, Issue:18

    Topics: Aged; Antibiotics, Antineoplastic; Conjunctival Diseases; Conjunctival Neoplasms; Cryotherapy; Diagn

2005
Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:7

    Topics: Adenocarcinoma, Sebaceous; Antibiotics, Antineoplastic; Carcinoma in Situ; Carcinoma, Squamous Cell;

2006
Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 cases.
    The American journal of surgical pathology, 2007, Volume: 31, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Cell Nucleolus; Cell Nucleus; Chemother

2007
Complications of management in primary acquired melanosis with atypia.
    The British journal of ophthalmology, 2007, Volume: 91, Issue:11

    Topics: Combined Modality Therapy; Conjunctival Diseases; Cryosurgery; Female; Humans; Melanosis; Middle Age

2007
Resolution of primary acquired melanosis with atypia after minimal mitomycin C treatment.
    Clinical & experimental ophthalmology, 2007, Volume: 35, Issue:9

    Topics: Aged; Alkylating Agents; Conjunctiva; Conjunctival Diseases; Cornea; Drug Administration Schedule; F

2007
Primary acquired melanosis with atypia treated with mitomycin C.
    International ophthalmology, 2009, Volume: 29, Issue:4

    Topics: Alkylating Agents; Conjunctival Diseases; Conjunctival Neoplasms; Cryosurgery; Humans; Male; Melanom

2009
Use of mitomycin C in the treatment of conjunctival primary acquired melanosis with atypia.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:10

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Biopsy; Conjunctiva; Conjunctival Diseases; Fe

1996
[Mitomycin as local therapeutic drug in ocular neoplasms].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1997, Volume: 94, Issue:7

    Topics: Antibiotics, Antineoplastic; Conjunctival Neoplasms; Corneal Diseases; Eye Neoplasms; Follow-Up Stud

1997
[Mitomycin C in treatment of conjunctival melanoma and primary acquired melanosis].
    Klinische Monatsblatter fur Augenheilkunde, 1998, Volume: 212, Issue:6

    Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Chemotherapy, Adjuvant; Combined Modality Ther

1998
Cytologic changes in the conjunctiva mimicking malignancy after topical mitomycin C chemotherapy.
    Ophthalmology, 1999, Volume: 106, Issue:9

    Topics: Administration, Topical; Aged; Antibiotics, Antineoplastic; Biopsy; Cell Nucleus; Conjunctiva; Conju

1999
Amniotic membrane transplantation in the management of conjunctival malignant melanoma and primary acquired melanosis with atypia.
    The British journal of ophthalmology, 2001, Volume: 85, Issue:6

    Topics: Administration, Topical; Aged; Amnion; Conjunctival Neoplasms; Corneal Transplantation; Female; Huma

2001
Management of conjunctival and corneal melanoma with surgical excision, amniotic membrane allograft, and topical chemotherapy.
    American journal of ophthalmology, 2001, Volume: 132, Issue:4

    Topics: Adult; Amnion; Antibiotics, Antineoplastic; Combined Modality Therapy; Conjunctival Neoplasms; Corne

2001
Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report.
    Journal of glaucoma, 2001, Volume: 10, Issue:5

    Topics: Antihypertensive Agents; Diagnosis, Differential; Female; Glaucoma, Open-Angle; Humans; Intraocular

2001
[The treatment of a primary acquired melanosis of the conjunctiva with atypia by low dose of Mitomycin C 0.02 % - case report with follow up of 2 years].
    Klinische Monatsblatter fur Augenheilkunde, 2001, Volume: 218, Issue:12

    Topics: Administration, Topical; Aged; Biopsy; Cell Transformation, Neoplastic; Conjunctiva; Conjunctival Ne

2001
Dramatic regression of conjunctival and corneal acquired melanosis with topical mitomycin C.
    The British journal of ophthalmology, 2002, Volume: 86, Issue:2

    Topics: Aged; Antibiotics, Antineoplastic; Eye Neoplasms; Follow-Up Studies; Humans; Male; Melanosis; Mitomy

2002