mitomycin has been researched along with Cell Transformation, Viral in 24 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Cell Transformation, Viral: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cells from Fanconi anemia (FA) patients have defective DNA repair and are hypersensitive to DNA crosslinking agents such as mitomycin C (MMC)." | 3.69 | Fanconi anemia cells have a normal gene structure for topoisomerase I. ( Grompe, M; Jakobs, PM; Moses, RE; Neeley, TL; Saito, H, 1994) |
| "Lethal effects of mitomycin C (MMC), 4-nitroquinoline 1-oxide (4NQO) and ultraviolet light (UV) on fibroblast cell lines derived from a colon cancer-prone substrain of Wistar-Furth rats (WF/OSAKA rats) were measured in terms of the cellular colony-forming ability, and compared with the sensitivity to these agents of human fibroblasts from patients with adenomatosis coli and rectum (ACR)." | 3.66 | Increased sensitivity of cultured fibroblasts from colon cancer-prone rats to cytotoxicity of carcinogens and to viral transformation: a comparison with fibroblasts from patients with adenomatosis coli. ( Ikenaga, M; Kitamura, H; Miyamoto, M; Tsujimura, T; Utsunomiya, J, 1983) |
| "Leukemias and squamous cell carcinomas (SCCs) are the most predominant FA-associated cancers, with the latter exhibiting markedly early disease onset and aggressiveness." | 1.35 | Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. ( Cha, E; Duensing, S; Higginbotham, JM; Hoskins, EE; Kelly, P; Morris, TA; Spardy, N; Wells, SI; Wikenheiser-Brokamp, KA; Williams, DA, 2009) |
| "Therefore, genomic instability generated NCCAs are a key driving force in cancer progression." | 1.33 | Stochastic cancer progression driven by non-clonal chromosome aberrations. ( Bremer, SW; Heng, HH; Liu, G; Reddy, PV; Stevens, JB; Tainsky, MA; Wang, YA; Wu, GS; Ye, CJ; Ye, KJ, 2006) |
| "Mitomycin C treated tumor cell suspensions, when cocultured with normal human blood leukocytes, markedly depressed the expected blastogenic responses in vitro to concanavalin A, pokeweed mitogen, and phytohemagglutin." | 1.27 | Lymphoblastoid cell-induced suppression of human peripheral blood leukocyte mitogenic responses. ( Friedman, F; Friedman, H; Hsu, KH; Nonoyama, M; Specter, S; Zhang, JL, 1984) |
| "Mitomycin C treatment of fresh E rosetting cells or those exposed to BEBV for up to 10 days in culture abrogates growth regression and the subsequent appearance of LCLEBV killer cells." | 1.27 | Regulation of the growth of Epstein-Barr virus-infected B cells. I. Growth regression by E rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8+ memory cells. ( Bluestein, HG; Konttinen, YT; Zvaifler, NJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoskins, EE | 1 |
| Morris, TA | 1 |
| Higginbotham, JM | 1 |
| Spardy, N | 1 |
| Cha, E | 1 |
| Kelly, P | 1 |
| Williams, DA | 1 |
| Wikenheiser-Brokamp, KA | 1 |
| Duensing, S | 1 |
| Wells, SI | 1 |
| Shukla, SJ | 1 |
| Dolan, ME | 1 |
| Heng, HH | 1 |
| Stevens, JB | 1 |
| Liu, G | 1 |
| Bremer, SW | 1 |
| Ye, KJ | 1 |
| Reddy, PV | 1 |
| Wu, GS | 1 |
| Wang, YA | 1 |
| Tainsky, MA | 1 |
| Ye, CJ | 1 |
| Ganzenmueller, T | 1 |
| Matthaei, M | 1 |
| Muench, P | 1 |
| Scheible, M | 1 |
| Iftner, A | 1 |
| Hiller, T | 1 |
| Leiprecht, N | 1 |
| Probst, S | 1 |
| Stubenrauch, F | 1 |
| Iftner, T | 1 |
| Zhang, JL | 1 |
| Friedman, F | 1 |
| Hsu, KH | 1 |
| Specter, S | 1 |
| Friedman, H | 1 |
| Nonoyama, M | 1 |
| Gruenert, DC | 1 |
| Cleaver, JE | 1 |
| Yoshimura, N | 1 |
| Yata, J | 2 |
| Tsujimura, T | 1 |
| Miyamoto, M | 1 |
| Ikenaga, M | 1 |
| Utsunomiya, J | 1 |
| Kitamura, H | 1 |
| Lee, SE | 1 |
| Pulaski, CR | 1 |
| He, DM | 1 |
| Benjamin, DM | 1 |
| Voss, M | 1 |
| Um, J | 1 |
| Hendrickson, EA | 1 |
| Saito, H | 1 |
| Grompe, M | 1 |
| Neeley, TL | 1 |
| Jakobs, PM | 1 |
| Moses, RE | 1 |
| Baldassarre, F | 1 |
| Mallardo, M | 1 |
| Mezza, E | 1 |
| Scala, G | 1 |
| Quinto, I | 1 |
| Ostermeyer, AG | 1 |
| Anderson, SM | 1 |
| Kwee, ML | 1 |
| van der Kleij, JM | 1 |
| van Essen, AJ | 1 |
| Begeer, JH | 1 |
| Joenje, H | 1 |
| Arwert, F | 1 |
| ten Kate, LP | 1 |
| Okano, M | 1 |
| Hess, RD | 1 |
| Brandner, G | 1 |
| Tomkins, DJ | 1 |
| Care, M | 1 |
| Carreau, M | 1 |
| Buchwald, M | 2 |
| Kraakman-van der Zwet, M | 1 |
| Overkamp, WJ | 1 |
| Friedl, AA | 1 |
| Klein, B | 1 |
| Verhaegh, GW | 1 |
| Jaspers, NG | 1 |
| Midro, AT | 1 |
| Eckardt-Schupp, F | 1 |
| Lohman, PH | 1 |
| Zdzienicka, MZ | 1 |
| Rossman, TG | 1 |
| Wolosin, D | 1 |
| Wing, MG | 1 |
| Rogers, K | 1 |
| Jacob, G | 1 |
| Rees, RC | 1 |
| Minakuchi, J | 1 |
| Konttinen, YT | 1 |
| Bluestein, HG | 1 |
| Zvaifler, NJ | 1 |
| Duckworth-Rysiecki, G | 1 |
| Toji, L | 1 |
| Ng, J | 1 |
| Clarke, C | 1 |
| Maddon, PJ | 1 |
| Dalgleish, AG | 1 |
| McDougal, JS | 1 |
| Clapham, PR | 1 |
| Weiss, RA | 1 |
| Axel, R | 1 |
| Majone, F | 1 |
| Montaldi, A | 1 |
| Saggioro, D | 1 |
| Bianchi, LC | 1 |
| Levis, AG | 1 |
1 review available for mitomycin and Cell Transformation, Viral
| Article | Year |
|---|---|
Use of CEPH and non-CEPH lymphoblast cell lines in pharmacogenetic studies.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Cell Line, Transformed; Cell Transfor | 2005 |
23 other studies available for mitomycin and Cell Transformation, Viral
| Article | Year |
|---|---|
Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.
Topics: Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Proliferation; C | 2009 |
Stochastic cancer progression driven by non-clonal chromosome aberrations.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cul | 2006 |
The E7 protein of the cottontail rabbit papillomavirus immortalizes normal rabbit keratinocytes and reduces pRb levels, while E6 cooperates in immortalization but neither degrades p53 nor binds E6AP.
Topics: Animals; Cell Line; Cell Nucleus; Cell Transformation, Viral; Cottontail rabbit papillomavirus; Cycl | 2008 |
Lymphoblastoid cell-induced suppression of human peripheral blood leukocyte mitogenic responses.
Topics: Animals; Burkitt Lymphoma; Callitrichinae; Cell Line; Cell Transformation, Viral; Cell-Free System; | 1984 |
Sensitivity of mitomycin C and nitrogen mustard crosslinks to extreme alkaline conditions.
Topics: Antibiotics, Antineoplastic; Cell Transformation, Neoplastic; Cell Transformation, Viral; Centrifuga | 1984 |
Helper and suppressor T-cells regulating killer cells of EB virus infected cells.
Topics: B-Lymphocytes; Cell Transformation, Viral; Glutaral; Herpesvirus 4, Human; Histocompatibility Antige | 1983 |
Increased sensitivity of cultured fibroblasts from colon cancer-prone rats to cytotoxicity of carcinogens and to viral transformation: a comparison with fibroblasts from patients with adenomatosis coli.
Topics: 4-Nitroquinoline-1-oxide; Adenoma; Animals; Carcinogens; Cell Division; Cell Survival; Cell Transfor | 1983 |
Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.
Topics: Animals; Base Sequence; Bleomycin; Cell Line; Cell Transformation, Viral; Cricetinae; Cricetulus; DN | 1995 |
Fanconi anemia cells have a normal gene structure for topoisomerase I.
Topics: Base Sequence; Camptothecin; Cell Line; Cell Survival; Cell Transformation, Viral; Cells, Cultured; | 1994 |
Regulation of NF-kappa B through the nuclear processing of p105 (NF-kappa B1) in Epstein-Barr virus-immortalized B cell lines.
Topics: B-Lymphocytes; Bacterial Proteins; Base Sequence; Cell Line; Cell Nucleus; Cell Transformation, Vira | 1995 |
Induction of growth factor-independence and GM-CSF secretion by the v-src oncogene in murine myeloid cells does not require membrane association of pp60v-src.
Topics: Animals; Cell Division; Cell Membrane; Cell Transformation, Viral; DNA, Recombinant; Gene Expression | 1996 |
An atypical case of Fanconi anemia in elderly sibs.
Topics: Animals; Cell Transformation, Viral; Cricetinae; Cricetulus; Fanconi Anemia; Female; Genetic Complem | 1997 |
High susceptibility of an Epstein-Barr virus-converted Burkitt's lymphoma cell line to cytotoxic drugs.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cell Division; Cell Line; Cell Transformation, Viral; Cytar | 1997 |
DNA-damage-inducible p53 activity in SV40-transformed cells.
Topics: Animals; Antigens, Polyomavirus Transforming; Cell Line, Transformed; Cell Transformation, Viral; Cy | 1997 |
Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.
Topics: Animals; Cell Cycle Proteins; Cell Line, Transformed; Cell Transformation, Viral; Chromosome Aberrat | 1998 |
Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts.
Topics: Abnormalities, Multiple; Antineoplastic Agents; Bleomycin; Camptothecin; Cell Line; Cell Line, Trans | 1999 |
Differential susceptibility to carcinogen-induced amplification of SV40 and dhfr sequences in SV40-transformed human keratinocytes.
Topics: Aphidicolin; Carcinogens; Cell Line, Transformed; Cell Transformation, Viral; Cycloheximide; Drug Re | 1992 |
Characterisation of suppressor cells generated following cryosurgery of an HSV-2-induced fibrosarcoma.
Topics: Animals; Antigen-Presenting Cells; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Cycle; Cell T | 1988 |
The lymphocyte subpopulations involved in cytotoxicity generated by co-culture with autologous and allogeneic Epstein-Barr virus-transformed cell line.
Topics: Adult; Antibodies, Monoclonal; Cell Line; Cell Transformation, Viral; Cells, Cultured; Cytotoxicity, | 1988 |
Regulation of the growth of Epstein-Barr virus-infected B cells. I. Growth regression by E rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8+ memory cells.
Topics: Adult; Antigens, Viral; B-Lymphocytes; Capsid Proteins; Cell Survival; Cell Transformation, Viral; H | 1985 |
Characterization of a simian virus 40-transformed Fanconi anemia fibroblast cell line.
Topics: Anemia, Aplastic; Cell Cycle; Cell Line; Cell Survival; Cell Transformation, Viral; Chromosomes; Cro | 1986 |
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
Topics: Ammonium Chloride; Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; B-Lymphocyte | 1986 |
Sister chromatid exchanges and chromosomal aberrations in mouse cells infected with the Abelson and Moloney leukemia viruses.
Topics: Abelson murine leukemia virus; Animals; Cell Line; Cell Transformation, Viral; Chromosome Aberration | 1988 |