mitomycin has been researched along with Cancer of Larynx in 19 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study is to evaluate the efficacy of a dose-escalated, accelerated, and hyperfractionated radiotherapy schedule with a concomitant single dose of mitomycin C in the treatment of patients with advanced laryngeal or hypopharyngeal cancer." | 9.11 | Biweekly escalated, accelerated hyperfractionated radiotherapy with concomitant single-dose mitomycin C results in a high rate of local control in advanced laryngeal and hypopharyngeal cancer. ( Aaltonen, LM; Atula, T; Kajanti, M; Kouri, M; Mäkitie, A; Mäntylä, M; Saarilahti, K, 2004) |
| "To assess the role of mitomycin C (MMC) in the management of pharyngoesophageal stricture after total laryngopharyngectomy and free flap reconstruction." | 7.72 | Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction. ( Annino, DJ; Goguen, LA, 2003) |
| " There was a significant correlation between the area under the time versus concentration curve (AUC) of MMC and the age of patients (r = 0." | 5.28 | Pharmacokinetic study of mitomycin C with emphasis on the influence of aging. ( Karato, A; Miya, T; Saijo, N; Sasaki, Y, 1992) |
| "The purpose of this study is to evaluate the efficacy of a dose-escalated, accelerated, and hyperfractionated radiotherapy schedule with a concomitant single dose of mitomycin C in the treatment of patients with advanced laryngeal or hypopharyngeal cancer." | 5.11 | Biweekly escalated, accelerated hyperfractionated radiotherapy with concomitant single-dose mitomycin C results in a high rate of local control in advanced laryngeal and hypopharyngeal cancer. ( Aaltonen, LM; Atula, T; Kajanti, M; Kouri, M; Mäkitie, A; Mäntylä, M; Saarilahti, K, 2004) |
| "To assess the role of mitomycin C (MMC) in the management of pharyngoesophageal stricture after total laryngopharyngectomy and free flap reconstruction." | 3.72 | Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction. ( Annino, DJ; Goguen, LA, 2003) |
| "Topical application of mitomycin C was effective to prevent anterior glottic synechia after transoral laser surgery for glottic carcinoma involving the anterior commissure." | 3.72 | [Mitomycin C: prevention and treatment of anterior glottic synechia]. ( Brasnu, D; de Monès, E; Hans, S; Laccourreye, O; Lagarde, F; Ménard, M, 2004) |
| " There was a significant correlation between the area under the time versus concentration curve (AUC) of MMC and the age of patients (r = 0." | 1.28 | Pharmacokinetic study of mitomycin C with emphasis on the influence of aging. ( Karato, A; Miya, T; Saijo, N; Sasaki, Y, 1992) |
| "Fifty-seven patients with advanced squamous carcinoma of the larynx and hypopharynx were entered on a pilot study of initial therapy using split course radiation therapy combined with simultaneous chemotherapy using mitomycin-C and 5-fluorouracil." | 1.27 | A pilot study of mitomycin-C/5-fluorouracil infusion combined with split course radiation therapy for carcinomas of the larynx and hypopharynx. ( Beale, FA; Cummings, BJ; Elhakim, T; Harwood, AR; Keane, TJ; Payne, DG; Rawlinson, E, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patterson, JM | 1 |
| McColl, E | 1 |
| Carding, PN | 1 |
| Hildreth, AJ | 1 |
| Kelly, C | 1 |
| Wilson, JA | 1 |
| Echternach, M | 1 |
| Arndt, S | 1 |
| Mattern, D | 1 |
| Maier, W | 1 |
| Richter, B | 1 |
| Veen, EJ | 1 |
| Dikkers, FG | 1 |
| Annino, DJ | 1 |
| Goguen, LA | 1 |
| OHTA, F | 1 |
| MIYANAMI, M | 1 |
| Schmidberger, H | 1 |
| Rave-Fränk, M | 1 |
| Kim, S | 1 |
| Hille, A | 1 |
| Pradier, O | 1 |
| Hess, CF | 1 |
| de Monès, E | 1 |
| Lagarde, F | 1 |
| Hans, S | 1 |
| Ménard, M | 1 |
| Laccourreye, O | 1 |
| Brasnu, D | 1 |
| Saarilahti, K | 1 |
| Kajanti, M | 1 |
| Atula, T | 1 |
| Mäkitie, A | 1 |
| Aaltonen, LM | 1 |
| Kouri, M | 1 |
| Mäntylä, M | 1 |
| Agrawal, N | 1 |
| Morrison, GA | 1 |
| Koshkareva, Y | 1 |
| Gaughan, JP | 1 |
| Soliman, AM | 1 |
| Brozovic, A | 1 |
| Majhen, D | 1 |
| Roje, V | 1 |
| Mikac, N | 1 |
| Jakopec, S | 1 |
| Fritz, G | 1 |
| Osmak, M | 3 |
| Ambriovic-Ristov, A | 1 |
| Bizjak, L | 1 |
| Jernej, B | 1 |
| Kapitanović, S | 1 |
| Fujii, M | 1 |
| Ohnuma, T | 1 |
| Szrajer, L | 1 |
| Holland, JF | 1 |
| Biller, H | 1 |
| Okabe, M | 1 |
| Beketić-Oresković, L | 1 |
| Thomas, C | 1 |
| Koh, WJ | 1 |
| Keane, TJ | 2 |
| Cummings, BJ | 2 |
| O'Sullivan, B | 1 |
| Payne, D | 1 |
| Rawlinson, E | 2 |
| MacKenzie, R | 1 |
| Danjoux, C | 1 |
| Hodson, I | 1 |
| Juvekar, AS | 1 |
| Amonkar, AJ | 1 |
| D'cruz, AK | 1 |
| Saikaia, T | 1 |
| Pradhan, S | 1 |
| Miya, T | 1 |
| Sasaki, Y | 1 |
| Karato, A | 1 |
| Saijo, N | 1 |
| Harwood, AR | 1 |
| Beale, FA | 1 |
| Payne, DG | 1 |
| Elhakim, T | 1 |
1 review available for mitomycin and Cancer of Larynx
| Article | Year |
|---|---|
Topical use of MMC in the upper aerodigestive tract: a review on the side effects.
Topics: Administration, Topical; Adolescent; Adult; Airway Obstruction; Animals; Child; Child, Preschool; Ci | 2010 |
2 trials available for mitomycin and Cancer of Larynx
| Article | Year |
|---|---|
Biweekly escalated, accelerated hyperfractionated radiotherapy with concomitant single-dose mitomycin C results in a high rate of local control in advanced laryngeal and hypopharyngeal cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose | 2004 |
A randomized trial of radiation therapy compared to split course radiation therapy combined with mitomycin C and 5 fluorouracil as initial treatment for advanced laryngeal and hypopharyngeal squamous carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; | 1993 |
16 other studies available for mitomycin and Cancer of Larynx
| Article | Year |
|---|---|
Swallowing in the first year after chemoradiotherapy for head and neck cancer: clinician- and patient-reported outcomes.
Topics: Adult; Aged; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Deglutition; Deglutition Disorders | 2014 |
Recurrent laryngeal metastasis of a malignant melanoma: surgical therapy with the first application of mitomycin C.
Topics: Aged; Antigens, Neoplasm; Antineoplastic Agents; Combined Modality Therapy; Dysphonia; Female; Human | 2009 |
Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction.
Topics: Adenocarcinoma; Administration, Topical; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; | 2003 |
[Experiences in the use of mitomycin C in the field of otolaryngology].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Laryngeal Neoplasms; Larynx; Maxilla; Mitomycin; Neopl | 1961 |
[Radiation-induced mucositis and neutrophil granulocytes in oral mucosa].
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Combined Modality Therapy | 2003 |
[Mitomycin C: prevention and treatment of anterior glottic synechia].
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma; Female; Glottis; Humans; Laryngeal Neoplasms; L | 2004 |
Laryngeal cancer after topical mitomycin C application.
Topics: Administration, Topical; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Humans; Laryngeal Ne | 2006 |
Risk factors for adult laryngotracheal stenosis: a review of 74 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Dilatation; Female; Humans; Intuba | 2007 |
alpha(v)beta(3) Integrin-mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione-dependent elimination of drug-induced reactive oxidative species.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line, Tumor; Cell S | 2008 |
Characterization of carboplatin-resistant sublines derived from human larynx carcinoma cells.
Topics: Antineoplastic Agents; Carboplatin; Cell Survival; Cisplatin; Clone Cells; Dose-Response Relationshi | 1995 |
Effects of mitomycin-C and etoposide in cell culture and in nude mice: the role of G-CSF mutein.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Drug Screening As | 1993 |
Human larynx carcinoma cells resistant to cis-diamminedichloroplatinum(II): cross-resistance patterns.
Topics: Antineoplastic Agents; Cisplatin; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Huma | 1994 |
Regarding Keane et al.'s randomized trial comparing radiation alone to concomitant infusional 5-flurorouracil, bolus mitomycin-C and split-course radiation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Hypopharyngeal Neoplasms; Lary | 1994 |
Chemosensitivity of advanced larynx carcinoma cells in vitro and significance of multidrug resistance markers in these tumors.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; C | 1998 |
Pharmacokinetic study of mitomycin C with emphasis on the influence of aging.
Topics: Adult; Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; | 1992 |
A pilot study of mitomycin-C/5-fluorouracil infusion combined with split course radiation therapy for carcinomas of the larynx and hypopharynx.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Therapy, Combination; Female; | 1986 |