mitomycin has been researched along with Cancer of Head in 81 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "He had failure to thrive, and has microcephaly, slight facial dysmorphism, and constitutional short stature but no other phenotypic or hematological manifestations of Fanconi anemia (FA)." | 5.33 | A case report of a patient with microcephaly, facial dysmorphism, mitomycin-c-sensitive lymphocytes, and susceptibility to lymphoma. ( Abella, E; Bakhshi, S; Joenje, H; Madgy, D; Mohamed, AN; Oostra, A; Ravindranath, Y; Schindler, D, 2006) |
| " One patient with aggressive fibromatosis was treated with TNF alone (200 micrograms/m2, days 1-5 every third week) and 10 patients (four colon cancer, four head and neck cancer; one melanoma; one sarcoma) received mitomycin C (15 mg/m2, day 1) followed by TNF (60-180 micrograms/m2, days 1-3) every sixth week." | 5.08 | Tumor necrosis factor administration is associated with increased endogenous production of M-CSF and G-CSF but not GM-CSF in human cancer patients. ( Gooding, W; Kirkwood, JM; Logan, TF; Shadduck, RK, 1996) |
| "This monoinstitutional retrospective study compares the results of both treatment schedules: 315 patients with locally advanced carcinoma (UICC stage III and IV) of the oral cavity and the orohypopharynx were treated from January 1990 to March 2006 with a radiochemotherapy combination based on mitomycin C and fluorouracil (HART-CC: 203 patients, CFRT-CC: 112 patients, total dose: 70-72 Gy) with curative intent." | 3.75 | Hyperfractionated accelerated radiotherapy versus conventional fractionation both combined with chemotherapy in patients with locally advanced head and neck carcinomas: a retrospective analysis of a monoinstitutional series. ( Abu Jawad, J; Budach, V; Jahnke, K; Lehnerdt, G; Pöttgen, C; Sack, H; Stüben, G; Stuschke, M; Welz, H; Wierlemann, A; Wittig, A, 2009) |
| "Twelve patients with progressive dysphagia and video-fluoroscopic evidence of upper digestive tract stricture after head and neck cancer treatment were dilated by Maloney or Savory dilators followed by the application of mitomycin C (0." | 3.74 | Role of mitomycin in upper digestive tract stricture. ( Brodsky, MB; Day, TA; Gillespie, MB; Martin-Harris, B; Sharma, AK, 2007) |
| "Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) often requires postoperative chemoradiation with high risk of toxicity." | 2.94 | Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma. ( Betz, CS; Binder, M; Boettcher, A; Bokemeyer, C; Busch, CJ; Moeckelmann, N; Muenscher, A; Schafhausen, P; Vettorazzi, E; Zech, HB, 2020) |
| "Deleterious oral mucositis (OM) develops during radiotherapy (RT) or chemoradiotherapy for head-and-neck cancer (HNC) patients." | 2.77 | Phenylbutyrate mouthwash mitigates oral mucositis during radiotherapy or chemoradiotherapy in patients with head-and-neck cancer. ( Chung, YL; Jen, YM; Lin, YH; Wang, LW; Yen, SH, 2012) |
| "Patients with advanced head and neck cancer were treated with primary curative radiotherapy (66 Gy in 33 fractions with five fractions per week) +/-a single injection (15 mg/m(2)) of MMC at the end of the first week of radiotherapy." | 2.71 | Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial. ( Abeyakoon, S; Dinshaw, KA; Grau, C; Hadjieva, T; Jabeen, K; Overgaard, J; Prakash Agarwal, J; Rab Khan, A; Tatsuzaki, H; Turkan, S; Wahid, I, 2003) |
| "Progression-free and freedom from metastases rates were 29." | 2.71 | Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the radiotherapy coo ( Bamberg, M; Baumann, M; Budach, V; Budach, W; Geismar, D; Grabenbauer, G; Herrmann, T; Hinkelbein, W; Jahnke, K; Lammert, I; Stueben, G; Stuschke, M; Wernecke, KD; Wust, P, 2005) |
| "The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and neck." | 2.71 | A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. ( Dellian, M; Dühmke, E; Pachmann, S; Schalhorn, A; Schymura, B; Wilkowski, R, 2005) |
| " However, the degree of toxicity was limited in our trial and therefore attempts to increase the dosage and/or revise the administration schedule for cancer of the pharynx and T1 to T3 tumor disease appear warranted." | 2.69 | Survival results of neoadjuvant chemotherapy for advanced squamous cell carcinoma of the head and neck. ( Ikari, T; Kano, S; Kawaida, M; Kawaura, M; Kohno, N; Nakamizo, M; Tanaka, K, 2000) |
| "Between March 1991 and October 1993, 49 patients with inoperable head and neck carcinoma were randomly assigned to receive either radiation therapy alone (group A) or radiotherapy combined with simultaneous application of Mitomycin C and Bleomycin (group B)." | 2.68 | Radiotherapy, combined with simultaneous chemotherapy with mitomycin C and bleomycin for inoperable head and neck cancer--preliminary report. ( Budihna, M; Furlan, L; Lesnicar, H; Rudolf, Z; Smid, L; Soba, E; Zakotnik, B; Zargi, M, 1995) |
| "N&V and leukopenia were the major side effects." | 2.68 | Salvage chemotherapy with PEM and long-CF regimen in CDDP refractory advanced head and neck cancer. ( Ichikawa, G; Inuyama, Y; Kawaida, M; Kohno, N; Ohnuma, T; Shirasaka, T, 1995) |
| "All patients had verified squamous cell carcinoma and were referred for primary radiation therapy." | 2.68 | Conventional vs accelerated fractionation in head and neck cancer. ( Dobrowsky, E; Dobrowsky, W; Grasl, M; Kautzky, M; Köhler, W; Millesi, W; Naudé, J; Pavelka, R; Reichel, M; Wilson, GD, 1996) |
| "porfiromycin, there have been no statistically significant differences between the two arms with respect to white blood cell count (WBC), platelet, or hemoglobin nadirs." | 2.68 | Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck. ( Fischer, D; Fischer, JJ; Haffty, BG; Papac, R; Rockwell, S; Ross, D; Sartorelli, AC; Sasaki, CT; Son, YH; Wilson, LD, 1997) |
| "For advanced stages of head and neck cancers (T3, T4, N2, N3), we recently launched a pilot study combining platinum and irradiation, but according to a concomitant schedule." | 2.67 | [Role of neoadjuvant chemotherapy in the treatment of advanced head and neck tumors. Results of two randomized therapeutical trials conducted at the Institut Curie on 208 patients]. ( Asselain, B; Blaszka, B; Brunin, F; Jaulerry, C; Jouve, M; Mosseri, V; Point, D; Rodriguez, J; Validire, P; Zafrani, B, 1992) |
| "Advanced squamous cell carcinomas of the oral cavity, oro-, hypopharynx and larynx often have to be categorised as non resectable disease." | 2.43 | [Decision making in non resectable head and neck tumours]. ( Dietz, A; Dollner, R; Hildebrandt, G; Weber, A, 2005) |
| "Oral squamous cell carcinoma (OSCC) may develop in young adults." | 1.43 | Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma. ( Braakhuis, BJ; Brakenhoff, RH; Flach, GB; Graveland, AP; Joenje, H; Leemans, CR; Nieuwint, AW; Oostra, AB, 2016) |
| "Here, we tested primary head and neck cancers (HNC) and normal cells taken from the same patient, and found that although CD44 expression in both types of cells was high, GAGs bind only to the cancerous cells in a selective manner." | 1.37 | Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers. ( Bachar, G; Cohen, K; Feinmesser, R; Hod, R; Katz, O; Mizrachi, A; Peer, D; Shpitzer, T, 2011) |
| "He had failure to thrive, and has microcephaly, slight facial dysmorphism, and constitutional short stature but no other phenotypic or hematological manifestations of Fanconi anemia (FA)." | 1.33 | A case report of a patient with microcephaly, facial dysmorphism, mitomycin-c-sensitive lymphocytes, and susceptibility to lymphoma. ( Abella, E; Bakhshi, S; Joenje, H; Madgy, D; Mohamed, AN; Oostra, A; Ravindranath, Y; Schindler, D, 2006) |
| "Histologically, aneuploidy was detected in 71." | 1.29 | [Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]. ( Miyagi, M; Nakashima, T; Soda, T, 1994) |
| "Eighty patients with Stage III and IV head and neck cancer were treated with a four-drug regimen consisting of bleomycin, vincristine, methotrexate, and mitomycin-C (BOMM regimen)." | 1.28 | BOMM regimen for the treatment of advanced head and neck carcinoma. ( Inuyama, Y; Kohno, N; Ohnuma, T; Sakurai, S, 1991) |
| " After determination of dose-response relationships and toxicity, treated tumours were biopsied at different times and cell cycle distribution pattern, 3HTdR incorporation into DNA, histology and tumour volume were recorded." | 1.27 | Cell cycle perturbations in heterotransplanted squamous-cell carcinoma of the head and neck after mitomycin C and cisplatin treatment. ( Alm, P; Biörklund, A; Killander, D; Långström, E; Tropé, C; Wennerberg, J, 1984) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (27.16) | 18.7374 |
| 1990's | 23 (28.40) | 18.2507 |
| 2000's | 28 (34.57) | 29.6817 |
| 2010's | 7 (8.64) | 24.3611 |
| 2020's | 1 (1.23) | 2.80 |
| Authors | Studies |
|---|---|
| Zech, HB | 1 |
| Moeckelmann, N | 1 |
| Boettcher, A | 1 |
| Muenscher, A | 1 |
| Binder, M | 1 |
| Vettorazzi, E | 1 |
| Bokemeyer, C | 1 |
| Schafhausen, P | 1 |
| Betz, CS | 1 |
| Busch, CJ | 1 |
| Vossen, DM | 1 |
| Verhagen, CVM | 1 |
| Grénman, R | 1 |
| Kluin, RJC | 1 |
| Verheij, M | 1 |
| van den Brekel, MWM | 1 |
| Wessels, LFA | 1 |
| Vens, C | 1 |
| Patterson, JM | 1 |
| McColl, E | 1 |
| Carding, PN | 1 |
| Hildreth, AJ | 1 |
| Kelly, C | 1 |
| Wilson, JA | 1 |
| Budach, V | 5 |
| Stromberger, C | 1 |
| Poettgen, C | 1 |
| Baumann, M | 2 |
| Budach, W | 5 |
| Grabenbauer, G | 2 |
| Marnitz, S | 1 |
| Olze, H | 1 |
| Wernecke, KD | 2 |
| Ghadjar, P | 1 |
| Braakhuis, BJ | 1 |
| Nieuwint, AW | 1 |
| Oostra, AB | 1 |
| Joenje, H | 2 |
| Flach, GB | 1 |
| Graveland, AP | 1 |
| Brakenhoff, RH | 1 |
| Leemans, CR | 1 |
| Welz, H | 1 |
| Pöttgen, C | 1 |
| Abu Jawad, J | 1 |
| Wierlemann, A | 1 |
| Wittig, A | 1 |
| Stüben, G | 1 |
| Lehnerdt, G | 1 |
| Jahnke, K | 3 |
| Sack, H | 2 |
| Stuschke, M | 3 |
| Wolff, HA | 1 |
| Bosch, J | 1 |
| Jung, K | 1 |
| Overbeck, T | 1 |
| Hennies, S | 1 |
| Matthias, C | 1 |
| Hess, CF | 5 |
| Roedel, RM | 1 |
| Christiansen, H | 3 |
| Bachar, G | 1 |
| Cohen, K | 1 |
| Hod, R | 1 |
| Feinmesser, R | 1 |
| Mizrachi, A | 1 |
| Shpitzer, T | 1 |
| Katz, O | 1 |
| Peer, D | 1 |
| Yen, SH | 1 |
| Wang, LW | 1 |
| Lin, YH | 1 |
| Jen, YM | 1 |
| Chung, YL | 1 |
| Dobrowsky, W | 8 |
| Dobrowsky, E | 5 |
| Wilson, GD | 2 |
| Grau, C | 1 |
| Prakash Agarwal, J | 1 |
| Jabeen, K | 1 |
| Rab Khan, A | 1 |
| Abeyakoon, S | 1 |
| Hadjieva, T | 1 |
| Wahid, I | 1 |
| Turkan, S | 1 |
| Tatsuzaki, H | 1 |
| Dinshaw, KA | 1 |
| Overgaard, J | 1 |
| Smid, L | 4 |
| Budihna, M | 4 |
| Zakotnik, B | 4 |
| Soba, E | 4 |
| Strojan, P | 3 |
| Fajdiga, I | 3 |
| Zargi, M | 3 |
| Oblak, I | 2 |
| Dremelj, M | 1 |
| LeSnicar, H | 3 |
| KOOP, CE | 1 |
| TEWARSON, IP | 1 |
| Schmidberger, H | 2 |
| Rave-Fränk, M | 1 |
| Kim, S | 1 |
| Hille, A | 3 |
| Pradier, O | 4 |
| Van Der Heijden, MS | 1 |
| Brody, JR | 1 |
| Kern, SE | 1 |
| Hermann, RM | 2 |
| Weiss, E | 2 |
| Nitsche, M | 2 |
| Martin, A | 2 |
| Widder, J | 2 |
| Schmid, R | 1 |
| Pokrajac, B | 1 |
| Selzer, E | 1 |
| Pötter, R | 1 |
| Eisbruch, A | 1 |
| Normolle, DP | 1 |
| Haffty, BG | 3 |
| Wilson, LD | 2 |
| Son, YH | 4 |
| Cho, EI | 1 |
| Papac, RJ | 2 |
| Fischer, DB | 2 |
| Rockwell, S | 4 |
| Sartorelli, AC | 3 |
| Ross, DA | 1 |
| Sasaki, CT | 3 |
| Fischer, JJ | 4 |
| Geismar, D | 1 |
| Lammert, I | 1 |
| Stueben, G | 1 |
| Herrmann, T | 1 |
| Bamberg, M | 2 |
| Wust, P | 1 |
| Hinkelbein, W | 1 |
| Dietz, A | 1 |
| Weber, A | 1 |
| Dollner, R | 1 |
| Hildebrandt, G | 1 |
| Wilkowski, R | 1 |
| Pachmann, S | 1 |
| Schymura, B | 1 |
| Dellian, M | 1 |
| Schalhorn, A | 1 |
| Dühmke, E | 1 |
| Rastogi, M | 1 |
| Srivastava, M | 1 |
| Chufal, KS | 1 |
| Pant, MC | 1 |
| Srivastava, K | 1 |
| Bhatt, MB | 1 |
| Bakhshi, S | 1 |
| Schindler, D | 1 |
| Oostra, A | 1 |
| Mohamed, AN | 1 |
| Madgy, D | 1 |
| Ravindranath, Y | 1 |
| Abella, E | 1 |
| Hehr, T | 2 |
| Belka, C | 1 |
| Dietz, K | 1 |
| Ezzat, M | 1 |
| Shouman, T | 1 |
| Zaza, K | 1 |
| Safwat, A | 1 |
| El-Khoudary, A | 1 |
| El-Senosi, M | 1 |
| Ezzat, I | 1 |
| Classen, J | 1 |
| Welz, S | 1 |
| Ganswindt, U | 1 |
| Scheithauer, H | 1 |
| Koitschev, A | 1 |
| Gillespie, MB | 1 |
| Day, TA | 1 |
| Sharma, AK | 1 |
| Brodsky, MB | 1 |
| Martin-Harris, B | 1 |
| Schwentner, I | 1 |
| Schmutzhard, J | 1 |
| Andrle, J | 1 |
| Haidenberger, A | 1 |
| Thumfart, WF | 1 |
| De Vries, A | 1 |
| Sprinzl, GM | 1 |
| Cho, YH | 1 |
| Lee, SH | 1 |
| Kim, DW | 1 |
| Wu, HG | 1 |
| Hah, JH | 1 |
| Rhee, CS | 1 |
| Sung, MW | 1 |
| Kim, KH | 1 |
| Heo, DS | 1 |
| Karner, K | 1 |
| Jancar, B | 1 |
| Anicin, A | 1 |
| Vogl, SE | 2 |
| Lerner, H | 2 |
| Kaplan, BH | 2 |
| Camacho, F | 2 |
| Cinberg, J | 2 |
| Schoenfeld, D | 1 |
| Coughlin, C | 1 |
| McCormick, B | 1 |
| Wheeler, RH | 1 |
| Baker, SR | 1 |
| Liepman, MK | 1 |
| Ensminger, WD | 1 |
| Israel, L | 1 |
| Aguilera, J | 1 |
| Soudant, J | 1 |
| Penot, JC | 1 |
| Breau, JL | 1 |
| Morere, JF | 1 |
| Inuyama, Y | 3 |
| Mashino, S | 1 |
| Fujii, M | 1 |
| Tanaka, J | 1 |
| Takaoka, T | 1 |
| Kohno, N | 4 |
| Horiuchi, M | 1 |
| Veronesi, A | 1 |
| Magri, MD | 1 |
| Tirelli, U | 1 |
| Galligioni, E | 1 |
| Frustaci, S | 1 |
| Crivellari, D | 1 |
| Tumolo, S | 1 |
| Grigoletto, E | 1 |
| Hirokawa, T | 1 |
| Mizutani, Y | 1 |
| Wennerberg, J | 1 |
| Alm, P | 1 |
| Biörklund, A | 2 |
| Killander, D | 1 |
| Långström, E | 1 |
| Tropé, C | 2 |
| Stewart, DJ | 1 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Body, JJ | 1 |
| Rozencweig, M | 1 |
| Kenis, Y | 1 |
| Stupp, R | 1 |
| Vokes, EE | 2 |
| Furlan, L | 1 |
| Rudolf, Z | 1 |
| Ichikawa, G | 1 |
| Shirasaka, T | 1 |
| Kawaida, M | 2 |
| Ohnuma, T | 2 |
| Abram, AC | 1 |
| Nabizadeh, S | 1 |
| Feldman, PS | 1 |
| Cantrell, RW | 1 |
| Levine, PA | 1 |
| Weichselbaum, RR | 1 |
| Papac, R | 2 |
| Fischer, D | 2 |
| Sartorelli, A | 1 |
| Naudé, J | 4 |
| Millesi, W | 3 |
| Pavelka, R | 3 |
| Grasl, M | 2 |
| Köhler, W | 2 |
| Kautzky, M | 2 |
| Reichel, M | 3 |
| Miyagi, M | 1 |
| Soda, T | 1 |
| Nakashima, T | 1 |
| Logan, TF | 1 |
| Gooding, W | 1 |
| Kirkwood, JM | 1 |
| Shadduck, RK | 1 |
| Abitbol, AA | 2 |
| Sridhar, KS | 1 |
| Lewin, AA | 2 |
| Schwade, JG | 2 |
| Raub, W | 1 |
| Wolfson, A | 1 |
| Gonzalez-Angulo, C | 1 |
| Adessa, A | 1 |
| Goodwin, WJ | 1 |
| Markoe, AM | 2 |
| Iop, A | 1 |
| Cartei, G | 1 |
| Vigevani, E | 1 |
| Clocchiatti, L | 1 |
| Mansutti, M | 1 |
| Sibau, AM | 1 |
| Ross, D | 1 |
| Dinges, S | 1 |
| Boehmer, D | 1 |
| Schrader, M | 1 |
| Stadler, P | 1 |
| Feldmann, HJ | 1 |
| Creighton, C | 1 |
| Kau, R | 1 |
| Molls, M | 1 |
| Grasl, C | 1 |
| Ikari, T | 1 |
| Tanaka, K | 1 |
| Kawaura, M | 1 |
| Kano, S | 1 |
| Nakamizo, M | 1 |
| Eifel, PJ | 1 |
| Eberlein, K | 1 |
| Jackel, MC | 1 |
| Brunin, F | 1 |
| Rodriguez, J | 1 |
| Jaulerry, C | 1 |
| Mosseri, V | 1 |
| Jouve, M | 1 |
| Point, D | 1 |
| Asselain, B | 1 |
| Validire, P | 1 |
| Blaszka, B | 1 |
| Zafrani, B | 1 |
| Narasimha, K | 1 |
| Sridhar, K | 2 |
| Brandon, AH | 1 |
| Casiano, RR | 1 |
| Houdek, PV | 1 |
| Serago, C | 1 |
| Miller, DJ | 1 |
| Pfister, DG | 1 |
| Bosl, GJ | 1 |
| Sakurai, S | 1 |
| Schratter-Sehn, AU | 1 |
| Handl-Zeller, L | 1 |
| Strassl, H | 2 |
| Braun, OM | 2 |
| Macmillan, CH | 1 |
| Carrick, K | 1 |
| Bradley, PJ | 1 |
| Morgan, DA | 1 |
| Andreasson, L | 1 |
| Mercke, C | 1 |
| Scheike, O | 1 |
| Andersson, T | 1 |
| Brismar, J | 1 |
| Elner, A | 1 |
| Hellekant, C | 1 |
| Landberg, T | 1 |
| Kaneda, T | 1 |
| Kawabe, Y | 1 |
| Fountzilas, G | 2 |
| Daniilidis, J | 2 |
| Kalogera-Fountzila, A | 1 |
| Apostolidis, T | 1 |
| Vritsios, A | 2 |
| Tourkantonis, A | 1 |
| Nicolaou, A | 1 |
| Sideras, T | 1 |
| Haritanti, A | 1 |
| Anastasakis, C | 1 |
| Delis, V | 1 |
| Neumeister, B | 1 |
| Popp, W | 1 |
| Scherrer, R | 1 |
| Rausch, EM | 1 |
| Krisch, K | 1 |
| Holzner, JH | 1 |
| Weissberg, JB | 1 |
| Sasaki, C | 1 |
| Lawrence, R | 1 |
| Ichino, Y | 1 |
| Ishikawa, T | 1 |
| John, M | 1 |
| Flam, M | 1 |
| Wittlinger, P | 1 |
| Podolsky, W | 1 |
| Padmanabhan, A | 1 |
| Mowry, PA | 1 |
| Fujimura, T | 1 |
| Yonemura, Y | 1 |
| Sekino, H | 1 |
| Sugiyama, K | 1 |
| Nishimura, G | 1 |
| Yamaguchi, A | 1 |
| Miyazaki, I | 1 |
| Nakajima, K | 1 |
| Hisazumi, H | 1 |
| Saitoh, Y | 1 |
| Kakiuchi, H | 1 |
| Tabata, T | 1 |
| Uchida, K | 1 |
| Abe, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Controlled Phase III Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs Standard Follow-up in Surgical Resectable HNSCC After Adjuvant Therapy[NCT03700905] | Phase 3 | 276 participants (Anticipated) | Interventional | 2018-08-21 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for mitomycin and Cancer of Head
| Article | Year |
|---|---|
[Decision making in non resectable head and neck tumours].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 2005 |
A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Co | 2006 |
[Advances in the treatment of head and neck tumors. 2. Radiochemotherapy].
Topics: Cisplatin; Combined Modality Therapy; Fluorouracil; Head and Neck Neoplasms; Humans; Mitomycin; Neop | 1995 |
Chemoradiation for carcinoma of the cervix: advances and opportunities.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Chemotherapy, A | 2000 |
32 trials available for mitomycin and Cancer of Head
| Article | Year |
|---|---|
Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Chemotherapy, Ad | 2020 |
Hyperfractionated accelerated radiation therapy (HART) of 70.6 Gy with concurrent 5-FU/Mitomycin C is superior to HART of 77.6 Gy alone in locally advanced head and neck cancer: long-term results of the ARO 95-06 randomized phase III trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe | 2015 |
Phenylbutyrate mouthwash mitigates oral mucositis during radiotherapy or chemoradiotherapy in patients with head-and-neck cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Double-Blind Method; E | 2012 |
In vivo cell kinetic measurements in a randomized trial of continuous hyperfractionated accelerated radiotherapy with or without mitomycin C in head-and-neck cancer.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell | 2003 |
Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Moda | 2003 |
Postoperative concomitant irradiation and chemotherapy with mitomycin C and bleomycin for advanced head-and-neck carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Co | 2003 |
Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Thera | 2005 |
Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the radiotherapy coo
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Combined | 2005 |
Phase I study of continuous mitomycin-C infusion in concomitant radiochemotherapy of primary inoperable advanced head and neck cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Disease- | 2005 |
A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemot | 2005 |
Mitomycin and fluorouracil in combination with concomitant radiotherapy: a potentially curable approach for locally advanced head and neck squamous cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; | 2005 |
A randomized study of accelerated fractionation radiotherapy with and without mitomycin C in the treatment of locally advanced head and neck cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; C | 2005 |
Hyperfractionated, accelerated chemoradiation with concurrent mitomycin-C and cisplatin in locally advanced head and neck cancer, a phase I/II study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Cisplatin; Combined Modality The | 2006 |
Modified radical neck dissection and minimal invasive tumor surgery in the middle of split course of concomitant chemoradiotherapy of advanced HNSCC.
Topics: Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols | 2007 |
Patterns of failure in patients with locally advanced head and neck cancer treated postoperatively with irradiation or concomitant irradiation with Mitomycin C and Bleomycin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Combined Modali | 2007 |
concomitant chemoradiotherapy with mitomycin C and cisplatin in advanced unresectable carcinoma of the head and neck: phase I-II clinical study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co | 2008 |
Radiotherapy, combined with simultaneous chemotherapy with mitomycin C and bleomycin for inoperable head and neck cancer--preliminary report.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Ch | 1995 |
Salvage chemotherapy with PEM and long-CF regimen in CDDP refractory advanced head and neck cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Admi | 1995 |
Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Dicumarol; Female; | 1993 |
Tumor necrosis factor administration is associated with increased endogenous production of M-CSF and G-CSF but not GM-CSF in human cancer patients.
Topics: Colonic Neoplasms; Fibroma; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Sti | 1996 |
Conventional vs accelerated fractionation in head and neck cancer.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; M | 1996 |
Hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and mitomycin-C (+/- granulocyte-colony stimulating factor) in the treatment of patients with locally advanced head and neck carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; F | 1997 |
Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck.
Topics: Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose Fractionation | 1997 |
Chemo-radiotherapy for locally advanced head and neck cancer--long-term results of a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Combined | 1997 |
Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose | 1998 |
Survival results of neoadjuvant chemotherapy for advanced squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, | 2000 |
Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chi-Square Distribution; Combine | 2000 |
[Role of neoadjuvant chemotherapy in the treatment of advanced head and neck tumors. Results of two randomized therapeutical trials conducted at the Institut Curie on 208 patients].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Combined Modality Therapy; Fem | 1992 |
Hyperfractionated radiation therapy and concurrent 5-fluorouracil, cisplatin and mitomycin-C in head and neck carcinoma. A pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, | 1992 |
[Primary clinical effects of chemotherapy mainly with cisplatin, peplomycin (PP therapy) against head and neck cancer--the multi-institutional joint research in Tokai district].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomyci | 1987 |
Induction chemotherapy with cisplatinum, 5-fluorouracil, bleomycin, mitomycin C and hydroxyurea for previously untreated locally advanced squamous cell carcinomas of the head and neck.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squam | 1989 |
Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Combined Modality Therapy; Female; | 1989 |
45 other studies available for mitomycin and Cancer of Head
| Article | Year |
|---|---|
Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association.
Topics: Alleles; Cell Line, Tumor; DNA Repair; DNA, Neoplasm; Fanconi Anemia Complementation Group Proteins; | 2018 |
Swallowing in the first year after chemoradiotherapy for head and neck cancer: clinician- and patient-reported outcomes.
Topics: Adult; Aged; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Deglutition; Deglutition Disorders | 2014 |
Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.
Topics: Adult; Carcinoma, Squamous Cell; Chromosome Breakage; DNA Damage; Fanconi Anemia; Female; Genetic Pr | 2016 |
Hyperfractionated accelerated radiotherapy versus conventional fractionation both combined with chemotherapy in patients with locally advanced head and neck carcinomas: a retrospective analysis of a monoinstitutional series.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Combined Modality Therapy; Dose Fra | 2009 |
High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer.
Topics: Antineoplastic Agents; Combined Modality Therapy; Disease Progression; Fluorouracil; Head and Neck N | 2010 |
Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers.
Topics: Adult; Aged; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Drug Carriers; | 2011 |
RHABDOMYOSARCOMA OF THE HEAD AND NECK IN CHILDREN.
Topics: Adolescent; Child; Cyclophosphamide; Dactinomycin; Facial Neoplasms; Facial Paralysis; Head; Head an | 1964 |
[Radiation-induced mucositis and neutrophil granulocytes in oral mucosa].
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Combined Modality Therapy | 2003 |
Functional screen of the fanconi anemia pathway in cancer cells by Fancd2 immunoblot.
Topics: Breast Neoplasms; Drug Resistance, Neoplasm; Fanconi Anemia; Fanconi Anemia Complementation Group D2 | 2004 |
Concomitant radiochemotherapy in primary inoperable advanced head and neck cancer with 5-fluorouracil and mitomycin-C.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antine | 2004 |
Hyperfractionated accelerated radiochemotherapy (HFA-RCT) with mitomycin C for advanced head and neck cancer.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Combined Modality Therapy; Dose Fract | 2004 |
Testing new chemoradiation regimens for head-and-neck cancer.
Topics: Antibiotics, Antineoplastic; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Mitomycin; | 2005 |
A case report of a patient with microcephaly, facial dysmorphism, mitomycin-c-sensitive lymphocytes, and susceptibility to lymphoma.
Topics: Adolescent; Antineoplastic Agents; Chromosome Aberrations; Disease Susceptibility; Face; Head and Ne | 2006 |
Role of mitomycin in upper digestive tract stricture.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Degl | 2007 |
Long-term survival of resectable subset after induction chemotherapy in patients with locally advanced head and neck cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Car | 2008 |
Mitomycin-C, methotrexate, bleomycin and cis-diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carci | 1982 |
Failure of effective initial chemotherapy to modify the course of stage IV (MO) squamous cancer of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Drug Evaluation; | 1982 |
Intensive sequential chemotherapy with bleomycin, Oncovin, mitomycin C, and methotrexate followed by adriamycin, cisplatin, and cyclosphosphamide in squamous cell cancer of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carci | 1983 |
Bleomycin and cis-platinum with or without mitomycin C in 110 previously untreated patients with head and neck cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Drug Admin | 1983 |
[Studies on a neo-adjuvant chemotherapy for head and neck cancer].
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell | 1983 |
Non-platinum-containing combination chemotherapy for stage III-IV head and neck squamous carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamid | 1983 |
[Experimental chemotherapy using a transplanted head and neck cancer model in athymic nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Female | 1984 |
[Silicone elastomers for the local administration of antineoplastic drugs].
Topics: Animals; Antineoplastic Agents; Delayed-Action Preparations; Doxorubicin; Fluorouracil; Head and Nec | 1983 |
Cell cycle perturbations in heterotransplanted squamous-cell carcinoma of the head and neck after mitomycin C and cisplatin treatment.
Topics: Animals; Biopsy; Carcinoma, Squamous Cell; Cell Division; Cisplatin; Dose-Response Relationship, Dru | 1984 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Phase I clinical trial with a combination of methotrexate and mitomycin C.
Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; Ma | 1981 |
Fine needle aspiration (FNA) in diagnosing recurrent squamous cell carcinoma of the head and neck: truth or consequences?
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Carcinoma, Squamous Cell; Cobalt Rad | 1993 |
Measurable impact: multimodality therapy of head and neck cancer.
Topics: Combined Modality Therapy; Dicumarol; Head and Neck Neoplasms; Humans; Mitomycin | 1993 |
Mitomycin C (MMC) and unconventional fractionation (V-CHART) in advanced head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Drug Administration Schedule; Female; Hea | 1995 |
[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck].
Topics: Adult; Aged; Aged, 80 and over; Aneuploidy; Antineoplastic Agents; Carbazilquinone; Carcinoma, Squam | 1994 |
Mitomycin C, cisplatin, and 5-fluorouracil for advanced and/or recurrent head and neck squamous cell carcinomas.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; An | 1997 |
Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined C | 1998 |
Radiotherapy combined with simultaneous chemotherapy with mitomycin-C and 5-fluorouracil for inoperable head and neck cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluo | 2001 |
Chemotherapy of solid tumors in private practice in Malaysia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Drug | 1992 |
BOMM: new solution or old problem?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Head and Neck N | 1991 |
BOMM regimen for the treatment of advanced head and neck carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma | 1991 |
[Incidence of osteoradionecrosis after combined radiotherapy-chemotherapy of head and neck tumors].
Topics: Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Head and Neck Neoplasms; Humans; | 1991 |
Concomitant chemo/radiotherapy for advanced carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squam | 1991 |
Intra-arterial mitomycin C and intravenous bleomycin as induction chemotherapy in advanced head and neck cancer--a phase II study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Combined | 1986 |
[Combined therapy of locally advanced squamous epithelial cancers in the area of the head and neck].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squam | 1988 |
Histologic tumor regression grades in squamous cell carcinoma of the head and neck after preoperative radiochemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Moda | 1989 |
Generation of human cytotoxic T lymphocytes against autologous solid tumors by autologous mixed lymphocyte tumor cell culture with T cell growth factor.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Cells, Cultured; Cytotoxicity Tests, Im | 1985 |
Clinical evidence of feasibility and efficacy of simultaneous irradiation and chemotherapy in advanced squamous cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Brachytherapy; Carcinom | 1986 |
[Huge Virchow's metastasis in gastric cancer made resectable by hyperthermochemoradiotherapy].
Topics: Adenocarcinoma; Aged; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Hypertherm | 1986 |
[Balloon occluded arterial infusion with direct hemoperfusion in recurrent cancers of the head and neck].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Embolization | 1988 |