mitomycin has been researched along with Brain Neoplasms in 35 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cytotoxic T lymphocytes (CTL) against autologous malignant brain tumor were generated in peripheral blood lymphoid cells (PBL) prepared from a patient with a malignant brain tumor by stimulation of the cultured PBL for 7 days with attenuated crossreactive malignant melanoma (MM2) cells pretreated with mitomycin C." | 3.69 | Induction of specific cytotoxic T lymphocytes against autologous brain tumor by crossreactive allo-tumor cell stimulation. ( Fujimoto, S; Kurisaka, M; Maeda, N; Mori, K; Saitoh, S, 1997) |
| "Mitomycin C has antitumor activity against squamous cell lung carcinoma when used alone or in combination with MVP." | 2.67 | A phase III trial of mitomycin C alone versus mitomycin C, vinblastine, and cisplatin for metastatic squamous cell lung carcinoma. ( Dalton, RJ; Etzell, PS; Foley, JF; Jett, JR; Kardinal, CG; Mailliard, JA; Maksymiuk, AW; Marschke, RF; Su, JQ; Veeder, MH, 1992) |
| "Esthesioneuroblastoma (olfactory neuroblastoma) is a rare neuroendocrine tumor that arises in the upper nasal cavity from the olfactory epithelium." | 2.40 | Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience. ( Buckner, JC; Lewis, JE; McElroy, EA, 1998) |
| "Patients with brain metastases of triple negative breast cancer (TNBC) have a poor prognosis owing to the lack of targeted therapies, the aggressive nature of TNBC, and the presence of the blood-brain barrier (BBB) that blocks penetration of most drugs." | 1.51 | Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages. ( Cai, P; He, C; Henderson, JT; Lip, H; Rauth, AM; Wang, Z; Wu, XY; Zhang, T, 2019) |
| "He then underwent excision of the brain metastases and consecutive radiation by X-knife." | 1.32 | [A case of liver metastases from gastric cancer successfully treated with induced hypertensive chemotherapy]. ( Arai, K; Iwasaki, Y; Katayanagi, S; Matsumoto, H; Miyamoto, H; Takahashi, K; Yamaguchi, T, 2003) |
| "The chemotherapy for malignant brain tumors creates two major problems to be solved viz systemic toxicity and interference by the blood brain barrier." | 1.29 | [Pharmacodynamic study of mitomycin C mixed with fibrin glue for treatment of malignant brain tumors]. ( Kawasaki, H; Shimizu, T; Takakura, K; Umezawa, Y, 1994) |
| "Of the 15 patients who developed brain metastases after prior chemotherapy, 12 had received MAC at least once prior to the diagnosis of brain metastases, and in 5 patients, MAC was the first chemotherapy given after the diagnosis of brain metastases." | 1.28 | Intracerebral choriocarcinoma. ( Jones, WB; Lewis, JL; Wagner-Reiss, KM, 1990) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| "Intracarotid CDDP infusion in combination with angiotensin II was performed in two patients with metastatic brain tumor, lung carcinoma (LC) and ovarian carcinoma (OC)." | 1.27 | [Intracarotid arterial infusion with CDDP in combination with angiotensin II]. ( Hino, N; Mitsuhata, N; Nishigaki, S; Suga, K; Tagusagawa, Y, 1984) |
| "Fifteen consenting patients with brain metastases recurrent after cranial irradiation were treated with intraarterial mitomycin-C, 15 mg/m2, administered in a total final volume of 100 ml 0." | 1.27 | Intraarterial mitomycin-C for recurrent brain metastases. ( Benoit, BG; Danjoux, C; Grahovac, Z; Hugenholtz, H; Maroun, JA; Richard, MT; Riding, MD; Russell, NA; Stewart, DJ, 1987) |
| "The disease appeared to be a diffuse encephalopathy frequently affecting the higher cortical functions." | 1.27 | Neurologic dysfunction in patients treated for small cell carcinoma of the lung: a clinical and radiological study. ( Chak, LY; Cox, RS; Kushlan, PD; Porzig, KJ; Sikic, BI; Wasserstein, P; Zatz, LM, 1986) |
| " Both dosage and releasing time can be adjusted." | 1.27 | [Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites]. ( Himuro, H; Inoue, N; Kaetsu, I; Kitamura, K; Kubo, O; Sakairi, M; Tajika, T; Tajika, Y; Tohyama, T; Yoshida, M, 1986) |
| "A case of brain metastasis in ovarian cancer is reported." | 1.27 | [Metastatic brain tumor after chemotherapy of ovarian cancer]. ( Chen, JT; Fujimoto, I; Fukuda, K; Hasumi, K; Masubuchi, K; Sakamoto, A; Yamauchi, K, 1987) |
| "Primary chemotherapy of brain metastases yielded responses in 27 of 52 patients (52%) treated with Cytoxan (cyclophosphamide) (C), 5-fluorouracil (F) and prednisone (P); 19 of 35 (54%) receiving CFP-methotrexate (M) and vincristine (V); 3 of 7 (43%) treated with MVP, and 1 of 6 (17%) receiving Cytoxan plus Adriamycin (doxorubicin) (CA)." | 1.27 | Chemotherapy induces regression of brain metastases in breast carcinoma. ( Lane, WW; Nemoto, T; Rosner, D, 1986) |
| "In those with metastatic brain tumors, the median survival time was 280 days, 1-year survival rate 43." | 1.27 | [Clinical application of a sustained release anticancer pellet]. ( Aoyama, I; Handa, H; Hashi, K; Kamijyo, Y; Mori, K; Oda, Y; Okumura, T; Tokuriki, Y; Yamashita, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (40.00) | 18.7374 |
| 1990's | 13 (37.14) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kokoshka, JM | 1 |
| Ireland, CM | 1 |
| Barrows, LR | 1 |
| Iwasa, K | 1 |
| Moriyasu, M | 1 |
| Yamori, T | 1 |
| Turuo, T | 1 |
| Lee, DU | 1 |
| Wiegrebe, W | 1 |
| Zhang, RX | 1 |
| Li, J | 1 |
| Zhang, T | 2 |
| Amini, MA | 1 |
| He, C | 2 |
| Lu, B | 1 |
| Ahmed, T | 1 |
| Lip, H | 2 |
| Rauth, AM | 2 |
| Wu, XY | 2 |
| Cai, P | 1 |
| Wang, Z | 1 |
| Henderson, JT | 1 |
| Li, H | 1 |
| Liu, T | 1 |
| Chen, X | 2 |
| Xie, L | 1 |
| Chen, Y | 1 |
| Douglass, T | 1 |
| Jeffes, EW | 1 |
| Xu, Q | 1 |
| Williams, CC | 1 |
| Arpajirakul, N | 1 |
| Delgado, C | 1 |
| Kleinman, M | 1 |
| Sanchez, R | 1 |
| Dan, Q | 1 |
| Kim, RC | 1 |
| Wepsic, HT | 1 |
| Jadus, MR | 1 |
| Yuan, S | 1 |
| Wang, Y | 1 |
| Jiang, S | 1 |
| Yang, Y | 1 |
| Song, Y | 1 |
| Tu, C | 1 |
| Katayanagi, S | 1 |
| Arai, K | 1 |
| Iwasaki, Y | 1 |
| Takahashi, K | 1 |
| Yamaguchi, T | 1 |
| Matsumoto, H | 1 |
| Miyamoto, H | 1 |
| Giroux, MF | 1 |
| Baum, RA | 1 |
| Soulen, MC | 1 |
| Stewart, DJ | 3 |
| Maroun, JA | 2 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 2 |
| Hugenholtz, H | 2 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Mitsuhata, N | 1 |
| Hino, N | 1 |
| Tagusagawa, Y | 1 |
| Suga, K | 1 |
| Nishigaki, S | 1 |
| Tajima, H | 1 |
| Matsuki, N | 1 |
| Takeda, T | 1 |
| Horichi, H | 1 |
| Kumaki, T | 1 |
| Shima, K | 1 |
| Kawasaki, H | 1 |
| Shimizu, T | 1 |
| Takakura, K | 1 |
| Umezawa, Y | 1 |
| Halperin, EC | 1 |
| Herndon, J | 1 |
| Schold, SC | 1 |
| Brown, M | 1 |
| Vick, N | 1 |
| Cairncross, JG | 1 |
| Macdonald, DR | 1 |
| Gaspar, L | 1 |
| Fischer, B | 1 |
| Dropcho, E | 1 |
| Rosenfeld, S | 1 |
| Morowitz, R | 1 |
| Piepmeier, J | 1 |
| Hait, W | 1 |
| Byrne, T | 1 |
| Salter, M | 1 |
| Imperato, J | 1 |
| Khandekar, J | 1 |
| Paleologos, N | 1 |
| Burger, P | 1 |
| Bentel, GC | 1 |
| Friedman, A | 1 |
| Sekine, I | 1 |
| Sasaki, Y | 1 |
| Fujii, H | 1 |
| Ohtsu, T | 1 |
| Wakita, H | 1 |
| Igarashi, T | 1 |
| Itoh, K | 1 |
| Abe, K | 1 |
| Furuse, K | 1 |
| Kamimori, T | 1 |
| Kawahara, M | 1 |
| Kodama, N | 1 |
| Ogawara, M | 1 |
| Atagi, S | 1 |
| Naka, N | 1 |
| Akira, M | 1 |
| Kubota, K | 1 |
| Dahrouge, S | 1 |
| Agboola, O | 1 |
| Girard, A | 1 |
| Saitoh, S | 1 |
| Kurisaka, M | 1 |
| Mori, K | 3 |
| Maeda, N | 1 |
| Fujimoto, S | 1 |
| McElroy, EA | 1 |
| Buckner, JC | 1 |
| Lewis, JE | 1 |
| Veeder, MH | 1 |
| Jett, JR | 1 |
| Su, JQ | 1 |
| Mailliard, JA | 1 |
| Foley, JF | 1 |
| Dalton, RJ | 1 |
| Etzell, PS | 1 |
| Marschke, RF | 1 |
| Kardinal, CG | 1 |
| Maksymiuk, AW | 1 |
| Nitta, T | 1 |
| Nikkhah, G | 1 |
| Tonn, JC | 1 |
| Hoffmann, O | 1 |
| Kraemer, HP | 1 |
| Darling, JL | 1 |
| Schachenmayr, W | 1 |
| Schönmayr, R | 1 |
| Jones, WB | 1 |
| Wagner-Reiss, KM | 1 |
| Lewis, JL | 1 |
| Oda, Y | 2 |
| Kamijo, Y | 1 |
| Kang, Y | 1 |
| Okumura, T | 2 |
| Tokuriki, Y | 2 |
| Handa, H | 2 |
| Hashi, K | 2 |
| Kawakami, K | 1 |
| Kawamoto, K | 1 |
| Oka, N | 1 |
| Kawamura, Y | 1 |
| Matsumura, H | 1 |
| Ito, T | 1 |
| Ohyama, A | 1 |
| Grahovac, Z | 1 |
| Russell, NA | 1 |
| Benoit, BG | 1 |
| Riding, MD | 1 |
| Danjoux, C | 1 |
| Mira, JG | 1 |
| Taylor, SL | 1 |
| Stephens, RL | 1 |
| Chen, T | 1 |
| Petursson, SR | 1 |
| Chak, LY | 1 |
| Zatz, LM | 1 |
| Wasserstein, P | 1 |
| Cox, RS | 1 |
| Kushlan, PD | 1 |
| Porzig, KJ | 1 |
| Sikic, BI | 1 |
| Kubo, O | 1 |
| Himuro, H | 1 |
| Inoue, N | 1 |
| Tajika, Y | 1 |
| Tajika, T | 1 |
| Tohyama, T | 1 |
| Sakairi, M | 1 |
| Yoshida, M | 1 |
| Kaetsu, I | 1 |
| Kitamura, K | 1 |
| Nozue, AT | 1 |
| Fukuda, K | 1 |
| Chen, JT | 1 |
| Fujimoto, I | 1 |
| Yamauchi, K | 1 |
| Hasumi, K | 1 |
| Masubuchi, K | 1 |
| Sakamoto, A | 1 |
| Rosner, D | 1 |
| Nemoto, T | 1 |
| Lane, WW | 1 |
| Ito, H | 1 |
| Hasegawa, T | 1 |
| Shoin, K | 1 |
| Hwang, WZ | 1 |
| Hayashi, M | 1 |
| Yamamoto, S | 1 |
| Miyazaki, I | 1 |
| Kamijyo, Y | 1 |
| Yamashita, J | 1 |
| Aoyama, I | 1 |
3 reviews available for mitomycin and Brain Neoplasms
| Article | Year |
|---|---|
Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with firsthand examples.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Doxorubicin; Drug Carriers; Humans; Lung Neoplasms; | 2018 |
Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cisplatin; | 1998 |
[A history and prospect of adoptive immunotherapy against malignant glioma--past, now and future].
Topics: Brain Neoplasms; Glioma; Humans; Immunotherapy, Adoptive; Immunotoxins; Interleukin-2; Killer Cells, | 1992 |
3 trials available for mitomycin and Brain Neoplasms
| Article | Year |
|---|---|
A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined M | 1996 |
Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; beta Carotene; Brain Neoplasms; Cisplat | 1997 |
A phase III trial of mitomycin C alone versus mitomycin C, vinblastine, and cisplatin for metastatic squamous cell lung carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Car | 1992 |
29 other studies available for mitomycin and Brain Neoplasms
| Article | Year |
|---|---|
Cell-based screen for identification of inhibitors of tubulin polymerization.
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Forma | 1996 |
In vitro cytotoxicity of the protoberberine-type alkaloids.
Topics: Animals; Antineoplastic Agents, Phytogenic; Berberine; Berberine Alkaloids; Brain Neoplasms; Breast | 2001 |
Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Disease Progression; Dox | 2019 |
A rare case of primary congenital glaucoma in combination with neurofibromatosis 1: a case report.
Topics: Alkylating Agents; Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Hydrophthalmos; Infan | 2015 |
Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9
Topics: Animals; Antibodies; Brain Neoplasms; Cell Death; Chemokines, CXC; Chemotactic Factors; Female; Free | 2002 |
[Study on chemosensitivity assay in vitro in the peripheral blood lymphocyte and the tumor cells].
Topics: Antineoplastic Agents; Brain Neoplasms; Doxorubicin; Drug Screening Assays, Antitumor; Glioma; Human | 2000 |
[A case of liver metastases from gastric cancer successfully treated with induced hypertensive chemotherapy].
Topics: Aged; Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Brain Neoplasm | 2003 |
Chemoembolization of liver metastasis from breast carcinoma.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcin | 2004 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
[Intracarotid arterial infusion with CDDP in combination with angiotensin II].
Topics: Adenocarcinoma, Papillary; Aged; Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Bra | 1984 |
[A case of cutaneous and brain metastasis of gastric carcinoma, treated effectively by chemotherapy with CDDP, MMC, etoposide and 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Ne | 1994 |
[Pharmacodynamic study of mitomycin C mixed with fibrin glue for treatment of malignant brain tumors].
Topics: Animals; Brain Neoplasms; Delayed-Action Preparations; Fibrin Tissue Adhesive; Male; Mice; Mice, Inb | 1994 |
Recurrent breast cancer treated successfully with mitomycin-C and vinblastine after failure of both doxorubicin-containing regimen and paclitaxel--a case report.
Topics: Adenocarcinoma, Scirrhous; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Br | 1996 |
A pilot study of concurrent whole-brain radiotherapy and chemotherapy combined with cisplatin, vindesine and mitomycin in non-small-cell lung cancer with brain metastasis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Non-Small-C | 1997 |
Induction of specific cytotoxic T lymphocytes against autologous brain tumor by crossreactive allo-tumor cell stimulation.
Topics: Aged; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antigens, CD; Antigens, Neoplasm; Autoant | 1997 |
The MTT assay for chemosensitivity testing of human tumors of the central nervous system. Part II: Evaluation of patient- and drug-specific variables.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Survival; Colony-Forming Units Assay; Color | 1992 |
Intracerebral choriocarcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choriocarcinoma; Cisplatin; | 1990 |
[Evaluation of the sustained release of anticancer agents from silicone pellets].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Cytarabine; Delayed-Acti | 1985 |
[Flow cytometric studies of brain tumors--5: New sensitivity test of antineoplastic agents for brain tumors and its clinical application].
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Cell Cycle; Cell Survival; Colony-Formin | 1986 |
Intraarterial mitomycin-C for recurrent brain metastases.
Topics: Adolescent; Adult; Animals; Brain Neoplasms; Carotid Artery, Internal; Humans; Infusions, Intra-Arte | 1987 |
Simultaneous chemotherapy-radiotherapy with prophylactic cranial irradiation for inoperable adeno and large cell lung carcinoma: a Southwest Oncology Group Study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcin | 1988 |
Adenoid cystic carcinoma of the esophagus. Complete response to combination chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Adenoid Cystic; Cisplati | 1986 |
Neurologic dysfunction in patients treated for small cell carcinoma of the lung: a clinical and radiological study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Brain Neoplasms; | 1986 |
[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Implants; Dysge | 1986 |
Effects of mitomycin C in the central nervous system in newborn mice with special reference to neutral crest cells.
Topics: Animals; Animals, Newborn; Brain; Brain Neoplasms; Mice; Mitomycin; Mitomycins; Neural Crest | 1986 |
[Metastatic brain tumor after chemotherapy of ovarian cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cisplatin; Cyclop | 1987 |
Chemotherapy induces regression of brain metastases in breast carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Autopsy; Brain Neoplasms; Breast Neopla | 1986 |
[Necrotomy of brain stem glioma and local administration of anticancer agents].
Topics: Administration, Topical; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; B | 1985 |
[Clinical application of a sustained release anticancer pellet].
Topics: Antineoplastic Agents; Brain Neoplasms; Delayed-Action Preparations; Drug Administration Schedule; F | 1985 |