mitomycin has been researched along with Bone Marrow Diseases in 17 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Bone Marrow Diseases: Diseases involving the BONE MARROW.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of mitomycin for metastatic colorectal cancer has been limited by mitomycin's myelosuppressive potential." | 9.07 | Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer. ( Baker, L; Gullo, JJ; Leming, PD; Lokich, JJ; LoRusso, P; McCulloch, W; Poplin, EA; Schein, P; Schulz, JJ; Veach, SR, 1994) |
| "The use of mitomycin for metastatic colorectal cancer has been limited by mitomycin's myelosuppressive potential." | 5.07 | Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer. ( Baker, L; Gullo, JJ; Leming, PD; Lokich, JJ; LoRusso, P; McCulloch, W; Poplin, EA; Schein, P; Schulz, JJ; Veach, SR, 1994) |
| " The diagnostic feature of FA is increased chromosomal breakage in blood lymphocytes cultured with diepoxybutane or mitomycin C." | 3.80 | Comparison of chromosome breakage in non-mosaic and mosaic patients with Fanconi anemia, relatives, and patients with other inherited bone marrow failure syndromes. ( Alter, BP; Fargo, JH; Giri, N; Olson, SB; Rochowski, A; Savage, SA, 2014) |
| "We evaluated Fanconi anemia diagnosis on blood lymphocytes and skin fibroblasts from a cohort of 87 bone marrow failure patients (55 children and 32 adults) with no obvious full clinical picture of Fanconi anemia, by performing a combination of chromosomal breakage tests, FANCD2-monoubiquitination assays, a new flow cytometry-based mitomycin C sensitivity test in fibroblasts, and, when Fanconi anemia was diagnosed, complementation group and mutation analyses." | 3.75 | Diagnosis of Fanconi anemia in patients with bone marrow failure. ( Baruchel, A; Brethon, B; Cassinat, B; Chamousset, D; de Villartay, JP; Gluckman, E; Larghero, J; Le Roux, G; Leblanc, T; Pinto, FO; Socié, G; Soulier, J; Stoppa-Lyonnet, D, 2009) |
| " The current diagnostic test for FA consists of cytogenetic quantitation of chromosomal breakage in response to diepoxybutane (DEB) or mitomycin C (MMC)." | 3.71 | A novel diagnostic screen for defects in the Fanconi anemia pathway. ( D'Andrea, AD; Haining, N; Montes de Oca, R; Moreau, LA; Nathan, DG; Shimamura, A; Svenson, JL, 2002) |
| " The aim of this phase I study was to determine the toxicity profile and the optimal dosage of KW-2149." | 2.68 | Phase I and pharmacokinetic study of a novel mitomycin C analog KW-2149. ( Ardiet, C; Catimel, G; De Bruijn, E; Dirix, L; Dumortier, A; Evene, E; Joossens, E; Koier, I; Provè, A; Schrijvers, D, 1995) |
| " Pharmacokinetic examination after intravenous injection of low-dose MMC (0." | 1.29 | A case of advanced gastric cancer complicated by severe toxicity induced by a combination of tegafur, uracil and mitomycin C, and associated with abnormal pharmacokinetics. ( Boku, N; Ishii, H; Kaneko, K; Kusada, O; Muro, K; Muto, M; Ohkuwa, M; Ohtsu, A; Sasaki, Y; Tajiri, H; Yoshida, S, 1996) |
| "Eighty-four patients with advanced gastric cancer treated in four centres in Scotland between June 1980 and December 1982 were reviewed following treatment with 5-fluorouracil, adriamycin and mitomycin-C (FAM)." | 1.27 | Advanced gastric cancer: experience in Scotland using 5-fluorouracil, adriamycin and mitomycin-C. ( Allan, SG; Calman, KC; Carter, DC; Cunningham, D; Hutcheon, AW; Kaye, SB; McArdle, CS; Sangster, G; Smyth, JF; Soukop, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tummala, H | 1 |
| Kirwan, M | 1 |
| Walne, AJ | 1 |
| Hossain, U | 1 |
| Jackson, N | 1 |
| Pondarre, C | 1 |
| Plagnol, V | 1 |
| Vulliamy, T | 1 |
| Dokal, I | 1 |
| Fargo, JH | 1 |
| Rochowski, A | 1 |
| Giri, N | 1 |
| Savage, SA | 1 |
| Olson, SB | 1 |
| Alter, BP | 1 |
| Pinto, FO | 1 |
| Leblanc, T | 1 |
| Chamousset, D | 1 |
| Le Roux, G | 1 |
| Brethon, B | 1 |
| Cassinat, B | 1 |
| Larghero, J | 1 |
| de Villartay, JP | 1 |
| Stoppa-Lyonnet, D | 1 |
| Baruchel, A | 1 |
| Socié, G | 1 |
| Gluckman, E | 1 |
| Soulier, J | 1 |
| Shimamura, A | 1 |
| Montes de Oca, R | 1 |
| Svenson, JL | 1 |
| Haining, N | 1 |
| Moreau, LA | 1 |
| Nathan, DG | 1 |
| D'Andrea, AD | 1 |
| Lorvidhaya, V | 1 |
| Chitapanarux, I | 1 |
| Sangruchi, S | 1 |
| Lertsanguansinchai, P | 1 |
| Kongthanarat, Y | 1 |
| Tangkaratt, S | 1 |
| Visetsiri, E | 1 |
| Muranaka, A | 1 |
| Otsuka, N | 1 |
| Saito, J | 1 |
| Yanagimoto, S | 1 |
| Tomomitsu, T | 1 |
| Ito, Y | 1 |
| Morita, R | 1 |
| Cunningham, D | 1 |
| Soukop, M | 1 |
| McArdle, CS | 1 |
| Carter, DC | 1 |
| Smyth, JF | 1 |
| Allan, SG | 1 |
| Kaye, SB | 1 |
| Sangster, G | 1 |
| Calman, KC | 1 |
| Hutcheon, AW | 1 |
| Dirix, L | 1 |
| Catimel, G | 1 |
| Koier, I | 1 |
| Provè, A | 1 |
| Schrijvers, D | 1 |
| Joossens, E | 1 |
| De Bruijn, E | 1 |
| Ardiet, C | 1 |
| Evene, E | 1 |
| Dumortier, A | 1 |
| Poplin, EA | 1 |
| LoRusso, P | 1 |
| Lokich, JJ | 1 |
| Gullo, JJ | 1 |
| Leming, PD | 1 |
| Schulz, JJ | 1 |
| Veach, SR | 1 |
| McCulloch, W | 1 |
| Baker, L | 1 |
| Schein, P | 1 |
| Ashizawa, T | 1 |
| Okabe, M | 1 |
| Gomi, K | 1 |
| Hirata, T | 1 |
| Tummarello, D | 1 |
| Graziano, F | 1 |
| Isidori, P | 1 |
| Santo, A | 1 |
| Cetto, G | 1 |
| Fedeli, A | 1 |
| Rossi, G | 1 |
| Cellerino, R | 1 |
| Boku, N | 1 |
| Ohtsu, A | 1 |
| Muro, K | 1 |
| Kaneko, K | 1 |
| Muto, M | 1 |
| Ohkuwa, M | 1 |
| Ishii, H | 1 |
| Sasaki, Y | 1 |
| Tajiri, H | 1 |
| Yoshida, S | 1 |
| Kusada, O | 1 |
| Kook, H | 1 |
| Cho, D | 1 |
| Cho, SH | 1 |
| Hong, WP | 1 |
| Kim, CJ | 1 |
| Park, JY | 1 |
| Yoon, WS | 1 |
| Ryang, DW | 1 |
| Hwang, TJ | 1 |
| Morton, AR | 1 |
| Anderson, H | 1 |
| Howell, A | 1 |
| Powles, TI | 1 |
| Ashley, S | 1 |
| Tada, H | 1 |
| Ri, T | 1 |
| Yoshida, H | 1 |
| Ishimoto, K | 1 |
| Kaneko, M | 1 |
| Yamashiro, Y | 1 |
| Shinohara, T | 1 |
| Becouarn, Y | 1 |
| Calabet, J | 1 |
| Brunet, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Controlled Trial of the Efficacy of Adjuvant Chemotherapy in Patients With Residual Lesions After Concurrent Radiochemotherapy for Locally Advanced Cervical Cancer[NCT04409860] | 120 participants (Anticipated) | Interventional | 2020-05-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for mitomycin and Bone Marrow Diseases
| Article | Year |
|---|---|
Concurrent mitomycin C, 5-fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: a randomized trial.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; B | 2003 |
Phase I and pharmacokinetic study of a novel mitomycin C analog KW-2149.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Biotransformation; Bone Marrow Diseases; Carcino | 1995 |
Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer.
Topics: Adult; Aged; Amifostine; Bone Marrow Diseases; Colorectal Neoplasms; Female; Humans; Male; Middle Ag | 1994 |
Consolidation biochemotherapy for patients with advanced nonsmall cell lung carcinoma responding to induction PVM (cisplatin, vinblastine, mitomycin-C) regimen. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carcinoma, Non-Sm | 1996 |
Fanconi anemia screening by diepoxybutane and mitomicin C tests in Korean children with bone marrow failure syndromes.
Topics: Adolescent; Bone Marrow Diseases; Child; Child, Preschool; Epoxy Compounds; Fanconi Anemia; Female; | 1998 |
12 other studies available for mitomycin and Bone Marrow Diseases
| Article | Year |
|---|---|
ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function.
Topics: Acetylcysteine; Anemia, Aplastic; Bone Marrow Diseases; Bone Marrow Failure Disorders; Cell Line, Tu | 2014 |
Comparison of chromosome breakage in non-mosaic and mosaic patients with Fanconi anemia, relatives, and patients with other inherited bone marrow failure syndromes.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Bone Marrow Diseases; Bone Marrow Failure Disorders; Chil | 2014 |
Diagnosis of Fanconi anemia in patients with bone marrow failure.
Topics: Adolescent; Adult; Bone Marrow Diseases; Child; Child, Preschool; Cohort Studies; Cytogenetic Analys | 2009 |
A novel diagnostic screen for defects in the Fanconi anemia pathway.
Topics: Blotting, Western; Bone Marrow Diseases; Cell Line, Transformed; Chromosome Breakage; Chromosomes, H | 2002 |
[Basic studies on diagnosis of bone marrow diseases using NMR].
Topics: Animals; Bone Marrow; Bone Marrow Diseases; Evaluation Studies as Topic; Hematopoiesis; Magnetic Res | 1983 |
Advanced gastric cancer: experience in Scotland using 5-fluorouracil, adriamycin and mitomycin-C.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Doxorubicin; D | 1984 |
Reduced bone marrow toxicity of KW-2149, a mitomycin C derivative, in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow Diseases; Colony-Formi | 1993 |
A case of advanced gastric cancer complicated by severe toxicity induced by a combination of tegafur, uracil and mitomycin C, and associated with abnormal pharmacokinetics.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bone Marrow Diseas | 1996 |
Myelotoxicity of methotrexate, mitozantrone, and mitomycin C.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Breast Neoplasms; Female | 1987 |
Myelosuppression after methotrexate, mitozantrone, and mitomycin C combination chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Humans; Methotrexate; Mitomyci | 1987 |
A case of Shwachman syndrome with increased spontaneous chromosome breakage.
Topics: Bone Marrow Diseases; Chromosome Aberrations; Chromosome Fragility; Exocrine Pancreatic Insufficienc | 1987 |
Phase II study of a 5-fluorouracil, teniposide and mitomycin-C combination chemotherapy in advanced colorectal carcinomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Colonic Neoplasms; Diarrhea; D | 1988 |