Page last updated: 2024-11-06

mitomycin and Bleb

mitomycin has been researched along with Bleb in 55 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy of sodium hyaluronate eye drops for prevention of late-onset bleb leakage after trabeculectomy with mitomycin C (MMC)."9.13Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C. ( Fujiwara, T; Iida, T; Koizumi, H; Sagara, H; Suzuki, K; Yago, K, 2008)
"To investigate the potential of colchicine to improve bleb function after trabeculectomy."7.91The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits. ( Akaishi, T; Kokubun, T; Nakamura, M; Nakazawa, T; Omodaka, K; Sato, K; Shiga, Y; Shimazaki, A; Tsuda, S; Yamamoto, K, 2019)
" The triamcinolone + mitomycin C acetate group presented better indices as for the maximum bleb height and vascularization of the bleb central area (p=0."7.88Healing modulation in glaucoma surgery after application of subconjunctival triamcinolone acetate alone or combined with mitomycin C: an experimetal study. ( Araújo, ID; Cronemberger, S; Rangel, HMDA; Rolim, HT; Vidigal, P, 2018)
"To determine if sequential treatment with Bevacizumab (Avastin), a monoclonal, VEGF antibody that blocks angiogenesis; Saratin, a 12 kD polypeptide with anti-inflammatory and anti-thrombotic properties; and Ilomastat, a matrix metalloproteinase (MMP) inhibitor, prolongs bleb life following glaucoma filtration surgery (GFS) in a rabbit model."7.81Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model. ( Levine, MA; Lukowski, ZL; Martorana, GM; Meyers, CA; Min, J; Schaefer, JL; Schultz, GS; Sherwood, MB, 2015)
"To compare the effects of silver nanoparticles (AgNPs) and mitomycin C (MMC) on intraocular pressure (IOP) and external, histologic, and immunohistochemical bleb characteristics in a rabbit model of filtration surgery."7.79Topical silver nanoparticles result in improved bleb function by increasing filtration and reducing fibrosis in a rabbit model of filtration surgery. ( Butler, MR; Chevez-Barrios, P; Frankfort, BJ; Orengo-Nania, S; Prospero Ponce, CM; Weinstock, YE, 2013)
"To compare the histopathologic and morphologic findings of encapsulated blebs following Ahmed glaucoma valve implantation and primary standard trabeculectomy with mitomycin-C."7.78Comparative study of encapsulated blebs following Ahmed glaucoma valve implantation and trabeculectomy with mitomycin-C. ( Bae, K; Kee, C; Suh, W, 2012)
"To investigate the relationship between intrascleral bleb height and intraocular pressure (IOP) following deep sclerectomy with collagen implant (DSCI) and mitomycin C (MMC) in eyes with clinically flat blebs."7.76Postoperative IOP is related to intrascleral bleb height in eyes with clinically flat blebs following deep sclerectomy with collagen implant and mitomycin. ( Mavrakanas, N; Mendrinos, E; Shaarawy, T, 2010)
"To analyse clinical outcomes of trabeculectomy with mitomycin C (MMC) in eyes with uveitic glaucoma (UG) with inactive uveitis and compare them to those in eyes with primary open-angle glaucoma (POAG)."7.75Initial trabeculectomy with mitomycin C in eyes with uveitic glaucoma with inactive uveitis. ( Araie, M; Kaburaki, T; Kawashima, H; Koshino, T; Numaga, J; Shirato, S; Tomidokoro, A, 2009)
"Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C."7.75Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C. ( Katada, T; Kawakami, H; Mikamo, H; Mochizuki, K; Sawada, A; Watanabe, K; Yamamoto, T, 2009)
"Antimetabolites, especially mitomycin C (MMC), increase the incidence of late bleb-related endophthalmitis in trabeculectomy."7.73Determinants of bleb morphology in minimally invasive, clear-cornea micropenetrating glaucoma surgery with mitomycin C. ( Flesner, P; Jensen, PK; Kessing, SV, 2006)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."7.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"Diode laser application with G-probe appears to be a useful modality of treatment for ocular hypotony and overfiltering blebs resulting from trabeculectomy with mitomycin-C."5.12Effect of diode laser application with G-probe on ocular hypotony after trabeculectomy with mitomycin-C. ( Abdollahi, A; Amini, H; Ghaffary, E; Razeghinejad, MR, 2006)
"To investigate the potential of colchicine to improve bleb function after trabeculectomy."3.91The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits. ( Akaishi, T; Kokubun, T; Nakamura, M; Nakazawa, T; Omodaka, K; Sato, K; Shiga, Y; Shimazaki, A; Tsuda, S; Yamamoto, K, 2019)
"The objective of this study is to investigate the results of an adaptive approach of bleb revision surgery for late onset hypotony after trabeculectomy with mitomycin C because of bleb leakage and/or scleral melting."3.88Results of an Adaptive Surgical Approach for Managing Late Onset Hypotony After Trabeculectomy With Mitomycin C. ( Hoffmann, EM; Lamparter, J; Pfeiffer, N; Prokosch-Willing, V; Toshev, AP; Ul Hassan, SN, 2018)
" The triamcinolone + mitomycin C acetate group presented better indices as for the maximum bleb height and vascularization of the bleb central area (p=0."3.88Healing modulation in glaucoma surgery after application of subconjunctival triamcinolone acetate alone or combined with mitomycin C: an experimetal study. ( Araújo, ID; Cronemberger, S; Rangel, HMDA; Rolim, HT; Vidigal, P, 2018)
"To examine outcomes of trabeculectomy with mitomycin C for uncontrolled glaucoma when performed by glaucoma trainee surgeons."3.85Primary Trabeculectomy Outcomes by Glaucoma Fellows in a Tertiary Hospital in Brazil. ( Abe, RY; Costa, VP; Shigueoka, LS; Vasconcellos, JPC, 2017)
"To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1."3.85Revision of encapsulated blebs after trabeculectomy: Long-term comparison of standard bleb needling and modified needling procedure combined with transconjunctival scleral flap sutures. ( Culmann, PD; Grus, FH; Hoffmann, EM; Laspas, P; Pfeiffer, N; Poplawksi, A; Prokosch-Willing, V, 2017)
"To determine if sequential treatment with Bevacizumab (Avastin), a monoclonal, VEGF antibody that blocks angiogenesis; Saratin, a 12 kD polypeptide with anti-inflammatory and anti-thrombotic properties; and Ilomastat, a matrix metalloproteinase (MMP) inhibitor, prolongs bleb life following glaucoma filtration surgery (GFS) in a rabbit model."3.81Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model. ( Levine, MA; Lukowski, ZL; Martorana, GM; Meyers, CA; Min, J; Schaefer, JL; Schultz, GS; Sherwood, MB, 2015)
"Twelve filtering blebs of 8 patients were included: 4 cases of trabeculectomy without mitomycin C (MMC), 6 cases of trabeculectomy with MMC, and 2 cases of non-penetrating glaucoma surgery."3.80[Evaluation of conjunctival epithelium of filtering blebs by impression cytology]. ( Buetas, P; González, S; López, S; Matias-Guiu, X; Muniesa, MJ; Sánchez, C, 2014)
"To compare the effects of silver nanoparticles (AgNPs) and mitomycin C (MMC) on intraocular pressure (IOP) and external, histologic, and immunohistochemical bleb characteristics in a rabbit model of filtration surgery."3.79Topical silver nanoparticles result in improved bleb function by increasing filtration and reducing fibrosis in a rabbit model of filtration surgery. ( Butler, MR; Chevez-Barrios, P; Frankfort, BJ; Orengo-Nania, S; Prospero Ponce, CM; Weinstock, YE, 2013)
"To analyse blebs of phacotrabeculectomies performed with Ologen collagen implants (ProTop & MediKing, Taipei, Taiwan) and to compare these with blebs of mitomycin C (MMC)–augmented phacotrabeculectomies."3.77Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants. ( Aung, T; Boey, PY; Htoon, HM; Narayanaswamy, A; Perera, SA; Seah, SK; Tun, TA; Wong, TT; Zheng, C, 2011)
"We report on a patient with an overhanging bleb several years following trabeculectomy surgery with mitomycin C."3.77Dramatic dysesthetic overhanging bleb. ( Kapoor, KG; Syed, MF, 2011)
"To investigate the relationship between intrascleral bleb height and intraocular pressure (IOP) following deep sclerectomy with collagen implant (DSCI) and mitomycin C (MMC) in eyes with clinically flat blebs."3.76Postoperative IOP is related to intrascleral bleb height in eyes with clinically flat blebs following deep sclerectomy with collagen implant and mitomycin. ( Mavrakanas, N; Mendrinos, E; Shaarawy, T, 2010)
"Two eyes of 2 patients status postfornix-based trabeculectomy with mitomycin C were found to have symptomatic circumferential blebs."3.76Application of handheld cautery for reduction of symptomatic circumferential trabeculectomy blebs. ( Albano, M; Schwartz, AL, 2010)
" We compare and contrast the histopathology of a normally functioning mitomycin-C trabeculectomy site obtained from an eye enucleated for iris melanoma with abnormal blebs discussed in the literature."3.75Histopathology of a functioning mitomycin-C trabeculectomy. ( Lee, GA; Liang, SY; Whitehead, K, 2009)
"Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C."3.75Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C. ( Katada, T; Kawakami, H; Mikamo, H; Mochizuki, K; Sawada, A; Watanabe, K; Yamamoto, T, 2009)
"To analyse clinical outcomes of trabeculectomy with mitomycin C (MMC) in eyes with uveitic glaucoma (UG) with inactive uveitis and compare them to those in eyes with primary open-angle glaucoma (POAG)."3.75Initial trabeculectomy with mitomycin C in eyes with uveitic glaucoma with inactive uveitis. ( Araie, M; Kaburaki, T; Kawashima, H; Koshino, T; Numaga, J; Shirato, S; Tomidokoro, A, 2009)
"To compare the effects of variable mitomycin-C (MMC) applications during trabeculectomy on target intraocular pressure (IOP), number of antiglaucomatous therapy, bleb morphology and surgical complications."3.74Enhancement of the success rate in trabeculectomy: large-area mitomycin-C application. ( Aktaş, Z; Hasanreisoğlu, B; Onol, M, 2008)
"The mid-term appearance of the filtering bleb and surgical outcome following tunnel-trabeculectomy, in which protective measures were carried out to avoid contact between the mitomycin C (MMC) and the conjunctival flap, are presented."3.74Protection of the conjunctival flap from contact with mitomycin C during tunnel-trabeculectomy. ( Karatas, M; Ophir, A, 2007)
"To investigate the comparative efficacy and safety of deep sclerectomy with and without intraoperative mitomycin C (MMC) application for lowering the intraocular pressure (IOP)."3.73Deep sclerectomy augmented with mitomycin C. ( Anand, N; Atherley, C, 2005)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."3.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"Antimetabolites, especially mitomycin C (MMC), increase the incidence of late bleb-related endophthalmitis in trabeculectomy."3.73Determinants of bleb morphology in minimally invasive, clear-cornea micropenetrating glaucoma surgery with mitomycin C. ( Flesner, P; Jensen, PK; Kessing, SV, 2006)
"The primary endpoint measured was bleb morphology and vascularity using the Moorfields Bleb Grading System."2.75Bleb morphology and vascularity after trabeculectomy with intravitreal ranibizumab: a pilot study. ( Kahook, MY, 2010)
"The filtering blebs were evaluated clinically and with SL-OCT on day 1 and 1, 2, 4 and 12 weeks following surgery."2.73A pilot study on slit lamp-adapted optical coherence tomography imaging of trabeculectomy filtering blebs. ( Keunen, JE; Klevering, BJ; Theelen, T; Wesseling, P, 2007)
"Main postoperative complications were transient: 4 eyes with seidel phenomenon at 24 hours (10."1.46Two-year Results After Deep Sclerectomy With Nonabsorbable Uveoscleral Implant (Esnoper-Clip): Surgical Area Analysis Using Anterior Segment Optical Coherence Tomography. ( Castellvi-Manent, J; Loscos-Arenas, J; Moll-Udina, A; Romanic-Bubalo, N; Romera-Romero, P; Valldeperas, X, 2017)
"Secondary glaucoma is a serious complication in patients with transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP)."1.40Long-term outcomes and complications of trabeculectomy for secondary glaucoma in patients with familial amyloidotic polyneuropathy. ( Ando, Y; Eiki, D; Hara, R; Inoue, T; Kawaji, T; Tanihara, H, 2014)
"The meiboscores of the bleb-contacting upper eyelid areas were significantly higher than those for the bleb-noncontacting upper eyelid areas (P < 0."1.40Meibomian gland loss due to trabeculectomy. ( Horikiri, H; Noji, H; Ogasawara, M; Sagara, H; Sekiryu, T; Sugano, Y, 2014)
"the Wuerzburg bleb classification score (WBCS) aims at an objective and standardized assessment of the developing filtering bleb after trabeculectomy, in order to detect and treat bleb scarring at the earliest possible stage of development."1.37The prognostic value of the wuerzburg bleb classification score for the outcome of trabeculectomy. ( Ellinger, P; Grehn, F; Guthoff, R; Kann, G; Klink, J; Klink, T, 2011)
"Filtering blebs with various types of glaucoma were examined using Stratus OCT."1.36Stratus optical coherence tomography study of filtering blebs after primary trabeculectomy with a fornix-based conjunctival flap. ( Baba, T; Hirooka, K; Shiraga, F; Takagishi, M; Takenaka, H, 2010)
"Postoperative complications were: ocular hypotony (1 case), bleb fibrosis (2 cases), bleb-related endophthalmitis (1 case)."1.36[Non-pentrating deep sclerectomy--between safety and efficacy]. ( Cantemir, A; Chiseliţă, D; Ilieş, I, 2010)
"Bleb wall reflectivity of developing blebs on AS-OCT 2 weeks postoperatively was correlated with mature bleb function at 6-month postoperative visit."1.36Early trabeculectomy bleb walls on anterior-segment optical coherence tomography. ( Hangai, M; Hirose, F; Inoue, R; Nakanishi, H; Nakano, N; Ojima, T; Unoki, N; Yoshimura, N, 2010)
"Visualization of filtering bleb structure in vivo is an objective and helpful method of evaluation of functioning status following trabeculectomy."1.35[Evaluation on the cellular level the filtering bleb following trabeculectomy, using the HRT II Cornea Module]. ( Jurowska-Liput, J; Krzyzanowska, P; Nizankowska, MH; Szelepin, Ł, 2008)
"SDOCT showed the bleb cavity (23."1.35High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment. ( Aquino, MC; Chew, PT; See, JL; Singh, M; Thean, LS, 2009)
"Thirty-one blebs of 24 patients underwent noncontact in vivo confocal microscopy using the Rostock Cornea Module of the Heidelberg Retina Tomograph II (50x noncontact Nikon lens, 1-2 mum resolution, field of view: 500x500 mum)."1.35Noncontact in vivo scanning laser microscopy of filtering blebs. ( Liebmann, JM; Palmiero, PM; Ritch, R; Sbeity, Z; Tello, C, 2009)
"No patients presented recurrence of the bleb leak or AMT-related complications during entire follow-up."1.35Long-term results of amniotic membrane transplantation-assisted bleb revision for leaking blebs. ( Fujioka, M; Nagai-Kusuhara, A; Nakamura, M; Negi, A, 2008)
"Within this group, blebs were classified into three different categories according to their optical coherence tomography pattern: type A (featuring a thick wall and a single large fluid-filled space), type B (featuring a thin wall and multiple large fluid-filled spaces) and type C (featuring multiple, irregular and flattened fluid-filled spaces)."1.33Filtering blebs imaging by optical coherence tomography. ( Barboni, P; Savini, G; Zanini, M, 2005)
"Twenty-four glaucoma filtering blebs in 24 eyes of 17 patients."1.33Comparison of two clinical Bleb grading systems. ( Ashraff, NN; Hall, RC; Purdie, G; Wells, AP, 2006)
"Each bleb was incised segmentally and the cut edges of the conjunctiva and Tenon capsule were sutured to the underlying sclera."1.33Surgical reduction of symptomatic, circumferential, filtering blebs. ( Anis, S; Liebmann, J; Ritch, R; Shihadeh, W, 2006)
"Two additional filtering blebs were treated with balanced saline solution (BSS), two received mitomycin-C (MMC) (0."1.33A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis). ( Sherwood, MB, 2006)
"Clinically, it appears as vesiculobullous lesions of the oral cavity and eyes, but other tissues such as the nasopharyngeal and laryngeal mucosa can also be affected."1.32Mucous membrane pemphigoid: nasal and laryngeal manifestations. ( Ali, I; Capper, JW; Martinez Devesa, P; Whiteside, OJ, 2003)
"To report delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis."1.32Delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis. ( Cruz-Villegas, V; Flynn, HW; Miller, D; Scott, IU, 2004)
"To assess the efficacy of a bleb revision technique with regard to improvement in intraocular pressure (IOP) and visual acuity after hypotony maculopathy and to evaluate the influence of duration of hypotony on visual outcome."1.32Bleb revision for hypotony maculopathy after trabeculectomy. ( Bashford, KP; Shafranov, G; Shields, MB, 2004)
"In the study 6 patients with cystic blebs after trabeculectomy with mitomycin C was presented."1.32[Surgical management of pathologic filtering blebs in pediatric glaucoma]. ( Chipczyńska, B; Grałek, M; Kanigowska, K; Klimczak-Slaczka, D, 2004)
"Late bleb leaks may follow months to years after filtering surgery especially with the use of antimetabolites."1.31[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps]. ( Ayed, T; Hamard, H; Hamard, P; Quesnot, S; Tazartes, M, 2001)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's28 (50.91)29.6817
2010's26 (47.27)24.3611
2020's1 (1.82)2.80

Authors

AuthorsStudies
Grover, DS1
Kornmann, HL1
Fellman, RL1
Laspas, P1
Culmann, PD1
Grus, FH1
Prokosch-Willing, V2
Poplawksi, A1
Pfeiffer, N2
Hoffmann, EM2
Abe, RY1
Shigueoka, LS1
Vasconcellos, JPC1
Costa, VP1
Romera-Romero, P1
Loscos-Arenas, J1
Moll-Udina, A1
Romanic-Bubalo, N1
Castellvi-Manent, J1
Valldeperas, X1
Lamparter, J1
Ul Hassan, SN1
Toshev, AP1
Rangel, HMDA1
Rolim, HT1
Vidigal, P1
Araújo, ID1
Cronemberger, S1
Kokubun, T1
Yamamoto, K1
Sato, K1
Akaishi, T1
Shimazaki, A1
Nakamura, M2
Shiga, Y1
Tsuda, S1
Omodaka, K1
Nakazawa, T1
Butler, MR1
Prospero Ponce, CM1
Weinstock, YE1
Orengo-Nania, S1
Chevez-Barrios, P1
Frankfort, BJ1
Kawaji, T1
Inoue, T1
Hara, R1
Eiki, D1
Ando, Y1
Tanihara, H1
Muniesa, MJ1
González, S1
Buetas, P1
López, S1
Sánchez, C1
Matias-Guiu, X1
Sagara, H2
Sekiryu, T1
Noji, H1
Ogasawara, M1
Sugano, Y1
Horikiri, H1
Martorana, GM1
Schaefer, JL1
Levine, MA1
Lukowski, ZL1
Min, J1
Meyers, CA1
Schultz, GS1
Sherwood, MB2
Onol, M1
Aktaş, Z1
Hasanreisoğlu, B1
Hirooka, K2
Takagishi, M2
Baba, T2
Takenaka, H1
Shiraga, F2
Lee, E1
Doyle, E1
Jenkins, C1
Jurowska-Liput, J1
Krzyzanowska, P1
Szelepin, Ł1
Nizankowska, MH1
Prata, TS1
De Moraes, CG1
Palmiero, PM2
Tello, C2
Liebmann, J2
Ritch, R3
Okuda, T1
Higashide, T1
Fukuhira, Y1
Sumi, Y1
Shimomura, M1
Sugiyama, K1
Budenz, DL1
Radcliffe, N1
Blumenthal, EZ1
Liang, SY1
Lee, GA1
Whitehead, K1
Kaburaki, T1
Koshino, T1
Kawashima, H1
Numaga, J1
Tomidokoro, A1
Shirato, S1
Araie, M1
Singh, M1
See, JL1
Aquino, MC1
Thean, LS1
Chew, PT1
Sbeity, Z1
Liebmann, JM1
Sawada, A1
Mochizuki, K1
Katada, T1
Kawakami, H1
Yamamoto, T1
Mikamo, H1
Watanabe, K1
Carpineto, P1
Agnifili, L1
Nubile, M1
Fasanella, V1
Doronzo, E1
Mastropasqua, A1
Ciancaglini, M1
Schwartz, AL1
Albano, M1
Nakano, N1
Hangai, M1
Nakanishi, H1
Inoue, R1
Unoki, N1
Hirose, F1
Ojima, T1
Yoshimura, N1
Mavrakanas, N1
Mendrinos, E1
Shaarawy, T1
Chiseliţă, D1
Cantemir, A1
Ilieş, I1
Kahook, MY1
Boey, PY1
Narayanaswamy, A1
Zheng, C1
Perera, SA1
Htoon, HM1
Tun, TA1
Seah, SK1
Wong, TT1
Aung, T1
Klink, T1
Kann, G1
Ellinger, P1
Klink, J1
Grehn, F1
Guthoff, R1
Sen, E1
Balikoglu-Yilmaz, M1
Bozdag-Pehlivan, S1
Sungu, N1
Aksakal, FN1
Altinok, A1
Tuna, T1
Unlu, N1
Ustun, H1
Koklu, G1
Öztürk, F1
Gonçalves, ED1
Paris, Fdos S1
Gomes, JÁ1
Kanecadan, L1
Campos, M1
Kapoor, KG1
Syed, MF1
Bae, K1
Suh, W1
Kee, C1
Whiteside, OJ1
Martinez Devesa, P1
Ali, I1
Capper, JW1
Scott, IU1
Cruz-Villegas, V1
Flynn, HW1
Miller, D1
Bashford, KP1
Shafranov, G1
Shields, MB1
O'Brart, DP1
Shiew, M1
Edmunds, B1
Klimczak-Slaczka, D1
Grałek, M1
Chipczyńska, B1
Kanigowska, K1
Anand, N2
Atherley, C1
Savini, G1
Zanini, M1
Barboni, P1
Wells, AP1
Ashraff, NN1
Hall, RC1
Purdie, G1
Arora, S1
Clowes, M1
Kessing, SV1
Flesner, P1
Jensen, PK1
Ophir, A1
Karatas, M1
Anis, S1
Shihadeh, W1
Theelen, T1
Wesseling, P1
Keunen, JE1
Klevering, BJ1
Iida, T1
Suzuki, K1
Fujiwara, T1
Koizumi, H1
Yago, K1
Amini, H1
Razeghinejad, MR1
Ghaffary, E1
Abdollahi, A1
Nagai-Kusuhara, A1
Fujioka, M1
Negi, A1
Hamard, P1
Tazartes, M1
Ayed, T1
Quesnot, S1
Hamard, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Occlusion Prevention for Trabeculectomy Procedures Using Combination Ranibizumab and Mitomycin C (MMC) During Surgery (OCTOPUS Study)[NCT00661583]Phase 1/Phase 230 participants (Actual)Interventional2008-04-30Completed
Anterior Segment Optical Coherence Tomography Findings in Patients With Ahmed Glaucoma Drainage Implants With Either a Pericardial Patch Graft and Fibrin Tissue Glue or a Partial-Thickness Scleral Flap and Conventional Sutures[NCT00453024]Phase 240 participants (Anticipated)Interventional2007-02-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Assessment of Ocular Adverse Events

To assess ocular adverse events of combination ranibizumab and MMC therapy at 6 months (NCT00661583)
Timeframe: 6 months

InterventionNumber of Reported Adverse Events (Number)
Ranibizumab Alone0
Ranibizumab and MMC0
MMC Alone0

Percent of Subjects With a Qualified Success and Viable Bleb at 6 Months.

To determine percent of subjects with a qualified success and viable bleb at 6 months (IOP between 6mm Hg and 22 mm Hg with pressure controlled with and without adjunctive medications) (NCT00661583)
Timeframe: 6 months

Interventionpercentage of subjects (Number)
Ranibizumab Alone100
Ranibizumab and MMC100
MMC Alone100

Mean Change in in Intraocular Pressure.

Mean change in in intraocular pressure at 3 months and at 6 months (NCT00661583)
Timeframe: 6 months

,,
InterventionmmHg (Mean)
month 3 minus baselinemonth 6 minus baseline
MMC Alone-8.35-8.00
Ranibizumab Alone-6.40-6.60
Ranibizumab and MMC-6.40-4.90

Mean Change in Visual Acuity

Mean change in visual acuity in logMAR. (NCT00661583)
Timeframe: 6 months

,,
InterventionlogMAR (Mean)
Month 3 minus baselineMonth 6 minus baseline
MMC Alone0.130.13
Ranibizumab Alone-0.01-0.05
Ranibizumab and MMC0.010.05

Trials

7 trials available for mitomycin and Bleb

ArticleYear
Bleb morphology and vascularity after trabeculectomy with intravitreal ranibizumab: a pilot study.
    American journal of ophthalmology, 2010, Volume: 150, Issue:3

    Topics: Aged; Alkylating Agents; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Hu

2010
Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2010, Volume: 26, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Blister; Cicatrix; Conjunctiva; Doxycyc

2010
Bullous keratopathy.
    Ophthalmology, 2011, Volume: 118, Issue:11

    Topics: Blister; Combined Modality Therapy; Corneal Diseases; Corneal Transplantation; Eye Pain; Follow-Up S

2011
A randomised, prospective study comparing trabeculectomy with viscocanalostomy with adjunctive antimetabolite usage for the management of open angle glaucoma uncontrolled by medical therapy.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Cataract; Female; Filtering Surgery; Fluor

2004
A pilot study on slit lamp-adapted optical coherence tomography imaging of trabeculectomy filtering blebs.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:6

    Topics: Aged; Alkylating Agents; Aqueous Humor; Blister; Conjunctiva; Diagnostic Techniques, Ophthalmologica

2007
Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C.
    Eye (London, England), 2008, Volume: 22, Issue:4

    Topics: Adult; Aged; Aqueous Humor; Blister; Epithelium, Corneal; Female; Follow-Up Studies; Humans; Hyaluro

2008
Effect of diode laser application with G-probe on ocular hypotony after trabeculectomy with mitomycin-C.
    Photomedicine and laser surgery, 2006, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Alkylating Agents; Blister; Feasibility Studies; Female; Humans; Laser Therapy; M

2006

Other Studies

48 other studies available for mitomycin and Bleb

ArticleYear
Response to letter to the Editor Regarding MMC and pH.
    Journal of glaucoma, 2020, Volume: 29, Issue:8

    Topics: Blister; Filtering Surgery; Glaucoma; Humans; Hydrogen-Ion Concentration; Intraocular Pressure; Mito

2020
Revision of encapsulated blebs after trabeculectomy: Long-term comparison of standard bleb needling and modified needling procedure combined with transconjunctival scleral flap sutures.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Antibiotics, Antineoplastic; Blister; Conjunctiva; Female; Follow-Up Studies; Humans; Intraocular Pr

2017
Primary Trabeculectomy Outcomes by Glaucoma Fellows in a Tertiary Hospital in Brazil.
    Journal of glaucoma, 2017, Volume: 26, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Blister; Brazil; Education, Medical, Graduate; Fe

2017
Two-year Results After Deep Sclerectomy With Nonabsorbable Uveoscleral Implant (Esnoper-Clip): Surgical Area Analysis Using Anterior Segment Optical Coherence Tomography.
    Journal of glaucoma, 2017, Volume: 26, Issue:10

    Topics: Aged; Aged, 80 and over; Anterior Eye Segment; Antibiotics, Antineoplastic; Antihypertensive Agents;

2017
Results of an Adaptive Surgical Approach for Managing Late Onset Hypotony After Trabeculectomy With Mitomycin C.
    Journal of glaucoma, 2018, Volume: 27, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Blister; Combined Modality Therapy; Female; Glaucoma; Humans; Intrao

2018
Healing modulation in glaucoma surgery after application of subconjunctival triamcinolone acetate alone or combined with mitomycin C: an experimetal study.
    Revista do Colegio Brasileiro de Cirurgioes, 2018, Jul-30, Volume: 45, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Blister; Conjunctiva; Disease Models, Animal; Drug Therapy, Combi

2018
The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits.
    PloS one, 2019, Volume: 14, Issue:3

    Topics: Alkylating Agents; Animals; Blister; Colchicine; Drug Therapy, Combination; Eye Diseases; Male; Mito

2019
Topical silver nanoparticles result in improved bleb function by increasing filtration and reducing fibrosis in a rabbit model of filtration surgery.
    Investigative ophthalmology & visual science, 2013, Jul-24, Volume: 54, Issue:7

    Topics: Administration, Topical; Analysis of Variance; Animals; Anti-Infective Agents, Local; Antibiotics, A

2013
Long-term outcomes and complications of trabeculectomy for secondary glaucoma in patients with familial amyloidotic polyneuropathy.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Adult; Aged; Blister; Female; Glaucoma; Humans; Intraocular Pressure; Kaplan-Meier Estimate; Male; M

2014
[Evaluation of conjunctival epithelium of filtering blebs by impression cytology].
    Archivos de la Sociedad Espanola de Oftalmologia, 2014, Volume: 89, Issue:6

    Topics: Aged; Aged, 80 and over; Aqueous Humor; Blister; Conjunctival Diseases; Conjunctivitis; Cytological

2014
Meibomian gland loss due to trabeculectomy.
    Japanese journal of ophthalmology, 2014, Volume: 58, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Blister; Conjunctiva; Cross-Sectional Studies; Ey

2014
Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Bevacizumab; Bl

2015
Enhancement of the success rate in trabeculectomy: large-area mitomycin-C application.
    Clinical & experimental ophthalmology, 2008, Volume: 36, Issue:4

    Topics: Aged; Blister; Glaucoma; Humans; Incidence; Intraocular Pressure; Intraoperative Care; Middle Aged;

2008
Stratus optical coherence tomography study of filtering blebs after primary trabeculectomy with a fornix-based conjunctival flap.
    Acta ophthalmologica, 2010, Volume: 88, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Blister; Conjunctiva; Exfoliation Syndrome; Female; Glaucoma; Glauco

2010
Trabeculectomy surgery augmented with intra-Tenon injection of mitomycin C.
    Acta ophthalmologica, 2008, Volume: 86, Issue:8

    Topics: Aged; Blister; Choroid Diseases; Cysts; Eye Diseases; Glaucoma; Humans; Hyphema; Injections; Intraoc

2008
[Evaluation on the cellular level the filtering bleb following trabeculectomy, using the HRT II Cornea Module].
    Klinika oczna, 2008, Volume: 110, Issue:10-12

    Topics: Aqueous Humor; Blister; Epithelial Cells; Glaucoma, Open-Angle; Humans; Microscopy, Confocal; Mitomy

2008
Slit-lamp-adapted optical coherence tomography for assessment of an overhanging filtering bleb.
    Acta ophthalmologica, 2010, Volume: 88, Issue:8

    Topics: Aged; Alkylating Agents; Blister; Combined Modality Therapy; Conjunctival Diseases; Diagnostic Techn

2010
A thin honeycomb-patterned film as an adhesion barrier in an animal model of glaucoma filtration surgery.
    Journal of glaucoma, 2009, Volume: 18, Issue:3

    Topics: Absorbable Implants; Animals; Blister; Conjunctival Diseases; Disease Models, Animal; Filtering Surg

2009
Late-onset bleb leakage.
    Journal of glaucoma, 2009, Volume: 18, Issue:3

    Topics: Aged; Blister; Fluorescein; Glaucoma; Humans; Intraocular Pressure; Male; Mitomycin; Ocular Hypotens

2009
Histopathology of a functioning mitomycin-C trabeculectomy.
    Clinical & experimental ophthalmology, 2009, Volume: 37, Issue:3

    Topics: Anterior Eye Segment; Blister; Eye Enucleation; Glaucoma; Humans; Iris Neoplasms; Male; Melanoma; Mi

2009
Correlation between optical coherence tomography scan and histological specimen of a filtering bleb.
    Acta ophthalmologica, 2010, Volume: 88, Issue:2

    Topics: Animals; Aqueous Humor; Blister; Conjunctiva; Disease Models, Animal; Female; Filtering Surgery; His

2010
Initial trabeculectomy with mitomycin C in eyes with uveitic glaucoma with inactive uveitis.
    Eye (London, England), 2009, Volume: 23, Issue:7

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Blister; Combined Modality Therapy; Education, Medical, Co

2009
High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment.
    Clinical & experimental ophthalmology, 2009, Volume: 37, Issue:4

    Topics: Aged; Anterior Eye Segment; Blister; Combined Modality Therapy; Cross-Sectional Studies; Female; Gla

2009
Noncontact in vivo scanning laser microscopy of filtering blebs.
    Journal of glaucoma, 2009, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aqueous Humor; Blister; Combined Modality Therapy; Conju

2009
Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C.
    Journal of glaucoma, 2009, Volume: 18, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Blister; Conjunctiva; Drug Therapy, Combination; Endophthalmitis; Eye

2009
Conjunctival and corneal findings in bleb-associated endophthalmitis: an in vivo confocal microscopy study.
    Acta ophthalmologica, 2011, Volume: 89, Issue:4

    Topics: Aged; Aged, 80 and over; Blister; Case-Control Studies; Conjunctivitis; Endophthalmitis; Female; Gla

2011
Application of handheld cautery for reduction of symptomatic circumferential trabeculectomy blebs.
    Journal of glaucoma, 2010, Volume: 19, Issue:7

    Topics: Aged; Ambulatory Surgical Procedures; Blister; Conjunctival Diseases; Electrocoagulation; Female; Gl

2010
Early trabeculectomy bleb walls on anterior-segment optical coherence tomography.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010, Volume: 248, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Blister; Conjunctiva; Cross-Sectional Studies; Fe

2010
Postoperative IOP is related to intrascleral bleb height in eyes with clinically flat blebs following deep sclerectomy with collagen implant and mitomycin.
    The British journal of ophthalmology, 2010, Volume: 94, Issue:4

    Topics: Aged; Aged, 80 and over; Blister; Collagen; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressu

2010
[Non-pentrating deep sclerectomy--between safety and efficacy].
    Oftalmologia (Bucharest, Romania : 1990), 2010, Volume: 54, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antihypertensive Agents; Blister; Drug Therapy, Comb

2010
Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants.
    The British journal of ophthalmology, 2011, Volume: 95, Issue:3

    Topics: Aged; Blister; Case-Control Studies; Collagen; Female; Humans; Intraocular Pressure; Male; Mitomycin

2011
The prognostic value of the wuerzburg bleb classification score for the outcome of trabeculectomy.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2011, Volume: 225, Issue:1

    Topics: Antimetabolites; Blister; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Follow-Up St

2011
Dramatic dysesthetic overhanging bleb.
    International ophthalmology, 2011, Volume: 31, Issue:5

    Topics: Antibiotics, Antineoplastic; Blister; Combined Modality Therapy; Female; Glaucoma, Open-Angle; Human

2011
Comparative study of encapsulated blebs following Ahmed glaucoma valve implantation and trabeculectomy with mitomycin-C.
    Korean journal of ophthalmology : KJO, 2012, Volume: 26, Issue:4

    Topics: Adult; Blister; Female; Glaucoma; Glaucoma Drainage Implants; Humans; Infant; Male; Middle Aged; Mit

2012
Mucous membrane pemphigoid: nasal and laryngeal manifestations.
    The Journal of laryngology and otology, 2003, Volume: 117, Issue:11

    Topics: Adjuvants, Immunologic; Adult; Airway Obstruction; Blister; Female; Hand Dermatoses; Humans; Immunos

2003
Delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis.
    American journal of ophthalmology, 2004, Volume: 137, Issue:3

    Topics: Antifungal Agents; Blister; Combined Modality Therapy; Cryotherapy; Endophthalmitis; Eye Infections,

2004
Bleb revision for hypotony maculopathy after trabeculectomy.
    Journal of glaucoma, 2004, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blister; Combined Modality Therapy; Female; Humans; Intr

2004
[Surgical management of pathologic filtering blebs in pediatric glaucoma].
    Klinika oczna, 2004, Volume: 106, Issue:1-2 Suppl

    Topics: Adolescent; Anti-Bacterial Agents; Blister; Child; Endophthalmitis; Female; Glaucoma; Humans; Male;

2004
Deep sclerectomy augmented with mitomycin C.
    Eye (London, England), 2005, Volume: 19, Issue:4

    Topics: Aged; Antihypertensive Agents; Blister; Cicatrix; Conjunctiva; Epidemiologic Methods; Exudates and T

2005
Filtering blebs imaging by optical coherence tomography.
    Clinical & experimental ophthalmology, 2005, Volume: 33, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Child; Combined Modality Thera

2005
Comparison of two clinical Bleb grading systems.
    Ophthalmology, 2006, Volume: 113, Issue:1

    Topics: Blister; Diagnostic Techniques, Ophthalmological; Fluorouracil; Glaucoma; Humans; Mitomycin; Prospec

2006
Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:2

    Topics: Aged; Blister; Conjunctiva; Conjunctival Diseases; Female; Fluorouracil; Glaucoma; Humans; Intraocul

2006
Determinants of bleb morphology in minimally invasive, clear-cornea micropenetrating glaucoma surgery with mitomycin C.
    Journal of glaucoma, 2006, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Antimetabolites; Blister; Child; Combined Modality Therapy; Conjunctiva; Co

2006
Protection of the conjunctival flap from contact with mitomycin C during tunnel-trabeculectomy.
    Eye (London, England), 2007, Volume: 21, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Blister; Conjunctiva; Female; Follow-Up Studies; Humans; Intraocular

2007
Surgical reduction of symptomatic, circumferential, filtering blebs.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2006, Volume: 124, Issue:6

    Topics: Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Blister; Combined Modality Therapy; Conjunctiv

2006
A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis).
    Transactions of the American Ophthalmological Society, 2006, Volume: 104

    Topics: Alkylating Agents; Animals; Antimetabolites; Blister; Conjunctiva; Connective Tissue; Connective Tis

2006
Long-term results of amniotic membrane transplantation-assisted bleb revision for leaking blebs.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008, Volume: 246, Issue:4

    Topics: Adult; Aged; Alkylating Agents; Amnion; Blister; Combined Modality Therapy; Female; Humans; Intraocu

2008
[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps].
    Journal francais d'ophtalmologie, 2001, Volume: 24, Issue:5

    Topics: Adult; Aged; Antimetabolites; Blister; Combined Modality Therapy; Conjunctival Diseases; Female; Flu

2001