mitomycin has been researched along with B16 Melanoma in 25 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three mouse cancer cell lines [CT26 mouse colon cancer cells, B16 melanoma cells and Lewis lung carcinoma (LLC)], 5 human carcinoma cell lines (human esophageal squamous cell carcinoma cell lines TE8 and HEC46 and the human pancreatic carcinoma cell lines PK-9, AsPC-1 and SUIT-2) and 5 chemotherapeutic agents [mitoxantrone (MIT), mitomycin C(MMC), 5-fluorouracil (5FU), camptothecin (CPT-11) and cisplatin (CDDP)] that are frequently used in a clinical setting for cancer treatment were utilized to investigate the surface expression level of calreticulin and HLA class I after exposure to chemotherapeutic agents." | 3.81 | The key role of calreticulin in immunomodulation induced by chemotherapeutic agents. ( Hirano, S; Kuroda, A; Kuwatani, T; Kyogoku, N; Maki, T; Miyauchi, K; Shichinohe, T; Takeuchi, S; Tsuchikawa, T; Wada, M; Yamamura, Y, 2015) |
| " A yellow crystalline product, named rebeccamycin, was isolated from the mycelium and was found to have activity against P388 leukemia, L1210 leukemia and B16 melanoma implanted in mice." | 3.67 | Production and biological activity of rebeccamycin, a novel antitumor agent. ( Bradner, WT; Bush, JA; Catino, JJ; Long, BH; Tomita, K, 1987) |
| "61 cases of the gastric cancers have been treated with Replenishing Qi and Invigorating Spleen (RQIS) combined with chemotherapy." | 2.67 | [Clinical and experimental study in treating gastric cancer with replenishing qi and invigorating spleen oral liquid combined with chemotherapy]. ( Chen, CH; Sun, GZ; Wang, GM, 1994) |
| " The seven agents combined with CI-973 were mitomycin C, cyclophosphamide, doxorubicin, vinblastine, etoposide, ifosfamide, and methotrexate." | 1.29 | Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo. ( Elliott, WL; Howard, CT; Leopold, WR; Roberts, BJ, 1994) |
| " Pharmacokinetic analysis of each plasma concentration indicated that for each conjugate, the in vitro drug release reported previously was useful for the approximate estimation of the in vivo regeneration of MMC." | 1.29 | Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate. ( Nagai, T; Onishi, H; Song, Y, 1993) |
| "We have investigated the therapeutic effect of CH-271 fusion polypeptide containing both cell-binding domain (C-274) and heparin-binding domain (H-271) of fibronectin in combination with anticancer drugs such as doxorubicin (DOX) or mitomycin C (MMC) on tumor metastasis of different types of tumors." | 1.29 | Antimetastatic effect by anti-adhesion therapy with cell-adhesive peptide of fibronectin in combination with anticancer drugs. ( Azuma, I; Igarashi, Y; Ishizaki, Y; Kato, I; Kobayashi, H; Komazawa, H; Saiki, I; Yoneda, J, 1993) |
| " Taking advantage of this pharmacodynamic effect, we have previously shown that FAA in combination with hyperthermia (HT) can produce a marked improvement in antitumor response in mice." | 1.29 | Flavone acetic acid increases the cytotoxicity of mitomycin C when combined with hyperthermia. ( Baba, H; Maehara, Y; Newman, RA; Sugimachi, K; Takeuchi, H, 1996) |
| "Similar results were observed against B16 melanoma inoculated into BDF1 mice." | 1.28 | [Potentiation of the therapeutic effect of chemotherapy and hyperthermia on experimental tumor and reduction of immunotoxicity of mitomycin C by juzen-taiho-toh, a Chinese herbal medicine]. ( Komiyama, K; Umezawa, I; Zhibo, Y, 1989) |
| "Three metastatic variants, BL6 (high metastasis), F1 (nonmalignant) and F10 (intermediate malignancy) of the B16 murine melanoma, and a pulmonary metastatic line BL6-ML8 of the BL6 primary tumour have been examined for spontaneous sister chromatid exchange (SCE)." | 1.27 | Spontaneous sister chromatid exchange in metastatic variants of the murine B16 melanoma and human astrocytomas in culture. ( Hunt, G; Lakshmi, MS; Sherbet, GV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (28.00) | 18.7374 |
| 1990's | 13 (52.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamura, Y | 1 |
| Tsuchikawa, T | 1 |
| Miyauchi, K | 1 |
| Takeuchi, S | 1 |
| Wada, M | 1 |
| Kuwatani, T | 1 |
| Kyogoku, N | 1 |
| Kuroda, A | 1 |
| Maki, T | 1 |
| Shichinohe, T | 1 |
| Hirano, S | 1 |
| Park, HR | 1 |
| Ju, EJ | 1 |
| Jo, SK | 1 |
| Jung, U | 1 |
| Kim, SH | 1 |
| Yee, ST | 1 |
| Inami, M | 1 |
| Kawamura, I | 2 |
| Tsujimoto, S | 1 |
| Nishigaki, F | 2 |
| Matsumoto, S | 2 |
| Naoe, Y | 1 |
| Sasakawa, Y | 1 |
| Matsuo, M | 1 |
| Manda, T | 2 |
| Goto, T | 1 |
| Tasciotti, E | 1 |
| Zoppè, M | 1 |
| Giacca, M | 1 |
| Papo, N | 1 |
| Shai, Y | 1 |
| Wang, GM | 1 |
| Chen, CH | 1 |
| Sun, GZ | 1 |
| Hill, HZ | 2 |
| Hill, GJ | 2 |
| Cieszka, K | 1 |
| Azure, M | 1 |
| Chowdhary, I | 1 |
| Sayre, RM | 1 |
| Elliott, WL | 1 |
| Roberts, BJ | 1 |
| Howard, CT | 1 |
| Leopold, WR | 1 |
| Harada, M | 1 |
| Matsuzaki, G | 1 |
| Shinomiya, Y | 1 |
| Kurosawa, S | 1 |
| Ito, O | 1 |
| Okamoto, T | 1 |
| Takenoyama, M | 1 |
| Sumitika, H | 1 |
| Nishimura, Y | 1 |
| Nomoto, K | 1 |
| Ueda, H | 1 |
| Mukumoto, S | 1 |
| Shimomura, K | 1 |
| Schlehaider, UK | 1 |
| Song, Y | 1 |
| Onishi, H | 1 |
| Nagai, T | 1 |
| Takeuchi, H | 2 |
| Baba, H | 2 |
| Inutsuka, S | 1 |
| Sakaguchi, Y | 1 |
| Kusumoto, T | 1 |
| Kusumoto, H | 1 |
| Maehara, Y | 2 |
| Sugimachi, K | 2 |
| Saiki, I | 1 |
| Yoneda, J | 1 |
| Kobayashi, H | 1 |
| Igarashi, Y | 1 |
| Komazawa, H | 1 |
| Ishizaki, Y | 1 |
| Kato, I | 1 |
| Azuma, I | 1 |
| Newman, RA | 1 |
| Ashizawa, T | 1 |
| Okamoto, A | 1 |
| Okabe, M | 1 |
| Kobayashi, S | 1 |
| Arai, H | 1 |
| Saito, H | 1 |
| Kasai, M | 1 |
| Gomi, K | 1 |
| Kobayashi, E | 1 |
| Motoki, K | 1 |
| Uchida, T | 1 |
| Fukushima, H | 1 |
| Koezuka, Y | 1 |
| Yamano, Y | 1 |
| Yoshimura, A | 1 |
| Shibuya, M | 1 |
| Kudoh, S | 1 |
| Trush, MA | 1 |
| Thompson, DC | 1 |
| Komiyama, K | 1 |
| Zhibo, Y | 1 |
| Umezawa, I | 1 |
| Nakata, K | 1 |
| Yoshida, H | 1 |
| Kashimoto, S | 1 |
| Sohmura, Y | 1 |
| Nakamura, S | 1 |
| Taguchi, T | 1 |
| Ishizeki, S | 1 |
| Ohtsuka, M | 1 |
| Irinoda, K | 1 |
| Kukita, K | 1 |
| Nagaoka, K | 1 |
| Nakashima, T | 1 |
| Benomar, A | 1 |
| Ming, WJ | 1 |
| Taraboletti, G | 1 |
| Ghezzi, P | 1 |
| Balotta, C | 1 |
| Cianciolo, GJ | 1 |
| Snyderman, R | 1 |
| Doré, JF | 1 |
| Mantovani, A | 1 |
| Bush, JA | 1 |
| Long, BH | 1 |
| Catino, JJ | 1 |
| Bradner, WT | 1 |
| Tomita, K | 1 |
| Lakshmi, MS | 1 |
| Hunt, G | 1 |
| Sherbet, GV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of Romidepsin Given on Days One, Three, and Five in Patients With Thyroid and Other Advanced Cancers[NCT00048334] | Phase 1 | 28 participants (Actual) | Interventional | 2002-10-26 | Completed | ||
| Phase I Study of Topical Romidepsin (Depsipeptide) in Early Stage Cutaneous T-Cell Lymphoma[NCT01445340] | Phase 1 | 6 participants (Actual) | Interventional | 2007-04-21 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mitomycin and B16 Melanoma
| Article | Year |
|---|---|
[Clinical and experimental study in treating gastric cancer with replenishing qi and invigorating spleen oral liquid combined with chemotherapy].
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Therapy, Combi | 1994 |
24 other studies available for mitomycin and B16 Melanoma
| Article | Year |
|---|---|
The key role of calreticulin in immunomodulation induced by chemotherapeutic agents.
Topics: Animals; Antigens, Surface; Antineoplastic Agents; Apoptosis; Calreticulin; Camptothecin; Carcinoma, | 2015 |
Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice.
Topics: Angelica; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferat | 2009 |
Effects of FK317, a novel anti-cancer agent, on survival of mice bearing B16BL6 melanoma and Lewis lung carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Drug Evaluation; Female; Melanoma, Experiment | 2002 |
Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat.
Topics: Acyclovir; Antibiotics, Antineoplastic; Antiviral Agents; Apoptosis; Fibrinolytic Agents; Gene Produ | 2003 |
New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells.
Topics: Anti-Infective Agents; Antimicrobial Cationic Peptides; Cell Death; Cell Membrane; Fluoresceins; Hem | 2003 |
A multitherapy resistance factor from melanoma reveals that killing by near UV is different from genotoxic agents.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line; Dactinomycin; Drug Resistance, Multiple; Gamm | 1995 |
Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Neoplasms; Cyclophosph | 1994 |
Generation of tumor-specific cytotoxic T lymphocytes in vivo by combined treatment with inactivated tumor cells and recombinant interleukin-2.
Topics: Animals; Antigens, Neoplasm; Female; Immunotherapy; Interleukin-2; Lung Neoplasms; Melanoma, Experim | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
Influence of an autocrine diffusible resistance factor on cell survival after exposure to therapeutic agents.
Topics: Animals; Biological Factors; Cell Survival; Drug Resistance; Melanoma, Experimental; Mice; Mitomycin | 1993 |
Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate.
Topics: Animals; Antineoplastic Agents; Cell Division; Chitin; Chitosan; Chromatography, High Pressure Liqui | 1993 |
[Potentiation of cytotoxicity of anticancer drugs by flavone acetic acid].
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Drug Synergism; Flavonoids; Hyperthermia, | 1993 |
Antimetastatic effect by anti-adhesion therapy with cell-adhesive peptide of fibronectin in combination with anticancer drugs.
Topics: Amino Acid Sequence; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Dose-Re | 1993 |
Flavone acetic acid increases the cytotoxicity of mitomycin C when combined with hyperthermia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Division; Cell Survival; Combined | 1996 |
Characteristics of the antitumor activity of M-16 and M-18, major metabolites of a new mitomycin C derivative KW-2149, in mice.
Topics: Animals; Antineoplastic Agents; Biotransformation; Breast Neoplasms; Cell Survival; HeLa Cells; Huma | 1995 |
KRN7000, a novel immunomodulator, and its antitumor activities.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Female; Galactosylceramides; Immunologic Fac | 1995 |
[Combined effect of adoptive immunotherapy (AIT) with lymphokine-activated killer (LAK) cells and interleukin-2 (IL-2) and chemotherapy in tumor-bearing mice].
Topics: Animals; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Immunotherapy, Adoptive; Inter | 1997 |
Enhancement of chemical activation via radical-dependent mechanisms: an emerging concept in chemical-chemical interactions.
Topics: Animals; Bleomycin; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Chemical Phenomena; Chemistr | 1988 |
[Potentiation of the therapeutic effect of chemotherapy and hyperthermia on experimental tumor and reduction of immunotoxicity of mitomycin C by juzen-taiho-toh, a Chinese herbal medicine].
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drugs, Chinese Herbal; Female; Hyperthermia, Ind | 1989 |
[Combined effect of PT-050 (recombinant human TNF) and antitumor drugs on syngeneic murine tumors].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxo | 1986 |
Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Azabicyclo Compounds; Carcinoma, Ehrlic | 1987 |
Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice.
Topics: Animals; Cell Line; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Cycloheximide; Huma | 1987 |
Production and biological activity of rebeccamycin, a novel antitumor agent.
Topics: Actinomycetales; Adenocarcinoma; Aminoglycosides; Animals; Anti-Bacterial Agents; Antibiotics, Antin | 1987 |
Spontaneous sister chromatid exchange in metastatic variants of the murine B16 melanoma and human astrocytomas in culture.
Topics: Animals; Astrocytoma; Ethyl Methanesulfonate; Humans; Melanoma, Experimental; Mice; Mitomycin; Mitom | 1988 |