mitomycin has been researched along with Ataxia Telangiectasia in 11 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| "By comparing fibroblast strains derived from individuals exhibiting chromosome instability and/or mutagen hypersensitivity (Cockayne syndrome, ataxia telangiectasia, and Fanconi anemia) with strains derived from healthy donors, the fibroblast micronucleus assay has been established as a reproducible measure of the genotypic variation in spontaneous or mitomycin C (MMC)-induced chromosomal instability." | 3.67 | Micronucleus assay in human fibroblasts: a measure of spontaneous chromosomal instability and mutagen hypersensitivity. ( Dimnik, LS; Greentree, CL; Hennig, UG; Hoar, DI; Rudd, NL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gueven, N | 1 |
| Becherel, OJ | 1 |
| Kijas, AW | 1 |
| Chen, P | 1 |
| Howe, O | 1 |
| Rudolph, JH | 1 |
| Gatti, R | 1 |
| Date, H | 1 |
| Onodera, O | 1 |
| Taucher-Scholz, G | 1 |
| Lavin, MF | 1 |
| Mladenov, E | 1 |
| Tsaneva, I | 1 |
| Anachkova, B | 1 |
| Jaspers, NG | 1 |
| de Wit, J | 1 |
| Regulski, MR | 1 |
| Bootsma, D | 1 |
| Cohen, MM | 2 |
| Simpson, SJ | 2 |
| Fruchtman, CE | 1 |
| Martin, AO | 1 |
| Nagasawa, H | 1 |
| Little, FF | 1 |
| Burke, MJ | 1 |
| McCone, EF | 1 |
| Targovnik, HS | 1 |
| Chan, GL | 1 |
| Little, JB | 1 |
| Loberg, LI | 1 |
| Luther, MJ | 1 |
| Gauger, JR | 1 |
| McCormick, DL | 1 |
| Johnson, MA | 1 |
| Bryant, PE | 1 |
| Jones, NJ | 2 |
| Taniguchi, T | 1 |
| Garcia-Higuera, I | 1 |
| Xu, B | 1 |
| Andreassen, PR | 1 |
| Gregory, RC | 1 |
| Kim, ST | 1 |
| Lane, WS | 1 |
| Kastan, MB | 1 |
| D'Andrea, AD | 1 |
| Stewart, SA | 1 |
| Thompson, LH | 1 |
| Rudd, NL | 1 |
| Hoar, DI | 1 |
| Greentree, CL | 1 |
| Dimnik, LS | 1 |
| Hennig, UG | 1 |
11 other studies available for mitomycin and Ataxia Telangiectasia
| Article | Year |
|---|---|
Aprataxin, a novel protein that protects against genotoxic stress.
Topics: Apraxias; Ataxia; Ataxia Telangiectasia; Cell Culture Techniques; Chromatin; DNA Damage; DNA Repair; | 2004 |
Activation of the S phase DNA damage checkpoint by mitomycin C.
Topics: Androstadienes; Antibiotics, Antineoplastic; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Pr | 2007 |
Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Ataxia Telangiectasia; Bleomycin; Carcinogens; Cell Sur | 1982 |
The effect of bleomycin on DNA synthesis in ataxia telangiectasia lymphoid cells.
Topics: Ataxia Telangiectasia; Bleomycin; Cells, Cultured; DNA; DNA Repair; Humans; Lymphocytes; Mitomycin; | 1982 |
The cytogenetic response of Fanconi's anemia lymphoblastoid cell lines to various clastogens.
Topics: Adult; Anemia, Aplastic; Ataxia Telangiectasia; Bleomycin; Cell Line; Child; Child, Preschool; Epoxy | 1982 |
Study of basal cell nevus syndrome fibroblasts after treatment with DNA-damaging agents.
Topics: Adolescent; Adult; Ataxia Telangiectasia; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Child; D | 1984 |
60 Hz magnetic fields do not enhance cell killing by genotoxic chemicals in Ataxia telangiectasia and normal lymphoblastoid cells.
Topics: Antibiotics, Antineoplastic; Ataxia Telangiectasia; Cell Division; Cell Line; Cell Survival; Colony- | 2000 |
Isolation of camptothecin-sensitive chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineopla | 2000 |
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Trans | 2002 |
Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells.
Topics: Animals; Ataxia Telangiectasia; Cell Line; Cisplatin; Cricetinae; Cricetulus; DNA; DNA Repair; Dose- | 1990 |
Micronucleus assay in human fibroblasts: a measure of spontaneous chromosomal instability and mutagen hypersensitivity.
Topics: Adult; Anemia, Aplastic; Ataxia Telangiectasia; Cell Nucleus; Cells, Cultured; Chromosomes; Cockayne | 1988 |