Page last updated: 2024-11-06

mitomycin and Anterior Urethral Stricture

mitomycin has been researched along with Anterior Urethral Stricture in 21 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Research Excerpts

ExcerptRelevanceReference
"Evaluation of the safety and efficacy of intraurethral Mitomycin C (MMC) hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy."9.22Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy. ( Derakhshandeh, K; Fasihi, M; Karimian, B; Moradi, M, 2016)
"To determine the efficacy of mitomycin C in reducing the recurrence of anterior urethral stricture after internal optical urethrotomy (IOU)."9.20Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy. ( Ahmad, M; Ali, L; Khan, I; Orakzai, N; Shahzad, M, 2015)
"Forty male patients with anterior urethral strictures were randomized to undergo internal urethrotomy with or without urethral submucosal mitomycin C injection."9.12Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy. ( Ghassami, F; Mazdak, H; Meshki, I, 2007)
"To describe our experience with direct visual internal urethrotomy (DVIU) and mitomycin C (MMC) for recurrent bulbar and bulbomembranous urethral strictures of radiation and non-radiation-induced etiologies."7.85Internal Urethrotomy With Intralesional Mitomycin C: An Effective Option for Endoscopic Management of Recurrent Bulbar and Bulbomembranous Urethral Strictures. ( Farrell, MR; Lawrenz, CW; Levine, LA, 2017)
"To analyze the urothelial responses to mitomycin C treatment after urethral injury in rats, as the urothelium might play a role in the pathogenesis of urethral stricture."7.81Morphological effects of mitomycin C on urothelial responses to experimentally-induced urethral stricture in rats. ( Chang, IY; Han, M; Huh, JS; Kim, JN; Kim, SO; Maeng, YH; Yoon, SP, 2015)
"To evaluate our longitudinal experience using visual internal urethrotomy (VIU) with intralesional mitomycin C (MMC) and short-term clean intermittent catheterization (CIC) for urethral strictures and bladder neck contractures (BNC) after failure of endoscopic management."7.81Visual Internal Urethrotomy With Intralesional Mitomycin C and Short-term Clean Intermittent Catheterization for the Management of Recurrent Urethral Strictures and Bladder Neck Contractures. ( Farrell, MR; Levine, LA; Sherer, BA, 2015)
"Mitomycin C (MMC) is an excellent antifibrosis antigen that has been used in many fields, but its effect on a urethral stricture remains controversial."7.01Efficacy of Mitomycin C Combined with Direct Vision Internal Urethrotomy for Urethral Strictures: A Systematic Review and Meta-Analysis. ( Cai, T; Lin, J; Lin, L; Lv, T; Xu, C; Zhu, Z, 2023)
"Mitomycin-C was administered to the injured urethra in the form of irrigation for 5 min."5.32Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. ( Ayyildiz, A; Caydere, M; Erol, D; Germiyanoglu, C; Gülerkaya, B; Nuhoglu, B; Ustün, H, 2004)
"Evaluation of the safety and efficacy of intraurethral Mitomycin C (MMC) hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy."5.22Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy. ( Derakhshandeh, K; Fasihi, M; Karimian, B; Moradi, M, 2016)
"To determine the efficacy of mitomycin C in reducing the recurrence of anterior urethral stricture after internal optical urethrotomy (IOU)."5.20Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy. ( Ahmad, M; Ali, L; Khan, I; Orakzai, N; Shahzad, M, 2015)
"Forty male patients with anterior urethral strictures were randomized to undergo internal urethrotomy with or without urethral submucosal mitomycin C injection."5.12Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy. ( Ghassami, F; Mazdak, H; Meshki, I, 2007)
"To describe our experience with direct visual internal urethrotomy (DVIU) and mitomycin C (MMC) for recurrent bulbar and bulbomembranous urethral strictures of radiation and non-radiation-induced etiologies."3.85Internal Urethrotomy With Intralesional Mitomycin C: An Effective Option for Endoscopic Management of Recurrent Bulbar and Bulbomembranous Urethral Strictures. ( Farrell, MR; Lawrenz, CW; Levine, LA, 2017)
"To analyze the urothelial responses to mitomycin C treatment after urethral injury in rats, as the urothelium might play a role in the pathogenesis of urethral stricture."3.81Morphological effects of mitomycin C on urothelial responses to experimentally-induced urethral stricture in rats. ( Chang, IY; Han, M; Huh, JS; Kim, JN; Kim, SO; Maeng, YH; Yoon, SP, 2015)
"To evaluate our longitudinal experience using visual internal urethrotomy (VIU) with intralesional mitomycin C (MMC) and short-term clean intermittent catheterization (CIC) for urethral strictures and bladder neck contractures (BNC) after failure of endoscopic management."3.81Visual Internal Urethrotomy With Intralesional Mitomycin C and Short-term Clean Intermittent Catheterization for the Management of Recurrent Urethral Strictures and Bladder Neck Contractures. ( Farrell, MR; Levine, LA; Sherer, BA, 2015)
"Mitomycin C (MMC) is an excellent antifibrosis antigen that has been used in many fields, but its effect on a urethral stricture remains controversial."3.01Efficacy of Mitomycin C Combined with Direct Vision Internal Urethrotomy for Urethral Strictures: A Systematic Review and Meta-Analysis. ( Cai, T; Lin, J; Lin, L; Lv, T; Xu, C; Zhu, Z, 2023)
" No adverse events were reported."1.46Mitomycin-C and urethral dilatation: A safe, effective, and minimally invasive procedure for recurrent vesicourethral anastomotic stenoses. ( Bettez, M; Jundi, M; Richard, PO; Sourial, MW; Tu, LM, 2017)
"Mitomycin-C was administered to the injured urethra in the form of irrigation for 5 min."1.32Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. ( Ayyildiz, A; Caydere, M; Erol, D; Germiyanoglu, C; Gülerkaya, B; Nuhoglu, B; Ustün, H, 2004)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (23.81)29.6817
2010's12 (57.14)24.3611
2020's4 (19.05)2.80

Authors

AuthorsStudies
Xu, C1
Zhu, Z1
Lin, L1
Lv, T1
Cai, T1
Lin, J1
Xu, F1
Guan, Y1
Xue, L1
Lan, X1
Gao, K1
Chong, T1
Rozanski, AT1
Zhang, LT1
Holst, DD1
Copacino, SA1
Vanni, AJ1
Buckley, JC1
Pang, KH1
Chapple, CR2
Chatters, R1
Downey, AP1
Harding, CK1
Hind, D1
Watkin, N1
Osman, NI1
Farrell, MR3
Lawrenz, CW1
Levine, LA3
Sourial, MW1
Richard, PO1
Bettez, M1
Jundi, M1
Tu, LM1
Park, JJ1
Kuo, TL1
Lang, IJ1
Kluth, LA1
Uyeturk, U1
Gucuk, A1
Firat, T1
Kemahli, E1
Kukner, A1
Ozyalvacli, ME1
Chang, IY1
Kim, JN1
Kim, SO1
Han, M1
Huh, JS1
Maeng, YH1
Yoon, SP1
Mellon, MJ1
Sherer, BA2
Voelzke, BB1
Ali, L1
Shahzad, M1
Orakzai, N1
Khan, I1
Ahmad, M1
Moradi, M1
Derakhshandeh, K1
Karimian, B1
Fasihi, M1
Ayyildiz, A2
Nuhoglu, B2
Gülerkaya, B1
Caydere, M1
Ustün, H1
Germiyanoglu, C1
Erol, D1
Mazdak, H1
Meshki, I1
Ghassami, F1
Mundy, AR1
Akgül, T1
Ng, CF1
Chan, SY1

Reviews

3 reviews available for mitomycin and Anterior Urethral Stricture

ArticleYear
Efficacy of Mitomycin C Combined with Direct Vision Internal Urethrotomy for Urethral Strictures: A Systematic Review and Meta-Analysis.
    Urologia internationalis, 2023, Volume: 107, Issue:4

    Topics: Humans; Mitomycin; Recurrence; Urethra; Urethral Stricture

2023
Efficacy and safety of injection treatment after internal urethrotomy on the prevention of stricture recurrence: a network meta-analysis.
    Minerva chirurgica, 2020, Volume: 75, Issue:6

    Topics: Antibiotics, Antineoplastic; Decision Trees; Humans; Mitomycin; Network Meta-Analysis; Placebos; Pla

2020
A Systematic Review and Meta-analysis of Adjuncts to Minimally Invasive Treatment of Urethral Stricture in Men.
    European urology, 2021, Volume: 80, Issue:4

    Topics: Captopril; Humans; Injections, Intralesional; Male; Mitomycin; Recurrence; Tamoxifen; Triamcinolone;

2021

Trials

3 trials available for mitomycin and Anterior Urethral Stricture

ArticleYear
Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy.
    Korean journal of urology, 2015, Volume: 56, Issue:9

    Topics: Adult; Follow-Up Studies; Humans; Injections, Intralesional; Male; Middle Aged; Mitomycin; Nucleic A

2015
Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy.
    Journal of injury & violence research, 2016, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Humans; Hydrogel,

2016
Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy.
    European urology, 2007, Volume: 51, Issue:4

    Topics: Adolescent; Adult; Aged; Humans; Male; Middle Aged; Mitomycin; Recurrence; Urethra; Urethral Strictu

2007

Other Studies

15 other studies available for mitomycin and Anterior Urethral Stricture

ArticleYear
The Effect of Radiation Therapy on the Efficacy of Internal Urethrotomy With Intralesional Mitomycin C for Recurrent Vesicourethral Anastomotic Stenoses and Bladder Neck Contractures: A Multi-Institutional Experience.
    Urology, 2021, Volume: 147

    Topics: Aged; Anastomosis, Surgical; Combined Modality Therapy; Cryosurgery; Follow-Up Studies; Humans; Inje

2021
Internal Urethrotomy With Intralesional Mitomycin C: An Effective Option for Endoscopic Management of Recurrent Bulbar and Bulbomembranous Urethral Strictures.
    Urology, 2017, Volume: 110

    Topics: Antibiotics, Antineoplastic; Combined Modality Therapy; Endoscopy; Humans; Injections, Intralesional

2017
Mitomycin-C and urethral dilatation: A safe, effective, and minimally invasive procedure for recurrent vesicourethral anastomotic stenoses.
    Urologic oncology, 2017, Volume: 35, Issue:12

    Topics: Aged; Anastomosis, Surgical; Antibiotics, Antineoplastic; Cystoscopy; Dilatation; Follow-Up Studies;

2017
Mitomycin C in the treatment of anterior urethral strictures.
    Nature reviews. Urology, 2018, Volume: 15, Issue:12

    Topics: Animals; Combined Modality Therapy; Humans; Mitomycin; Rats; Treatment Outcome; Urethra; Urethral St

2018
[Endoscopic management of anterior urethral strictures by use of direct visual internal urethrotomy with mitomycin C and clean intermittent catheterization].
    Der Urologe. Ausg. A, 2019, Volume: 58, Issue:7

    Topics: Antibiotics, Antineoplastic; Endoscopy; Humans; Intermittent Urethral Catheterization; Male; Mitomyc

2019
Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model.
    Journal of endourology, 2014, Volume: 28, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Collagen; Disease

2014
Morphological effects of mitomycin C on urothelial responses to experimentally-induced urethral stricture in rats.
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:7

    Topics: Animals; Cell Proliferation; Disease Models, Animal; DNA Damage; Male; Mitomycin; Nucleic Acid Synth

2015
Editorial Comment to Morphological effects of mitomycin C on urothelial responses to experimentally-induced urethral stricture in rats.
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:7

    Topics: Animals; Male; Mitomycin; Nucleic Acid Synthesis Inhibitors; Urethra; Urethral Stricture; Urothelium

2015
Visual Internal Urethrotomy With Intralesional Mitomycin C and Short-term Clean Intermittent Catheterization for the Management of Recurrent Urethral Strictures and Bladder Neck Contractures.
    Urology, 2015, Volume: 85, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Contracture; Humans; Injections, Intrales

2015
Editorial Comment.
    Urology, 2015, Volume: 85, Issue:6

    Topics: Contracture; Humans; Intermittent Urethral Catheterization; Male; Mitomycin; Urethra; Urethral Stric

2015
Reply: To PMID 26099892.
    Urology, 2015, Volume: 85, Issue:6

    Topics: Contracture; Humans; Intermittent Urethral Catheterization; Male; Mitomycin; Urethra; Urethral Stric

2015
Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.
    International journal of urology : official journal of the Japanese Urological Association, 2004, Volume: 11, Issue:12

    Topics: Animals; Antibiotics, Antineoplastic; Cicatrix; Disease Models, Animal; Dose-Response Relationship,

2004
Adjuncts to visual internal urethrotomy to reduce the recurrence rate of anterior urethral strictures.
    European urology, 2007, Volume: 51, Issue:6

    Topics: Adolescent; Adult; Aged; Humans; Male; Middle Aged; Mitomycin; Recurrence; Urethra; Urethral Strictu

2007
Re: Hamid Mazdak, Iraj Meshki and Fatemeh Ghassami. Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy. Eur Urol 2007;51:1089-92.
    European urology, 2007, Volume: 52, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Humans; Mitomycin; Rats; Secondary Pre

2007
Re: Hamid Mazdak, Iraj Meshki and Fatemeh Ghassami. Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy. Eur Urol 2007;51:1089-92.
    European urology, 2007, Volume: 52, Issue:3

    Topics: Antibiotics, Antineoplastic; Follow-Up Studies; Humans; Mitomycin; Secondary Prevention; Treatment O

2007