mitomycin has been researched along with Aneuploid in 27 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunofluorescent staining of kinetochores in micronuclei (MN) of cytochalasin-B-blocked cells was used to distinguish between clastogenic and aneuploidogenic effects of cigarette smoke condensate (CSC), mitomycin C (MMC) and vincristine sulfate (VS) in Chinese hamster lung V79 cells by using an anti-kinetochore antibody." | 7.68 | Clastogenic and aneuploidogenic effects of cigarette smoke condensate, mitomycin C and vincristine sulfate. ( Nath, J; Ong, T, 1992) |
| " CHB were induced by the clastogen mitomycin C (MMC) as well as by the aneuploidogen colcemid, with frequencies similar to MN in both cases, and to multinucleated cells in the case of colcemid." | 3.71 | Micronuclei and chromatid buds are the result of related genotoxic events. ( Montero-Montoya, R; Serrano-García, L, 2001) |
| "We evaluated the DNA cytophotometry in 446 bladder washing samples from 64 patients under mitomycin C after superficial bladder cancer during an observation period of up to 5 years." | 3.69 | Cytophotometry in the monitoring of bladder cancer under intravesical chemotherapy. ( Foeger, A; Maier, U; Marberger, M; Simak, R; Susani, M; Wiener, H; Zhang, ZF, 1996) |
| "The influence of sampling time on the frequencies of micronuclei, centromere-positive micronuclei and chromosome nondisjunction was investigated in binucleated lymphocytes following treatment with a known clastogen (mitomycin C) or an aneuploidy-inducing agent (vincristine sulfate)." | 3.69 | Micronuclei, centromere-positive micronuclei and chromosome nondisjunction in cytokinesis blocked human lymphocytes following mitomycin C or vincristine treatment. ( Antoccia, A; Degrassi, F; Marcos, R; Ramirez, MJ; Sgura, A; Tanzarella, C, 1997) |
| "Micronuclei (MN) obtained from mouse bone marrow cells, in vivo exposed to 3 typical clastogens (procarbazine, azathioprine, ethyl methanesulfonate) and 3 typical aneuploidogens (vinblastine, tubulazole, colchicine), were examined for C-band, area and DNA content." | 3.68 | Discrimination of aneuploidogens from clastogens by C-banding, DNA and area measurements of micronuclei from mouse bone marrow. ( Deleener, A; Kirsch-Volders, M; Van Hummelen, P; Vanparys, P, 1992) |
| "The possibility of using a micronucleus (MN) assay in mouse germ cells for the identification of aneuploidogenic agents was evaluated by comparing the pattern of effects induced by 4 chemicals with different mechanisms of action (adriamycin, ADM; mitomycin C, MMC; chloral hydrate, CH; ethylenedinitrilotetraacetic acid, EDTA)." | 3.68 | Detection of aneuploidy in male germ cells of mice by means of a meiotic micronucleus assay. ( Levis, AG; Russo, A, 1992) |
| "19 advanced gastric cancer (AGC) patients were divided into the following groups: group A (n = 7): in addition to their oral intake, received a PNS for 5 days, which yielded 117 Kj." | 2.67 | [Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients]. ( Cao, WX; Xiao, HB; Yin, HR, 1994) |
| "it induces aneuploidy) of DEB, no mechanism was suggested to explain such observations." | 1.43 | 1,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes. ( Barajas Torres, RL; Borjas Gutiérrez, C; Domínguez Cruz, MD; González García, JR; Magaña Torres, MT; Ramírez Dueñas, Mde L, 2016) |
| "Aneuploidy was confirmed using G-banding combined with chromosome painting analysis for mutants showing LOH at every microsatellite marker on chromosome 11." | 1.35 | The mouse lymphoma assay detects recombination, deletion, and aneuploidy. ( Chen, L; Chen, T; Honma, M; Mei, N; Moore, MM; Sawyer, JR; Wang, J, 2009) |
| "A possible predisposition to aneuploidy in trisomic 21 individuals, their parents, and a control group was evaluated." | 1.31 | Aneuploidy induced in lymphocytes of parents of trisomic 21 children. ( Caria, H; Chaveca, T; Rueff, J, 2001) |
| "Benzo[a]pyrene (BP) induced aneuploidy at 2." | 1.30 | Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79. ( Glatt, HR; Hayashi, M; Matsuoka, A; Ozaki, M; Sakamoto, H; Sofuni, T; Takeshita, K, 1997) |
| "DNA cytometry showed nonaneuploidy in all of these." | 1.30 | Cytologic and DNA cytometric diagnosis and therapy monitoring of squamous cell carcinoma in situ and malignant melanoma of the cornea and conjunctiva. ( Böcking, A; Kersten, A; Krallmann, R; Motherby, H; Nadjari, B; Ross, B; Sundmacher, R, 1999) |
| "Mitomycin-C (MMC) was used as a positive control for the induction of micronuclei." | 1.29 | The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens. ( Lynch, AM; Parry, JM, 1993) |
| "Histologically, aneuploidy was detected in 71." | 1.29 | [Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]. ( Miyagi, M; Nakashima, T; Soda, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 17 (62.96) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barajas Torres, RL | 1 |
| Domínguez Cruz, MD | 1 |
| Borjas Gutiérrez, C | 1 |
| Ramírez Dueñas, Mde L | 1 |
| Magaña Torres, MT | 1 |
| González García, JR | 1 |
| Wang, J | 1 |
| Sawyer, JR | 1 |
| Chen, L | 1 |
| Chen, T | 1 |
| Honma, M | 1 |
| Mei, N | 1 |
| Moore, MM | 1 |
| Dezentje, DA | 1 |
| Arking, DE | 1 |
| Kortenhorst, MS | 1 |
| West, K | 1 |
| Chakravarti, A | 1 |
| Kern, SE | 1 |
| Salazar, AM | 1 |
| Miller, HL | 1 |
| McNeely, SC | 1 |
| Sordo, M | 1 |
| Ostrosky-Wegman, P | 1 |
| States, JC | 1 |
| Attia, SM | 1 |
| Kliesch, U | 1 |
| Schriever-Schwemmer, G | 1 |
| Badary, OA | 1 |
| Hamada, FM | 1 |
| Adler, ID | 1 |
| Rosefort, C | 1 |
| Fauth, E | 1 |
| Zankl, H | 1 |
| Raouf, A | 1 |
| Brown, L | 1 |
| Vrcelj, N | 1 |
| To, K | 1 |
| Kwok, W | 1 |
| Huntsman, D | 1 |
| Eaves, CJ | 1 |
| Schneider, BM | 1 |
| Würgler, FE | 1 |
| Romagna, F | 1 |
| Lynch, AM | 1 |
| Parry, JM | 1 |
| Miyagi, M | 1 |
| Soda, T | 1 |
| Nakashima, T | 1 |
| Cao, WX | 1 |
| Xiao, HB | 1 |
| Yin, HR | 1 |
| Elhajouji, A | 1 |
| Van Hummelen, P | 2 |
| Kirsch-Volders, M | 2 |
| Simak, R | 1 |
| Wiener, H | 1 |
| Foeger, A | 1 |
| Susani, M | 1 |
| Zhang, ZF | 1 |
| Maier, U | 1 |
| Marberger, M | 1 |
| Russo, A | 2 |
| Priante, G | 1 |
| Tommasi, AM | 1 |
| Sgura, A | 1 |
| Antoccia, A | 1 |
| Ramirez, MJ | 1 |
| Marcos, R | 1 |
| Tanzarella, C | 1 |
| Degrassi, F | 1 |
| Matsuoka, A | 2 |
| Ozaki, M | 1 |
| Takeshita, K | 1 |
| Sakamoto, H | 2 |
| Glatt, HR | 1 |
| Hayashi, M | 2 |
| Sofuni, T | 2 |
| Liu, YG | 1 |
| Wu, ZL | 1 |
| Chen, JK | 1 |
| Matsuura, K | 1 |
| Nadjari, B | 1 |
| Kersten, A | 1 |
| Ross, B | 1 |
| Motherby, H | 1 |
| Krallmann, R | 1 |
| Sundmacher, R | 1 |
| Böcking, A | 1 |
| Serrano-García, L | 1 |
| Montero-Montoya, R | 1 |
| Caria, H | 1 |
| Chaveca, T | 1 |
| Rueff, J | 1 |
| Deleener, A | 1 |
| Vanparys, P | 2 |
| Levis, AG | 1 |
| Nath, J | 1 |
| Ong, T | 1 |
| Rudd, NL | 1 |
| Williams, SE | 1 |
| Evans, M | 1 |
| Hennig, UG | 1 |
| Hoar, DI | 1 |
| Vermeiren, F | 1 |
| Sysmans, M | 1 |
| Temmerman, R | 1 |
| Thomson, EJ | 1 |
| Perry, PE | 1 |
1 trial available for mitomycin and Aneuploid
| Article | Year |
|---|---|
[Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients].
Topics: Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Chemotherapy, A | 1994 |
26 other studies available for mitomycin and Aneuploid
| Article | Year |
|---|---|
1,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes.
Topics: Aneuploidy; Butadienes; Cells, Cultured; Epoxy Compounds; Healthy Volunteers; Humans; Lymphocytes; M | 2016 |
The mouse lymphoma assay detects recombination, deletion, and aneuploidy.
Topics: Aneuploidy; Animals; Antimetabolites; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Prol | 2009 |
Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects.
Topics: Aneuploidy; Cell Line, Tumor; Dose-Response Relationship, Drug; Fanconi Anemia Complementation Group | 2009 |
Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy.
Topics: Aneuploidy; Arsenites; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kina | 2010 |
Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by fluorescence in situ hybridization with the mouse minor satellite DNA probe.
Topics: Aneugens; Aneuploidy; Animals; Antibiotics, Antineoplastic; Bone Marrow; Chromosomes; Colchicine; DN | 2003 |
Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay.
Topics: Adult; Aneugens; Aneuploidy; Chromosomes, Human, X; Cytokinesis; Diminazene; Female; Humans; In Vitr | 2004 |
Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY.
Topics: Aneuploidy; Antibiotics, Antineoplastic; BRCA2 Protein; Breast; Breast Neoplasms; Cross-Linking Reag | 2005 |
Distinct area distribution differences of micronuclei induced by clastogenic and aneuploidogenic chemicals in the bone marrow of the CD-1 mouse.
Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Male; Mice; Micronuclei, Chro | 1995 |
The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Centromere; Chloral Hydrat | 1993 |
[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck].
Topics: Adult; Aged; Aged, 80 and over; Aneuploidy; Antineoplastic Agents; Carbazilquinone; Carcinoma, Squam | 1994 |
Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes.
Topics: Adult; Aneuploidy; Benzimidazoles; Carbamates; Cell Division; Cell Survival; Cells, Cultured; Centro | 1995 |
Cytophotometry in the monitoring of bladder cancer under intravesical chemotherapy.
Topics: Administration, Intravesical; Aged; Aneuploidy; Antibiotics, Antineoplastic; Carcinoma, Transitional | 1996 |
PRINS localization of centromeres and telomeres in micronuclei indicates that in mouse splenocytes chromatid non-disjunction is a major mechanism of aneuploidy.
Topics: Aneuploidy; Animals; Centromere; Demecolcine; DNA; DNA, Satellite; In Situ Hybridization; Male; Mice | 1996 |
Micronuclei, centromere-positive micronuclei and chromosome nondisjunction in cytokinesis blocked human lymphocytes following mitomycin C or vincristine treatment.
Topics: Aneuploidy; Cell Division; Centromere; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 7; Cyto | 1997 |
Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Cycle; Cell Line; CHO Ce | 1997 |
Differential effects of aneugens and clastogens on incidences of multinucleated cells and of micronucleate cells in Chinese hamster lung (V79) cell line in vitro.
Topics: Aneuploidy; Animals; Cell Line; Cell Nucleus; Colchicine; Cricetinae; Cricetulus; Cyclophosphamide; | 1998 |
A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Line; Cricetinae; Cricet | 1999 |
Cytologic and DNA cytometric diagnosis and therapy monitoring of squamous cell carcinoma in situ and malignant melanoma of the cornea and conjunctiva.
Topics: Aneuploidy; Antibiotics, Antineoplastic; Carcinoma in Situ; Carcinoma, Squamous Cell; Conjunctival N | 1999 |
Micronuclei and chromatid buds are the result of related genotoxic events.
Topics: Aneuploidy; Animals; Chromatids; Demecolcine; Humans; Micronuclei, Chromosome-Defective; Mitomycin; | 2001 |
Aneuploidy induced in lymphocytes of parents of trisomic 21 children.
Topics: Adult; Aneuploidy; Cyclophosphamide; Down Syndrome; Humans; Lymphocytes; Micronuclei, Chromosome-Def | 2001 |
Discrimination of aneuploidogens from clastogens by C-banding, DNA and area measurements of micronuclei from mouse bone marrow.
Topics: Aneuploidy; Animals; Azacitidine; Azathioprine; Bone Marrow; Chromosome Banding; Colchicine; Dioxola | 1992 |
Detection of aneuploidy in male germ cells of mice by means of a meiotic micronucleus assay.
Topics: Aneuploidy; Animals; Chloral Hydrate; Doxorubicin; Edetic Acid; Male; Meiosis; Mice; Mice, Inbred BA | 1992 |
Clastogenic and aneuploidogenic effects of cigarette smoke condensate, mitomycin C and vincristine sulfate.
Topics: Aneuploidy; Animals; Cell Line; Cricetinae; Micronucleus Tests; Mitomycin; Mutagens; Nicotiana; Plan | 1992 |
Kinetochore analysis of micronuclei allows insights into the actions of colcemid and mitomycin C.
Topics: Aneuploidy; Chromosome Aberrations; Demecolcine; Evaluation Studies as Topic; Fibroblasts; Fluoresce | 1991 |
The micronucleus assay as a test for the detection of aneugenic activity.
Topics: Aneuploidy; Animals; Azathioprine; Bone Marrow; Cell Division; Colchicine; Cyclophosphamide; Dioxola | 1990 |
The identification of micronucleated chromosomes: a possible assay for aneuploidy.
Topics: Aneuploidy; Cells, Cultured; Chromosomes; Demecolcine; Dose-Response Relationship, Radiation; Fluore | 1988 |