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mitomycin and Aneuploid

mitomycin has been researched along with Aneuploid in 27 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Research Excerpts

ExcerptRelevanceReference
"Immunofluorescent staining of kinetochores in micronuclei (MN) of cytochalasin-B-blocked cells was used to distinguish between clastogenic and aneuploidogenic effects of cigarette smoke condensate (CSC), mitomycin C (MMC) and vincristine sulfate (VS) in Chinese hamster lung V79 cells by using an anti-kinetochore antibody."7.68Clastogenic and aneuploidogenic effects of cigarette smoke condensate, mitomycin C and vincristine sulfate. ( Nath, J; Ong, T, 1992)
" CHB were induced by the clastogen mitomycin C (MMC) as well as by the aneuploidogen colcemid, with frequencies similar to MN in both cases, and to multinucleated cells in the case of colcemid."3.71Micronuclei and chromatid buds are the result of related genotoxic events. ( Montero-Montoya, R; Serrano-García, L, 2001)
"We evaluated the DNA cytophotometry in 446 bladder washing samples from 64 patients under mitomycin C after superficial bladder cancer during an observation period of up to 5 years."3.69Cytophotometry in the monitoring of bladder cancer under intravesical chemotherapy. ( Foeger, A; Maier, U; Marberger, M; Simak, R; Susani, M; Wiener, H; Zhang, ZF, 1996)
"The influence of sampling time on the frequencies of micronuclei, centromere-positive micronuclei and chromosome nondisjunction was investigated in binucleated lymphocytes following treatment with a known clastogen (mitomycin C) or an aneuploidy-inducing agent (vincristine sulfate)."3.69Micronuclei, centromere-positive micronuclei and chromosome nondisjunction in cytokinesis blocked human lymphocytes following mitomycin C or vincristine treatment. ( Antoccia, A; Degrassi, F; Marcos, R; Ramirez, MJ; Sgura, A; Tanzarella, C, 1997)
"Micronuclei (MN) obtained from mouse bone marrow cells, in vivo exposed to 3 typical clastogens (procarbazine, azathioprine, ethyl methanesulfonate) and 3 typical aneuploidogens (vinblastine, tubulazole, colchicine), were examined for C-band, area and DNA content."3.68Discrimination of aneuploidogens from clastogens by C-banding, DNA and area measurements of micronuclei from mouse bone marrow. ( Deleener, A; Kirsch-Volders, M; Van Hummelen, P; Vanparys, P, 1992)
"The possibility of using a micronucleus (MN) assay in mouse germ cells for the identification of aneuploidogenic agents was evaluated by comparing the pattern of effects induced by 4 chemicals with different mechanisms of action (adriamycin, ADM; mitomycin C, MMC; chloral hydrate, CH; ethylenedinitrilotetraacetic acid, EDTA)."3.68Detection of aneuploidy in male germ cells of mice by means of a meiotic micronucleus assay. ( Levis, AG; Russo, A, 1992)
"19 advanced gastric cancer (AGC) patients were divided into the following groups: group A (n = 7): in addition to their oral intake, received a PNS for 5 days, which yielded 117 Kj."2.67[Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients]. ( Cao, WX; Xiao, HB; Yin, HR, 1994)
"it induces aneuploidy) of DEB, no mechanism was suggested to explain such observations."1.431,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes. ( Barajas Torres, RL; Borjas Gutiérrez, C; Domínguez Cruz, MD; González García, JR; Magaña Torres, MT; Ramírez Dueñas, Mde L, 2016)
"Aneuploidy was confirmed using G-banding combined with chromosome painting analysis for mutants showing LOH at every microsatellite marker on chromosome 11."1.35The mouse lymphoma assay detects recombination, deletion, and aneuploidy. ( Chen, L; Chen, T; Honma, M; Mei, N; Moore, MM; Sawyer, JR; Wang, J, 2009)
"A possible predisposition to aneuploidy in trisomic 21 individuals, their parents, and a control group was evaluated."1.31Aneuploidy induced in lymphocytes of parents of trisomic 21 children. ( Caria, H; Chaveca, T; Rueff, J, 2001)
"Benzo[a]pyrene (BP) induced aneuploidy at 2."1.30Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79. ( Glatt, HR; Hayashi, M; Matsuoka, A; Ozaki, M; Sakamoto, H; Sofuni, T; Takeshita, K, 1997)
"DNA cytometry showed nonaneuploidy in all of these."1.30Cytologic and DNA cytometric diagnosis and therapy monitoring of squamous cell carcinoma in situ and malignant melanoma of the cornea and conjunctiva. ( Böcking, A; Kersten, A; Krallmann, R; Motherby, H; Nadjari, B; Ross, B; Sundmacher, R, 1999)
"Mitomycin-C (MMC) was used as a positive control for the induction of micronuclei."1.29The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens. ( Lynch, AM; Parry, JM, 1993)
"Histologically, aneuploidy was detected in 71."1.29[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]. ( Miyagi, M; Nakashima, T; Soda, T, 1994)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's17 (62.96)18.2507
2000's7 (25.93)29.6817
2010's2 (7.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barajas Torres, RL1
Domínguez Cruz, MD1
Borjas Gutiérrez, C1
Ramírez Dueñas, Mde L1
Magaña Torres, MT1
González García, JR1
Wang, J1
Sawyer, JR1
Chen, L1
Chen, T1
Honma, M1
Mei, N1
Moore, MM1
Dezentje, DA1
Arking, DE1
Kortenhorst, MS1
West, K1
Chakravarti, A1
Kern, SE1
Salazar, AM1
Miller, HL1
McNeely, SC1
Sordo, M1
Ostrosky-Wegman, P1
States, JC1
Attia, SM1
Kliesch, U1
Schriever-Schwemmer, G1
Badary, OA1
Hamada, FM1
Adler, ID1
Rosefort, C1
Fauth, E1
Zankl, H1
Raouf, A1
Brown, L1
Vrcelj, N1
To, K1
Kwok, W1
Huntsman, D1
Eaves, CJ1
Schneider, BM1
Würgler, FE1
Romagna, F1
Lynch, AM1
Parry, JM1
Miyagi, M1
Soda, T1
Nakashima, T1
Cao, WX1
Xiao, HB1
Yin, HR1
Elhajouji, A1
Van Hummelen, P2
Kirsch-Volders, M2
Simak, R1
Wiener, H1
Foeger, A1
Susani, M1
Zhang, ZF1
Maier, U1
Marberger, M1
Russo, A2
Priante, G1
Tommasi, AM1
Sgura, A1
Antoccia, A1
Ramirez, MJ1
Marcos, R1
Tanzarella, C1
Degrassi, F1
Matsuoka, A2
Ozaki, M1
Takeshita, K1
Sakamoto, H2
Glatt, HR1
Hayashi, M2
Sofuni, T2
Liu, YG1
Wu, ZL1
Chen, JK1
Matsuura, K1
Nadjari, B1
Kersten, A1
Ross, B1
Motherby, H1
Krallmann, R1
Sundmacher, R1
Böcking, A1
Serrano-García, L1
Montero-Montoya, R1
Caria, H1
Chaveca, T1
Rueff, J1
Deleener, A1
Vanparys, P2
Levis, AG1
Nath, J1
Ong, T1
Rudd, NL1
Williams, SE1
Evans, M1
Hennig, UG1
Hoar, DI1
Vermeiren, F1
Sysmans, M1
Temmerman, R1
Thomson, EJ1
Perry, PE1

Trials

1 trial available for mitomycin and Aneuploid

ArticleYear
[Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1994, Volume: 16, Issue:2

    Topics: Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Chemotherapy, A

1994

Other Studies

26 other studies available for mitomycin and Aneuploid

ArticleYear
1,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes.
    Cytogenetic and genome research, 2016, Volume: 148, Issue:2-3

    Topics: Aneuploidy; Butadienes; Cells, Cultured; Epoxy Compounds; Healthy Volunteers; Humans; Lymphocytes; M

2016
The mouse lymphoma assay detects recombination, deletion, and aneuploidy.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:1

    Topics: Aneuploidy; Animals; Antimetabolites; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Prol

2009
Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects.
    Cancer biology & therapy, 2009, Volume: 8, Issue:4

    Topics: Aneuploidy; Cell Line, Tumor; Dose-Response Relationship, Drug; Fanconi Anemia Complementation Group

2009
Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy.
    Chemical research in toxicology, 2010, Feb-15, Volume: 23, Issue:2

    Topics: Aneuploidy; Arsenites; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kina

2010
Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by fluorescence in situ hybridization with the mouse minor satellite DNA probe.
    Environmental and molecular mutagenesis, 2003, Volume: 41, Issue:2

    Topics: Aneugens; Aneuploidy; Animals; Antibiotics, Antineoplastic; Bone Marrow; Chromosomes; Colchicine; DN

2003
Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay.
    Mutagenesis, 2004, Volume: 19, Issue:4

    Topics: Adult; Aneugens; Aneuploidy; Chromosomes, Human, X; Cytokinesis; Diminazene; Female; Humans; In Vitr

2004
Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY.
    Journal of the National Cancer Institute, 2005, Sep-07, Volume: 97, Issue:17

    Topics: Aneuploidy; Antibiotics, Antineoplastic; BRCA2 Protein; Breast; Breast Neoplasms; Cross-Linking Reag

2005
Distinct area distribution differences of micronuclei induced by clastogenic and aneuploidogenic chemicals in the bone marrow of the CD-1 mouse.
    Mutation research, 1995, Volume: 334, Issue:1

    Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Male; Mice; Micronuclei, Chro

1995
The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens.
    Mutation research, 1993, Volume: 287, Issue:1

    Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Centromere; Chloral Hydrat

1993
[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck].
    Nihon Jibiinkoka Gakkai kaiho, 1994, Volume: 97, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aneuploidy; Antineoplastic Agents; Carbazilquinone; Carcinoma, Squam

1994
Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes.
    Environmental and molecular mutagenesis, 1995, Volume: 26, Issue:4

    Topics: Adult; Aneuploidy; Benzimidazoles; Carbamates; Cell Division; Cell Survival; Cells, Cultured; Centro

1995
Cytophotometry in the monitoring of bladder cancer under intravesical chemotherapy.
    European urology, 1996, Volume: 29, Issue:4

    Topics: Administration, Intravesical; Aged; Aneuploidy; Antibiotics, Antineoplastic; Carcinoma, Transitional

1996
PRINS localization of centromeres and telomeres in micronuclei indicates that in mouse splenocytes chromatid non-disjunction is a major mechanism of aneuploidy.
    Mutation research, 1996, Volume: 372, Issue:2

    Topics: Aneuploidy; Animals; Centromere; Demecolcine; DNA; DNA, Satellite; In Situ Hybridization; Male; Mice

1996
Micronuclei, centromere-positive micronuclei and chromosome nondisjunction in cytokinesis blocked human lymphocytes following mitomycin C or vincristine treatment.
    Mutation research, 1997, Aug-01, Volume: 392, Issue:1-2

    Topics: Aneuploidy; Cell Division; Centromere; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 7; Cyto

1997
Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.
    Mutagenesis, 1997, Volume: 12, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Cycle; Cell Line; CHO Ce

1997
Differential effects of aneugens and clastogens on incidences of multinucleated cells and of micronucleate cells in Chinese hamster lung (V79) cell line in vitro.
    Mutation research, 1998, Feb-23, Volume: 413, Issue:1

    Topics: Aneuploidy; Animals; Cell Line; Cell Nucleus; Colchicine; Cricetinae; Cricetulus; Cyclophosphamide;

1998
A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test.
    Mutagenesis, 1999, Volume: 14, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Line; Cricetinae; Cricet

1999
Cytologic and DNA cytometric diagnosis and therapy monitoring of squamous cell carcinoma in situ and malignant melanoma of the cornea and conjunctiva.
    Analytical and quantitative cytology and histology, 1999, Volume: 21, Issue:5

    Topics: Aneuploidy; Antibiotics, Antineoplastic; Carcinoma in Situ; Carcinoma, Squamous Cell; Conjunctival N

1999
Micronuclei and chromatid buds are the result of related genotoxic events.
    Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:1

    Topics: Aneuploidy; Animals; Chromatids; Demecolcine; Humans; Micronuclei, Chromosome-Defective; Mitomycin;

2001
Aneuploidy induced in lymphocytes of parents of trisomic 21 children.
    Teratogenesis, carcinogenesis, and mutagenesis, 2001, Volume: 21, Issue:5

    Topics: Adult; Aneuploidy; Cyclophosphamide; Down Syndrome; Humans; Lymphocytes; Micronuclei, Chromosome-Def

2001
Discrimination of aneuploidogens from clastogens by C-banding, DNA and area measurements of micronuclei from mouse bone marrow.
    Mutation research, 1992, Volume: 271, Issue:1

    Topics: Aneuploidy; Animals; Azacitidine; Azathioprine; Bone Marrow; Chromosome Banding; Colchicine; Dioxola

1992
Detection of aneuploidy in male germ cells of mice by means of a meiotic micronucleus assay.
    Mutation research, 1992, Volume: 281, Issue:3

    Topics: Aneuploidy; Animals; Chloral Hydrate; Doxorubicin; Edetic Acid; Male; Meiosis; Mice; Mice, Inbred BA

1992
Clastogenic and aneuploidogenic effects of cigarette smoke condensate, mitomycin C and vincristine sulfate.
    Mutagenesis, 1992, Volume: 7, Issue:6

    Topics: Aneuploidy; Animals; Cell Line; Cricetinae; Micronucleus Tests; Mitomycin; Mutagens; Nicotiana; Plan

1992
Kinetochore analysis of micronuclei allows insights into the actions of colcemid and mitomycin C.
    Mutation research, 1991, Volume: 261, Issue:1

    Topics: Aneuploidy; Chromosome Aberrations; Demecolcine; Evaluation Studies as Topic; Fibroblasts; Fluoresce

1991
The micronucleus assay as a test for the detection of aneugenic activity.
    Mutation research, 1990, Volume: 244, Issue:2

    Topics: Aneuploidy; Animals; Azathioprine; Bone Marrow; Cell Division; Colchicine; Cyclophosphamide; Dioxola

1990
The identification of micronucleated chromosomes: a possible assay for aneuploidy.
    Mutagenesis, 1988, Volume: 3, Issue:5

    Topics: Aneuploidy; Cells, Cultured; Chromosomes; Demecolcine; Dose-Response Relationship, Radiation; Fluore

1988