mitomycin has been researched along with Abnormalities, Autosome in 279 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C (MMC) and diepoxybutane (DEB), while the sensitivity of these patients to ionizing radiation is still controversial." | 7.74 | Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation. ( Mohseni-Meybodi, A; Mozdarani, H; Vosough, P, 2007) |
| "Fanconi anemia (FA) is a clinically and genetically heterogenous disease that is usually diagnosed on the basis of chromosomal instability reflecting the hypersensitivity towards the DNA cross-linking agents diepoxybutane (DEB) and/or mitomycin C." | 7.69 | Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia. ( Friedl, R; Hentze, S; Hoehn, H; Schindler, D; Schroeder-Kurth, T; Seyschab, H; Sun, Y, 1995) |
| "The effects of a bifunctional alkylating agent mitomycin C (MMC), an effective inducer of chromosome aberrations and sister-chromatid exchanges (SCEs), have been studied in untreated leprosy patients." | 7.68 | Differential sensitivity of peripheral blood lymphocytes of untreated leprosy patients to mitomycin C. ( D'Souza, D; Das, BC; Thomas, IM, 1990) |
| "The authors studied the effect of mitomycin C (MMC) and bromodeoxyuridine (BrdU) on the induction of chromosome aberrations on lymphocytes of four patients with Fanconi anemia (FA) and of one normal subject." | 7.68 | Effect of mitomycin C and bromodeoxyuridine on Fanconi anemia lymphocytes. ( Carnevale, A; Frias, S; Mendoza, S; Molina, B, 1991) |
| "Baseline and mitomycin C (MMC)-induced sister chromatid exchanges (SCEs) in two human tumor cell lines (a colon tumor and a melanoma) and in a normal fibroblast cell line were analyzed and compared." | 7.66 | Baseline and mitomycin-C-induced sister chromatic exchanges ina melanoma and a colon tumor cell line. ( Au, WW; Hsu, TC; Li, S; Schmoyer, RL, 1982) |
| "Hydroxyurea (HU) is an agent that induces replicative stress by inhibiting ribonucleotide reductase (RNR), which synthesizes deoxyribonucleotide triphosphates (dNTPs) necessary for DNA replication and repair." | 5.42 | Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells. ( Altamirano-Lozano, M; Carnevale, A; Frias, S; Gómez, L; Marchetti, F; Molina, B; Ortiz, R; Ramos, S; Torres, L, 2015) |
| "Chromosomal aberrations were first measured after exposure to mitomicyn C (MMC) or hydroxyurea (HU)." | 5.35 | Differential expression of TP53 associated genes in Fanconi anemia cells after mitomycin C and hydroxyurea treatment. ( Acuña, H; Coleman, MA; Frias, S; Gómez, L; Hinz, JM; Jones, IM; Martinez, A; Molina, B, 2008) |
| "He had failure to thrive, and has microcephaly, slight facial dysmorphism, and constitutional short stature but no other phenotypic or hematological manifestations of Fanconi anemia (FA)." | 5.33 | A case report of a patient with microcephaly, facial dysmorphism, mitomycin-c-sensitive lymphocytes, and susceptibility to lymphoma. ( Abella, E; Bakhshi, S; Joenje, H; Madgy, D; Mohamed, AN; Oostra, A; Ravindranath, Y; Schindler, D, 2006) |
| "It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C (MMC) and diepoxybutane (DEB), while the sensitivity of these patients to ionizing radiation is still controversial." | 3.74 | Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation. ( Mohseni-Meybodi, A; Mozdarani, H; Vosough, P, 2007) |
| "Fanconi anemia (FA) is an autosomal recessive disorder characterized by aplastic anemia, cancer susceptibility, and cellular sensitivity to mitomycin C." | 3.73 | The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. ( D'Andrea, AD; Gurtan, AM; Stuckert, P, 2006) |
| " Moreover, in human cells exposed to mitomycin C, short interfering RNA-mediated knock-down of BRIP1 leads to a substantial increase in chromosome aberrations, a characteristic phenotype of cells derived from individuals with Fanconi anemia." | 3.73 | The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. ( Bridge, WL; Franklin, RJ; Hiom, K; Vandenberg, CJ, 2005) |
| "Fanconi anemia (FA) is a clinically and genetically heterogenous disease that is usually diagnosed on the basis of chromosomal instability reflecting the hypersensitivity towards the DNA cross-linking agents diepoxybutane (DEB) and/or mitomycin C." | 3.69 | Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia. ( Friedl, R; Hentze, S; Hoehn, H; Schindler, D; Schroeder-Kurth, T; Seyschab, H; Sun, Y, 1995) |
| "Following upon earlier work the response of MCF-7 breast cancer cells to mitomycin C, a known genotoxicant, was examined." | 3.69 | A study of induced genotoxicity in MCF-7 cells. ( Bland, KI; Mark, HF; Naram, R; Santoro, K, 1995) |
| "The effects of a bifunctional alkylating agent mitomycin C (MMC), an effective inducer of chromosome aberrations and sister-chromatid exchanges (SCEs), have been studied in untreated leprosy patients." | 3.68 | Differential sensitivity of peripheral blood lymphocytes of untreated leprosy patients to mitomycin C. ( D'Souza, D; Das, BC; Thomas, IM, 1990) |
| "The authors studied the effect of mitomycin C (MMC) and bromodeoxyuridine (BrdU) on the induction of chromosome aberrations on lymphocytes of four patients with Fanconi anemia (FA) and of one normal subject." | 3.68 | Effect of mitomycin C and bromodeoxyuridine on Fanconi anemia lymphocytes. ( Carnevale, A; Frias, S; Mendoza, S; Molina, B, 1991) |
| "The correction of chromosomal hypersensitivity to mitomycin C (MMC) in Fanconi anemia (FA) human lymphoblasts is observed by growth in a medium conditioned by normal human cells." | 3.68 | Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. I. Involvement of interleukin-6. ( Moustacchi, E; Rosselli, F; Sanceau, J; Wietzerbin, J, 1992) |
| "The level of chromosome aberrations induced by mitomycin C and cytosine arabinoside in the cultured lymphocytes from patients with chronic alcoholism is elevated, as compared to that observed in the cultured lymphocytes of healthy persons." | 3.67 | [Sensitivity of the lymphocyte chromosomes of chronic alcoholism patients to mutagenic exposure]. ( Drozdov, ES; Karon, BI; Lil'in, ET; Nesvizhskiĭ, IuV; Seleznev, IuV, 1985) |
| "Baseline and mitomycin C (MMC)-induced sister chromatid exchanges (SCEs) in two human tumor cell lines (a colon tumor and a melanoma) and in a normal fibroblast cell line were analyzed and compared." | 3.66 | Baseline and mitomycin-C-induced sister chromatic exchanges ina melanoma and a colon tumor cell line. ( Au, WW; Hsu, TC; Li, S; Schmoyer, RL, 1982) |
| "Hydroxyurea (HU) is an agent that induces replicative stress by inhibiting ribonucleotide reductase (RNR), which synthesizes deoxyribonucleotide triphosphates (dNTPs) necessary for DNA replication and repair." | 1.42 | Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells. ( Altamirano-Lozano, M; Carnevale, A; Frias, S; Gómez, L; Marchetti, F; Molina, B; Ortiz, R; Ramos, S; Torres, L, 2015) |
| "Cytogenetic biomarkers such as chromosome aberrations (CAs), sister chromatid exchanges (SCEs) and cytochalasin-B blocked micronuclei (CBMN), were studied in blood lymphocytes treated with radiation, or antineoplastic agent (MMC), and APG." | 1.39 | Modulation of radiation-induced and mitomycin C-induced chromosome damage by apigenin in human lymphocytes in vitro. ( Sharma, NK, 2013) |
| "The rate of chromosomal aberrations was normal in AOA2 cells after treatment with CPT, MMC, H₂O₂ and X-rays." | 1.37 | Role of senataxin in DNA damage and telomeric stability. ( Chessa, L; De Amicis, A; Delia, D; Fanciulli, M; Ferrari, F; Piane, M, 2011) |
| "Pre-treatment with quercetin significantly reduced the frequency of mitomycin C (MMC) induced MN as well as CA, but no clear correlation between the dose and effect could be observed." | 1.37 | Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo. ( Giri, A; Giri, S; Mazumdar, M, 2011) |
| "Mitomycin C (MMC) was used as a positive control." | 1.36 | Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes. ( Abdul, AB; Al-Zubairi, AS; Syam, MM, 2010) |
| " These data indicate that Rad21 gene dosage is critical for the ionising radiation (IR) response." | 1.36 | Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice. ( Appeldoorn, E; Balakrishnan, K; Beasley, M; Bertoncello, I; Bertonchello, I; Essers, J; Lavin, MF; Malaterre, J; McKay, MJ; Ramsay, RG; Thomaszewski, JM; Tomaszewski, JM; Vazquez, M; Verschoor, S; Xu, H; Yan, Y, 2010) |
| "Chromosomal aberrations were first measured after exposure to mitomicyn C (MMC) or hydroxyurea (HU)." | 1.35 | Differential expression of TP53 associated genes in Fanconi anemia cells after mitomycin C and hydroxyurea treatment. ( Acuña, H; Coleman, MA; Frias, S; Gómez, L; Hinz, JM; Jones, IM; Martinez, A; Molina, B, 2008) |
| "Hereditary cases of breast and ovarian cancer are often attributed to germ-line mutations of the BRCA1 tumor suppressor gene." | 1.35 | E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. ( Baer, R; Cheng, JT; Jasin, M; Lokshin, M; Ludwig, T; Modi, AP; Reid, LJ; Shakya, R, 2008) |
| "Apigenin was studied at three different doses i." | 1.35 | Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells. ( Afzal, M; Siddique, YH, 2009) |
| "The treatment of apigenin results in a significant, dose dependent decrease in the genotoxic damage, induced by mitomycin C and cyclophosphamide." | 1.35 | Antigenotoxic effect of apigenin against anti-cancerous drugs. ( Afzal, M; Beg, T; Siddique, YH, 2008) |
| "Next, we examined if chromosome aberrations were induced by exposure of human dental pulp cells (designated here as D824 cells) at seven to nine passages to chemical agents with carcinogenic activity." | 1.33 | In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agents. ( Fisher, LW; Inaba, T; Robey, PG; Tsutsui, T; Tsutsui, TW, 2006) |
| "Results from the chromosomal aberrations assay demonstrated that PbTxs are potent inducers of CHO-K1-BH4 chromosome damage." | 1.33 | The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro. ( Baden, DG; Bourdelais, AJ; Gibson, JE; Hu, Q; Sayer, AN, 2006) |
| "Mitomycin C (MMC) was used as a positive control (2 mg/kg b." | 1.33 | A study on the investigation of cadmium chloride genotoxicity in rat bone marrow using micronucleus test and chromosome aberration analysis. ( Celik, A; Cömelekoğlu, U; Yalin, S, 2005) |
| "He had failure to thrive, and has microcephaly, slight facial dysmorphism, and constitutional short stature but no other phenotypic or hematological manifestations of Fanconi anemia (FA)." | 1.33 | A case report of a patient with microcephaly, facial dysmorphism, mitomycin-c-sensitive lymphocytes, and susceptibility to lymphoma. ( Abella, E; Bakhshi, S; Joenje, H; Madgy, D; Mohamed, AN; Oostra, A; Ravindranath, Y; Schindler, D, 2006) |
| "To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to high-frequency electromagnetic fields (HFEMFs) at 2." | 1.33 | Effect of high-frequency electromagnetic fields with a wide range of SARs on chromosomal aberrations in murine m5S cells. ( Hirose, H; Komatsubara, Y; Koyama, S; Miyakoshi, J; Sakurai, T; Suzuki, Y; Taki, M, 2005) |
| "Mitomycin C (MMC) was also used as positive control (2mg/kg b." | 1.33 | Evaluation of cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow by gavage administration. ( Aşkin, A; Camlica, Y; Celik, A; Cömelekoğlu, U; Mazmanci, B, 2005) |
| "Therefore, genomic instability generated NCCAs are a key driving force in cancer progression." | 1.33 | Stochastic cancer progression driven by non-clonal chromosome aberrations. ( Bremer, SW; Heng, HH; Liu, G; Reddy, PV; Stevens, JB; Tainsky, MA; Wang, YA; Wu, GS; Ye, CJ; Ye, KJ, 2006) |
| "Here we studied chromosome aberrations (CA) and sister chromatid exchanges (SCE) by the use of the crosslinking agent mitomycin C (MMC), in chicken DT40 cells with the HR genes disrupted by targeted replacement." | 1.32 | Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks. ( Sasaki, MS; Sonoda, E; Tachibana, A; Takata, M; Takeda, S, 2004) |
| "Nicotine treatment did not increase the micronucleus frequencies in polychromatic erythrocytes while the positive control compound mitomycin C yielded the expected result." | 1.32 | Nicotine is not clastogenic at doses of 1 or 2 mg/kg body weight given orally to male mice. ( Adler, ID; Attia, SM, 2003) |
| "Mitomycin C (MMC) was used as a positive control (2 mg/kg BW)." | 1.32 | Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow. ( Aşkin, A; Camlica, Y; Celik, A; Cömelekoglu, U; Mazmanci, B, 2003) |
| "A 54-year-old man with colon cancer underwent hemicolectomy." | 1.32 | Therapy-related erythroleukemia caused by the administration of UFT and mitomycin C in a patient with colon cancer. ( Miyazaki, M; Nakamori, Y; Shinohara, K; Taguchi, A; Tominaga, T, 2003) |
| "Werner's syndrome (WS) and Bloom's syndrome (BS) are rare autosomal genetic diseases that predispose to cancer and are associated with genomic instability." | 1.31 | Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients. ( Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H, 2002) |
| "MMC did not induce chromosome aberrations in either cell line treated in G(2) but did with the same effectiveness in both cell lines treated in S-phase." | 1.31 | A comparison of the roles of p53 mutation and AraC inhibition in the enhancement of bleomycin-induced chromatid aberrations in mouse and human cells. ( Allio, T; Donner, EM; Preston, RJ, 2000) |
| "coli host." | 1.31 | Concurrent detection of gene mutations and chromosome aberrations induced by five chemicals in a CHL/IU cell line incorporating a gpt shuttle vector. ( Kaneko, H; Odawara, K; Yamada, T, 2000) |
| "To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to power-line frequency magnetic fields (extremely low frequency magnetic fields; ELFMF) at high-flux densities." | 1.31 | Increased chromatid-type chromosomal aberrations in mouse m5S cells exposed to power-line frequency magnetic fields. ( Ding, GR; Miyakoshi, J; Shingu, K; Yaguchi, H; Yoshida, M, 2000) |
| "Single strand DNA breaks and chromosomal aberrations were measured by comet assay and cytokinesis-blocked micronucleus(CBMN) test in vitro when human lymphocytes were exposed to 2,450-MHz microwave (5." | 1.31 | [Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro]. ( He, J; Jin, L; Lu, D; Zhang, M, 2002) |
| " All dosing was achieved using a dosing volume of 90% (900 microl/ml), and the vehicle control cultures were treated with 900 microl/ml of fully supplemented RPMI culture medium with 1% Pluronic F68." | 1.31 | p-Aramid RFP do not induce chromosomal aberrations in a standardized in vitro genotoxicity assay using human lymphocytes. ( Donner, M; Murli, H; Warheit, DB, 2001) |
| " The results showed a distinct dose-response relationship in the induction of chromosomal aberrations." | 1.30 | [Chromosomal aberrations induced in human spermatozoa by mitomycin C]. ( Cai, M; Huang, J; Huang, T; Liu, X, 1997) |
| "Benzo[a]pyrene (BP) induced aneuploidy at 2." | 1.30 | Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79. ( Glatt, HR; Hayashi, M; Matsuoka, A; Ozaki, M; Sakamoto, H; Sofuni, T; Takeshita, K, 1997) |
| "2 MHz) alone and in combination with a chemical DNA-damaging agent (mitomycin C)." | 1.30 | Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C. ( Collier, M; Maes, A; Van Gorp, U; Vandoninck, S; Verschaeve, L, 1997) |
| "No effect of betaCM on spontaneous chromosome aberrations was found." | 1.30 | Comparative studies on genotoxicity and antigenotoxicity of natural and synthetic beta-carotene stereoisomers. ( Ma, GJ; Qin, HL; Wu, JZ; Xue, KX; Yuan, S, 1998) |
| "High degree of mutagen sensitivity in cancer patients may also be playing a major role in cancer onset at an early age." | 1.30 | Mitomycin C induced chromosomal aberrations in young cancer patients. ( Alladi, P; Bakshi, SR; Bhatavdekar, JM; Patel, DD; Patel, RK; Rawal, UM; Roy, SK; Shah, PM; Trivedi, AH, 1998) |
| "To determine the fate of chromosome aberrations induced primarily by clastogenic chemicals, aberrations of chromosome 9 in cultured human peripheral blood lymphocytes were analyzed after exposure to mitomycin C (MMC) at G(0) phase." | 1.30 | Chromosome-type aberrations induced in chromosome 9 after treatment of human peripheral blood lymphocytes with mitomycin C at the G(0) phase. ( Kusakabe, H; Takahashi, T; Tanaka, N, 1999) |
| "The endpoints studied were chromosome aberrations and damaged cells." | 1.30 | Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C in vivo. ( Mukherjee, A; Mukhopadhyay, MJ; Saha, A, 1998) |
| "Enhancement of chromosome aberrations induced by MMC was observed when CHO K1 cells were treated with Cd2+ during the G1 phase." | 1.29 | Inorganic cadmium increases the frequency of chemically induced chromosome aberrations in cultured mammalian cells. ( Miyahara, T; Sasaki, YF; Yamada, H, 1993) |
| "Trichloroacetic acid (TCA) was tested for its ability to induce chromosomal damage in cultured human peripheral blood lymphocytes and in bone marrow cells of male and female C57BL/6JfBL10/Alpk mice." | 1.29 | Trichloroacetic acid: investigation into the mechanism of chromosomal damage in the in vitro human lymphocyte cytogenetic assay and the mouse bone marrow micronucleus test. ( Coutts, C; Fox, DA; Fox, V; Griffiths, K; Howard, CA; Mackay, JM; Styles, JA; Wyatt, I, 1995) |
| ") doses for dose-response and sub-acute (0." | 1.29 | Use of chick, Gallus domesticus, as an in vivo model for the study of chromosome aberration: a study with mitomycin C and probable location of a 'hot spot'. ( Bhunya, SP; Jena, GB, 1995) |
| "Moreover, chromosomal aberrations were not detected in bone marrow cells of CD-1 male mice, even at high rhEPO concentrations (100,000 IU/kg) in vivo." | 1.29 | Induction of micronucleated erythrocytes by recombinant human erythropoietin. ( Kurata, Y; Sawai, T; Takeshita, Y; Yajima, N, 1993) |
| "The endpoint studied were chromosomal aberrations and damaged cells." | 1.29 | Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo. ( Das, T; Roychoudhury, A; Sharma, A; Talukder, G, 1993) |
| "The cytogenetic endpoints scored were chromosomal aberrations and damaged cells." | 1.29 | Clastogenic activity of pure chlorophyll and anticlastogenic effects of equivalent amounts of crude extract of Indian spinach leaf and chlorophyllin following dietary supplementation to mice. ( Sarkar, D; Sharma, A; Talukder, G, 1996) |
| "MMC was confirmed to increase both chromosome aberrations in Don cells and revertant colonies in TA102." | 1.29 | Microbial mutagenicity and in vitro chromosome aberration induction by FK973, a new antitumor agent. ( Hattori, Y; Hirai, O; Mine, Y; Miyamae, Y; Miyamoto, A; Takashima, M; Zaizen, K, 1994) |
| "This entity of severe intrauterine growth retardation and increased mitomycin C sensitivity is hypothesised to be a distinct chromosome breakage syndrome." | 1.29 | Severe intrauterine growth retardation with increased mitomycin C sensitivity: a further chromosome breakage syndrome. ( Leversha, M; Rogers, JG; Woods, CG, 1995) |
| "The frequency of chromosome aberrations induced by mitomycin C or bleomycin was not changed by o-vanillin treatment." | 1.29 | o-Vanillin enhances chromosome aberrations induced by alkylating agents in cultured Chinese hamster cells. ( Matsumura, H; Ohta, T; Watanabe, K, 1993) |
| "The frequencies of chromosomal aberrations induced by adriamycin and mitomycin C which could be activated by NADPH-cytochrome P-450 reductase were almost the same in the MM1 and CHL cells, suggesting that the reductive activation of these compounds by this enzyme in microsomes may not be involved in the induction of chromosomal aberrations." | 1.28 | Isolation of a menadione-resistant subclone from Chinese hamster lung (CHL) cells in culture. ( Ishidate, M; Sawada, M; Sofuni, T, 1991) |
| " For the study of the main results are as follows: (1) the MMC induced increase in the frequency of aberration cells at metaphase (ACF), that of the frequency of micronucleated cells at G1, S and G2 phases (cultured in vitro, C-MNCF) and that of the frequency of micronucleated cells at G0 phase (Non-cultured, NC-MNCF) are all dose-dependent and their dose-response relation can be described by power regression; (2) the MMC-induced micronucleus formation at G0 phase is not related to chromosome aberration, but the change of NC-MNCF is positively related to the change of CAF as same as C-MNCF; (3) the MMC-induced MNCFs detected in binucleated cells by the cytokinesis block method increase slightly as compared with C-MNCFs, and the ratio of MNCF/ACF is less (about 0." | 1.28 | [Preliminary studies of the relationship between micronucleus formation and cell cycle]. ( Ma, GJ; Shen, ZL; Wang, YP; Xue, KX, 1991) |
| "The frequency of SCEs and chromosome aberrations induced by mitomycin C (MMC) or UV was enhanced by the posttreatment with tea tannin components." | 1.28 | Tea tannin components modify the induction of sister-chromatid exchanges and chromosome aberrations in mutagen-treated cultured mammalian cells and mice. ( Imanishi, H; Kato, T; Ohta, T; Sasaki, YF; Shirasu, Y; Watanabe, M, 1991) |
| "The frequencies of chromosomal aberrations induced by MMC and ENNG were correspondingly decreased at these pH values." | 1.28 | Effect of pH on the activity and stability of clastogens in the in vitro chromosomal aberration test with Chinese hamster ovary K1 cells. ( Fukuda, I; Morita, T; Nagaki, T; Okumura, K, 1991) |
| " The dose-response relationships were the same with or without concomitant treatment with MMC (10(-6) M)." | 1.28 | Quantitative analyses of the induction of chromosome aberrations and sister-chromatid exchanges in human lymphocytes exposed to gamma-rays and mitomycin-C in combination. ( Iijima, K; Morimoto, K, 1991) |
| "Posttreatment with acetaldehyde, the major metabolite of ethanol, also potentiated the chromosome aberrations induced by UV, MMS, MMC or BLM." | 1.28 | Ethanol and acetaldehyde potentiate the clastogenicity of ultraviolet light, methyl methanesulfonate, mitomycin C and bleomycin in Chinese hamster ovary cells. ( Ho, IC; Lee, TC; Lin, YC, 1989) |
| "The frequency of chromosome aberrations observed in the eggs fertilized with sperm recovered from the early spermatid to late spermatocyte stage with X-irradiation of 4 Gy (16-20 days after X-irradiation) was markedly higher than that in the eggs fertilized with sperm recovered from spermatozoa to late spermatid stage (0-8 days after X-irradiation)." | 1.28 | X-ray- and mitomycin C (MMC)-induced chromosome aberrations in spermiogenic germ cells and the repair capacity of mouse eggs for the X-ray and MMC damage. ( Matsuda, Y; Seki, N; Tobari, I; Utsugi-Takeuchi, T, 1989) |
| "Lymphocytes from 21 male smokers, 10 untreated lung cancer patients, and 11 controls were cultured with and without exposure to mitomycin C." | 1.28 | No difference between smoking lung cancer patients and smoking controls in the frequency of spontaneous and mitomycin C induced chromosome aberrations in lymphocytes. ( Johansson, M; Orndal, C, 1989) |
| "A new human colon cancer cell line (020588) has been derived by means of a combined in vitro matrix-in vivo xenograft technique." | 1.28 | A human colon cancer cell line established from collagen matrix cultures transplanted into nude mice. ( Agrez, MV; Chua, FK; Fagan, K; Ferguson, NW; Heath, JW, 1991) |
| "Six female outpatients with Alzheimer's disease (AD) along with four female controls of a similar age range were analyzed for sister chromatid exchangers (SCEs), cell cycle kinetics, and sensitivity to mutagens, in lymphocyte cultures." | 1.27 | Sister chromatid exchanges and cell cycle kinetics in Alzheimer's disease. ( Albu, P; Ferris, SH; Fischman, HK; Rainer, JD; Reisberg, B, 1984) |
| "Lymphocytes from two sisters with Fanconi's anemia (FA) were studied for cell cycle kinetics, sister chromatid exchanges (SCEs), and chromosomal aberrations when they had undergone one, two, or three or more divisions in mitomycin C (MMC)-treated cultures." | 1.27 | Proliferative kinetics and mitomycin C-induced chromosome damage in Fanconi's anemia lymphocytes. ( Koizumi, A; Miura, K; Morimoto, K, 1983) |
| "These results indicate that chromosomal aberrations, especially chromatid breaks and probably gaps, induced by this chemical, effectively contribute to micronucleus formation." | 1.27 | Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow. ( Hayashi, M; Ishidate, M; Sofuni, T, 1984) |
| " Time-response and dose-response were studied for chromosomal aberrations induced by transplacental treatment of mouse embryos." | 1.27 | New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos. ( Adler, ID, 1983) |
| "Three main aspects involved in the chemical induction of anaphase-telophase aberrations in the first mitosis after treatment were analyzed: 1) the relationship between the frequency of anaphase-telophase aberrations and the time of fixation after treatment; 2) the dose-response relationships; and 3) the proliferative rate of cells exposed to chemicals which interact with DNA by different mechanisms." | 1.27 | Anaphase-telophase analysis of chromosomal damage induced by chemicals. ( Dulout, FN; Olivero, OA, 1984) |
| " The data revealed a distinct dose-response effect." | 1.27 | A simplified method for micronucleus preparation from hepatic cells. ( Das, RK; Roy, B, 1988) |
| " This new testing system appears to be a sensitive method of measuring the direct effects of toxic chemicals which yields results in a short term." | 1.27 | Toxic effects of chemicals on mouse post-blastocyst development--a trial to establish a testing system for embryotoxicity. ( Katayama, S; Matsumoto, N, 1985) |
| "The results indicate that Fanconi's anemia lymphocytes fail to exhibit an increased sensitivity to the antimitotic and clastogenic effects of paraquat and streptonigrin." | 1.27 | Cytogenetic toxicity of paraquat and streptonigrin in Fanconi's anemia. ( Arwert, F; de Koning, H; Joenje, H; Nieuwint, AW; Oostra, AB; Roozendaal, KJ, 1987) |
| " For treatments resulting in fewer than 2 lethal hits, MNU, ENU, and MC gave rise to apparently linear dose-response curves for gene mutations (hgprt and tk genes) as well as for chromosomal aberrations." | 1.27 | Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea. ( Jensen, JC; Thilly, WG, 1986) |
| "The formation of chromosome aberrations induced by alkylating agents such as mitomycin C has been shown to require the passage of the treated cell through S phase." | 1.27 | Mitomycin-induced chromatid breaks in HeLa cells: a consequence of incomplete DNA replication. ( Hittelman, WN; Sognier, MA, 1986) |
| "Baseline and mitomycin C (MMC)-induced chromosomal aberrations and sister chromatid exchanges (SCEs) in blood lymphocytes of patients with cervical precancerous and cancerous lesions and normal women were studied." | 1.27 | Mitomycin C induced chromosomal aberrations and sister chromatid exchanges (SCEs) in lymphocytes of patients with precancerous and cancerous lesions of the uterine cervix. ( Das, BC; Luthra, UK; Mitra, AB; Murty, VV; Sharma, A, 1987) |
| "This drug also did not induce chromosomal aberrations in spermatogonium, spermatocyte, or bone marrow cells." | 1.27 | Mutagenicity tests of the antithyroid agent thiamazole. Cytogenetic studies on male mice. ( Hashimoto, T; Komatsu, S; Ohno, S; Takeuchi, K, 1987) |
| "Sensitivity to the induction of chromosomal aberrations by X-rays was also measured." | 1.27 | Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro. ( Dahlberg, WK; Little, JB; Nichols, WW; Nove, J; Strong, LC; Troilo, P, 1987) |
| "Sodium fluoride (NaF) has previously been shown to be clastogenic in vitro in Syrian hamster cells and human fibroblasts." | 1.27 | Extrapolation from in vitro tests to human risk: experience with sodium fluoride clastogenicity. ( Roberts, SA; Scott, D, 1987) |
| "Mitomycin-C treated stocks showed as many as 46." | 1.27 | Effect of mitomycin-C and cyclophosphamide on the polytene chromosomes of Anopheles stephensi (Culicidae:Diptera). ( Chaudhry, A; Dhar, M; Sharma, GP; Sobti, RC, 1987) |
| "Different types of chromosomal aberrations were scored in the first division metaphases." | 1.27 | Caffeine post-treatment causes a shift in the chromosome aberration types induced by mitomycin C, suggesting a caffeine-sensitive mechanism of DNA repair in G2. ( Ceccherini, I; Loprieno, N; Sbrana, I, 1988) |
| "Mitomycin C was routinely used as a positive clastogenic control." | 1.27 | Nitrilotriacetic acid (NTA) does not induce chromosomal damage in mammalian cells either in vitro or in vivo. ( Levis, AG; Mariot, R; Montaldi, A; Paleologo, M; Zordan, M, 1988) |
| "Ring chromosomes were not lost over time as rapidly as predicted by the SCE frequencies observed." | 1.27 | Spontaneous and 3-aminobenzamide-induced sister-chromatid exchange frequencies estimated by ring chromosome analysis. ( Bodycote, J; Doida, Y; Fero, ML; Hahn, P; Kapp, LN; Morgan, WF, 1986) |
| "Post-treatment with vanillin at 500 mg/kg caused about 50% decrease in the frequency of micronucleated polychromatic erythrocytes (MN-PCEs)." | 1.27 | Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin. ( Imanishi, H; Inouye, T; Ohta, T; Sasaki, YF; Shirasu, Y; Watanebe, M, 1988) |
| "Mitomycin C (MMC) treatment of lymphocyte cultures from 6 patients having a Robertsonian translocation showed that in cases 1 and 2, who were already mosaics, MMC induced a statistically significant increase of the number of cells with the dissociated translocation." | 1.27 | Mitomycin C effect on Robertsonian translocations. ( Carnevale, A; Frias, S; Molina, B; Zavaleta, MJ, 1988) |
| " The consistent dose-response relations were obtained in cultures treated with mitomycin C, caffeine and colcemid." | 1.27 | Measurement of micronuclei by cytokinesis-block method in cultured Chinese hamster cells: comparison with types and rates of chromosome aberrations. ( Sasaki, MS; Wakata, A, 1987) |
| "Tests were done to determine whether chromosomal aberrations could be identified in spermatocytes as being responsible for the dominant lethal effects." | 1.26 | Aberration induction by mitomycin C in early primary spermatocytes of mice. ( Adler, ID, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 96 (34.41) | 18.7374 |
| 1990's | 80 (28.67) | 18.2507 |
| 2000's | 71 (25.45) | 29.6817 |
| 2010's | 32 (11.47) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yilmaz, S | 1 |
| Uçar, A | 1 |
| Göktaş, B | 1 |
| Gorniewska, AM | 1 |
| Kluzek, K | 1 |
| Gackowska, L | 1 |
| Kubiszewska, I | 1 |
| Zdzienicka, MZ | 7 |
| Bialkowska, A | 1 |
| Dutta, A | 2 |
| De, R | 1 |
| Dolai, TK | 1 |
| Pal, P | 1 |
| Ghosh, S | 1 |
| Mitra, PK | 1 |
| Halder, A | 1 |
| Yavuz Kocaman, A | 1 |
| Güzelkokar, M | 1 |
| Erikel, E | 1 |
| Yuzbasioglu, D | 1 |
| Unal, F | 1 |
| Sharma, NK | 2 |
| Sevindik, N | 1 |
| Rencuzogullari, E | 2 |
| Liu, G | 2 |
| Stevens, JB | 2 |
| Horne, SD | 1 |
| Abdallah, BY | 1 |
| Ye, KJ | 2 |
| Bremer, SW | 2 |
| Ye, CJ | 2 |
| Chen, DJ | 2 |
| Heng, HH | 2 |
| Shimada, K | 1 |
| Yamamoto, M | 2 |
| Takashima, M | 2 |
| Wako, Y | 1 |
| Kawasako, K | 1 |
| Aoki, Y | 1 |
| Seki, J | 1 |
| Miyamae, Y | 2 |
| Wakata, A | 2 |
| El Ghamrasni, S | 1 |
| Cardoso, R | 1 |
| Halaby, MJ | 1 |
| Zeegers, D | 1 |
| Harding, S | 1 |
| Kumareswaran, R | 1 |
| Yavorska, T | 1 |
| Chami, N | 1 |
| Jurisicova, A | 1 |
| Sanchez, O | 1 |
| Hande, MP | 2 |
| Bristow, R | 1 |
| Hakem, R | 2 |
| Hakem, A | 1 |
| Peng, M | 1 |
| Xie, J | 1 |
| Ucher, A | 1 |
| Stavnezer, J | 1 |
| Cantor, SB | 1 |
| Molina, B | 4 |
| Marchetti, F | 1 |
| Gómez, L | 2 |
| Ramos, S | 1 |
| Torres, L | 1 |
| Ortiz, R | 1 |
| Altamirano-Lozano, M | 1 |
| Carnevale, A | 3 |
| Frias, S | 4 |
| Kataria, SK | 1 |
| Chhillar, AK | 1 |
| Kumar, A | 1 |
| Tomar, M | 1 |
| Malik, V | 1 |
| Abraham, SK | 1 |
| Khandelwal, N | 1 |
| Hintzsche, H | 1 |
| Stopper, H | 1 |
| Beckta, JM | 1 |
| Dever, SM | 1 |
| Gnawali, N | 1 |
| Khalil, A | 1 |
| Sule, A | 1 |
| Golding, SE | 1 |
| Rosenberg, E | 1 |
| Narayanan, A | 1 |
| Kehn-Hall, K | 1 |
| Xu, B | 1 |
| Povirk, LF | 1 |
| Valerie, K | 1 |
| Parplys, AC | 1 |
| Zhao, W | 1 |
| Sharma, N | 1 |
| Groesser, T | 1 |
| Liang, F | 1 |
| Maranon, DG | 1 |
| Leung, SG | 1 |
| Grundt, K | 1 |
| Dray, E | 1 |
| Idate, R | 1 |
| Østvold, AC | 1 |
| Schild, D | 1 |
| Sung, P | 2 |
| Wiese, C | 1 |
| Hashimoto, K | 1 |
| Wada, K | 2 |
| Matsumoto, K | 2 |
| Moriya, M | 1 |
| Rossi, LF | 1 |
| Luaces, JP | 1 |
| Browne, M | 1 |
| Chirino, MG | 1 |
| Merani, MS | 1 |
| Mudry, MD | 1 |
| Marsden, CG | 1 |
| Jensen, RB | 1 |
| Zagelbaum, J | 1 |
| Rothenberg, E | 1 |
| Morrical, SW | 1 |
| Wallace, SS | 1 |
| Sweasy, JB | 1 |
| Martinez, A | 1 |
| Hinz, JM | 1 |
| Acuña, H | 1 |
| Jones, IM | 1 |
| Coleman, MA | 1 |
| Reid, LJ | 1 |
| Shakya, R | 1 |
| Modi, AP | 1 |
| Lokshin, M | 1 |
| Cheng, JT | 1 |
| Jasin, M | 2 |
| Baer, R | 1 |
| Ludwig, T | 1 |
| Siddique, YH | 2 |
| Afzal, M | 2 |
| Li, F | 1 |
| Xu, J | 2 |
| Zhou, J | 1 |
| Zhao, L | 1 |
| Sheng, J | 1 |
| Sun, G | 1 |
| Hu, Q | 3 |
| Kulkarni, R | 1 |
| Reither, A | 1 |
| Thomas, RA | 1 |
| Tucker, JD | 2 |
| van der Lelij, P | 1 |
| Godthelp, BC | 5 |
| van Zon, W | 1 |
| van Gosliga, D | 1 |
| Oostra, AB | 3 |
| Steltenpool, J | 1 |
| de Groot, J | 1 |
| Scheper, RJ | 1 |
| Wolthuis, RM | 1 |
| Waisfisz, Q | 1 |
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| Joenje, H | 6 |
| de Winter, JP | 1 |
| van de Vrugt, HJ | 1 |
| Eaton, L | 1 |
| Hanlon Newell, A | 1 |
| Al-Dhalimy, M | 1 |
| Liskay, RM | 1 |
| Olson, SB | 2 |
| Grompe, M | 2 |
| Perumal, V | 1 |
| Solomon, PF | 1 |
| Jayanth, VR | 1 |
| Hicks, JK | 1 |
| Chute, CL | 1 |
| Paulsen, MT | 1 |
| Ragland, RL | 1 |
| Howlett, NG | 1 |
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| Glover, TW | 1 |
| Canman, CE | 1 |
| Al-Zubairi, AS | 1 |
| Abdul, AB | 1 |
| Syam, MM | 1 |
| Smeenk, G | 1 |
| de Groot, AJ | 1 |
| Romeijn, RJ | 1 |
| van Buul, PP | 3 |
| Mullenders, LH | 2 |
| Pastink, A | 2 |
| Xu, H | 1 |
| Balakrishnan, K | 1 |
| Malaterre, J | 1 |
| Beasley, M | 1 |
| Yan, Y | 1 |
| Essers, J | 3 |
| Appeldoorn, E | 1 |
| Tomaszewski, JM | 1 |
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| Verschoor, S | 1 |
| Lavin, MF | 1 |
| Bertoncello, I | 1 |
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| Ramsay, RG | 1 |
| McKay, MJ | 1 |
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| Piane, M | 1 |
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| Chessa, L | 1 |
| Mazumdar, M | 1 |
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| Kim, TM | 1 |
| Ko, JH | 1 |
| Choi, YJ | 1 |
| Hu, L | 1 |
| Hasty, P | 1 |
| Liao, PH | 1 |
| Lin, RH | 1 |
| Yang, ML | 1 |
| Li, YC | 1 |
| Kuan, YH | 1 |
| Kocaman, AY | 1 |
| Istifli, ES | 1 |
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| Roberts, DJ | 1 |
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| Yurt, P | 1 |
| Thakur, AK | 1 |
| DeVito, GL | 1 |
| Murli, H | 2 |
| Stankowski, LF | 1 |
| Leung, JW | 1 |
| Wang, Y | 1 |
| Fong, KW | 1 |
| Huen, MS | 1 |
| Li, L | 1 |
| Chen, J | 1 |
| Nishimura, K | 1 |
| Ishiai, M | 3 |
| Horikawa, K | 1 |
| Fukagawa, T | 1 |
| Takata, M | 5 |
| Takisawa, H | 1 |
| Kanemaki, MT | 1 |
| Rjiba-Touati, K | 1 |
| Ayed-Boussema, I | 1 |
| Guedri, Y | 1 |
| Achour, A | 1 |
| Bacha, H | 1 |
| Abid, S | 1 |
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| Tanabe, H | 1 |
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| Satoh, T | 2 |
| Sofuni, T | 6 |
| Goto, M | 1 |
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| Sacharczuk, M | 1 |
| Jaszczak, K | 1 |
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| Prasad, S | 1 |
| Naik, P | 1 |
| Vijayalaxmi, KK | 1 |
| Nakamori, Y | 1 |
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| Reifsteck, CA | 1 |
| Speckhart, SA | 1 |
| Jakobs, PM | 2 |
| O'Dwyer, ME | 1 |
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| Hodgson, SV | 1 |
| Mathew, CG | 1 |
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| Bagby, GC | 1 |
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1 review available for mitomycin and Abnormalities, Autosome
| Article | Year |
|---|---|
Current topics in the pathology of bladder cancer.
Topics: Carcinoma in Situ; Carcinoma, Transitional Cell; Chromosome Aberrations; Chromosomes, Human, 1-3; Cy | 1983 |
1 trial available for mitomycin and Abnormalities, Autosome
| Article | Year |
|---|---|
Effect of short-term dietary administration of eugenol in humans.
Topics: Acetaminophen; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Biotransformat | 1996 |
277 other studies available for mitomycin and Abnormalities, Autosome
| Article | Year |
|---|---|
Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit.
Topics: Antineoplastic Agents; Antioxidants; Chromosome Aberrations; Fruit; Fruit and Vegetable Juices; Huma | 2019 |
Distinct cellular phenotype linked to defective DNA interstrand crosslink repair and homologous recombination.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Centrosome; Chromosome Aberrations; Clone Cells; Cric | 2017 |
Incidence of Fanconi anaemia in phenotypically normal aplastic anaemia patients in West Bengal.
Topics: Anemia, Aplastic; Biomarkers; Child; Child, Preschool; Chromosome Aberrations; Fanconi Anemia; Femal | 2018 |
The genotoxic and antigenotoxic potential of the methanolic root extract of Glycyrrhiza glabra L. on human peripheral blood lymphocytes.
Topics: Adult; Chromosome Aberrations; Female; Glycyrrhiza; Humans; Lymphocytes; Male; Micronucleus Tests; M | 2018 |
In vitro genotoxic and antigenotoxic effects of cynarin.
Topics: Adult; Anticarcinogenic Agents; Cells, Cultured; Chromosome Aberrations; Cinnamates; Comet Assay; DN | 2019 |
Modulation of radiation-induced and mitomycin C-induced chromosome damage by apigenin in human lymphocytes in vitro.
Topics: Adult; Antioxidants; Apigenin; Chromosome Aberrations; Drug Interactions; Female; Humans; Lymphocyte | 2013 |
The genotoxic and antigenotoxic effects of Salvia fruticosa leaf extract in human blood lymphocytes.
Topics: Animals; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; | 2014 |
Genome chaos: survival strategy during crisis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chromosomal Instability; Chromosome | 2014 |
Repeated-dose liver micronucleus assay of mitomycin C in young adult rats.
Topics: Age Factors; Animals; Biomarkers; Body Weight; Bone Marrow; Carcinogens; Chromosome Aberrations; Coo | 2015 |
Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.
Topics: Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA E | 2015 |
Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
Topics: Adaptor Proteins, Signal Transducing; Animals; Basic-Leucine Zipper Transcription Factors; BRCA1 Pro | 2014 |
Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells.
Topics: Cell Line; Chromosome Aberrations; Cytogenetic Analysis; Drug Synergism; Fanconi Anemia; G2 Phase; H | 2015 |
Cytogenetic and hematological alterations induced by acute oral exposure of imidacloprid in female mice.
Topics: Administration, Oral; Animals; Blood Sedimentation; Chromosome Aberrations; Dose-Response Relationsh | 2016 |
Antigenotoxic effects of resveratrol: assessment of in vitro and in vivo response.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; | 2016 |
Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining.
Topics: Alanine; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Cell Cycle Proteins; Cell Death; Cel | 2015 |
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Topics: Cell Line; Chromatin; Chromosome Aberrations; DNA; DNA Damage; DNA Replication; DNA-Binding Proteins | 2015 |
Physical interaction between SLX4 (FANCP) and XPF (FANCQ) proteins and biological consequences of interaction-defective missense mutations.
Topics: Amino Acid Sequence; Animals; Chromosome Aberrations; Cockayne Syndrome; DNA Repair; DNA-Binding Pro | 2015 |
Chaetophractus villosus as a sentinel organism: Baseline values of mitotic index, chromosome aberrations and sister chromatid exchanges.
Topics: Animals; Chromosome Aberrations; DNA Damage; Female; Lymphocytes; Male; Mitomycin; Mitotic Index; Si | 2016 |
The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.
Topics: BRCA2 Protein; Breast Neoplasms; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Damage; DN | 2016 |
Differential expression of TP53 associated genes in Fanconi anemia cells after mitomycin C and hydroxyurea treatment.
Topics: Cell Line; Chromosome Aberrations; Cross-Linking Reagents; DNA Damage; Fanconi Anemia; Gene Expressi | 2008 |
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.
Topics: Animals; BRCA1 Protein; Breast Neoplasms; Cell Line; Chromosome Aberrations; Cross-Linking Reagents; | 2008 |
Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells.
Topics: Animals; Antimutagenic Agents; Apigenin; Bone Marrow; Chromosome Aberrations; Dose-Response Relation | 2009 |
Inhibition of mitomycin C-induced chromosomal aberrations by micrometer powder of selenium-enriched green tea in mice spermatocytes.
Topics: Alkylating Agents; Animals; Chromosome Aberrations; Diet; Dietary Supplements; Dose-Response Relatio | 2009 |
Mitochondrial mutant cells are hypersensitive to ionizing radiation, phleomycin and mitomycin C.
Topics: Cell Line; Chromosome Aberrations; Humans; Mitochondria; Mitomycin; Mitotic Index; Mutation; Phleomy | 2009 |
The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.
Topics: Acetyltransferases; Camptothecin; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Chromosome | 2009 |
Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chromosome Aberrations; DNA Mismatch Repair; Embryo, | 2009 |
Modification of 2-deoxy-D-glucose on radiation-and chemotherapeutic drug-induced chromosomal aberrations.
Topics: Antineoplastic Agents; Bleomycin; Cell Line, Tumor; Chromosome Aberrations; Deoxyglucose; Humans; In | 2009 |
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.
Topics: Base Sequence; Cell Cycle; Cell Line; Chromosome Aberrations; Cisplatin; Cross-Linking Reagents; DNA | 2010 |
Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes.
Topics: Adult; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromosome Aberrations; Cytochalasin B; Huma | 2010 |
Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.
Topics: Animals; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Damage; DNA-Binding Proteins; Embryonic | 2010 |
Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.
Topics: Animals; Bone Marrow Cells; Cell Cycle Proteins; Cell Line; Chromosomal Proteins, Non-Histone; Chrom | 2010 |
Role of senataxin in DNA damage and telomeric stability.
Topics: Camptothecin; Cell Line, Tumor; Chromosome Aberrations; DNA Damage; DNA Helicases; DNA Repair; Human | 2011 |
Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo.
Topics: Administration, Oral; Antioxidants; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, | 2011 |
The phenotype of FancB-mutant mouse embryonic stem cells.
Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Chromosome Aberrations; Embryonic Stem | 2011 |
Evaluation of differential representative values between Chinese hamster cells and human lymphocytes in mitomycin C-induced cytogenetic assays and caspase-3 activity.
Topics: Analysis of Variance; Animals; Caspase 3; Caspase Inhibitors; Cell Line; CHO Cells; Chromosome Aberr | 2012 |
In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes.
Topics: Antimutagenic Agents; Bicyclic Monoterpenes; Cell Proliferation; Cell Survival; Cells, Cultured; Chr | 2013 |
Interlaboratory assessment of mitotic index by flow cytometry confirms superior reproducibility relative to microscopic scoring.
Topics: Adult; Benzo(a)pyrene; Chromosome Aberrations; Cyclophosphamide; Etoposide; Flow Cytometry; Humans; | 2012 |
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.
Topics: Amino Acid Sequence; Chromosome Aberrations; Cross-Linking Reagents; DNA Repair; Fanconi Anemia; Fan | 2012 |
Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Topics: Adenosine Triphosphatases; Animals; BRCA2 Protein; Cell Cycle Proteins; Cell Survival; Cells, Cultur | 2012 |
Role of recombinant human erythropoietin in mitomycin C-induced genotoxicity: analysis of DNA fragmentation, chromosome aberrations and micronuclei in rat bone-marrow cells.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; DNA Fra | 2013 |
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Stu | 2002 |
Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia.
Topics: Analgesia; Animals; Bone Marrow Cells; Chromosome Aberrations; Cytogenetics; DNA Repair; Gamma Rays; | 2003 |
Efficiency of Coleus aromaticus extract in modifying cyclophosphamide and mitomycin-C induced clastogenicity in mouse bone marrow cells.
Topics: Administration, Oral; Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; Cole | 2002 |
Therapy-related erythroleukemia caused by the administration of UFT and mitomycin C in a patient with colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, | 2003 |
Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro.
Topics: Adult; Antibiotics, Antineoplastic; Ascorbic Acid; Cells, Cultured; Chromosome Aberrations; Dose-Res | 2003 |
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
Topics: Aged; Alkylating Agents; Cell Cycle Proteins; Chromosome Aberrations; Clone Cells; DNA Mutational An | 2003 |
Study of low-intensity 2450-MHz microwave exposure enhancing the genotoxic effects of mitomycin C using micronucleus test and comet assay in vitro.
Topics: Antibiotics, Antineoplastic; Cell Culture Techniques; Chromosome Aberrations; Comet Assay; DNA Damag | 2002 |
Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Culture Techniques; Cell Division; Chick | 2003 |
Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells.
Topics: Amino Acid Sequence; Animals; Blotting, Western; BRCA1 Protein; BRCA2 Protein; Cell Division; Cell L | 2003 |
Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow.
Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Erythrocytes; Female; Insecticides; Micronuclei, | 2003 |
Disruption of the AtREV3 gene causes hypersensitivity to ultraviolet B light and gamma-rays in Arabidopsis: implication of the presence of a translesion synthesis mechanism in plants.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Catalytic Domain; Chromosome Aberrations; Da | 2003 |
CHROMOSOME EXCHANGES IN HUMAN LEUKOCYTES INDUCED BY MITOMYCIN C.
Topics: Chromosome Aberrations; Chromosomes; Leukocytes; Mitomycin; Mitomycins; Pharmacology; Research; Tiss | 1965 |
Nicotine is not clastogenic at doses of 1 or 2 mg/kg body weight given orally to male mice.
Topics: Administration, Oral; Animals; Bone Marrow Cells; Chromosome Aberrations; Dose-Response Relationship | 2003 |
[Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro].
Topics: Chromosome Aberrations; Comet Assay; DNA Breaks, Single-Stranded; Female; Humans; Lymphocytes; Male; | 2002 |
Aberration induction by mitomycin C in early primary spermatocytes of mice.
Topics: Animals; Antibiotics, Antineoplastic; Chromosome Aberrations; Genes, Lethal; Male; Mice; Mitomycin; | 1976 |
Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks.
Topics: Animals; B-Lymphocytes; Cell Death; Cells, Cultured; Chickens; Chromosome Aberrations; Cross-Linking | 2004 |
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.
Topics: Animals; Cell Cycle; Cell Line; Chromosome Aberrations; DNA; DNA Damage; DNA Repair; DNA-Binding Pro | 2004 |
Involvement of mammalian Mus81 in genome integrity and tumor suppression.
Topics: Alleles; Animals; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Embryo, Mammalian; Embry | 2004 |
Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo.
Topics: Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; Male; Mice; Mice, Inbred C | 2004 |
C-MYB, serum P-53M, genetic instability, labeling index and endoscopic findings in patients with adenoma or colorectal cancer.
Topics: Adenoma; Biomarkers, Tumor; Chromosome Aberrations; Colorectal Neoplasms; Disease Progression; DNA; | 2004 |
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Topics: Animals; Arabidopsis Proteins; Base Sequence; Cell Cycle; Cell Line; Chromatin; Chromosome Aberratio | 2005 |
Antimutagenicity of selenium-enriched rice on mice exposure to cyclophosphamide and mitomycin C.
Topics: Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Diet; Fe | 2005 |
Evaluation of cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow by gavage administration.
Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Erythrocytes; Female; Insecticides; Intubation, | 2005 |
Shortened telomeres in murine scid cells expressing mutant hRAD54 coincide with reduction in recombination at telomeres.
Topics: Alkylating Agents; Animals; Cell Line; Chromosome Aberrations; DNA Helicases; DNA-Activated Protein | 2005 |
Detection of numerical chromosomal aberrations by flow cytometry: a novel process for identifying aneugenic agents.
Topics: Adult; Aneugens; Cells, Cultured; Chromosome Aberrations; Etoposide; Female; Flow Cytometry; Griseof | 2005 |
Studies on the action of mitomycin C and bleomycin on telomere lengths of human lymphocyte chromosomes.
Topics: Adult; Antibiotics, Antineoplastic; Bleomycin; Chromosome Aberrations; Dose-Response Relationship, D | 2005 |
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.
Topics: Animals; BRCA1 Protein; Chickens; Chromosome Aberrations; Cisplatin; Cross-Linking Reagents; DNA Dam | 2005 |
Effect of high-frequency electromagnetic fields with a wide range of SARs on chromosomal aberrations in murine m5S cells.
Topics: Adsorption; Animals; Antibiotics, Antineoplastic; Cell Line; Chromosome Aberrations; Dose-Response R | 2005 |
Increased sensitivity to mitomycin C-induced sister chromatid exchange in lymphocytes from patients undergoing hyperbaric oxygen therapy.
Topics: Adult; Aged; Antioxidants; Chromosome Aberrations; Chromosomes, Human; DNA Damage; Female; Humans; H | 2006 |
Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VIII. Assessment of cytotoxicity and clastogenicity of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented
Topics: Animals; Benzo(a)pyrene; Caseins; Cell Proliferation; Cell Survival; Cells, Cultured; Chromosome Abe | 2005 |
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.
Topics: Animals; Antibiotics, Antineoplastic; Chromosome Aberrations; Chromosomes; DNA Damage; DNA Helicases | 2006 |
A case report of a patient with microcephaly, facial dysmorphism, mitomycin-c-sensitive lymphocytes, and susceptibility to lymphoma.
Topics: Adolescent; Antineoplastic Agents; Chromosome Aberrations; Disease Susceptibility; Face; Head and Ne | 2006 |
A study on the investigation of cadmium chloride genotoxicity in rat bone marrow using micronucleus test and chromosome aberration analysis.
Topics: Analysis of Variance; Animals; Bone Marrow Cells; Cadmium Chloride; Chromosome Aberrations; Erythroc | 2005 |
The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; Cell Line; Chromosome Aberrations; DNA; Dose-Respon | 2006 |
Cytogenetic investigation of subjects professionally exposed to radiofrequency radiation.
Topics: Adult; Chromosome Aberrations; Comet Assay; Cytogenetics; Electromagnetic Fields; Female; Humans; Ma | 2006 |
The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro.
Topics: Animals; Cell Proliferation; CHO Cells; Chromosome Aberrations; Cricetinae; Dinoflagellida; Marine T | 2006 |
Evidence of increased chromosomal instability in infertile males after exposure to mitomycin C and caffeine.
Topics: Adult; Caffeine; Chromosome Aberrations; DNA Repair; Humans; Infertility, Male; Lymphocytes; Male; M | 2006 |
Functional interplay between BRCA2/FancD1 and FancC in DNA repair.
Topics: Animals; BRCA2 Protein; Cell Nucleus; Chickens; Chromosome Aberrations; Cross-Linking Reagents; DNA | 2006 |
Stochastic cancer progression driven by non-clonal chromosome aberrations.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cul | 2006 |
Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1.
Topics: Animals; Bone Marrow Cells; BRCA2 Protein; Cell Proliferation; Chromosome Aberrations; Disease Model | 2006 |
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
Topics: Chromosome Aberrations; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Fanconi Ane | 2006 |
Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2.
Topics: Bleomycin; BRCA2 Protein; Cell Survival; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA Re | 2006 |
In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agents.
Topics: Adolescent; Adult; Animals; Calcium; Cell Transplantation; Cells, Cultured; Chromosome Aberrations; | 2006 |
Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair.
Topics: Cell Cycle Proteins; Cells, Cultured; Chromosome Aberrations; De Lange Syndrome; DNA Damage; DNA Rep | 2007 |
Modulatory effect of distillate of Ocimum sanctum leaf extract (Tulsi) on human lymphocytes against genotoxicants.
Topics: Adult; Benzopyrenes; Cell Survival; Chromium; Chromosome Aberrations; DNA; DNA Damage; Humans; Lymph | 2007 |
Antigenotoxic effect of apigenin against anti-cancerous drugs.
Topics: Antibiotics, Antineoplastic; Antimutagenic Agents; Antineoplastic Agents; Antineoplastic Agents, Alk | 2008 |
Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation.
Topics: Adult; Case-Control Studies; Child; Chromosome Aberrations; Cytogenetics; Fanconi Anemia; Female; He | 2007 |
Resistance to therapy caused by intragenic deletion in BRCA2.
Topics: Aged; Alleles; Amino Acid Sequence; Base Sequence; BRCA2 Protein; Carboplatin; Cell Line, Tumor; Chr | 2008 |
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly.
Topics: Base Sequence; Cell Line; Chromosome Aberrations; DNA Damage; DNA Primers; Fanconi Anemia; Humans; M | 2008 |
Sister chromatid exchanges and chromosomal aberrations induced by mitomycin C in mouse lymphocytes carrying a leukemogenic virus.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Crossing Over, Genetic; Leukemia, Experimental; Mice; | 1983 |
Wilms' tumour: association with cellular sensitivity to mitomycin C in patients and first-degree relatives.
Topics: Adult; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Child; Chromosome Aberrations; Disease | 1984 |
Mutant genes in Wilms' tumour.
Topics: Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Female; Humans; Kidney Neoplasms; Male; Mito | 1984 |
Hyperthermic potentiation of chromosome aberrations by anticancer antibiotics.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Cycle; Cells, Cultured; Chromosome Aberrations | 1982 |
Induction of chromosome aberrations by chemical mutagens in neural ganglia of Drosophila melanogaster.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Chromosome Aberrations; Cyclophosphamide; Drosophil | 1983 |
Disomic and diploid meiotic products in Saccharomyces cerevisiae. Effect of vincristine, vinblastine, adriamycin, bleomycin, mitomycin C and cyclophosphamide.
Topics: Antineoplastic Agents; Bleomycin; Chromosome Aberrations; Cyclophosphamide; Diploidy; Doxorubicin; M | 1983 |
New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bleomycin; Chromosome Aberrations; Embryo, Mammalian; Female; | 1983 |
The response of cells from patients with Huntington's chorea to mutagen-induced chromosome damage.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Crossing Over, Genetic; DNA; Ethyl Meth | 1982 |
Anaphase aberrations: a measure of genotoxicity in mutagen-treated fish cells.
Topics: Aminacrine; Anaphase; Animals; Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cells, Cultur | 1982 |
Proliferative kinetics and mitomycin C-induced chromosome damage in Fanconi's anemia lymphocytes.
Topics: Adult; Anemia, Aplastic; Cell Division; Cells, Cultured; Child; Chromosome Aberrations; Crossing Ove | 1983 |
Complementation studies between Fanconi's anemia cells with different DNA repair characteristics.
Topics: Anemia, Aplastic; Cell Line; Cells, Cultured; Chromosome Aberrations; DNA Repair; Fanconi Anemia; Ge | 1983 |
Cytogenetic differentiation of Fanconi anemia, "idiopathic" aplastic anemia, and Fanconi anemia heterozygotes.
Topics: Adolescent; Adult; Anemia, Aplastic; Blood Preservation; Child; Child, Preschool; Chromosome Aberrat | 1983 |
Mutagen hypersensitivity in Friedreich's ataxia.
Topics: Adult; Chromosome Aberrations; Crossing Over, Genetic; Ethyl Methanesulfonate; Female; Friedreich At | 1983 |
Induction of sister-chromatid exchanges (SCEs) and chromosomal aberrations by mitomycin C and methyl methanesulfonate in Chinese hamster ovary cells. An evaluation of methodology for detection of SCEs and of persistent DNA lesions towards the frequencies
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; | 1983 |
Effect of oxygen tension on chromosomal aberrations in Fanconi anaemia.
Topics: Adult; Anemia, Aplastic; Cells, Cultured; Child; Chromosome Aberrations; Fanconi Anemia; Female; Hum | 1983 |
[Correlation of the sister chromatid exchange level with chromosome aberrations induced by chemical mutagens in vivo].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Aziridines; Bone Marrow; Chromosome Aberrations; | 1983 |
[Effect of mouse age and genotype on the frequency of sister chromatid exchange in bone marrow cells].
Topics: Aging; Animals; Bone Marrow; Bromodeoxyuridine; Chromosome Aberrations; Crossing Over, Genetic; Geno | 1984 |
Mutagenic properties of methyl- and ethylbromophos in mammals.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Female; Insecticides; Male; Mice; Mice, Inbred Strains | 1984 |
Sister chromatid exchanges and cell cycle kinetics in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Bromodeoxyuridine; Cell Cycle; Chromosome Aberrations; Crossing Over, Genet | 1984 |
Anaphase-telophase analysis of chromosomal damage induced by chemicals.
Topics: Anaphase; Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Chromosome Aberrations; Cr | 1984 |
Clinical and cytogenetic diversity in Fanconi's anaemia.
Topics: Adolescent; Adult; Anemia, Aplastic; Child; Chromosome Aberrations; Chromosomes, Human; Diagnosis, D | 1984 |
Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow.
Topics: Animals; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Cytarabine; Erythrocytes, Abnormal; Male | 1984 |
Morphological and cytogenetic studies of dominant lethality induced by mitomycin C and cyclophosphamide in female germ cells. The use of Robertsonian translocations as a 'marker system' to identify the zygote pronuclei.
Topics: Animals; Antibiotics, Antineoplastic; Blastocyst; Chromosome Aberrations; Cyclophosphamide; Female; | 1984 |
The human lymphocyte in vitro cytogenetic assay: positive and negative control observations on approximately 30000 cells.
Topics: Antibiotics, Antineoplastic; Biotransformation; Chromatids; Chromosome Aberrations; Cyclophosphamide | 1984 |
Enhancement of induced sister chromatid exchange and chromosomal aberrations by inhibitors of DNA repair processes.
Topics: Animals; Aphidicolin; Caffeine; Chromosome Aberrations; Cricetinae; Cricetulus; Diterpenes; DNA; DNA | 1984 |
[Use of in-vitro treated human blood cells for the detection of the potential genotoxicity of chemical agents].
Topics: Acrylamides; Benzopyrenes; Carcinogens; Chromosome Aberrations; Cyclophosphamide; Ethyl Methanesulfo | 1984 |
Cell-stage dependence of the formation of SCEs and chromosomal aberrations.
Topics: Caffeine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; DNA Replication; Humans; Interphase; | 1984 |
Potentiation of induced sister chromatid exchanges and chromatid-type aberrations by inhibitors of DNA synthesis and repair in G2.
Topics: Aphidicolin; Caffeine; Cells, Cultured; Chromosome Aberrations; Diterpenes; DNA Repair; DNA Replicat | 1984 |
Issues relevant to the assessment of chemically induced chromosome damage in vivo and their relationship to chemical mutagenesis.
Topics: Animals; Benzene; Bone Marrow; Chromosome Aberrations; Chromosomes; Ethyl Methanesulfonate; Male; Mi | 1981 |
Differential sensitivity of muntjac lymphocyte chromosomes to mitomycin C, bromodeoxyuridine and hydroxylamine at different cell-cycle stages.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; Chromosome Aberrations; Chromosomes; Deer; Hydroxylamines; K | 1982 |
Baseline and mitomycin-C-induced sister chromatic exchanges ina melanoma and a colon tumor cell line.
Topics: Antibiotics, Antineoplastic; Cell Line; Chromosome Aberrations; Colonic Neoplasms; Crossing Over, Ge | 1982 |
Chromosomal mutations in human populations.
Topics: Adolescent; Adult; Aged; Azaguanine; Child; Chromosome Aberrations; Drug Resistance; Female; Humans; | 1982 |
Analysis of heterogeneity in Fanconi's anemia patients of different ethnic origin.
Topics: Adolescent; Anemia, Aplastic; Child; Chromosome Aberrations; Fanconi Anemia; Female; Humans; Hybrid | 1982 |
An in vivo/in vitro method for assessing micronucleus and chromosome aberration induction in rat bone marrow and spleen. 2. Studies with chlorambucil and mitomycin C.
Topics: Animals; Bone Marrow; Chlorambucil; Chromosome Aberrations; Evaluation Studies as Topic; In Vitro Te | 1995 |
Antagonizing effect of triphenyltin chloride on cytosine-1-beta-D-arabinofuranoside potentiation of chromosome aberrations induced by mitomycin C.
Topics: Animals; Caffeine; CHO Cells; Chromosome Aberrations; Cricetinae; Cytarabine; Drug Antagonism; Drug | 1994 |
Microbial mutagenicity and in vitro chromosome aberration induction by FK973, a new antitumor agent.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cells, Cultured; Chromosome Aberrations; Cricetin | 1994 |
Increased frequencies of micronuclei in early spermatids of rats following exposure of young primary spermatocytes to acrylamide.
Topics: Acrylamide; Acrylamides; Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Male; Mi | 1994 |
Sister-chromatid exchanges, chromosomal aberrations and cytotoxicity produced by topoisomerase II-targeted drugs in sensitive (A2780) and resistant (A2780-DX3) human ovarian cancer cells: correlations with the formation of DNA double-strand breaks.
Topics: Antineoplastic Agents; Cell Survival; Chromosome Aberrations; DNA Damage; DNA, Neoplasm; Doxorubicin | 1994 |
Chromosome analysis of human spermatozoa exposed to antineoplastic agents in vitro.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cattle; Chromosome Aberrations; Cricetinae; Cyclophospham | 1995 |
Retinoblastoma in association with the chromosome breakage syndromes Fanconi's anaemia and Bloom's syndrome: clinical and cytogenetic findings.
Topics: Bloom Syndrome; Child, Preschool; Chromosome Aberrations; Chromosomes; DNA; Eye Neoplasms; Fanconi A | 1995 |
Taurine and ellagic acid: two differently-acting natural antioxidants.
Topics: Animals; Antimutagenic Agents; Antioxidants; CHO Cells; Chromosome Aberrations; Cricetinae; Ellagic | 1995 |
A new complementation group of mitomycin C-hypersensitive Chinese hamster cell mutants that closely resembles the phenotype of fanconi anemia cells.
Topics: Alkylating Agents; Animals; Cell Survival; CHO Cells; Chromosome Aberrations; Cricetinae; Fanconi An | 1995 |
Severe intrauterine growth retardation with increased mitomycin C sensitivity: a further chromosome breakage syndrome.
Topics: Adult; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; Chromosome Fragility; DNA Dama | 1995 |
o-Vanillin enhances chromosome aberrations induced by alkylating agents in cultured Chinese hamster cells.
Topics: Alkylating Agents; Animals; Benzaldehydes; Bleomycin; Cells, Cultured; Chromosome Aberrations; Crice | 1993 |
Inorganic cadmium increases the frequency of chemically induced chromosome aberrations in cultured mammalian cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadmium; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cric | 1993 |
Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes; Cross-Linking Reagents; Drug Resistance; Epoxy | 1995 |
Trichloroacetic acid: investigation into the mechanism of chromosomal damage in the in vitro human lymphocyte cytogenetic assay and the mouse bone marrow micronucleus test.
Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Dr | 1995 |
Pre-exposure of mice to low dose or low dose rate ionizing radiation reduces chromosome aberrations induced by subsequent exposure to high dose of radiation or mitomycin C.
Topics: Adaptation, Physiological; Animals; Chromosome Aberrations; Cobalt; Female; Gamma Rays; Male; Mice; | 1995 |
Studies on the induction of cross-resistance by low dose radiation or by low concentrations of chemicals.
Topics: Adaptation, Physiological; Animals; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Female; H | 1994 |
Use of chick, Gallus domesticus, as an in vivo model for the study of chromosome aberration: a study with mitomycin C and probable location of a 'hot spot'.
Topics: Analysis of Variance; Animals; Bone Marrow; Bone Marrow Cells; Chickens; Chromosome Aberrations; Chr | 1995 |
Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector.
Topics: Base Sequence; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Chromosome Ab | 1994 |
Radial ray defects, renal ectopia, duodenal atresia and hydrocephalus: the extended spectrum for Fanconi anaemia.
Topics: Bone and Bones; Choristoma; Chromosome Aberrations; Consanguinity; Duodenum; Fanconi Anemia; Female; | 1994 |
Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability.
Topics: Animals; Cell Survival; CHO Cells; Chromosome Aberrations; Cisplatin; Cricetinae; DNA Damage; Dose-R | 1993 |
Induction of micronucleated erythrocytes by recombinant human erythropoietin.
Topics: Animals; Biotransformation; Bone Marrow; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricet | 1993 |
Chromosomal rearrangements in rock wallabies, Petrogale (Marsupialia: Macropodidae). VIII. An investigation of the nonrandom nature of karyotypic change.
Topics: Animals; Biological Evolution; Chromosome Aberrations; Chromosome Banding; Chromosome Fragility; Chr | 1993 |
Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo.
Topics: Analysis of Variance; Animals; Antimutagenic Agents; Arsenic; Arsenites; Bone Marrow; Chromosome Abe | 1993 |
Effects of crude garlic extract on mouse chromosomes in vivo.
Topics: Administration, Oral; Analysis of Variance; Animals; Arsenites; Bone Marrow; Bone Marrow Cells; Chro | 1996 |
A study of induced genotoxicity in MCF-7 cells.
Topics: Adenocarcinoma; Breast Neoplasms; Chromosome Aberrations; DNA Damage; DNA, Neoplasm; Dose-Response R | 1995 |
A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity.
Topics: Adenine; Aminoacridines; Animals; Cell Adhesion; Cell Line; Cell Survival; CHO Cells; Chromosome Abe | 1996 |
Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure.
Topics: Cell Culture Techniques; Cell Fusion; Cell Line, Transformed; Cell Survival; Chromosome Aberrations; | 1996 |
Severe intrauterine growth retardation with increased mitomycin C sensitivity, or Nijmegen breakage syndrome?
Topics: Chromosome Aberrations; Chromosome Disorders; Female; Fetal Growth Retardation; Humans; Male; Mitomy | 1995 |
Clastogenic activity of pure chlorophyll and anticlastogenic effects of equivalent amounts of crude extract of Indian spinach leaf and chlorophyllin following dietary supplementation to mice.
Topics: Animals; Antimutagenic Agents; Chlorophyll; Chlorophyllides; Chromosome Aberrations; Food; Male; Mic | 1996 |
Spontaneous and mitomycin-C-induced micronuclei in lymphocytes from subjects affected by Turner's syndrome.
Topics: Adolescent; Adult; Aging; Cell Division; Child; Child, Preschool; Chromosome Aberrations; Female; Hu | 1996 |
The NAD(P)H:quinone oxidoreductase locus in human colon carcinoma HCT 116 cells resistant to mitomycin C.
Topics: Antibiotics, Antineoplastic; Chromosome Aberrations; Colonic Neoplasms; Down-Regulation; Drug Resist | 1996 |
Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves): 1. The clastogen-suppressing effects of Tochu tea in CHO cells and mice.
Topics: Animals; Antimutagenic Agents; Beverages; CHO Cells; Chromatids; Chromosome Aberrations; Cricetinae; | 1997 |
A new semi-automated chromosome analysis system for in vitro chromosomal aberration tests.
Topics: Animals; Automation; CHO Cells; Chromosome Aberrations; Cricetinae; Cyclophosphamide; Humans; Lung; | 1997 |
Inhibition of clastogenic effects of arsenic through continued oral administration of garlic extract in mice in vivo.
Topics: Administration, Oral; Animals; Antimutagenic Agents; Arsenites; Azure Stains; Bone Marrow Cells; Chr | 1997 |
Effects of dietary consumption of black tea infusion alone and in combination with known clastogens on mouse bone marrow chromosomes in vivo.
Topics: Analysis of Variance; Animals; Antibiotics, Antineoplastic; Bone Marrow; Caustics; Chromosome Aberra | 1997 |
Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C.
Topics: Chromosome Aberrations; Cytogenetics; DNA; DNA Damage; Electrophoresis; Female; Humans; Hydrogen-Ion | 1997 |
Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Cycle; Cell Line; CHO Ce | 1997 |
Does topical instillation therapy influence chromosomal aberrations in superficial bladder cancer?
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; BCG Vacci | 1998 |
Induction of an adaptive response to quercetin, mitomycin C and hydrogen peroxide by low doses of quercetin in V79 Chinese hamster cells.
Topics: Adaptation, Physiological; Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Dose- | 1997 |
[Chromosomal aberrations induced in human spermatozoa by mitomycin C].
Topics: Animals; Antibiotics, Antineoplastic; Chromosome Aberrations; Cricetinae; Dose-Response Relationship | 1997 |
Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C in vivo.
Topics: Animals; Antimutagenic Agents; Chromosome Aberrations; Curcumin; Cyclophosphamide; Male; Mice; Mitom | 1998 |
Development of genotoxicity assay systems that use aquatic organisms.
Topics: Animals; Chromosome Aberrations; Embryo, Nonmammalian; Erythrocytes; Fishes; Gills; Japan; Micronucl | 1998 |
Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.
Topics: Animals; Cell Cycle Proteins; Cell Line, Transformed; Cell Transformation, Viral; Chromosome Aberrat | 1998 |
Comparative studies on genotoxicity and antigenotoxicity of natural and synthetic beta-carotene stereoisomers.
Topics: Adolescent; Adult; beta Carotene; Chromosome Aberrations; Eukaryota; Female; Humans; Lymphocytes; Ma | 1998 |
Caffeine effect on the mitotic delay induced by G2 treatment with UVC or mitomycin C.
Topics: Animals; Caffeine; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Damage; DNA Repair | 1998 |
Mitomycin C induced chromosomal aberrations in young cancer patients.
Topics: Adult; Age Factors; Aged; Antibiotics, Antineoplastic; Child; Child, Preschool; Chromatids; Chromoso | 1998 |
The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.
Topics: Animals; CHO Cells; Chromosome Aberrations; Chromosomes; Chromosomes, Human, Pair 4; Chromosomes, Hu | 1999 |
Chromosome-type aberrations induced in chromosome 9 after treatment of human peripheral blood lymphocytes with mitomycin C at the G(0) phase.
Topics: Adult; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, | 1999 |
Chromosomes and stress.
Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Chronic Disease; Conditioning, Psychological; El | 1999 |
Persistence of chromosomal alterations affecting the 1cen-q12 region in a human lymphoblastoid cell line exposed to diepoxybutane and mitomycin C.
Topics: Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes, Human, | 1999 |
A comparison of the roles of p53 mutation and AraC inhibition in the enhancement of bleomycin-induced chromatid aberrations in mouse and human cells.
Topics: Animals; Bleomycin; Cell Line; Cells, Cultured; Chromosome Aberrations; Cytarabine; DNA Repair; Dose | 2000 |
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.
Topics: Animals; Annexin A5; BRCA2 Protein; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cross-Link | 2000 |
The Rad51 paralog Rad51B promotes homologous recombinational repair.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Cell | 2000 |
Chromosomal aberrations, sister chromatid exchanges and high frequency cells in young patients with neurofibromatosis 1 (NF1).
Topics: Adolescent; Antimetabolites, Antineoplastic; Bleomycin; Child; Child, Preschool; Chromosome Aberrati | 2000 |
Chromosome painting reveals specific patterns of chromosome occurrence in mitomycin C- and diethylstilboestrol-induced micronuclei.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Hormonal; Carcinogens; Cells, Cultured; C | 2000 |
Concurrent detection of gene mutations and chromosome aberrations induced by five chemicals in a CHL/IU cell line incorporating a gpt shuttle vector.
Topics: Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cri | 2000 |
Cytogenetic effects of 50 Hz magnetic fields of different magnetic flux densities.
Topics: Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Radiation; Electromagnetic Fiel | 2000 |
Increased chromatid-type chromosomal aberrations in mouse m5S cells exposed to power-line frequency magnetic fields.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Survival; Chromatids; Chromosome Aberrat | 2000 |
Cytogenetic effects of 900 MHz (GSM) microwaves on human lymphocytes.
Topics: Chromosome Aberrations; Cytogenetics; Humans; In Vitro Techniques; Lymphocytes; Microwaves; Mitomyci | 2001 |
Severe combined immunodeficient cells expressing mutant hRAD54 exhibit a marked DNA double-strand break repair and error-prone chromosome repair defect.
Topics: Alkylating Agents; Animals; Chromosome Aberrations; Cricetinae; DNA Damage; DNA Helicases; DNA Repai | 2001 |
Suppressive effect of aspirin on chromosome aberration induced by mitomycin C in mice.
Topics: Alanine Transaminase; Animals; Antibiotics, Antineoplastic; Aspartate Aminotransferases; Aspirin; Ch | 2001 |
p-Aramid RFP do not induce chromosomal aberrations in a standardized in vitro genotoxicity assay using human lymphocytes.
Topics: Adult; Cells, Cultured; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Microscopy | 2001 |
Analysis of adaptive response to bleomycin and mitomycin C.
Topics: Adaptation, Physiological; Adult; Antibiotics, Antineoplastic; Bleomycin; Chromosome Aberrations; DN | 2002 |
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.
Topics: Amino Acid Sequence; Animals; CHO Cells; Chromatids; Chromosome Aberrations; Chromosome Segregation; | 2002 |
Redox-modulated xenobiotic action and ROS formation: a mirror or a window?
Topics: Cell Differentiation; Cell Division; Chromosome Aberrations; DNA Damage; Epoxy Compounds; Fanconi An | 2002 |
Application of mFISH for the analysis of chemically-induced chromosomal aberrations: a model for the formation of triradial chromosomes.
Topics: Alkylating Agents; Cell Line; Chromosome Aberrations; Humans; In Situ Hybridization, Fluorescence; I | 2002 |
A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells.
Topics: Aminobiphenyl Compounds; Animals; Cadmium; Cadmium Compounds; CHO Cells; Chromosome Aberrations; Cri | 1992 |
Poly-D-lysine in G2 potentiates chromosome damage induced by X-rays and mitomycin C in CHO cells.
Topics: Animals; CHO Cells; Chromosome Aberrations; Cricetinae; Drug Synergism; G2 Phase; Mitomycin; Polylys | 1992 |
Chromosomal analysis of Chinese hamster V79 cells exposed to multiple gamma-ray fractions: induction of adaptive response to mitomycin C.
Topics: Adaptation, Physiological; Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; DNA | 1992 |
Persistence of chromosomal lesions induced in actively proliferating bone marrow cells of the mouse.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromoso | 1992 |
In vitro effect of glutathione on mitomycin-C in human lymphocytes.
Topics: Chromosome Aberrations; Chromosome Disorders; Glutathione; Humans; Lymphocytes; Male; Mitomycin | 1992 |
Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. I. Involvement of interleukin-6.
Topics: Cell Division; Cell Line; Chromosome Aberrations; Culture Media; Dose-Response Relationship, Drug; F | 1992 |
Isolation of a menadione-resistant subclone from Chinese hamster lung (CHL) cells in culture.
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Cricetinae; Cri | 1991 |
Factors underlying variation in spontaneous and clastogen-induced sister chromatid exchanges and chromosome breakage frequencies.
Topics: 4-Nitroquinoline-1-oxide; Adult; Alkylating Agents; Bleomycin; Chromosome Aberrations; Female; Human | 1990 |
Cytogenetic analysis of human bile for mutagenicity and co-mutagenicity.
Topics: Adult; Bile; Cells, Cultured; Chromosome Aberrations; Female; Humans; Lymphocytes; Male; Mitomycin; | 1991 |
Effect of mitomycin C and bromodeoxyuridine on Fanconi anemia lymphocytes.
Topics: Bromodeoxyuridine; Child; Chromosome Aberrations; Fanconi Anemia; Humans; Lymphocytes; Mitomycin | 1991 |
[Preliminary studies of the relationship between micronucleus formation and cell cycle].
Topics: Adult; Cell Cycle; Chromosome Aberrations; Female; Humans; Lymphocytes; Male; Micronucleus Tests; Mi | 1991 |
Tea tannin components modify the induction of sister-chromatid exchanges and chromosome aberrations in mutagen-treated cultured mammalian cells and mice.
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Humans; Male; Mice; Micronucleus Tests; Mito | 1991 |
Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1.
Topics: Alkylating Agents; Animals; Cell Cycle; Chromosome Aberrations; Cricetinae; DNA; DNA Repair; Mitomyc | 1991 |
Effect of pH on the activity and stability of clastogens in the in vitro chromosomal aberration test with Chinese hamster ovary K1 cells.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cells, Cultured | 1991 |
Further investigations on the clastogenicity of paracetamol and acetylsalicylic acid in vitro.
Topics: Acetaminophen; Animals; Aspirin; Biotransformation; Cell Line; Cells, Cultured; Chromosome Aberratio | 1991 |
Chromosome damage induced by ethanol.
Topics: Antineoplastic Agents; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Ethanol; Fibrobl | 1991 |
Comutagenic and coclastogenic effects of selenium in vitro and in vivo.
Topics: Animals; Cell Line; Chromosome Aberrations; Erythrocytes; Male; Methylnitronitrosoguanidine; Methyln | 1991 |
Quantitative analyses of the induction of chromosome aberrations and sister-chromatid exchanges in human lymphocytes exposed to gamma-rays and mitomycin-C in combination.
Topics: Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Dose-Response Relationshi | 1991 |
Kinetochore analysis of micronuclei allows insights into the actions of colcemid and mitomycin C.
Topics: Aneuploidy; Chromosome Aberrations; Demecolcine; Evaluation Studies as Topic; Fibroblasts; Fluoresce | 1991 |
Sister chromatid exchange evaluation as an aid to the diagnosis and exclusion of Fanconi's anaemia by induced chromosome damage analysis.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Cross-Linking Reagents; DNA; DNA Damage | 1991 |
A human colon cancer cell line established from collagen matrix cultures transplanted into nude mice.
Topics: Animals; Carcinoembryonic Antigen; Cell Line; Chromosome Aberrations; Chromosome Disorders; Collagen | 1991 |
Micronuclei assay in cytokinesis-blocked binucleated and conventional mononucleated methods in human peripheral lymphocytes.
Topics: Adult; Alkylating Agents; Cell Division; Cells, Cultured; Chromosome Aberrations; Cyclophosphamide; | 1990 |
Differential sensitivity of peripheral blood lymphocytes of untreated leprosy patients to mitomycin C.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes; Leprosy; Lymphocytes; Male; Mitomycin; Mitomyc | 1990 |
Cocultivation of Fanconi anemia cells and of mouse lymphoma mutants leads to interspecies complementation of chromosomal hypersensitivity to DNA cross-linking agents.
Topics: Anemia, Aplastic; Animals; Cell Division; Cells, Cultured; Chromosome Aberrations; Fanconi Anemia; G | 1990 |
Induction of micronuclei by mitomycin C and colchicine in the marine mussel Mytilus galloprovincialis.
Topics: Animals; Bivalvia; Chromosome Aberrations; Colchicine; Micronucleus Tests; Mitomycin; Mitomycins; Ti | 1990 |
Application of antikinetochore antibody staining (CREST staining) to micronuclei in erythrocytes induced in vivo.
Topics: Alkylating Agents; Animals; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Colchicine; Eryt | 1990 |
Effect of treatment protocol and sample time on the frequencies of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Analysis of Variance; Animals; Benzidines; Bone Marrow; Bone Marro | 1990 |
Influence of radiofrequency radiation on chromosome aberrations in CHO cells and its interaction with DNA-damaging agents.
Topics: Animals; Cell Line; Cells, Cultured; Chromosome Aberrations; Doxorubicin; Mitomycin; Mitomycins; Rad | 1990 |
[The characteristics of the localization of induced ruptures in human chromosomes].
Topics: Adolescent; Adult; Alkylating Agents; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human, P | 1990 |
[Characterization of chromosomal aberrations induced in man by various antimitotic agents].
Topics: Antineoplastic Agents; Benzopyrans; Bleomycin; Cells, Cultured; Chromosome Aberrations; Cisplatin; H | 1985 |
A simplified method for micronucleus preparation from hepatic cells.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Liver; Liver Regeneration; Mice; Mitomycin; Mitomycin | 1988 |
Ethanol and acetaldehyde potentiate the clastogenicity of ultraviolet light, methyl methanesulfonate, mitomycin C and bleomycin in Chinese hamster ovary cells.
Topics: Acetaldehyde; Animals; Bleomycin; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Sy | 1989 |
X-ray- and mitomycin C (MMC)-induced chromosome aberrations in spermiogenic germ cells and the repair capacity of mouse eggs for the X-ray and MMC damage.
Topics: Animals; Caffeine; Chromatids; Chromosome Aberrations; DNA Damage; DNA Repair; Female; Male; Mice; M | 1989 |
Chromosomal hypersensitivity in mutant MCN-151 mouse cells exposed to mitomycin C.
Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes; Genetic Complementation Test | 1989 |
Enhancing effects of cinoxate and methyl sinapate on the frequencies of sister-chromatid exchanges and chromosome aberrations in cultured mammalian cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Chromosome Aberrations; Cinnamates; Cricetinae; DNA Re | 1989 |
No difference between smoking lung cancer patients and smoking controls in the frequency of spontaneous and mitomycin C induced chromosome aberrations in lymphocytes.
Topics: Aged; Aged, 80 and over; Chromosome Aberrations; Humans; Lung Neoplasms; Lymphocytes; Male; Middle A | 1989 |
Precocious desynapsis of XY-bivalent in mouse germinal cells: influence of mitomycin C on tumour-bearing and normal mice.
Topics: Animals; Cell Division; Chromosome Aberrations; Male; Mice; Mitomycin; Mitomycins; Tumor Cells, Cult | 1989 |
G2 effects of DNA-repair inhibitors on chromatid-type aberrations in root-tip cells treated with maleic hydrazide and mitomycin C.
Topics: Caffeine; Cell Cycle; Chromosome Aberrations; Chromosomes; Cytarabine; DNA Damage; DNA Repair; Floxu | 1989 |
Toxic effects of chemicals on mouse post-blastocyst development--a trial to establish a testing system for embryotoxicity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Blastocyst; Bleomycin; Chromosome Ab | 1985 |
Effect of 5-azacytidine (5-azaC) on the induction of chromatid aberrations (CA) and sister-chromatid exchanges (SCE).
Topics: Azacitidine; Cells, Cultured; Chromatids; Chromosome Aberrations; Drug Synergism; Humans; Lymphocyte | 1985 |
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
Topics: Amsacrine; Animals; Camptothecin; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Drug | 1988 |
Cytogenetic studies of individuals from four kindreds with multiple endocrine neoplasia type II syndrome.
Topics: Adult; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Female; Folic Acid; Humans; Kary | 1987 |
Stage-related induction of chromosomal aberrations and SCE in mouse embryos treated transplacentally during organogenesis with MMC and DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Aberrations; Embryo, Mammalian; Embryonic and | 1988 |
Cytogenetic toxicity of paraquat and streptonigrin in Fanconi's anemia.
Topics: Adolescent; Adult; Anemia, Aplastic; Cells, Cultured; Child; Chromosome Aberrations; Fanconi Anemia; | 1987 |
Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea.
Topics: Cell Line; Cell Survival; Chromosome Aberrations; Dose-Response Relationship, Drug; Ethylnitrosourea | 1986 |
The influence of a protein synthesis inhibitor on sister-chromatid exchange in the plant Vicia faba.
Topics: Chromosome Aberrations; Cycloheximide; DNA Replication; Fabaceae; Hydroxyurea; Mitomycin; Mitomycins | 1986 |
Mitomycin-induced chromatid breaks in HeLa cells: a consequence of incomplete DNA replication.
Topics: Chromatids; Chromosome Aberrations; DNA; DNA Replication; HeLa Cells; Humans; Interphase; Mitomycin; | 1986 |
[Genetic etiology of esophageal cancer--III. The spontaneous and mitomycin-C (MMC) induced sister chromatid exchanges (SCE) and chromosome aberrations in cultured lymphocytes from members of "high risk" and "low risk" esophageal cancer families in Linxian
Topics: Adolescent; Adult; Aged; Child; China; Chromosome Aberrations; Esophageal Neoplasms; Female; Humans; | 1986 |
In vitro induction of sister chromatid exchanges and chromosomal aberrations in peripheral lymphocytes of the oyster toadfish and American eel.
Topics: Animals; Bromodeoxyuridine; Cell Division; Chromosome Aberrations; Dose-Response Relationship, Drug; | 1986 |
A complex mosaic with tdic(13;18) (p11;p11), +13p-, +18p-, r(13) etc. in a male infant. II. Increased dissociation of dicentric chromosome by mitomycin C.
Topics: Abnormalities, Multiple; Bromodeoxyuridine; Cells, Cultured; Centromere; Chromosome Aberrations; Chr | 1986 |
In vitro micronucleus method with erythropoietin-differentiated erythrocytes.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Nucleus; Chromosome Aberrations; Erythrocytes | 1986 |
[Mitomycin C-induced mutagenesis].
Topics: Chromosome Aberrations; DNA Repair; Mitomycin; Mitomycins; Mutagenicity Tests; Mutagens; Plants | 1986 |
Measurement of micronuclei by cytokinesis-block method in cultured Chinese hamster cells: comparison with types and rates of chromosome aberrations.
Topics: Animals; Caffeine; Cell Division; Cell Line; Cell Nucleus; Chromosome Aberrations; Cricetinae; Crice | 1987 |
The lens and cataract: clastogenic responses in epithelial cells of the organ-cultured rat lens.
Topics: Animals; Bromodeoxyuridine; Chromosome Aberrations; Chromosomes; Culture Techniques; Epithelium; Len | 1987 |
Mitomycin C induced chromosomal aberrations and sister chromatid exchanges (SCEs) in lymphocytes of patients with precancerous and cancerous lesions of the uterine cervix.
Topics: Chromosome Aberrations; Female; Humans; Lymphocytes; Mitomycin; Mitomycins; Precancerous Conditions; | 1987 |
On the localization of mitomycin C-induced aberrations in normal human and Fanconi's anaemia cells.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Mapping; Chromosomes; DNA Replication; Dose-Resp | 1987 |
Cytogenetic analysis in workers occupationally exposed to nickel carbonyl.
Topics: Cells, Cultured; Chromosome Aberrations; Cocarcinogenesis; Environmental Exposure; Humans; Lymphocyt | 1987 |
Mutagenicity tests of the antithyroid agent thiamazole. Cytogenetic studies on male mice.
Topics: Animals; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Male; Methimazole; Mice; Mice, Inbred IC | 1987 |
Cytogenic analysis of dominant lethal effects of mitomycin C and ethyl methanesulfonate.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Ethyl Methanesulfonate; Female; Germ Cells; Male; Mice | 1987 |
Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro.
Topics: Cells, Cultured; Chromosome Aberrations; Colony-Forming Units Assay; DNA Damage; DNA Repair; Fibrobl | 1987 |
Extrapolation from in vitro tests to human risk: experience with sodium fluoride clastogenicity.
Topics: Cell Line; Cell Survival; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Mitomyci | 1987 |
Do some patients with Seckel syndrome have hematological problems and/or chromosome breakage?
Topics: Abnormalities, Multiple; Adolescent; Child; Chromosome Aberrations; Chromosome Fragility; Chromosome | 1987 |
Mutation at the APRT locus in Friend erythroleukaemia cells. 2. Sensitivity to mitomycin C induced cytogenetic damage.
Topics: Adenine Phosphoribosyltransferase; Animals; Cell Line; Chromosome Aberrations; Clone Cells; DNA Dama | 1987 |
Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance.
Topics: Animals; Cell Line; Chromosome Aberrations; Drug Resistance; Glycoproteins; Leukemia L1210; Membrane | 1987 |
A case of Shwachman syndrome with increased spontaneous chromosome breakage.
Topics: Bone Marrow Diseases; Chromosome Aberrations; Chromosome Fragility; Exocrine Pancreatic Insufficienc | 1987 |
Mouse strain differences in the induction of micronuclei by polycyclic aromatic hydrocarbons.
Topics: Animals; Biotransformation; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Cyclophosphamide; Mic | 1987 |
Effect of mitomycin-C and cyclophosphamide on the polytene chromosomes of Anopheles stephensi (Culicidae:Diptera).
Topics: Animals; Anopheles; Chromosome Aberrations; Chromosomes; Cyclophosphamide; Mitomycin; Mitomycins; Mu | 1987 |
Caffeine post-treatment causes a shift in the chromosome aberration types induced by mitomycin C, suggesting a caffeine-sensitive mechanism of DNA repair in G2.
Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Repair; Humans; Interphase; Lymphocytes; Mito | 1988 |
Nitrilotriacetic acid (NTA) does not induce chromosomal damage in mammalian cells either in vitro or in vivo.
Topics: Acetates; Adult; Animals; Cell Nucleus; Chromosome Aberrations; Humans; Lymphocytes; Male; Mice; Mit | 1988 |
Fanconi's anemia--chromosome breakage studies in homozygotes and heterozygotes.
Topics: Anemia, Aplastic; Cells, Cultured; Chromosome Aberrations; Epoxy Compounds; Fanconi Anemia; Heterozy | 1988 |
Sister chromatid exchanges and chromosomal aberrations in mouse cells infected with the Abelson and Moloney leukemia viruses.
Topics: Abelson murine leukemia virus; Animals; Cell Line; Cell Transformation, Viral; Chromosome Aberration | 1988 |
Kinetics of chromosomal aberrations and first mitosis division in human lymphocytes exposed to mitomycin C.
Topics: Cells, Cultured; Chromosome Aberrations; DNA Damage; Humans; In Vitro Techniques; Kinetics; Lymphocy | 1988 |
Enhanced synergism between caffeine and mitomycin C in the induction of cytogenetic aberrations in thymidine kinase-deficient Friend murine erythroleukaemia cells.
Topics: Animals; Caffeine; Cell Line; Chromosome Aberrations; Dose-Response Relationship, Drug; Drug Synergi | 1986 |
Chromosome aberrations in rat liver cells and bone marrow cells following treatment in vivo with mitomycin C.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Hepatectomy; Liver; Male; Mitomycin | 1986 |
Spontaneous and 3-aminobenzamide-induced sister-chromatid exchange frequencies estimated by ring chromosome analysis.
Topics: Animals; Azure Stains; Benzamides; Bromodeoxyuridine; Cell Cycle; Cell Line; Chromosome Aberrations; | 1986 |
Relative efficacy of short-term tests in detecting genotoxic effects of cadmium chloride in mice in vivo.
Topics: Animals; Bone Marrow; Cadmium; Cadmium Chloride; Cell Nucleus; Chromosome Aberrations; Cyclophospham | 1988 |
Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin.
Topics: Animals; Benzaldehydes; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Mice; Mice, Inbred Strain | 1988 |
Frequency and distribution of mitomycin C-induced structural chromosome aberrations in lymphocytes from non-Hodgkin lymphoma patients.
Topics: Adult; Aged; Aged, 80 and over; Cells, Cultured; Chromosome Aberrations; Female; Humans; Lymphocytes | 1988 |
Mitomycin C effect on Robertsonian translocations.
Topics: Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 13; | 1988 |
[Mitomycin C induced structural changes in heterochromatic regions of human chromosomes 1, 9, 16 and Y].
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Ch | 1988 |
Identification of two complementation groups in Fanconi anemia.
Topics: Anemia, Aplastic; Cell Line; Chromosome Aberrations; Fanconi Anemia; Genetic Complementation Test; H | 1985 |
[Mutagenicity of acetaminophen on Chinese hamster V79 cells].
Topics: Acetaminophen; Animals; Cell Cycle; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Dose- | 1985 |
Hypersensitivity of thymidine kinase-deficient Friend leukaemia cells to the induction of cytogenetic aberrations by mitomycin C.
Topics: Animals; Chromosome Aberrations; Clone Cells; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; N | 1985 |
The size of micronuclei in human lymphocytes varies according to inducing agent used.
Topics: Cell Nucleus; Cells, Cultured; Chromosome Aberrations; Demecolcine; Humans; Lymphocytes; Mitomycin; | 1985 |
[Sensitivity of the lymphocyte chromosomes of chronic alcoholism patients to mutagenic exposure].
Topics: Adult; Alcoholism; Antibiotics, Antineoplastic; Cells, Cultured; Chromosome Aberrations; Cytarabine; | 1985 |
The effect of fluoride on chromosome aberration and sister-chromatid exchange frequencies in cultured human lymphocytes.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes; Fluorides; Humans; Lymphocytes; Mitomycin; Mit | 1985 |
Chromosome fragments and other abnormalities induced by mitomycin C in the neuroblast of Chortophaga viridifasciata.
Topics: Anaphase; Animals; Centromere; Chromatids; Chromosome Aberrations; Grasshoppers; Mitomycin; Mitomyci | 1985 |
Beta-carotene as an inhibitor of benzo(a)pyrene and mitomycin C induced chromosomal breaks in the bone marrow of mice.
Topics: Animals; Antibiotics, Antineoplastic; beta Carotene; Bone Marrow; Bone Marrow Cells; Carotenoids; Ch | 1985 |
Spontaneous and mitomycin C induced structural chromosome aberrations in lymphocyte cultures from patients with adenomatosis of the colon and rectum.
Topics: Adenoma; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Cells, Cultured; Chromosome Aberratio | 1985 |