mitolactol and Lymphoma

mitolactol has been researched along with Lymphoma* in 2 studies

Other Studies

2 other study(ies) available for mitolactol and Lymphoma

Article	Year
The effect of dibromodulcitol on resting and dividing lymphoid cells. Chemico-biological interactions, 1976, Volume: 15, Issue:4 The effect of dibromodulcitol (DBD) on the incorporation of labelled precursors into DNA and RNA fractions of PHA-stimulated human lymphocytes and of P388F lymphoma cells at various stages of their growth was studied. Both cell systems showed sensitivity to the drug within the concentration rage of 1-10 mug/ml. When DBD was added before phytohaemagglutinin (PHA), h.han RNA. In contrast, by adding DBD after PHA, RNA labelling was much more inhibited than DNA. In the latter case, the decrease in DNA labelling occurred only 24 h after drug treatment whereas RNA labelling was decreased 1 h after treatment. Levels of DBD which normally produced 30% inhibition in plating efficiency of P388F lymphoma cells affected uridine-5-T incorporation to a different extent at different stages of growth of the culture. Enhanced RNA labelling occurred in early exponential stage while at later stages of growth, RNA synthesis was depressed. Topics: Adult; Cell Division; Cell Line; Humans; Idoxuridine; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Lymphoma; Male; Mitolactol; Transcription, Genetic	1976
[New cytostatics in oncological therapy]. Deutsche medizinische Wochenschrift (1946), 1974, Nov-29, Volume: 99, Issue:48 Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Chemical Phenomena; Chemistry; DNA Replication; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Lymphoma; Male; Mitolactol; Neoplasms; Nitrosourea Compounds; Testicular Neoplasms; Thyroid Neoplasms	1974

Article

Year

The effect of dibromodulcitol on resting and dividing lymphoid cells.

Chemico-biological interactions, 1976, Volume: 15, Issue:4

The effect of dibromodulcitol (DBD) on the incorporation of labelled precursors into DNA and RNA fractions of PHA-stimulated human lymphocytes and of P388F lymphoma cells at various stages of their growth was studied. Both cell systems showed sensitivity to the drug within the concentration rage of 1-10 mug/ml. When DBD was added before phytohaemagglutinin (PHA), h.han RNA. In contrast, by adding DBD after PHA, RNA labelling was much more inhibited than DNA. In the latter case, the decrease in DNA labelling occurred only 24 h after drug treatment whereas RNA labelling was decreased 1 h after treatment. Levels of DBD which normally produced 30% inhibition in plating efficiency of P388F lymphoma cells affected uridine-5-T incorporation to a different extent at different stages of growth of the culture. Enhanced RNA labelling occurred in early exponential stage while at later stages of growth, RNA synthesis was depressed.

Topics: Adult; Cell Division; Cell Line; Humans; Idoxuridine; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Lymphoma; Male; Mitolactol; Transcription, Genetic

1976

[New cytostatics in oncological therapy].

Deutsche medizinische Wochenschrift (1946), 1974, Nov-29, Volume: 99, Issue:48

Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Chemical Phenomena; Chemistry; DNA Replication; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Lymphoma; Male; Mitolactol; Neoplasms; Nitrosourea Compounds; Testicular Neoplasms; Thyroid Neoplasms

1974