mitolactol and Laryngeal-Diseases

Mitolactol (Dibromodulcitol "DBD"; RlobromolR) an alkylating agent was applied in a clinical series of twenty advanced or relapsing cases of malignant tumors of the orofacial region and the larynx. It was administered orally in a mean total dose of 127 mg/kg/30 days. In 45% of the patients the treatment resulted in a diminution of tumors by more than 50%, with remission lasting 1-4 months. 30% of the patients responded by a retreat of the tumor volume smaller than 50%, while no therapeutic effect was noted in 25% of the patients, or the objective finding proved to be worse. Subsequent radiotherapy improved the results, and remissions which followed combined chemo-radiotherapy were prolonged up to 9 months. The effect of DBD treatment proved better in orofacial than in laryngeal carcinoma.

Topics: Adult; Aged; Body Weight; Drug Evaluation; Facial Neoplasms; Female; Hemorrhage; Humans; Laryngeal Diseases; Laryngeal Neoplasms; Male; Middle Aged; Mitolactol; Mouth Neoplasms; Recurrence; Remission, Spontaneous