mitolactol and Cell-Transformation--Neoplastic

In a 18 years old, Ph1 negative woman a lymphoblastic lymphoma developed after 16 months of treatment for juvenile form of CGL. In the course of the disease we observed twice the myeloblastic transformation and once the low differentiated transformation of CGL. Based on available methods we are not in a position to exclude a particular form of lymphoblastic transformation of CGL involving lymph nodes without leukaemic blood picture.

Topics: Adolescent; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Cyclophosphamide; DNA Nucleotidylexotransferase; Doxorubicin; Female; Humans; Karyotyping; Leukemia, Myeloid; Lymph Nodes; Lymphoma, Non-Hodgkin; Mitolactol; Prednisone; Vincristine

In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and of Corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. This finding confirms the observation of others that major modification of the resistance to metastatic tumour formation can occur independently of classical immunological mechanisms. Special attention is drawn to the fact that cyclophosphamide enhances the formation of metastatic nodules in this model by factors of 100 to more than 1,000 whereas other cytostatic drugs including the cyclophosphamide congeners iphosphamide and trophosphamide are active only factors between 2 and 12. The possible practical significance of these findings is discussed.

Topics: Alkylating Agents; Animals; Antineoplastic Agents; Busulfan; Cell Transformation, Neoplastic; Globulins; Horses; Immunosuppression Therapy; Lung; Lung Neoplasms; Lymph Nodes; Male; Mice; Mice, Inbred Strains; Mitolactol; Neoplasm Metastasis; Neoplasm Transplantation; Nitrogen Mustard Compounds; Osteosarcoma; Propionibacterium acnes; Radiation Effects; Sarcoma, Experimental

Topics: Anemia; Azauridine; Blood Cell Count; Blood Platelets; Bone Marrow Examination; Busulfan; Cell Transformation, Neoplastic; Humans; Hydroxyurea; Karyotyping; Leukemia, Myeloid; Mitolactol; Nitrogen Mustard Compounds; Phenylalanine; Primary Myelofibrosis; Prognosis; Splenomegaly; Thrombocytosis