mitoguazone and Lymphoma--T-Cell--Peripheral

A patient with high fever, loss of weight and profound pancytopenia is reported. Peripheral T-cell lymphoma with hemophagocytosis was diagnosed. Bone marrow was the only localisation of the lymphoma. At presentation there were (i) a coagulopathy consistent with hemophagocytic histiocytosis (ii) the features of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). These different abnormalities disappeared after chemotherapy and reappeared during each of the 2 periods of disease progression. The patient died 6 months after diagnosis without ever achieving complete remission. As far as we are aware this is the first case report of T-cell lymphoma with hemophagocytic syndrome localised to the bone marrow and associated with SIADH.

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Diseases; Cisplatin; Cyclophosphamide; Cytarabine; Dexamethasone; Disease Progression; Doxorubicin; Fatal Outcome; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Ifosfamide; Inappropriate ADH Syndrome; Lymphoma, T-Cell, Peripheral; Methotrexate; Mitoguazone; Prednisone; Teniposide; Verapamil; Vincristine; Vindesine