mitoguazone and Hypoglycemia

The encapsulation efficiency and the leakage on storage of various types of liposomes prepared from different lipid compositions containing the anticancer drug methyl-GAG (methylglyoxal-bis-guanylhydrazone) were investigated. Treatment with methyl-GAG in a q.d. 1-4 schedule resulted in the murine leukemias P 388 and L 1210 (i.v.) in nearly the same increase in life span as the corresponding dose in liposomes. In a q.d. 1, 3 schedule methyl-GAG containing liposomes revealed comparable effects as the 4-day treatment with the free drug. The hypoglycemic effect of 80 mg/kg methyl-GAG, q.d. 1-4, could be normalized when the drug was administered in reverse-phase evaporation vesicles. We conclude that the liposomal encapsulation of methyl-GAG leads to a depot effect with a slight relief of toxicity.

Topics: Animals; Female; Hypoglycemia; Leukemia L1210; Leukemia P388; Liposomes; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitoguazone; Neoplasms, Experimental; Time Factors

Topics: Drug Evaluation; Humans; Hypoglycemia; Mitoguazone

Topics: Animals; Batrachoidiformes; Blood Glucose; Carbohydrate Metabolism; Fishes; Glucose; Glycosuria; Guanine Nucleotides; Hydrazines; Hyperglycemia; Hypoglycemia; Injections, Intravenous; Islets of Langerhans; Liver; Mitoguazone; Pharmacology; Pyruvaldehyde; Research; Toxicology