mitoguazone and Carcinoma--Hepatocellular

mitoguazone has been researched along with Carcinoma--Hepatocellular* in 1 studies

Other Studies

1 other study(ies) available for mitoguazone and Carcinoma--Hepatocellular

Article	Year
Induction of apoptotic cell death in human hepatocellular carcinoma SK-HEP-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone). Anti-cancer drugs, 1999, Volume: 10, Issue:3 The antitumor effects of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on the human hepatocellular carcinoma SK-HEP-1 cell line have been investigated. The growth of these cultured hepatocellular carcinoma cells was inhibited by MGBCP in a dose-dependent manner. Spermidine and spermine levels were dose-dependently depressed, and morphological changes due to programmed cell death (apoptosis) were observed in these MGBCP-treated hepatocellular carcinoma cells. These results suggest that in addition to reducing the growth rates, MGBCP can induce apoptotic cell death in this human hepatocellular carcinoma cell line. Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Mitoguazone; Polyamines; Tumor Cells, Cultured	1999

Article

Year

Induction of apoptotic cell death in human hepatocellular carcinoma SK-HEP-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone).

Anti-cancer drugs, 1999, Volume: 10, Issue:3

The antitumor effects of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on the human hepatocellular carcinoma SK-HEP-1 cell line have been investigated. The growth of these cultured hepatocellular carcinoma cells was inhibited by MGBCP in a dose-dependent manner. Spermidine and spermine levels were dose-dependently depressed, and morphological changes due to programmed cell death (apoptosis) were observed in these MGBCP-treated hepatocellular carcinoma cells. These results suggest that in addition to reducing the growth rates, MGBCP can induce apoptotic cell death in this human hepatocellular carcinoma cell line.

Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Mitoguazone; Polyamines; Tumor Cells, Cultured

1999