misoprostol and Vascular-Diseases

Fourteen patients with peripheral vascular disease received 200 microg of misoprostol 3 times a day during one month. The therapy with misoprostol caused clinical and biochemical improvement in all 14 patients. An elongation of pain free and maximum walking distance, shortening of pain duration and increase in arterial blood flow in both calves were observed. At the same time an activation of the fibrinolytic system, rise in the platelet aggregate ratio and increase in cAMP levels were noticed. It is suggested that misoprostol in human being caused rather activation of IP2 receptor.

Topics: Arteries; Calcium Channels; Cyclic AMP; Fibrinolytic Agents; Humans; Inositol 1,4,5-Trisphosphate Receptors; Leg; Misoprostol; Palliative Care; Platelet Aggregation Inhibitors; Receptors, Cytoplasmic and Nuclear; Regional Blood Flow; Vascular Diseases; Walking