misoprostol and Tachycardia--Paroxysmal

The purpose of this study was to compare the efficacy of 3 different techniques of cervical ripening and induction.. Patients who required cervical ripening and induction were randomized to one of 3 groups: (1) supracervical Foley catheter and intravaginal dinoprostone gel, (2) supracervical Foley catheter and 100 microg oral doses of misoprostol, or (3) serial 100-microg oral doses of misoprostol. Intravenous oxytocin was administered when a protraction disorder of labor was identified.. There were 339 women randomized. There was no significant difference in the time from first intervention to delivery in the 3 groups (P =.546). In each group, a similar percentage of women required oxytocin (P =.103). The rates of cesarean delivery were equivalent among the groups (P =.722). Rates of tachysystole were high but statistically equivalent among the 3 groups. There were no significant differences in Apgar scores or umbilical artery pH.. Oral 100 microg serial doses of misoprostol, with or without the use of a supracervical Foley catheter, were equivalent to the use of a supracervical Foley catheter and serial 4-mg doses of dinoprostone gel for cervical ripening and the induction of labor.

Topics: Adult; Catheterization; Cervical Ripening; Cesarean Section; Delivery, Obstetric; Dinoprostone; Female; Gels; Humans; Labor, Induced; Misoprostol; Oxytocics; Oxytocin; Pregnancy; Survival Analysis; Tachycardia, Paroxysmal; Time Factors