misoprostol has been researched along with Pain--Intractable* in 1 studies
1 trial(s) available for misoprostol and Pain--Intractable
Article | Year |
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Prostaglandin analog mechanisms are not effective in refractory chronic cluster headache.
Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 micrograms misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache. Topics: Adult; Chronic Disease; Cluster Headache; Cross-Over Studies; Double-Blind Method; Humans; Male; Middle Aged; Misoprostol; Pain, Intractable | 1998 |