misoprostol and Anaphylaxis

Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Sublingual; Adult; Anaphylaxis; Female; Humans; Misoprostol; Pregnancy; Shock

Topics: Anaphylaxis; Cervical Ripening; Cesarean Section; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Misoprostol; Nitric Oxide Donors; Oxytocics; Pregnancy; Pregnancy, Prolonged

Topics: Anaphylaxis; Cervical Ripening; Cesarean Section; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Misoprostol; Nitric Oxide Donors; Oxytocics; Pregnancy; Pregnancy, Prolonged

Misoprostol is a commonly used agent for induction of labor. Anaphylactic reactions are infrequent but possible complications of drugs administered to the pregnant patient. Although antibiotics, latex, and anesthetic agents are more common triggers for anaphylaxis, induction agents are also a rare cause.. A 21-year-old woman received buccal misoprostol as a ripening agent for postdate labor induction and experienced anaphylaxis and tachysystole. Prompt administration of epinephrine and emergent cesarean delivery allowed for the safe delivery of the neonate and minimal maternal morbidity.. When inducing labor, prompt identification and treatment of anaphylaxis and hypersensitivity reactions are necessary to prevent maternal and neonatal morbidity and mortality. Health care providers must be aware of uncommon reactions to medications used to induce labor.

Topics: Administration, Buccal; Anaphylaxis; Female; Humans; Labor, Induced; Misoprostol; Oxytocics; Pregnancy; Young Adult

Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adolescent; Anaphylaxis; Female; Humans; Misoprostol

Topics: Anaphylaxis; Anti-Asthmatic Agents; Aspirin; Bread; Cromolyn Sodium; Drug Therapy, Combination; Exercise; Food Hypersensitivity; Gliadin; Humans; Male; Middle Aged; Misoprostol

Exercise or aspirin intake enhances symptoms by increasing blood gliadin levels in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA). Misoprostol, a synthetic analogue of prostaglandin E1 (PGE1) compensates prostagrandins of which synthesis is inhibited by aspirin and protect the gastrointestinal mucosa. We projected to examine the effect of misoprostol in suppression the allergic symptom and elevation of blood gliadin levels in WDEIA induced by aspirin.. Two patients with a history of recurrent anaphylaxis associated with wheat ingestion accompanied with exercise, positive specific IgE and/or skin test were enrolled in the provocation test. On the provocation test of WDEIA, wheat ingestion, exercise, aspirin intake were combined on various ways. During the test, the patients' symptom and serum gliadins levels were monitored.. Although wheat with exercise did not induce any symptoms, addition of aspirin induced urticaria and elevation of blood gliadin levels in both cases. In case 1, premedication of misoprostol suppressed the urticaria and elevation of blood gliadin levels which were induced by exercise, wheat and aspirin intake. In case 2, premedication of misoprostol suppressed the urticaria and elevation of blood gliadin levels which were induced by wheat and aspirin intake.. These findings suggest that a synthetic analogue of PGE1 may suppresses the absorption of the allergen levels and outbreak the allergic symptom induced by aspirin in the patients with WDEIA.

Topics: Adult; Alprostadil; Anaphylaxis; Aspirin; Exercise; Female; Gliadin; Humans; Middle Aged; Misoprostol; Premedication; Wheat Hypersensitivity

Treatment with non-steroid anti-inflammatory drugs associated with a prostaglandin analogue is common, but the potential cardiovascular effects are largely unknown. The authors report a case of myocardial necrosis and anaphylactic shock due to treatment with diclofenac and misoprostol. The reintroduction of the treatment in hospital led to the recurrence of the initial cutaneous and cardiac symptoms in this patient.

Topics: Aged; Anaphylaxis; Anti-Ulcer Agents; Diclofenac; Humans; Male; Misoprostol; Myocardium; Necrosis

Topics: Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Combinations; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Misoprostol; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sulfones