misonidazole has been researched along with Neoplasms in 136 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 81 (59.56) | 18.7374 |
| 1990's | 16 (11.76) | 18.2507 |
| 2000's | 15 (11.03) | 29.6817 |
| 2010's | 23 (16.91) | 24.3611 |
| 2020's | 1 (0.74) | 2.80 |
| Authors | Studies |
|---|---|
| Cheeseman, C; Khlebnikov, V; Kumar, P; Liang, H; Shustov, G; Wiebe, LI; Yang, XH; Zheng, W | 1 |
| Angermeier, A; Della Manna, D; Larimer, BM; Li, Y; Reeves, KM; Song, PN; Sorace, AG; Wang, J; Yang, ES | 1 |
| Booth, CJ; Carlson, DJ; Carson, RE; Decker, RH; Huang, Y; Kelada, OJ; Liu, Y; Oelfke, U; Rockwell, S; Zheng, MQ | 1 |
| Grimes, DR; Warren, DR; Warren, S | 1 |
| Hirata, K; Nagara, T; Shiga, T; Toyonaga, T | 1 |
| Asgari, H; Sefidgar, M; Soltani, M | 1 |
| Fukuda, K; Hanaoka, K; Hosono, M; Inada, M; Ishikawa, K; Kanamori, S; Nakamatsu, K; Nishimura, Y; Tachibana, I; Tatebe, H | 1 |
| Hoskin, P; Tharmalingham, H | 1 |
| Shimizu, Y | 1 |
| Hosono, M; Ishikawa, K; Kanamori, S; Koike, R; Nakamatsu, K; Nishikawa, T; Nishimura, Y; Shibata, T; Tachibana, I; Tamura, M | 1 |
| Krohn, KA; Rajendran, JG | 1 |
| Bezak, E; Jennings, M; Marcu, LG | 1 |
| Fink, JR; Krohn, KA; Mankoff, DA; McLaughlin, LJ; Muzi, JP; Muzi, M; O'Sullivan, JN; Peterson, LM; Rajendran, JG | 1 |
| Higashino, K; Kuge, Y; Masaki, Y; Nishijima, K; Numata, Y; Sakamoto, S; Shimizu, Y; Tamaki, N; Tanaka, Y; Yamaguchi, Y; Yoshioka, T; Zhao, S | 1 |
| Yoshimoto, M | 1 |
| Shi, K; Vaupel, P; Ziegler, SI | 1 |
| Partridge, M; Warren, DR | 1 |
| Chen, Q; Deng, X; He, F; Huang, Y; Li, GC; Ling, CC; Liu, Y; Minami, A; Sun, X; Wen, B; Xing, L; Zanzonico, PB | 1 |
| Bal, M; Georgi, JC; Humm, JL; Lee, NY; Narayanan, M; Nehmeh, SA; O'Donoghue, J; Paulus, T; Schmidtlein, CR; Wang, W; Zanzonico, PB | 1 |
| Hu, M; Xie, P; Yu, JM | 1 |
| Bradley, D; Dalah, E; Nisbet, A | 1 |
| Ball, C; Bejot, R; Carroll, L; Elizarov, AM; Gouverneur, V; Hill, S; Kelly, C; Kersemans, V; King, RC; Kolb, HC; Miraghaie, R; Smart, S; Zhang, J | 1 |
| Haubner, R | 1 |
| Bentzen, L; Buus, S; Keiding, S; Mortensen, LS; Munk, OL; Nordsmark, M; Overgaard, J | 1 |
| Chitneni, SK; Dewhirst, MW; Palmer, GM; Zalutsky, MR | 1 |
| Barbet, J; Bourgeois, M; Cherel, M; Faivre-Chauvet, A; Guerard, F; Michel, N; Mougin-Degraef, M; Rajerison, H | 1 |
| Alber, M; Kaanders, JH; Mönnich, D; Oyen, WJ; Thorwarth, D; Troost, EG | 1 |
| Bergman, J; Eskola, O; Kulmala, J; Lehtiö, K; Minn, H; Oikonen, V; Tolvanen, T | 1 |
| Beck, R; Kumar, P; Machulla, HJ; McEwan, AJ; Picchio, M; Piert, M; Reischl, G; Schwaiger, M; Wester, HJ; Wiebe, LI; Ziegler, S | 1 |
| Burgman, P; Burnazi, E; Cai, S; Finn, RD; Humm, JL; Lewis, JS; Ling, CC; O'Donoghue, JA; Pugachev, A; Ruan, S; Smith-Jones, P; Welch, MJ; Wen, B; Zanzonico, P | 1 |
| Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, M; Troost, EG; van der Kogel, AJ | 1 |
| Blasberg, R; Humm, J; Ling, C; Serganova, I | 1 |
| Brady, M; Kelly, CJ | 1 |
| Kaanders, JH; Oyen, WJ; Schinagl, DA | 1 |
| Padhani, A | 1 |
| Chang, CW; Chen, CH; Chou, TK; Lin, WJ; Liu, RS; Wang, HE; Wang, SJ | 1 |
| Bergmann, R; Haase, C; Kampfrath, T; Mäding, P; Oswald, J; Pietzsch, J; Schwenzer, B; Treite, F | 1 |
| Lee, ST; Scott, AM | 1 |
| Ito, T; Nishimoto, S; Tanabe, K | 1 |
| Chu, F; Hilaris, BS; Kim, JH; Nori, D | 1 |
| Guichard, M; Malaise, EP | 1 |
| Coombs, A; Hanson, J; Moore, JL | 1 |
| Brown, JM | 3 |
| Adams, GE | 4 |
| Coleman, CN; Phillips, TL; Urtasun, RC; Wasserman, TH | 1 |
| Denekamp, J; Fowler, JF; Williams, MV | 1 |
| Phillips, TL | 1 |
| Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G | 1 |
| Chapman, JD | 2 |
| Onoyama, Y | 2 |
| Dische, S | 4 |
| Fowler, JF | 3 |
| Siemann, DW | 1 |
| Dar'ialova, SL; Kiseleva, ES | 1 |
| Brown, JM; White, RA; Workman, P | 1 |
| Fulton, DS; Raleigh, J; Tanasichuk, H; Urtasun, RC | 1 |
| Okajima, S; Okumura, Y | 1 |
| Abe, Y; Hong, SS; Kaneta, K; Matsuzawa, T | 1 |
| Abe, Y; Hong, SS; Isobe, Y; Kaneta, K; Kawaguchi, T; Matsuzawa, T; Umegaki, Y; Yamakawa, M | 1 |
| Abe, M; Dodo, Y; Ono, K; Takahashi, M | 1 |
| Abe, M; Hiraoka, M; Ono, K; Takahashi, M | 1 |
| Carter, SK; Coleman, CN; Friedman, MK; Gribble, M; Halsey, J; Hirst, VK; Ignoffo, R; Jacobs, C; Leibel, S; Phillips, TL | 1 |
| Franko, AJ; Sutherland, RM | 1 |
| Nakatsugawa, S; Sugahara, T | 1 |
| Phillips, TL; VanRaalte, G; Wasserman, TH | 1 |
| Gangji, D; Schwade, JG; Strong, JM | 1 |
| Gangji, D; Schwade, JG; Shoemaker, DD; Strong, JM; Upton, DK | 1 |
| Phillips, TL; Stetz, J; Wasserman, TH | 1 |
| Bennett, MH; Dische, S; Hauck, J; Minchinton, AI; Riley, PJ; Saunders, MI; Stratford, MR | 1 |
| Krishnan, D; Singh, DR | 1 |
| Ash, DV; Smith, MR | 1 |
| Brown, JM; Workman, P | 1 |
| White, RA; Workman, P | 1 |
| Denekamp, J; Fowler, JF; Joiner, MC; McNally, NJ | 1 |
| Cooper, JS; Waltzman, SB | 1 |
| Casciari, JJ; Graham, MM; Rasey, JS | 1 |
| Maxwell, RJ | 1 |
| Stratford, IJ; Workman, P | 1 |
| Cowan, DS; Hicks, KO; Wilson, WR | 1 |
| Cherif, A; Harrod, VL; Inoue, T; Kim, CG; Kim, EE; Kuang, LR; Newman, RA; Nornoo, A; Podoloff, DA; Wallace, S; Yang, DJ | 1 |
| Evans, ML; Graham, MM; Koh, WJ; Krohn, KA; Lewellen, TK; Peterson, LM; Rasey, JS | 1 |
| Cook, GJ; Fogelman, I | 1 |
| Avril, N; Schwaiger, M; Weber, WA | 1 |
| Karim, AB | 1 |
| Kärcher, KH; Kogelnik, HD; Seitz, W; Szepesi, T | 1 |
| Gomer, CJ; Johnson, RJ; Lawrence, GA; Levin, VA; Marques, RA; Phillips, TL; Sadee, W; VanRaalte, G; Wasserman, TH | 1 |
| Anderson, P; Dische, S; Flockhart, IR; Lee, ME; Saunders, MI | 1 |
| Kogelnik, HD; Mamoli, B; Müller, M; Rathkolb, O; Wessely, P | 1 |
| Bleehen, NM; Owen, LN; White, RA; Workman, P | 1 |
| Arnott, SJ | 1 |
| Bataini, JP; Bernier, J; Brugère, J; Brunin, F; de Narbonne, J; Jaulerry, C | 1 |
| Overgaard, J | 1 |
| Ash, DV; Bugden, RD; Smith, MR | 1 |
| Cheng, CC; Kimler, BF; Mansfield, CM; McDonald, T; Podrebarac, EG | 1 |
| Abdelaal, AS; Nias, AH | 1 |
| Bleehen, NM; Plowman, PN; Wiltshire, CR; Workman, P | 1 |
| Stratford, MR | 1 |
| Stratford, IJ | 1 |
| Evans, ML; Graham, MM; Grierson, JR; Griffin, TW; Koh, WJ; Krohn, KA; Lewellen, TK; Rasey, JS | 1 |
| Coppola, M; Vulpis, N | 1 |
| Gross, M; Hoeckel, M; Karbach, U; Mueller-Klieser, W; Schlenger, KH; Vaupel, P; Walenta, S | 1 |
| González González, D | 1 |
| Adams, GE; Bremner, JC; Edwards, HS; Fielden, EM; Stratford, IJ | 1 |
| Bonasera, TA; Dence, CS; Hwang, DR; Welch, MJ | 1 |
| Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Orchard, RA; Saunders, MI; Stratford, MR | 1 |
| Chapman, JD; Franko, AJ; Koch, CJ; Raleigh, JA; Urtasun, RC | 1 |
| Coleman, CN | 1 |
| Asakura, H | 1 |
| Mulcahy, RT; Trump, DL | 1 |
| Franko, AJ | 1 |
| Blekkenhorst, G; Cridland, S; Sealy, R | 1 |
| Wideröe, R | 1 |
| Mulcahy, RT | 1 |
| Sutherland, RM | 1 |
| Guichard, M; Lespinasse, F; Malaise, EP; Reynaud-Bougnoux, A | 1 |
| Sugahara, T | 1 |
| Durand, RE; Olive, PL; Rasey, JS | 1 |
| Guichard, M; Lespinasse, F; Malaise, EP | 1 |
| Nakajima, T; Onoyama, Y; Tanaka, M | 1 |
| Browning, S; Davila, E; Furner, RL; Gorowski, E; Johnson, R; Klein, L; Ostroy, F; Presant, CA; Vogel, CL | 1 |
| Gonzalez, DG; Maes, RA; Meering, PG; van Peperzeel, HA | 1 |
39 review(s) available for misonidazole and Neoplasms
| Article | Year |
|---|---|
Hypoxia imaging and radiotherapy: bridging the resolution gap.
Topics: Cell Hypoxia; Humans; Hypoxia; Misonidazole; Neoplasms; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiotherapy Dosage | 2017 |
Clinical trials targeting hypoxia.
Topics: Animals; Cell Hypoxia; Female; Humans; Male; Misonidazole; Neoplasms; Niacinamide; Oxygen Consumption; Radiation-Sensitizing Agents; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Treatment Outcome; Tumor Hypoxia | 2019 |
[Accumulation Mechanism of 2-Nitroimidazole-based Hypoxia Imaging Probes Revealed by Imaging Mass Spectrometry].
Topics: Animals; Glutathione; Glutathione Transferase; Humans; Hypoxia; Mass Spectrometry; Mice; Misonidazole; Molecular Imaging; Molecular Probes; Multidrug Resistance-Associated Proteins; Neoplasms; Nitroimidazoles; Positron-Emission Tomography | 2018 |
F-18 fluoromisonidazole for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy.
Topics: Animals; Cell Hypoxia; Humans; Misonidazole; Molecular Imaging; Neoplasms; Precision Medicine; Tumor Microenvironment | 2015 |
PET-specific parameters and radiotracers in theoretical tumour modelling.
Topics: Cell Proliferation; Coordination Complexes; Dideoxynucleosides; Diffusion; Fluorodeoxyglucose F18; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hydrogen-Ion Concentration; Hypoxia; Misonidazole; Models, Theoretical; Multimodal Imaging; Neoplasms; Neovascularization, Pathologic; Organometallic Compounds; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones; Tomography, X-Ray Computed | 2015 |
[Current Status and Prospects on PET Radiopharmaceuticals for Radiotherapy].
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Coordination Complexes; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones | 2015 |
[Advances in research on hypoxic imaging in cancer radiotherapy].
Topics: Cell Hypoxia; Humans; Misonidazole; Neoplasms; Positron-Emission Tomography; Radiography; Radiotherapy, Intensity-Modulated | 2009 |
PET radiopharmaceuticals in radiation treatment planning - synthesis and biological characteristics.
Topics: Amino Acids; Biological Transport; Cell Hypoxia; Fluorodeoxyglucose F18; Glucose; Humans; Lipid Metabolism; Misonidazole; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Planning, Computer-Assisted; Receptors, Somatostatin | 2010 |
Molecular imaging of hypoxia.
Topics: Humans; Hypoxia; Misonidazole; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Positron-Emission Tomography; Radiography; Radiopharmaceuticals | 2011 |
Contribution of [64Cu]-ATSM PET in molecular imaging of tumour hypoxia compared to classical [18F]-MISO--a selected review.
Topics: Cell Hypoxia; Coordination Complexes; Copper Radioisotopes; Humans; Misonidazole; Neoplasms; Organometallic Compounds; Positron-Emission Tomography; Radiation-Sensitizing Agents; Thiosemicarbazones | 2011 |
Tumor hypoxia imaging.
Topics: Biomarkers; Cell Hypoxia; Fluorodeoxyglucose F18; Humans; Misonidazole; Models, Biological; Neoplasm Metastasis; Neoplasms; Oxygen; Positron-Emission Tomography | 2006 |
PET imaging of tumour hypoxia.
Topics: Cell Hypoxia; Coordination Complexes; Humans; Magnetic Resonance Imaging; Misonidazole; Neoplasms; Organometallic Compounds; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones | 2006 |
Hypoxia positron emission tomography imaging with 18f-fluoromisonidazole.
Topics: Animals; Brain Ischemia; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Fluorine Radioisotopes; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Misonidazole; Myocardial Ischemia; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Stroke | 2007 |
[Molecular design of hypoxic tumor cell-targeting drugs and imaging probes].
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Drug Delivery Systems; Drug Design; Humans; Misonidazole; Molecular Probe Techniques; Molecular Probes; Neoplasms; Prodrugs; Radiation-Sensitizing Agents | 2007 |
[Recent data on biological and clinical properties of radiosensitizers (author's transl)].
Topics: Animals; Bleomycin; Carcinogens; Cell Cycle; Cell Survival; Female; Humans; In Vitro Techniques; Male; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitrobenzenes; Radiation-Sensitizing Agents | 1980 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Sensitizers and protectors in clinical oncology.
Topics: Alkylating Agents; Amifostine; Animals; Drug Synergism; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1981 |
[Modification of the radiation effects for overcoming radiation-resistant hypoxic tumor tissue].
Topics: Amifostine; Animals; Central Nervous System Diseases; Dogs; Humans; Hyperthermia, Induced; In Vitro Techniques; Intestines; Lymphocytes; Metronidazole; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nerve Tissue; Nitro Compounds; Oxygen; Radiation Dosage; Radiation-Protective Agents; Radiation-Sensitizing Agents; Rats | 1983 |
Review: total doses in fractionated radiotherapy--implications of new radiobiological data.
Topics: Animals; Combined Modality Therapy; DNA Repair; Dose-Response Relationship, Radiation; Humans; Kidney; Lung; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Skin | 1984 |
Modification of chemotherapy by nitroimidazoles.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; DNA Repair; Drug Synergism; Glutathione; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Metronidazole; Misonidazole; Mouth Neoplasms; Neoplasms; Radiation-Sensitizing Agents; Rectal Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms | 1984 |
[Cancer and radiotherapy. (4). Hypoxic cell sensitizers and hyperthermia combined with radiation in cancer treatment].
Topics: Acetophenones; Animals; Hot Temperature; Humans; Mice; Misonidazole; Neoplasms; Nitrofurans; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1982 |
On the nature of the radiobiologically hypoxic fraction in tumors.
Topics: Animals; Misonidazole; Neoplasms; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents | 1980 |
Hypoxia-mediated drugs for radiation and chemotherapy.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electrons; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage; Structure-Activity Relationship; Technology, Pharmaceutical | 1981 |
Radiation sensitization studies in Japan.
Topics: Animals; Cell Survival; Drug Evaluation; Half-Life; Humans; Japan; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1981 |
New techniques in the pharmacokinetic analysis of cancer drugs. III. Nuclear magnetic resonance.
Topics: Antineoplastic Agents; Fluorouracil; Folic Acid; Humans; Magnetic Resonance Spectroscopy; Misonidazole; Neoplasms | 1993 |
The experimental development of bioreductive drugs and their role in cancer therapy.
Topics: Animals; Antineoplastic Agents; Aziridines; Combined Modality Therapy; DNA Damage; Humans; Indolequinones; Indoles; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1993 |
Relevance of positron emission tomography (PET) in oncology.
Topics: Carbon Radioisotopes; Fluorides; Fluorodeoxyglucose F18; Humans; Lymphatic Metastasis; Magnetic Resonance Imaging; Methionine; Misonidazole; Neoplasm Staging; Neoplasms; Radioisotopes; Radiopharmaceuticals; Sensitivity and Specificity; Thymidine; Tomography, Emission-Computed; Tomography, X-Ray Computed | 1999 |
Hypoxic sensitizers--implications for radiation therapy.
Topics: Animals; Female; Glioblastoma; Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen Consumption; Radiation-Sensitizing Agents; Recurrence; Uterine Cervical Neoplasms | 1979 |
Advances in radiotherapy.
Topics: Fast Neutrons; Humans; Hyperbaric Oxygenation; Metronidazole; Misonidazole; Neoplasms; Neutrons; Particle Accelerators; Radiation-Sensitizing Agents; Radiotherapy | 1978 |
Pharmacokinetics and subcellular localization of radiosensitizers.
Topics: Etanidazole; Humans; Hydrogen-Ion Concentration; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Bioreductive drugs in cancer therapy.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1992 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
[Chemical modifiers of radiotherapy].
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Vidarabine | 1987 |
Misonidazole and other hypoxia markers: metabolism and applications.
Topics: Animals; Fluorescent Dyes; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Oxygen | 1986 |
Eighth annual Juan del Regato lecture. Chemical modifiers of radiosensitivity--theory and reality: a review.
Topics: Dose-Response Relationship, Radiation; Humans; Hyperbaric Oxygenation; Hypoxia; Misonidazole; Neoplasms; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Vasoconstriction | 1985 |
[Radiosensitization research in cancer therapy].
Topics: Animals; Antineoplastic Agents; Cells, Cultured; DNA Repair; Humans; Hyperthermia, Induced; Misonidazole; Neoplasms; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents | 1985 |
15 trial(s) available for misonidazole and Neoplasms
| Article | Year |
|---|---|
A prospective clinical trial of tumor hypoxia imaging with 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) before and during radiation therapy.
Topics: Adult; Aged; Aged, 80 and over; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Misonidazole; Molecular Imaging; Multimodal Imaging; Neoplasms; Positron-Emission Tomography; Prognosis; Prospective Studies; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2013 |
Radiosensitizers and protectors.
Topics: Amifostine; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen; Pyrimidines; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1984 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Dose-response relationships for human tumors: implications for clinical trials of dose modifying agents.
Topics: Animals; Clinical Trials as Topic; Dose-Response Relationship, Radiation; Etanidazole; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
[Clinical trials of hypoxic cell sensitizer misonidazole].
Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Random Allocation; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1983 |
Clinical trials with hypoxic cell sensitizers-the European experience.
Topics: Animals; Brain Neoplasms; Clinical Trials as Topic; Head and Neck Neoplasms; Humans; Methods; Misonidazole; Neoplasms; Nitroimidazoles; Urinary Bladder Neoplasms | 1983 |
Misonidazole with dexamethasone rescue: an escalating dose toxicity study.
Topics: Adolescent; Adult; Aged; Dexamethasone; Dose-Response Relationship, Drug; Humans; Middle Aged; Misonidazole; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
MRC randomized studied of misonidazole in combination with radiotherapy.
Topics: Clinical Trials as Topic; Humans; Misonidazole; Neoplasms; Nitroimidazoles | 1982 |
Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer.
Topics: Administration, Oral; Drug Administration Schedule; Drug Evaluation; Humans; Misonidazole; Nausea; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Sensation; Vomiting | 1979 |
Misonidazole-a drug for trial in radiotherapy and oncology.
Topics: Anorexia; Clinical Trials as Topic; Drug Eruptions; Female; Humans; Male; Misonidazole; Nausea; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Seizures | 1979 |
[Clinical testing of the radiosensitizer RO-07-0582 (misonidazole). Dose tolerance, toxicity and pharmacokinetic studies, preliminary report (author's transl)].
Topics: Bone Neoplasms; Clinical Trials as Topic; Glioma; Humans; Kinetics; Misonidazole; Neoplasms; Nitroimidazoles; Otorhinolaryngologic Diseases; Sarcoma | 1978 |
Hypoxic cell radiosensitizers.
Topics: Animals; Clinical Trials as Topic; Humans; Hyperbaric Oxygenation; Hypoxia; Metronidazole; Mice; Misonidazole; Neoplasms; Radiation-Sensitizing Agents | 1978 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
86 other study(ies) available for misonidazole and Neoplasms
| Article | Year |
|---|---|
Design, synthesis, and preliminary biological evaluation of 6-O-glucose-azomycin adducts for diagnosis and therapy of hypoxic tumors.
Topics: Cell Hypoxia; Cell Line, Tumor; Drug Design; Glucose Transport Proteins, Facilitative; Glucosides; Glycosides; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Radiopharmaceuticals; Transcriptional Activation | 2012 |
Topics: Cell Hypoxia; CTLA-4 Antigen; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Programmed Cell Death 1 Receptor; Tumor Microenvironment | 2022 |
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Humans; Kinetics; Male; Mice, Inbred BALB C; Misonidazole; Muscles; Neoplasms; Oxygen; Positron-Emission Tomography; Tomography, X-Ray Computed; Tumor Burden | 2017 |
Players of 'hypoxia orchestra' - what is the role of FMISO?
Topics: Humans; Misonidazole; Neoplasms; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Tumor Hypoxia | 2017 |
Modeling of FMISO [F
Topics: Blood Flow Velocity; Capillaries; Cell Hypoxia; Computer Simulation; Humans; Microcirculation; Misonidazole; Models, Cardiovascular; Nanoparticles; Neoplasms; Neovascularization, Pathologic; Numerical Analysis, Computer-Assisted; Oxygen; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Regional Blood Flow; Tumor Microenvironment | 2018 |
Tumor Hypoxia Detected by
Topics: Adult; Aged; Disease-Free Survival; Dose Fractionation, Radiation; Humans; Middle Aged; Misonidazole; Neoplasms; Positron Emission Tomography Computed Tomography; Prognosis; ROC Curve; Time Factors; Treatment Outcome; Tumor Hypoxia | 2018 |
18F-Fluoromisonidazole Quantification of Hypoxia in Human Cancer Patients Using Image-Derived Blood Surrogate Tissue Reference Regions.
Topics: Adult; Aged; Aged, 80 and over; Aorta; Brain Neoplasms; Cerebellum; Disease Progression; Female; Heart; Humans; Hypoxia; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Misonidazole; Neoplasms; Oxygen; Positron-Emission Tomography; Predictive Value of Tests; Proportional Hazards Models; Radiopharmaceuticals; Tissue Distribution; Treatment Outcome | 2015 |
The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites.
Topics: Animals; Diagnostic Imaging; Hypoxia; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Molecular Probes; Molecular Weight; Neoplasms; Radionuclide Imaging; Reproducibility of Results; Tandem Mass Spectrometry; Tissue Distribution | 2015 |
Molecular Imaging of Tumor Hypoxia: Existing Problems and Their Potential Model-Based Solutions.
Topics: Biomarkers, Tumor; Computer Simulation; Contrast Media; Diffusion; Humans; Microcirculation; Misonidazole; Models, Biological; Molecular Imaging; Neoplasms; Neovascularization, Pathologic; Oxygen; Phantoms, Imaging; Signal-To-Noise Ratio; Tumor Hypoxia; Tumor Microenvironment | 2016 |
The role of necrosis, acute hypoxia and chronic hypoxia in
Topics: Computer Simulation; Humans; Hypoxia; Misonidazole; Models, Theoretical; Necrosis; Neoplasms; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Spheroids, Cellular | 2016 |
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Topics: Animals; Antigens, Neoplasm; Arabinofuranosyluracil; Autoradiography; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; Gene Expression; Green Fluorescent Proteins; Herpesvirus 1, Human; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Immunohistochemistry; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous | 2008 |
Evaluation of a compartmental model for estimating tumor hypoxia via FMISO dynamic PET imaging.
Topics: Algorithms; Computer Simulation; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Misonidazole; Models, Biological; Neoplasms; Oxygen; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Simulation of tissue activity curves of (64)Cu-ATSM for sub-target volume delineation in radiotherapy.
Topics: Algorithms; Blood Vessels; Cell Hypoxia; Computer Simulation; Contrast Media; Coordination Complexes; Copper Radioisotopes; Diffusion; Humans; Misonidazole; Models, Biological; Neoplasms; Organometallic Compounds; Oxygen; Positron-Emission Tomography; Radiotherapy; Radiotherapy Planning, Computer-Assisted; Thiosemicarbazones | 2010 |
Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.
Topics: Animals; Biomarkers; Cell Hypoxia; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemical Phenomena; Drug Evaluation, Preclinical; Female; Glutathione; Kinetics; Mice; Misonidazole; Models, Biological; Neoplasms; Oxidation-Reduction; Positron-Emission Tomography; Propanols; Radioactive Tracers; Triazoles; Xanthine Oxidase | 2010 |
Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode.
Topics: Biosensing Techniques; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hypoxia; Microchemistry; Microelectrodes; Misonidazole; Neoplasms; Oxygen; Positron-Emission Tomography; Sarcoma; Soft Tissue Neoplasms | 2010 |
Modelling and simulation of the influence of acute and chronic hypoxia on [18F]fluoromisonidazole PET imaging.
Topics: Acute Disease; Chronic Disease; Computer Simulation; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Models, Biological; Neoplasms; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals | 2012 |
18F-Fluoroerythronitroimidazole radiation dosimetry in cancer studies.
Topics: Female; Fluorine Radioisotopes; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Radiation Dosage; Radiopharmaceuticals; Tomography, Emission-Computed | 2002 |
Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Female; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Organ Specificity; Oxidation-Reduction; Oxygen; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2005 |
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent mic
Topics: Animals; Autoradiography; Benzimidazoles; Cell Hypoxia; Coordination Complexes; Fluorodeoxyglucose F18; Humans; Immunohistochemistry; Male; Microscopy, Fluorescence; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Rats; Rats, Nude; Thiosemicarbazones; Transplantation, Heterologous | 2005 |
Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Fluorine Radioisotopes; Glioblastoma; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radionuclide Imaging | 2006 |
A model to simulate tumour oxygenation and dynamic [18F]-Fmiso PET data.
Topics: Cell Hypoxia; Computer Simulation; Humans; Image Interpretation, Computer-Assisted; Misonidazole; Models, Biological; Neoplasms; Neovascularization, Pathologic; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals | 2006 |
From anatomical to biological target volumes: the role of PET in radiation treatment planning.
Topics: Cell Hypoxia; Clinical Trials as Topic; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Misonidazole; Neoplasms; Observer Variation; Patient Care Planning; Positron-Emission Tomography; Radiation Tolerance; Radiopharmaceuticals; Radiotherapy; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed; Tumor Burden | 2006 |
A robotic synthesis of [18F]fluoromisonidazole ([18F]FMISO).
Topics: Fluorine Radioisotopes; Hypoxia; Misonidazole; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Robotics | 2007 |
Experimental hypoxia is a potent stimulus for radiotracer uptake in vitro: comparison of different tumor cells and primary endothelial cells.
Topics: Cell Hypoxia; Cell Line; Cell Line, Tumor; Cells, Cultured; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression; HT29 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Misonidazole; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A | 2007 |
Drug testing using a soft agar stem cell assay on patient and xenograft tumor material.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cisplatin; Colony-Forming Units Assay; Drug Synergism; Etoposide; Female; Granulosa Cell Tumor; Humans; Melphalan; Methotrexate; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms; Ovarian Neoplasms; Transplantation, Heterologous; Tumor Stem Cell Assay; Vinblastine | 1984 |
Clinical perspectives for the use of new hypoxic cell sensitizers.
Topics: Animals; Cyclophosphamide; Dogs; Drug Therapy, Combination; Etanidazole; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Solubility | 1982 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The detection and measurement of hypoxic cells in solid tumors.
Topics: Anaerobiosis; Animals; Brain Neoplasms; Carbon Radioisotopes; Cell Line; Cell Survival; Cricetinae; Cricetulus; Humans; Hypoxia; Lung; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Mice; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Rats; Tomography, Emission-Computed | 1984 |
The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.
Topics: Administration, Oral; Animals; Biological Availability; Dog Diseases; Dogs; Drug Evaluation, Preclinical; Etanidazole; Female; Injections, Intravenous; Kinetics; Male; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1980 |
Chemical modifiers of cancer treatment. Part 1. Banff, Canada, 27 November-1 December, 1983.
Topics: Animals; Combined Modality Therapy; Humans; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The effect of a hypoxic cell sensitizer on cancer radiotherapy: an analysis by a model.
Topics: Humans; Hypoxia; Mathematics; Misonidazole; Models, Theoretical; Neoplasms; Nitroimidazoles | 1984 |
Radiosensitizing drugs in relation to individualized treatment.
Topics: Alkylating Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Hypoxia; In Vitro Techniques; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sulfhydryl Reagents | 1984 |
Combined treatment of radiation and local injections of misonidazole.
Topics: Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
[Clinical studies of combined therapy of radiation and local injection of misonidazole].
Topics: Adult; Aged; Female; Humans; Injections; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiotherapy Dosage | 1983 |
[Clinical study on radiotherapy in combination with misonidazole].
Topics: Aged; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Pharyngeal Neoplasms; Radiation-Sensitizing Agents | 1983 |
Phase I trial of intravenous L-phenylalanine mustard plus the sensitizer misonidazole.
Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Melphalan; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1983 |
Evaluation of the bioavailability of misonidazole (NSC#261037) in capsule and tablet form and pharmacologic effects of daily dosage.
Topics: Adult; Biological Availability; Capsules; Drug Administration Schedule; Drug Evaluation; Half-Life; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Tablets | 1982 |
Sensitizers in radiotherapy.
Topics: Antineoplastic Agents; Elementary Particles; Hyperbaric Oxygenation; Hyperthermia, Induced; Misonidazole; Neoplasms; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1982 |
I.V. misonidazole (NSC 261037). Report of initial clinical experience.
Topics: Adult; Aged; Bile; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1981 |
Misonidazole dose and tumor level relationships. Effects of individual variation in rate of misonidazole metabolism and absorption from the gastrointestinal tract.
Topics: Biological Availability; Dose-Response Relationship, Drug; Half-Life; Humans; Intestinal Absorption; Kinetics; Misonidazole; Neoplasms; Nitroimidazoles | 1981 |
Clinical trials of misonidazole in the United States.
Topics: Drug Evaluation; Head and Neck Neoplasms; Humans; Misonidazole; Neoplasm Metastasis; Neoplasms; Nervous System Diseases; Nitroimidazoles | 1981 |
The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid.
Topics: Breast Neoplasms; Female; Humans; Misonidazole; Necrosis; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Uterine Cervical Neoplasms | 1981 |
Role of hypoxic sensitizers in radiotherapy.
Topics: Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen; Radiation-Sensitizing Agents | 1981 |
Radiosensitizers: rationale and potential.
Topics: Animals; Cell Survival; Female; Humans; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1981 |
Causes of apparent low levels of misonidazole in human tumours.
Topics: Adipose Tissue; Animals; Brain Neoplasms; Humans; In Vitro Techniques; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Misonidazole; Muscles; Neoplasms; Nitroimidazoles; Rats | 1980 |
Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Lipid Metabolism; Male; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Solubility; Time Factors | 1980 |
Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.
Topics: Animals; Biological Availability; Dog Diseases; Dogs; Half-Life; Kinetics; Male; Misonidazole; Neoplasms; Nitroimidazoles | 1980 |
Misonidazole in fractionated radiotherapy: are many small fractions best?
Topics: Animals; Cell Survival; Drug Administration Schedule; Female; Male; Misonidazole; Models, Biological; Neoplasms; Nitroimidazoles; Oxygen; Radiotherapy Dosage | 1980 |
Radiosensitisers.
Topics: Humans; Hyperbaric Oxygenation; Misonidazole; Neoplasms; Nervous System Diseases; Radiation-Sensitizing Agents | 1980 |
Nature and incidence of misonidazole-produced ototoxicity.
Topics: Adult; Aged; Female; Hearing Loss, Sensorineural; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1981 |
A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidazole PET time-activity data.
Topics: Animals; Biological Transport, Active; Biophysical Phenomena; Biophysics; Computer Simulation; Evaluation Studies as Topic; Humans; Hypoxia; Misonidazole; Models, Biological; Monte Carlo Method; Neoplasms; Radiation-Sensitizing Agents; Rats; Tomography, Emission-Computed | 1995 |
Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
Topics: Acridines; Animals; Cell Hypoxia; Cell Membrane; Cricetinae; Cricetulus; Diffusion; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Phenanthridines | 1996 |
Development of new markers for hypoxic cells: [131I]Iodomisonidazole and [131I]Iodoerythronitroimidazole.
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Female; Iodine Radioisotopes; Lung Neoplasms; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Cells, Cultured | 1996 |
Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Fluorine Radioisotopes; Humans; Lung Neoplasms; Male; Misonidazole; Neoplasms; Prostatic Neoplasms; Tomography, Emission-Computed | 1996 |
Tumor hypoxia: the role of nuclear medicine.
Topics: Animals; Cell Hypoxia; Fluorine Radioisotopes; Humans; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1998 |
Hypoxic-cell sensitisers.
Topics: Cell Survival; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen Consumption; Radiation Tolerance | 1978 |
Hypoxic-cell sensitisers.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Hypoxia; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles | 1978 |
[Clinical experiences with the radiation-sensitizing agent misonidazole].
Topics: Brain Neoplasms; Cardiovascular System; Central Nervous System; Digestive System; Drug Eruptions; Eye; Female; Humans; Liver; Male; Misonidazole; Neoplasms; Nitroimidazoles | 1978 |
Electroneurographic investigations of misonidazole polyneuropathy.
Topics: Action Potentials; Adult; Aged; Female; Humans; Male; Middle Aged; Misonidazole; Motor Neurons; Neoplasms; Nerve Fibers; Neural Conduction; Nitroimidazoles; Peripheral Nerves; Peripheral Nervous System Diseases; Peroneal Nerve; Sural Nerve; Time Factors | 1979 |
The penetration of misonidazole into spontaneous canine tumours.
Topics: Adenocarcinoma; Anesthesia, Intravenous; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Dog Diseases; Dogs; Female; Fibrosarcoma; Half-Life; Lymphoma, Non-Hodgkin; Male; Mammary Glands, Animal; Meningioma; Misonidazole; Neoplasms; Nitroimidazoles; Osteosarcoma; Pentobarbital | 1979 |
[New aspects of radiotherapy. I. Significance of hypoxia in irradiation of solid tumors].
Topics: Dose-Response Relationship, Radiation; Hot Temperature; Humans; Hyperbaric Oxygenation; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles | 1979 |
Distribution of misonidazole in human tumours and normal tissues.
Topics: Brain Neoplasms; Breast Neoplasms; Female; Genital Neoplasms, Female; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Thyroid Diseases; Tissue Distribution; Urinary Bladder Neoplasms | 1979 |
Development and testing of new hypoxic cell radiosensitizers.
Topics: Animals; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Fibroblasts; Lung; Metronidazole; Misonidazole; Neoplasms; Oxygen; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1979 |
Regression, recurrence and cure in an irradiated mouse tumour.
Topics: Animals; Dose-Response Relationship, Radiation; Female; Male; Mammary Neoplasms, Experimental; Mice; Misonidazole; Neoplasm Recurrence, Local; Neoplasms; Time Factors | 1979 |
Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
Topics: Adult; Aged; Bronchial Neoplasms; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Misonidazole; Neoplasm Metastasis; Neoplasms; Nitroimidazoles; Saliva; Skin Neoplasms | 1978 |
Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole.
Topics: Cell Hypoxia; Fluorine Radioisotopes; Humans; Misonidazole; Neoplasms; Tomography, Emission-Computed | 1992 |
Chromosome aberrations and radiosensitizers.
Topics: Chromosome Aberrations; Humans; In Vitro Techniques; Iothalamic Acid; Lymphocytes; Misonidazole; Neoplasms; Radiation-Sensitizing Agents | 1991 |
Pathophysiological approaches to identifying tumor hypoxia in patients.
Topics: Cell Hypoxia; Cold Temperature; Electrodes; Humans; Luminescent Measurements; Misonidazole; Needles; Neoplasms; Spectrophotometry | 1991 |
Hypoxia and local tumour control. Part 1.
Topics: Cell Hypoxia; Combined Modality Therapy; Humans; Misonidazole; Neoplasms | 1991 |
Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs.
Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Hypoxia and local tumour control. Part 2.
Topics: Cell Hypoxia; Combined Modality Therapy; Humans; Misonidazole; Neoplasms | 1991 |
No-carrier-added synthesis of 3-[18F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol. A potential PET agent for detecting hypoxic but viable tissues.
Topics: Fluorine Radioisotopes; Misonidazole; Neoplasms; Oxygen; Tomography, Emission-Computed | 1989 |
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.
Topics: Aged; Etanidazole; Female; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia.
Topics: Autoradiography; Carcinoma, Small Cell; Humans; Lung Neoplasms; Melanoma; Misonidazole; Neoplasms; Oxygen; Tritium | 1986 |
Clinical chemosensitization by misonidazole and related compounds: a critical evaluation.
Topics: Antineoplastic Agents; Humans; Misonidazole; Neoplasms; Radiation-Sensitizing Agents | 1988 |
Misonidazole levels following misonidazole and hyperbaric oxygen exposure.
Topics: Animals; Humans; Hyperbaric Oxygenation; Mice; Mice, Inbred CBA; Misonidazole; Neoplasms; Neoplasms, Experimental | 1987 |
Optimization of cancer radiotherapy with selective sensitizers.
Topics: Cells, Cultured; Chemical Phenomena; Chemistry; Combined Modality Therapy; Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen Consumption; Radiation Dosage; Radiation-Sensitizing Agents; Razoxane | 1987 |
Misonidazole-induced chemopotentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea toxicity in O6-methylguanine-DNA methyltransferase proficient (Mer+) and deficient (Mer-) cell lines.
Topics: Animals; Cell Line; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; HeLa Cells; Humans; Lomustine; Methyltransferases; Mice; Misonidazole; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase | 1986 |
Importance of critical metabolites and cellular interactions in the biology of microregions of tumors.
Topics: Adenocarcinoma; Animals; Cell Communication; Cell Cycle; Culture Techniques; Glucose; Humans; Intestinal Mucosa; Mammary Neoplasms, Experimental; Misonidazole; Neoplasms; Oxygen; Oxyhemoglobins; Rectal Neoplasms | 1986 |
Partial hypoxia as a cause of radioresistance in a human tumor xenograft: its influence illustrated by the sensitizing effect of misonidazole and hyperbaric oxygen.
Topics: Animals; Combined Modality Therapy; Humans; Hyperbaric Oxygenation; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous | 1986 |
Comparison between the binding of [3H]misonidazole and AF-2 in Chinese hamster V79 spheroids.
Topics: Animals; Cell Line; Cell Separation; Cricetinae; Cricetulus; Flow Cytometry; Furylfuramide; Misonidazole; Models, Biological; Neoplasms; Nitrofurans; Oxygen; Scintillation Counting | 1986 |
Influence of buthionine sulfoximine and misonidazole on glutathione level and radiosensitivity of human tumor xenografts.
Topics: Adenocarcinoma; Animals; Buthionine Sulfoximine; Cell Line; Colonic Neoplasms; Female; Glutathione; Humans; Melanoma; Methionine Sulfoximine; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Radiation Tolerance; Transplantation, Heterologous | 1986 |
[Radiation sensitizers: with special reference to hypoxic cell sensitizers].
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Humans; Misonidazole; Neoplasms; Oxygen; Partial Pressure; Radiation-Sensitizing Agents | 1986 |
Phase I trial of misonidazole (NSC#261037) plus cyclophosphamide in solid tumors.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Middle Aged; Misonidazole; Neoplasms | 1985 |
Kinetic aspects of misonidazole and its major metabolite in radiotherapy.
Topics: Adult; Aged; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1985 |
[Role of radiation biology in the standardization and optimization of radiotherapy].
Topics: Adolescent; Adult; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Misonidazole; Neoplasms; Radiation-Sensitizing Agents | 1985 |