mirtazapine has been researched along with Sleep Apnea, Obstructive in 6 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine is an a2A antagonist and mixed 5-HT2/5-HT3 antagonist that has been proposed as a potential treatment for obstructive sleep apnea (OSA)." | 2.73 | Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. ( Buchanan, PR; Crompton, R; Desai, AV; Gendreau, RM; Grunstein, RR; Kranzler, J; Marshall, NS; Melehan, KL; Rao, SG; Wong, KK; Yee, BJ; Zack, N, 2008) |
| "The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS)." | 2.61 | Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders. ( Aricò, I; Bonanni, E; Bonsignore, M; Caretto, M; Caruso, D; Di Perri, MC; Galletta, S; Lecca, RM; Lombardi, C; Maestri, M; Miccoli, M; Palagini, L; Provini, F; Puligheddu, M; Savarese, M; Silvestri, R; Simoncini, T; Spaggiari, MC, 2019) |
| "In an animal model of central apnea the use of mirtazapine produced a significant reduction of apneas." | 1.32 | Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS). ( Castillo, JL; Guilleminault, C; Menendez, P; Segovia, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silvestri, R | 1 |
| Aricò, I | 1 |
| Bonanni, E | 1 |
| Bonsignore, M | 1 |
| Caretto, M | 1 |
| Caruso, D | 1 |
| Di Perri, MC | 1 |
| Galletta, S | 1 |
| Lecca, RM | 1 |
| Lombardi, C | 1 |
| Maestri, M | 1 |
| Miccoli, M | 1 |
| Palagini, L | 1 |
| Provini, F | 1 |
| Puligheddu, M | 1 |
| Savarese, M | 1 |
| Spaggiari, MC | 1 |
| Simoncini, T | 1 |
| Marshall, NS | 1 |
| Yee, BJ | 1 |
| Desai, AV | 1 |
| Buchanan, PR | 1 |
| Wong, KK | 1 |
| Crompton, R | 1 |
| Melehan, KL | 1 |
| Zack, N | 2 |
| Rao, SG | 1 |
| Gendreau, RM | 1 |
| Kranzler, J | 2 |
| Grunstein, RR | 1 |
| Levendowski, DJ | 1 |
| Rao, S | 1 |
| Wong, K | 1 |
| Gendreau, M | 1 |
| Zavora, T | 1 |
| Westbrook, PR | 1 |
| Kohler, M | 1 |
| Bloch, KE | 1 |
| Stradling, JR | 1 |
| Castillo, JL | 1 |
| Menendez, P | 1 |
| Segovia, L | 1 |
| Guilleminault, C | 1 |
| Carley, DW | 1 |
| Olopade, C | 1 |
| Ruigt, GS | 1 |
| Radulovacki, M | 1 |
2 reviews available for mirtazapine and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders.
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Continuous Positive Airway Pressure; Depression | 2019 |
Pharmacological approaches to the treatment of obstructive sleep apnoea.
Topics: Animals; Cholinesterase Inhibitors; Humans; Mianserin; Mirtazapine; Protriptyline; Pulmonary Ventila | 2009 |
3 trials available for mirtazapine and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Histamine H1 Antagonists; Hu | 2008 |
Assessment of the test-retest reliability of laboratory polysomnography.
Topics: Adrenergic alpha-Antagonists; Adult; Body Mass Index; Continuous Positive Airway Pressure; Female; H | 2009 |
Efficacy of mirtazapine in obstructive sleep apnea syndrome.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; | 2007 |
1 other study available for mirtazapine and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS).
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Continuous Positive Airway Pressure; Disorders | 2004 |