mirtazapine has been researched along with Serotonin Syndrome in 24 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide." | 7.85 | Metoclopramide-induced Serotonin Syndrome. ( Harada, T; Hirosawa, T; Morinaga, K; Shimizu, T, 2017) |
| "To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine." | 7.72 | Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004) |
| "To document a case of serotonin syndrome associated with the combined use of fluvoxamine and mirtazapine, and to discuss the pharmacodynamic and pharmacokinetic interactions that were the likely causes of this potentially serious adverse drug reaction (ADR)." | 7.71 | Serotonin syndrome induced by fluvoxamine and mirtazapine. ( Demers, JC; Malone, M, 2001) |
| "To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction." | 7.71 | Severe serotonin syndrome induced by mirtazapine monotherapy. ( González-Macías, J; Hernández, JL; Infante, J; Ramos, FJ; Rebollo, M, 2002) |
| "Serotonin syndrome is a potentially life-threatening complication of serotonergic agents." | 6.52 | Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report. ( Ong, CT; Sung, SF; Tong, SH; Wu, CS, 2015) |
| "Serotonin syndrome is a rare neuropsychiatric complication caused by serotonergic drugs." | 5.56 | [Serotonin syndrome shortly after the administration of low-dose mirtazapine]. ( Boesen, MS; Lindelof, M; Sagar, M, 2020) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2) receptor antagonistic." | 5.36 | Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2010) |
| "A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide." | 3.85 | Metoclopramide-induced Serotonin Syndrome. ( Harada, T; Hirosawa, T; Morinaga, K; Shimizu, T, 2017) |
| "To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine." | 3.72 | Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004) |
| "To document a case of serotonin syndrome associated with the combined use of fluvoxamine and mirtazapine, and to discuss the pharmacodynamic and pharmacokinetic interactions that were the likely causes of this potentially serious adverse drug reaction (ADR)." | 3.71 | Serotonin syndrome induced by fluvoxamine and mirtazapine. ( Demers, JC; Malone, M, 2001) |
| "To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction." | 3.71 | Severe serotonin syndrome induced by mirtazapine monotherapy. ( González-Macías, J; Hernández, JL; Infante, J; Ramos, FJ; Rebollo, M, 2002) |
| "Serotonin syndrome is a potentially life-threatening complication of serotonergic agents." | 2.52 | Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report. ( Ong, CT; Sung, SF; Tong, SH; Wu, CS, 2015) |
| "Serotonin syndrome is a rare neuropsychiatric complication caused by serotonergic drugs." | 1.56 | [Serotonin syndrome shortly after the administration of low-dose mirtazapine]. ( Boesen, MS; Lindelof, M; Sagar, M, 2020) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2) receptor antagonistic." | 1.36 | Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2010) |
| "Serotonin syndrome is a potentially life-threatening condition that results from excessive serotonin agonism of the central and peripheral nervous system." | 1.35 | A case study of delayed serotonin syndrome: lessons learned. ( Ahned, N; Pearce, S; Varas, GM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Khalil, M | 1 |
| Sack, A | 1 |
| Elson, R | 1 |
| Pleat, J | 1 |
| Sagar, M | 1 |
| Lindelof, M | 1 |
| Boesen, MS | 1 |
| Harada, T | 1 |
| Hirosawa, T | 1 |
| Morinaga, K | 1 |
| Shimizu, T | 1 |
| Ansermot, N | 1 |
| Hodel, PF | 1 |
| Eap, CB | 1 |
| Wu, CS | 1 |
| Tong, SH | 1 |
| Ong, CT | 1 |
| Sung, SF | 1 |
| Schuch, LG | 1 |
| Yip, A | 1 |
| Nouri, KF | 1 |
| Gregersen, M | 1 |
| Cason, B | 1 |
| Kukreja, J | 1 |
| Wozniak, C | 1 |
| Brzezinski, M | 1 |
| Pearce, S | 1 |
| Ahned, N | 1 |
| Varas, GM | 1 |
| Freijo Guerrero, J | 1 |
| Tardón Ruiz de Gauna, L | 1 |
| Gómez, JJ | 1 |
| Aguilera Celorrio, L | 1 |
| Butler, MC | 1 |
| Di Battista, M | 1 |
| Warden, M | 1 |
| Gillman, PK | 1 |
| Shioda, K | 1 |
| Nisijima, K | 1 |
| Yoshino, T | 1 |
| Kato, S | 1 |
| Steele, D | 1 |
| Keltner, NL | 1 |
| McGuiness, TM | 1 |
| Decoutere, L | 1 |
| De Winter, S | 1 |
| Vander Weyden, L | 1 |
| Spriet, I | 1 |
| Schrooten, M | 1 |
| Tournoy, J | 1 |
| Fagard, K | 1 |
| Dimellis, D | 1 |
| Aga, VM | 1 |
| Barklage, NE | 1 |
| Jefferson, JW | 1 |
| Houlihan, DJ | 1 |
| Norman, TR | 1 |
| Freeman, WD | 1 |
| Chabolla, DR | 1 |
| Benazzi, F | 1 |
| Birkenhäger, TK | 1 |
| Moleman, P | 1 |
| Demers, JC | 1 |
| Malone, M | 1 |
| Isbister, GK | 1 |
| Dawson, AH | 1 |
| Whyte, IM | 1 |
| Hernández, JL | 1 |
| Ramos, FJ | 1 |
| Infante, J | 1 |
| Rebollo, M | 1 |
| González-Macías, J | 1 |
| Duggal, HS | 1 |
| Fetchko, J | 1 |
2 reviews available for mirtazapine and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report.
Topics: Acute Disease; Acute Kidney Injury; Adult; Benzodiazepines; Humans; Male; Mianserin; Mirtazapine; Ol | 2015 |
[Two new antidepressants: mirtazapine and venlafaxine].
Topics: Adrenergic alpha-Antagonists; Benzamides; Cyclohexanols; Depressive Disorder; Drug Interactions; Fem | 1999 |
22 other studies available for mirtazapine and Serotonin Syndrome
| Article | Year |
|---|---|
A 5-year single-centre retrospective study of potential drug interactions in burns inpatients with psychiatric comorbidities.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Arrhythmias, Cardiac; Burns; Comorbidity; Drug Int | 2020 |
[Serotonin syndrome shortly after the administration of low-dose mirtazapine].
Topics: Aged; Female; Humans; Mianserin; Mirtazapine; Serotonin Syndrome | 2020 |
Metoclopramide-induced Serotonin Syndrome.
Topics: Adult; Antiemetics; Bipolar Disorder; Drug Interactions; Female; Humans; Metoclopramide; Mianserin; | 2017 |
Serotonin toxicity after addition of mirtazapine to escitalopram.
Topics: Adult; Antidepressive Agents; Citalopram; Drug Therapy, Combination; Female; Humans; Mianserin; Mirt | 2014 |
Serotonin Syndrome Following an Uncomplicated Orthopedic Surgery in a Patient With Post-Traumatic Stress Disorder.
Topics: Adult; Citalopram; Diskectomy; Drug-Related Side Effects and Adverse Reactions; Humans; Low Back Pai | 2016 |
A case study of delayed serotonin syndrome: lessons learned.
Topics: Adrenergic alpha-Antagonists; Aged; Assisted Living Facilities; Drug Interactions; Female; Humans; M | 2009 |
[Serotonin syndrome after administration of mirtazapine in a critical care unit].
Topics: Aged; Antidepressive Agents, Tricyclic; Critical Care; Humans; Intensive Care Units; Male; Mianserin | 2009 |
Sertraline-induced serotonin syndrome followed by mirtazapine reaction.
Topics: Adult; Antidepressive Agents; Cyproheptadine; Depressive Disorder, Major; Humans; Male; Mianserin; M | 2010 |
Bupropion, bayesian logic and serotonin toxicity.
Topics: Animals; Bupropion; Dopamine Uptake Inhibitors; Humans; Mianserin; Mirtazapine; Serotonin; Serotonin | 2010 |
Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome.
Topics: Animals; Body Temperature; Disease Models, Animal; Fever; Male; Mianserin; Mirtazapine; Rats; Rats, | 2010 |
Are neuroleptic malignant syndrome and serotonin syndrome the same syndrome?
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Dibenzothiazepines; Drug Therapy, Combinatio | 2011 |
A venlafaxine and mirtazapine-induced serotonin syndrome confirmed by de- and re-challenge.
Topics: Aged, 80 and over; Cyclohexanols; Drug Therapy, Combination; Female; Humans; Mianserin; Mirtazapine; | 2012 |
Serotonin syndrome produced by a combination of venlafaxine and mirtazapine.
Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents, Tricyclic; Cyclohexanols; Drug Therapy, C | 2002 |
Linezolid, a monoamine oxidase inhibiting antibiotic, and antidepressants.
Topics: Acetamides; Aged; Anti-Infective Agents; Comorbidity; Depressive Disorder; Drug Interactions; Humans | 2003 |
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine.
Topics: Analgesics, Opioid; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Humans; Male; Mianser | 2004 |
Mechanism of action of mirtazapine: dual action or dual effect?
Topics: Antidepressive Agents, Tricyclic; Depression; Humans; Mianserin; Mirtazapine; Serotonin; Serotonin S | 2004 |
36-Year-old woman with loss of consciousness, fever, and tachycardia.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Back Pain; Depression; Diagnosis, Diffe | 2005 |
Serotonin syndrome with mirtazapine-fluoxetine combination.
Topics: Adrenergic alpha-Antagonists; Aged; Antidepressive Agents, Tricyclic; Depression; Drug Interactions; | 1998 |
Serotonin syndrome induced by fluvoxamine and mirtazapine.
Topics: Adrenergic alpha-Antagonists; Adult; Adverse Drug Reaction Reporting Systems; Anorexia Nervosa; Drug | 2001 |
Comment: serotonin syndrome induced by fluvoxamine and mirtazapine.
Topics: Drug Interactions; Fluvoxamine; Histamine H1 Antagonists; Humans; Mianserin; Mirtazapine; Selective | 2001 |
Severe serotonin syndrome induced by mirtazapine monotherapy.
Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Humans; Male; Mianserin; Mirtazapine; Serotonin | 2002 |
Serotonin syndrome and atypical antipsychotics.
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Depressive Disorder, Major; | 2002 |