mirtazapine has been researched along with Rett Syndrome in 3 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 5.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 1.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Flores Gutiérrez, J | 2 |
| Natali, G | 2 |
| Giorgi, J | 1 |
| De Leonibus, E | 1 |
| Tongiorgi, E | 3 |
| De Felice, C | 1 |
| Leoncini, S | 1 |
| Signorini, C | 1 |
| Hayek, J | 1 |
| Bittolo, T | 1 |
| Raminelli, CA | 1 |
| Deiana, C | 1 |
| Baj, G | 1 |
| Vaghi, V | 1 |
| Ferrazzo, S | 1 |
| Bernareggi, A | 1 |
1 trial available for mirtazapine and Rett Syndrome
| Article | Year |
|---|---|
Protective role of mirtazapine in adult female Mecp2
Topics: Animals; Disease Models, Animal; Female; Humans; Methyl-CpG-Binding Protein 2; Mice; Mirtazapine; Re | 2020 |
2 other studies available for mirtazapine and Rett Syndrome
| Article | Year |
|---|---|
Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes.
Topics: Adolescent; Adult; Animals; Antidepressive Agents; Body Weight; Disease Models, Animal; Female; Huma | 2022 |
Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.
Topics: Animals; Antidepressive Agents; Atrophy; Breath Tests; Cerebral Cortex; Desipramine; GABAergic Neuro | 2016 |