mirtazapine has been researched along with Restless Legs Syndrome in 11 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Restless Legs Syndrome: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine is known to often provoke restless legs syndrome (RLS)." | 7.74 | Factors potentiating the risk of mirtazapine-associated restless legs syndrome. ( Kim, JM; Kim, SW; Park, KH; Shin, IS; Yoon, JS; Youn, T, 2008) |
| "Mirtazapine is known to often provoke restless legs syndrome (RLS)." | 3.74 | Factors potentiating the risk of mirtazapine-associated restless legs syndrome. ( Kim, JM; Kim, SW; Park, KH; Shin, IS; Yoon, JS; Youn, T, 2008) |
| "The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS)." | 2.61 | Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders. ( Aricò, I; Bonanni, E; Bonsignore, M; Caretto, M; Caruso, D; Di Perri, MC; Galletta, S; Lecca, RM; Lombardi, C; Maestri, M; Miccoli, M; Palagini, L; Provini, F; Puligheddu, M; Savarese, M; Silvestri, R; Simoncini, T; Spaggiari, MC, 2019) |
| "Mirtazapine is a Food and Drug Administration-approved atypical antidepressant used off-label for insomnia." | 1.91 | A 9-year-old female with iron deficiency has severe periodic limb movements while taking mirtazapine for insomnia. ( Hawkins, M, 2023) |
| " In 9% of patients, RLS was recorded as a side effect related to the administration of AD." | 1.35 | Restless legs syndrome as side effect of second generation antidepressants. ( Gallwitz, T; Kirch, MH; Messer, T; Rottach, KG; Schaner, BM; Teufel, LM; Zivotofsky, AZ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Hawkins, M | 1 |
| Silvestri, R | 1 |
| Aricò, I | 1 |
| Bonanni, E | 1 |
| Bonsignore, M | 1 |
| Caretto, M | 1 |
| Caruso, D | 1 |
| Di Perri, MC | 1 |
| Galletta, S | 1 |
| Lecca, RM | 1 |
| Lombardi, C | 1 |
| Maestri, M | 1 |
| Miccoli, M | 1 |
| Palagini, L | 1 |
| Provini, F | 1 |
| Puligheddu, M | 1 |
| Savarese, M | 1 |
| Spaggiari, MC | 1 |
| Simoncini, T | 1 |
| Makiguchi, A | 1 |
| Nishida, M | 1 |
| Shioda, K | 1 |
| Suda, S | 1 |
| Nisijima, K | 1 |
| Kato, S | 1 |
| Kim, SW | 1 |
| Shin, IS | 1 |
| Kim, JM | 1 |
| Park, KH | 1 |
| Youn, T | 1 |
| Yoon, JS | 1 |
| Ağargün, MY | 1 |
| Kara, H | 1 |
| Ozbek, H | 1 |
| Tombul, T | 1 |
| Ozer, OA | 1 |
| Teive, HA | 1 |
| de Quadros, A | 1 |
| Barros, FC | 1 |
| Werneck, LC | 1 |
| Pae, CU | 2 |
| Kim, TS | 1 |
| Kim, JJ | 1 |
| Chae, JH | 2 |
| Lee, CU | 1 |
| Lee, SJ | 1 |
| Paik, IH | 1 |
| Lee, C | 1 |
| Chang, CC | 1 |
| Shiah, IS | 1 |
| Chang, HA | 1 |
| Mao, WC | 1 |
| Prospero-Garcia, KA | 1 |
| Torres-Ruiz, A | 1 |
| Ramirez-Bermudez, J | 1 |
| Velazquez-Moctezuma, J | 1 |
| Arana-Lechuga, Y | 1 |
| Teran-Perez, G | 1 |
| Rottach, KG | 1 |
| Schaner, BM | 1 |
| Kirch, MH | 1 |
| Zivotofsky, AZ | 1 |
| Teufel, LM | 1 |
| Gallwitz, T | 1 |
| Messer, T | 1 |
| Bahk, WM | 1 |
| Jun, TY | 1 |
| Kim, KS | 1 |
1 review available for mirtazapine and Restless Legs Syndrome
| Article | Year |
|---|---|
Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders.
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Continuous Positive Airway Pressure; Depression | 2019 |
1 trial available for mirtazapine and Restless Legs Syndrome
| Article | Year |
|---|---|
Fluoxetine-mirtazapine interaction may induce restless legs syndrome: report of 3 cases from a clinical trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Drug Interactions; Drug Therapy, Combinati | 2006 |
9 other studies available for mirtazapine and Restless Legs Syndrome
| Article | Year |
|---|---|
A 9-year-old female with iron deficiency has severe periodic limb movements while taking mirtazapine for insomnia.
Topics: Adult; Child; Female; Humans; Iron; Iron Deficiencies; Mirtazapine; Nocturnal Myoclonus Syndrome; Re | 2023 |
Mirtazapine-induced restless legs syndrome treated with pramipexole.
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Antiparkinson Agents; Benzothiazoles; Female; H | 2015 |
Factors potentiating the risk of mirtazapine-associated restless legs syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidepressive Agents, Tricycl | 2008 |
Restless legs syndrome induced by mirtazapine.
Topics: Antidepressive Agents; Depressive Disorder, Major; Humans; Male; Mianserin; Middle Aged; Mirtazapine | 2002 |
[Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report].
Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Female; Genes, Dominant; Humans; Mianserin; Mirt | 2002 |
Re-administration of mirtazapine could overcome previous mirtazapine- associated restless legs syndrome?
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Female; Humans; Mianserin; Middle Aged | 2004 |
Does domperidone potentiate mirtazapine-associated restless legs syndrome?
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Domperidone; Dopamine Antagonis | 2006 |
Restless legs syndrome as side effect of second generation antidepressants.
Topics: Acute Disease; Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Depressive Disorder, M | 2008 |
Mirtazapine may have the propensity for developing a restless legs syndrome? A case report.
Topics: Depressive Disorder; Electroencephalography; Female; Histamine H1 Antagonists; Humans; Mianserin; Mi | 2002 |