Page last updated: 2024-10-31

mirtazapine and Psychoses

mirtazapine has been researched along with Psychoses in 23 studies

Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Research Excerpts

ExcerptRelevanceReference
"To assess the efficacy of mirtazapine as an adjunctive treatment of negative symptoms in patients with chronic schizophrenia via meta-analysis."8.91Meta-Analysis of Efficacy of Mirtazapine as an Adjunctive Treatment of Negative Symptoms in Schizophrenia. ( Chiapelli, J; Fischer, BA; Himelhoch, S; Reese, C; Vidal, C, 2015)
" Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioural therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg/day for 6 months."7.96Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol. ( Amminger, GP; Berger, M; Li, E, 2020)
"To our knowledge, this is the second reported case of Status epilepticus that has been associated with the use of olanzapine, while only one report of seizures, but none of Status epilepticus connected to mirtazapine is found in the literature."7.75Status epilepticus in a patient treated with olanzapine and mirtazapine. ( Iacovides, A; Kaprinis, G; Nimatoudis, J; Sokolaki, S; Spyridi, S, 2009)
"Mirtazapine is an antidepressant with a mechanism that involves activating serotonin (5-HT1) receptors."6.47Mirtazapine relieves post-electroconvulsive therapy headaches and nausea: a case series and review of the literature. ( Huang, KC; Lee, WK; Li, TC; Shiah, IS; Sun, CJ; Tzang, RF, 2011)
"To assess the efficacy of mirtazapine as an adjunctive treatment of negative symptoms in patients with chronic schizophrenia via meta-analysis."4.91Meta-Analysis of Efficacy of Mirtazapine as an Adjunctive Treatment of Negative Symptoms in Schizophrenia. ( Chiapelli, J; Fischer, BA; Himelhoch, S; Reese, C; Vidal, C, 2015)
" The most often off-label prescribed drugs were quetiapine and mirtazapine for organic mental disorders (F0/G3), valproate and quetiapine in patients with disorders due to psychoactive substance use (F1), valproate in patients with psychotic disorders (F2), and risperidone and olanzapine in patients with affective disorders (F3)."4.12Off-label use of antidepressants, antipsychotics, and mood-stabilizers in psychiatry. ( Hefner, G; Klimke, A; Reißner, P; Toto, S; Wolff, J, 2022)
" Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioural therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg/day for 6 months."3.96Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol. ( Amminger, GP; Berger, M; Li, E, 2020)
" He had an ischemic stroke and developed a psychotic condition that was successfully treated by lowering the cabergoline and administering quetiapine and mirtazapine together."3.91Giant cabergoline-resistant prolactinoma in a man who presented with a psychotic episode during treatment: a case report. ( Casulari, LA; de Castro, LF; de Fátima Magalhães Gonzaga, M; Kessler, IM; Mendonça, JL, 2019)
"A 40-year old woman with a history of acute psychotic symptoms developed agranulocytosis and neutropenia after starting therapy that included lamotrigine, mirtazapine, quetiapine, and venlafaxine."3.78Fatal agranulocytosis associated with psychotropic medication use. ( Al-Najjar, T; Ali, BA; Nazer, LH; Shankar, G, 2012)
"To our knowledge, this is the second reported case of Status epilepticus that has been associated with the use of olanzapine, while only one report of seizures, but none of Status epilepticus connected to mirtazapine is found in the literature."3.75Status epilepticus in a patient treated with olanzapine and mirtazapine. ( Iacovides, A; Kaprinis, G; Nimatoudis, J; Sokolaki, S; Spyridi, S, 2009)
" Adding risperidone to mirtazapine probably does not necessitate a change of the dosage of either drug, but more extensive investigations are needed."2.69Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study. ( Doorschot, CH; Loonen, AJ; Oostelbos, MC; Sitsen, JM, 1999)
"Mirtazapine is an antidepressant with a mechanism that involves activating serotonin (5-HT1) receptors."2.47Mirtazapine relieves post-electroconvulsive therapy headaches and nausea: a case series and review of the literature. ( Huang, KC; Lee, WK; Li, TC; Shiah, IS; Sun, CJ; Tzang, RF, 2011)
"However, diagnosis of schizoaffective disorder is included both in DSM-IV-TR and ICD-10."2.41[Schizoaffective disorder: clinical symptoms and present-day approach to treatment]. ( Danileviciūte, V, 2002)
"Mirtazapine is a presynaptic alpha-2 antagonist that has dual action by increasing noradrenergic and serotonergic neurotransmission."2.40Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression. ( Barkin, RL; Fawcett, J, 1998)
"The widespread prevalence of coronavirus disease 2019 (COVID-19) means that inpatient psychiatric units will necessarily manage patients who have COVID-19 that is comorbid with acute psychiatric symptoms."1.62Suspected Recurrence of Symptomatic COVID-19: Management During Inpatient Psychiatric Treatment. ( Frankle, WG; Lequesne, E; Rohs, A; Zhang, E, 2021)
"Haloperidol was discontinued, but mirtazapine was continued, and the vivid dream activity persisted; however, reality testing when awake was intact."1.36Acute psychosis associated with dissociated sleep-wakefulness state after mirtazapine treatment. ( Felthous, AR; Hoevet, R; Wenger, PJ, 2010)
"Priapism is a "persistent erection not accompanied by sexual desire or stimulation, usually lasting more than six hours and typically involving only the corpora cavernosa."1.33Priapism and quetiapine: a case report. ( Dilley, JW; Harrison, G; Loeb, L; Nelson, K, 2006)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (13.04)18.2507
2000's8 (34.78)29.6817
2010's7 (30.43)24.3611
2020's5 (21.74)2.80

Authors

AuthorsStudies
Hefner, G1
Wolff, J1
Toto, S1
Reißner, P1
Klimke, A1
Berger, M1
Li, E1
Amminger, GP1
Haddad, PM1
Al Abdulla, M1
Latoo, J1
Iqbal, Y1
Sasao, A1
Yonemitsu, K1
Ohtsu, Y1
Tsutsumi, H1
Furukawa, S1
Kimura-Mishima, S1
Nishitani, Y1
Zhang, E1
Lequesne, E1
Rohs, A1
Frankle, WG1
Casulari, LA1
de Castro, LF1
Kessler, IM1
Mendonça, JL1
de Fátima Magalhães Gonzaga, M1
Vidal, C1
Reese, C1
Fischer, BA1
Chiapelli, J1
Himelhoch, S1
Tagai, K1
Nagata, T1
Shinagawa, S1
Tsuno, N1
Ozone, M1
Nakayama, K1
Godschalx-Dekker, JA1
Siegers, HP1
Spyridi, S1
Sokolaki, S1
Nimatoudis, J1
Iacovides, A1
Kaprinis, G1
Felthous, AR1
Wenger, PJ1
Hoevet, R1
Li, TC1
Shiah, IS1
Sun, CJ1
Tzang, RF1
Huang, KC1
Lee, WK1
Nazer, LH1
Shankar, G1
Ali, BA1
Al-Najjar, T1
Danileviciūte, V1
Klein, JP1
Fiedler, U1
Appel, H1
Quante, A1
Jockers-Scherübl, MC1
Harrison, G1
Dilley, JW1
Loeb, L1
Nelson, K1
Mutschler, J1
Czell, D1
Kaps, M1
Manzl, G1
Fawcett, J1
Barkin, RL1
Birkenhäger, TK1
Moleman, P2
Loonen, AJ1
Doorschot, CH1
Oostelbos, MC1
Sitsen, JM1
Moustgaard, G1
Poyurovsky, M1
Weizman, A1
Bruijn, JA1
Mulder, PG1
van den Broek, WW1

Reviews

5 reviews available for mirtazapine and Psychoses

ArticleYear
Meta-Analysis of Efficacy of Mirtazapine as an Adjunctive Treatment of Negative Symptoms in Schizophrenia.
    Clinical schizophrenia & related psychoses, 2015,Summer, Volume: 9, Issue:2

    Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Drug Therapy, Combination; Humans; Mianserin

2015
Mirtazapine relieves post-electroconvulsive therapy headaches and nausea: a case series and review of the literature.
    The journal of ECT, 2011, Volume: 27, Issue:2

    Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Electroconvulsive Therapy; Fema

2011
[Schizoaffective disorder: clinical symptoms and present-day approach to treatment].
    Medicina (Kaunas, Lithuania), 2002, Volume: 38, Issue:11

    Topics: Adolescent; Amisulpride; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antimanic

2002
Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression.
    Journal of affective disorders, 1998, Volume: 51, Issue:3

    Topics: Administration, Oral; Adult; Age Factors; Aged; Antidepressive Agents, Second-Generation; Clinical T

1998
[Two new antidepressants: mirtazapine and venlafaxine].
    Nederlands tijdschrift voor geneeskunde, 1999, May-01, Volume: 143, Issue:18

    Topics: Adrenergic alpha-Antagonists; Benzamides; Cyclohexanols; Depressive Disorder; Drug Interactions; Fem

1999

Trials

1 trial available for mirtazapine and Psychoses

ArticleYear
Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 10, Issue:1

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Depression; Depressive Disorder

1999

Other Studies

17 other studies available for mirtazapine and Psychoses

ArticleYear
Off-label use of antidepressants, antipsychotics, and mood-stabilizers in psychiatry.
    Journal of neural transmission (Vienna, Austria : 1996), 2022, Volume: 129, Issue:11

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Female; Humans; Male; Mental Disorders

2022
Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol.
    BMJ case reports, 2020, Oct-07, Volume: 13, Issue:10

    Topics: Adult; Cannabidiol; Cognitive Behavioral Therapy; Depressive Disorder, Major; Depressive Disorder, T

2020
Brief psychotic disorder associated with quarantine and mild COVID-19.
    BMJ case reports, 2020, Dec-16, Volume: 13, Issue:12

    Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety Disorders; COVID-19; Humans; Lorazepam; Ma

2020
High blood mirtazapine concentration in a newborn - A case of suspected postpartum infanticide.
    Legal medicine (Tokyo, Japan), 2021, Volume: 48

    Topics: Adult; Chromatography, Liquid; Depression, Postpartum; Female; Forensic Medicine; Homicide; Humans;

2021
Suspected Recurrence of Symptomatic COVID-19: Management During Inpatient Psychiatric Treatment.
    Journal of psychiatric practice, 2021, Mar-05, Volume: 27, Issue:2

    Topics: Adult; Alcoholism; Antidepressive Agents; Antipsychotic Agents; Clozapine; COVID-19; COVID-19 Nuclei

2021
Giant cabergoline-resistant prolactinoma in a man who presented with a psychotic episode during treatment: a case report.
    Journal of medical case reports, 2019, Jun-16, Volume: 13, Issue:1

    Topics: Cabergoline; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans;

2019
Mirtazapine improves visual hallucinations in Parkinson's disease: a case report.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2013, Volume: 13, Issue:2

    Topics: Aged, 80 and over; Antidepressive Agents; Antiparkinson Agents; Antipsychotic Agents; Female; Halluc

2013
Reduction of parkinsonism and psychosis with mirtazapine: a case report.
    Pharmacopsychiatry, 2014, Volume: 47, Issue:3

    Topics: Aged; Histamine H1 Antagonists; Humans; Male; Mianserin; Mirtazapine; Parkinsonian Disorders; Psycho

2014
Status epilepticus in a patient treated with olanzapine and mirtazapine.
    International journal of clinical pharmacology and therapeutics, 2009, Volume: 47, Issue:2

    Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Drug Interactions; Female;

2009
Acute psychosis associated with dissociated sleep-wakefulness state after mirtazapine treatment.
    Pharmacotherapy, 2010, Volume: 30, Issue:4

    Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Depressive Disorder, Major; Dreams; Ha

2010
Fatal agranulocytosis associated with psychotropic medication use.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2012, May-15, Volume: 69, Issue:10

    Topics: Adult; Agranulocytosis; Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Ag

2012
Massive creatine kinase elevations with quetiapine: report of two cases.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Creatine Kinase; Depressive Disorder,

2006
Priapism and quetiapine: a case report.
    Psychopharmacology bulletin, 2006, Volume: 39, Issue:1

    Topics: Amphetamine; Amphetamine-Related Disorders; Antipsychotic Agents; Comorbidity; Depressive Disorder;

2006
[Psychotic symptoms in a case of locked-in syndrome].
    Der Nervenarzt, 2006, Volume: 77, Issue:12

    Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Brain Stem; Cerebral Hemorrhage; Delusions;

2006
Treatment-refractory depression successfully treated with the combination of mirtazapine and lithium.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:2

    Topics: Antidepressive Agents, Tricyclic; Antimanic Agents; Depressive Disorder, Major; Drug Therapy, Combin

2000
Mirtazapine for neuroleptic-induced akathisia.
    The American journal of psychiatry, 2001, Volume: 158, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Haloperidol; Hum

2001
Treatment of mood-congruent psychotic depression with imipramine.
    Journal of affective disorders, 2001, Volume: 66, Issue:2-3

    Topics: Adolescent; Adult; Affect; Aged; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Im

2001