mirtazapine has been researched along with Neuroleptic Malignant Syndrome in 3 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 64-year-old man, diagnosed with recurrent depression, developed a neuroleptic malignant syndrome (nms) during treatment with olanzapine and mirtazapine." | 3.80 | [Electroconvulsion therapy for neuroleptic malignant syndrome]. ( Buggenhout, S; Sienaert, P; Vandenberghe, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ağaç, T | 1 |
| Gökçay, H | 1 |
| Solmaz, M | 1 |
| Buggenhout, S | 1 |
| Vandenberghe, J | 1 |
| Sienaert, P | 1 |
| Steele, D | 1 |
| Keltner, NL | 1 |
| McGuiness, TM | 1 |
3 other studies available for mirtazapine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
ATYPICAL NEUROLEPTIC MALIGNANT SYNDROME ASSOCIATED WITH MIRTAZAPINE USE.
Topics: Antipsychotic Agents; Humans; Mirtazapine; Neuroleptic Malignant Syndrome | 2023 |
[Electroconvulsion therapy for neuroleptic malignant syndrome].
Topics: Antipsychotic Agents; Benzodiazepines; Depressive Disorder; Electroconvulsive Therapy; Humans; Male; | 2014 |
Are neuroleptic malignant syndrome and serotonin syndrome the same syndrome?
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Dibenzothiazepines; Drug Therapy, Combinatio | 2011 |